Effects of selective COX-2 inhibition on allergen-induced bronchoconstriction and airway inflammation in asthma - Daham, Kameran; James, Anna; Balgoma, David; Kupczyk, Maciej; Billing, Bo; Lindeberg, Agneta; Henriksson, Elisabeth; FitzGerald, Garret A.; Wheelock, Craig E.; Dahlén, Sven-Erik; Dahlén, Barbro (Journal of allergy and clinical immunology, 2014)
Keywords: Adult; airway hyperresponsiveness; Airway management; Allergens - administration & dosage; Allergy and Immunology; Asthma; Asthma - drug therapy; Asthma - enzymology; Asthma - immunology; Asthma - pathology; Biosynthesis; Bronchial Provocation Tests; Bronchoconstriction - drug effects; Bronchoconstriction - immunology; COX; Cross-Over Studies; Cyclooxygenase 1 - metabolism; Cyclooxygenase 2 - metabolism; Cyclooxygenase 2 Inhibitors - therapeutic use; Drug dosages; Drug therapy; eicosanoids; Eosinophils - immunology; Eosinophils - pathology; Female; Forced Expiratory Volume; Humans; Inflammation - drug therapy; Inflammation - enzymology; Inflammation - immunology; Inflammation - pathology; leukotrienes; Male; mass spectrometry; Methacholine Chloride - administration & dosage; Middle Aged; Nitric oxide; Nitric Oxide - biosynthesis; Nonsteroidal anti-inflammatory drugs; NSAIDs; prostaglandin; Prostaglandins - urine; Pyridines - therapeutic use; Respiratory diseases; Sputum - cytology; Sulfones - therapeutic use; thromboxane; urinary metabolites; thromboxane; PGD2; airway hyperresponsiveness; Feno; PGE2; prostaglandin; PGI2; PGF1α; COX; leukotrienes; Asthma; urinary metabolites; PGE; eicosanoids; TXA2; TXB2; NSAIDs; mass spectrometry; TXA 2; PGE 2; Fractional exhaled nitric oxide; PGI 2; TXB 2; Nonsteroidal anti-inflammatory drugs; Prostaglandin E; Thromboxane B 2; Thromboxane A 2; F eno; Prostaglandin F 1α; PGD 2; Prostaglandin I 2; Prostaglandin D 2; Prostaglandin E 2; PGF 1α