Characterization of H7N9 influenza A viruses isolated from humans

• Published in: Nature (London) Vol. 501; no. 7468; pp. 551 - 555
• Main Authors: Watanabe, Tokiko, Kiso, Maki, Fukuyama, Satoshi, Nakajima, Noriko, Imai, Masaki, Yamada, Shinya, Murakami, Shin, Yamayoshi, Seiya, Iwatsuki-Horimoto, Kiyoko, Sakoda, Yoshihiro, Takashita, Emi, McBride, Ryan, Noda, Takeshi, Hatta, Masato, Imai, Hirotaka, Zhao, Dongming, Kishida, Noriko, Shirakura, Masayuki, de Vries, Robert P., Shichinohe, Shintaro, Okamatsu, Masatoshi, Tamura, Tomokazu, Tomita, Yuriko, Fujimoto, Naomi, Goto, Kazue, Katsura, Hiroaki, Kawakami, Eiryo, Ishikawa, Izumi, Watanabe, Shinji, Ito, Mutsumi, Sakai-Tagawa, Yuko, Sugita, Yukihiko, Uraki, Ryuta, Yamaji, Reina, Eisfeld, Amie J., Zhong, Gongxun, Fan, Shufang, Ping, Jihui, Maher, Eileen A., Hanson, Anthony, Uchida, Yuko, Saito, Takehiko, Ozawa, Makoto, Neumann, Gabriele, Kida, Hiroshi, Odagiri, Takato, Paulson, James C., Hasegawa, Hideki, Tashiro, Masato, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.09.2013; Nature Publishing Group
• Subjects: 631/326/596/1578; Analysis; Animals; Antiviral Agents - pharmacology; Avian influenza viruses; Cells, Cultured; Chickens - virology; Comparative analysis; DNA-Directed RNA Polymerases - antagonists & inhibitors; Dogs; Enzyme Inhibitors - pharmacology; Female; Ferrets - virology; Genetic aspects; Humanities and Social Sciences; Humans; Identification and classification; Influenza A virus - chemistry; Influenza A virus - drug effects; Influenza A virus - isolation & purification; Influenza A virus - pathogenicity; Influenza A Virus, H1N1 Subtype - drug effects; Influenza A Virus, H1N1 Subtype - enzymology; Influenza viruses; Influenza, Human - drug therapy; Influenza, Human - virology; letter; Macaca fascicularis - virology; Madin Darby Canine Kidney Cells; Male; Mice; Mice, Inbred BALB C; Models, Molecular; Monkey Diseases - pathology; Monkey Diseases - virology; multidisciplinary; Neuraminidase - antagonists & inhibitors; Neuraminidase inhibitors; Orthomyxoviridae Infections - pathology; Orthomyxoviridae Infections - transmission; Orthomyxoviridae Infections - virology; Pathology; Patient outcomes; Physiological aspects; Quail - virology; Science; Swine - virology; Swine, Miniature - virology; Virus Replication - drug effects; Zoonoses; Japan; China

Here, biological attributes of two early human isolates of the newly emerged H7N9 influenza viruses are characterized: the potential of these viruses to infect and/or transmit within various animal models is discussed, as is their relative sensitivity to neuraminidase inhibitors and experimental pol...