Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways - Tang, Chen-Yi; Wu, Mengrui; Zhao, Dongfeng; Edwards, Diep; McVicar, Abigail; Luo, Yuan; Zhu, Guochun; Wang, Yongjun; Zhou, Hou-De; Chen, Wei; Li, Yi-Ping (PLoS genetics, 2021)
Keywords: Activating Transcription Factor 4 - genetics; Adipocytes - metabolism; Adipogenesis - genetics; Animals; Biology and Life Sciences; Bone Morphogenetic Protein 7 - genetics; Bone Morphogenetic Protein Receptors, Type I - genetics; Bone morphogenetic proteins; Bones; Cellular signal transduction; Collagen Type I - genetics; Core Binding Factor Alpha 1 Subunit - genetics; Core Binding Factor Alpha 2 Subunit - genetics; DNA-Binding Proteins - genetics; Gene Expression Regulation, Developmental - genetics; Genetic aspects; Genetic regulation; Growth; Homeostasis; Homeostasis - genetics; Humans; Medicine and Health Sciences; Mesenchymal Stem Cells; Mice; Mice, Knockout; Osteoblasts - metabolism; Osteogenesis - genetics; Osteoporosis - genetics; Osteoporosis - pathology; Physiological aspects; Promoter Regions, Genetic - genetics; Repressor Proteins - genetics; RNA-Seq; Smad1 Protein - genetics; Twist-Related Protein 1 - genetics; Wnt proteins; Wnt Signaling Pathway - genetics; United States