Silicon Nanowire Biosensor for Highly Sensitive and Multiplexed Detection of Oral Squamous Cell Carcinoma Biomarkers in Saliva

• Published in: Analytical Sciences Vol. 31; no. 2; pp. 73 - 78
• Main Authors: ZHANG, Yulin, CHEN, Rongmei, XU, Lu, NING, Yong, XIE, Shenggao, ZHANG, Guo-Jun
• Format: Journal Article
• Language: English
• Published: Singapore The Japan Society for Analytical Chemistry 2015; Springer Nature Singapore; Japan Science and Technology Agency
• Subjects: Analytical Chemistry; Animals; biomarker; Biomarkers; Biomarkers, Tumor - analysis; Biosensing Techniques - instrumentation; Biosensing Techniques - methods; Biosensors; Buffers; Carcinoma, Squamous Cell - diagnosis; Chemistry; detection; Early Detection of Cancer; field effect transistor; Field effect transistors; Humans; Interleukin-8 - analysis; Mouth Neoplasms - diagnosis; Multiplexing; Nanowires; Nanowires - chemistry; Original Papers; Saliva; Saliva - chemistry; Semiconductor devices; Silicon; Silicon - chemistry; Silicon nanowire; Transistors, Electronic; Tumor Necrosis Factor-alpha - analysis; saliva; detection; biosensors; field effect transistor; biomarker; Silicon nanowire

Silicon nanowire (SiNW) field-effect transistor (FET) biosensors have already been used as powerful sensors for the direct detection of disease-related biomarkers. However, the multiplexed detection of biomarkers in real samples is still challenging. Interleukin 8 (IL-8) and tumor necrosis factor α...