Longitudinal weight differences, gene expression and blood biomarkers in BMI-discordant identical twins

• Published in: International Journal of Obesity Vol. 39; no. 6; pp. 899 - 909
• Main Authors: van Dongen, J, Willemsen, G, Heijmans, B T, Neuteboom, J, Kluft, C, Jansen, R, Penninx, B W J, Slagboom, P E, de Geus, E J C, Boomsma, D I
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2015; Nature Publishing Group
• Subjects: 38; 38/39; 38/61; 631/208; 631/208/199; 692/53; 692/699/2743/393; 692/700/139/2818; Adipose tissue; Adiposity - genetics; Adolescent; Adolescents; Adult; Age; Alanine; Alanine transaminase; Aspartate aminotransferase; Biobanks; Biological markers; Biomarkers; Biomarkers - blood; Birth weight; Blood; Body Mass Index; Body size; C-reactive protein; C-Reactive Protein - metabolism; Child development; Correlation analysis; Diabetes; Discordance; Epidemiology; Exercise; Female; Fibrinogen; Fibrinogen - metabolism; Gene Expression; Gene regulation; Genetic aspects; Health aspects; Health Promotion and Disease Prevention; Humans; Inflammation; Insulin; Insulin - blood; Interleukin 6; Interleukin 6 receptors; Internal Medicine; Life Style; Lipids; Lipids - blood; Longitudinal Studies; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolism; Netherlands - epidemiology; Obesity; original-article; Overweight; Peripheral blood; Public Health; Receptors, Interleukin-6 - blood; Tumor Necrosis Factor-alpha - blood; Tumor necrosis factor-α; Twins; Twins, Monozygotic; Netherlands

Background: Body mass index (BMI) discordant monozygotic (MZ) twins allow an examination of the causes and consequences of adiposity in a genetically controlled design. Few studies have examined longitudinal BMI discordance in MZ pairs. Objectives: The aim of this work was to study the development o...