Search for New Bioactive Marine Natural Products and Application to Drug Development

Natural products are well recognized as an important source of lead compounds in drug development. During the past >30 years, we have discovered >1000 novel bioactive natural products from Okinawan marine organisms (sponges, tunicates, cone shells, etc.) and microorganisms (fungi, bacteria, di...

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Published inChemical & pharmaceutical bulletin Vol. 64; no. 8; pp. 1079 - 1083
Main Author Kobayashi, Jun’ichi
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 2016
Pharmaceutical Society of Japan
Japan Science and Technology Agency
Subjects
Animal Shells - chemistry
Animals
Bacteria - chemistry
bioactive natural product
Biological Products - chemistry
dinoflagellate
Dinoflagellida - chemistry
Drug Discovery
Fungi - chemistry
marine bacteria
marine sponge
marine-derived fungi
Porifera
tunicate
Urochordata
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Summary:Natural products are well recognized as an important source of lead compounds in drug development. During the past >30 years, we have discovered >1000 novel bioactive natural products from Okinawan marine organisms (sponges, tunicates, cone shells, etc.) and microorganisms (fungi, bacteria, dinoflagellates, etc.). Some of them are used as bioprobes useful for basic studies of life sciences, while others are expected to be candidates of drug leads.
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ISSN:0009-2363
1347-5223
1347-5223
DOI:10.1248/cpb.c16-00281