A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes

• Published in: Nature medicine Vol. 25; no. 5; pp. 805 - 813
• Main Authors: Niewczas, Monika A., Pavkov, Meda E., Skupien, Jan, Smiles, Adam, Md Dom, Zaipul I., Wilson, Jonathan M., Park, Jihwan, Nair, Viji, Schlafly, Andrew, Saulnier, Pierre-Jean, Satake, Eiichiro, Simeone, Christopher A., Shah, Hetal, Qiu, Chengxiang, Looker, Helen C., Fiorina, Paolo, Ware, Carl F., Sun, Jennifer K., Doria, Alessandro, Kretzler, Matthias, Susztak, Katalin, Duffin, Kevin L., Nelson, Robert G., Krolewski, Andrzej S.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.05.2019; Nature Publishing Group
• Subjects: 692/163/2743/137; 692/308/174; 692/308/53; 692/308/575; 692/699/1585; Adult; Aged; Biological markers; Biomarkers; Biomarkers - blood; Biomedical and Life Sciences; Biomedicine; Blood Proteins - genetics; Blood Proteins - metabolism; Cancer Research; Chronic kidney failure; Cohort Studies; Complications and side effects; Cytokine receptors; Development and progression; Diabetes; Diabetes mellitus; Diabetes mellitus (insulin dependent); Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - genetics; Diabetic Nephropathies - blood; Diabetic Nephropathies - etiology; Diabetic Nephropathies - genetics; Diabetics; Disease Progression; End-stage renal disease; Female; Health aspects; Humans; Infectious Diseases; Inflammation; Inflammation Mediators - blood; Kidney diseases; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - etiology; Kidney Failure, Chronic - genetics; Kidneys; Male; Medical schools; Metabolic Diseases; Middle Aged; Molecular Medicine; Necrosis; Neurosciences; Prognosis; Prospective Studies; Proteins; Proteomics; Receptors, Tumor Necrosis Factor - blood; Receptors, Tumor Necrosis Factor - genetics; Risk; Risk Factors; Therapeutic applications; Tumor necrosis factor; Tumors; Type 2 diabetes

Chronic inflammation is postulated to be involved in the development of end-stage renal disease in diabetes, but which specific circulating inflammatory proteins contribute to this risk remain unknown. To study this, we examined 194 circulating inflammatory proteins in subjects from three independen...