Comparative metabolism as a key driver of wildlife species sensitivity to human and veterinary pharmaceuticals

• Published in: Philosophical transactions of the Royal Society of London. Series B. Biological sciences Vol. 369; no. 1656; p. 20130583
• Main Authors: Hutchinson, Thomas H., Madden, Judith C., Naidoo, Vinny, Walker, Colin H.
• Format: Journal Article
• Language: English
• Published: England The Royal Society 19.11.2014
• Subjects: Animals; Animals, Wild - metabolism; Birds; Environment; Environmental Pollutants - pharmacokinetics; Environmental Pollutants - toxicity; Exposure; Fish; Humans; Invertebrates; Medicines; Review; Species Specificity; Veterinary Drugs - pharmacokinetics; Veterinary Drugs - toxicity; environment; medicines; exposure; birds; invertebrates; fish

Human and veterinary drug development addresses absorption, distribution, metabolism, elimination and toxicology (ADMET) of the Active Pharmaceutical Ingredient (API) in the target species. Metabolism is an important factor in controlling circulating plasma and target tissue API concentrations and i...