Search for New Bioactive Marine Natural Products and Application to Drug Development
Natural products are well recognized as an important source of lead compounds in drug development. During the past >30 years, we have discovered >1000 novel bioactive natural products from Okinawan marine organisms (sponges, tunicates, cone shells, etc.) and microorganisms (fungi, bacteria, di...
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| Published in | Chemical & pharmaceutical bulletin Vol. 64; no. 8; pp. 1079 - 1083 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Japan
The Pharmaceutical Society of Japan
2016
Pharmaceutical Society of Japan Japan Science and Technology Agency |
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| Abstract | Natural products are well recognized as an important source of lead compounds in drug development. During the past >30 years, we have discovered >1000 novel bioactive natural products from Okinawan marine organisms (sponges, tunicates, cone shells, etc.) and microorganisms (fungi, bacteria, dinoflagellates, etc.). Some of them are used as bioprobes useful for basic studies of life sciences, while others are expected to be candidates of drug leads. |
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| AbstractList | Natural products are well recognized as an important source of lead compounds in drug development. During the past >30 years, we have discovered >1000 novel bioactive natural products from Okinawan marine organisms (sponges, tunicates, cone shells, etc.) and microorganisms (fungi, bacteria, dinoflagellates, etc.). Some of them are used as bioprobes useful for basic studies of life sciences, while others are expected to be candidates of drug leads. Natural products are well recognized as an important source of lead compounds in drug development. During the past >30 years, we have discovered >1000 novel bioactive natural products from Okinawan marine organisms (sponges, tunicates, cone shells, etc.) and microorganisms (fungi, bacteria, dinoflagellates, etc.). Some of them are used as bioprobes useful for basic studies of life sciences, while others are expected to be candidates of drug leads.Natural products are well recognized as an important source of lead compounds in drug development. During the past >30 years, we have discovered >1000 novel bioactive natural products from Okinawan marine organisms (sponges, tunicates, cone shells, etc.) and microorganisms (fungi, bacteria, dinoflagellates, etc.). Some of them are used as bioprobes useful for basic studies of life sciences, while others are expected to be candidates of drug leads. |
| Author | Kobayashi, Jun’ichi |
| Author_xml | – sequence: 1 fullname: Kobayashi, Jun’ichi organization: Graduate School of Pharmaceutical Sciences, Hokkaido University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27477644$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1007/BF01940735 10.1021/jo00017a044 10.1016/j.bmc.2005.09.033 10.1016/j.chembiol.2004.07.014 10.1021/jo00034a052 10.1016/S0040-4020(00)00838-3 10.1016/j.bmc.2007.02.043 10.1021/jo00041a053 10.1021/ja00317a079 10.1271/bbb.50644 10.1021/jo00261a040 10.1016/S0040-4039(00)74889-1 10.1021/jo9715377 10.1007/BF01971110 10.1016/0040-4020(95)00661-Q 10.1007/BF01960260 10.1016/S0040-4039(02)02869-1 10.1021/ol3034274 10.1021/ol802251q 10.1248/bpb.b14-00548 10.1021/ol4009975 10.1021/ol006223b 10.1016/j.tet.2009.01.032 10.1021/jo00045a048 10.1021/ja00020a081 10.1021/ja00245a031 10.1021/jo970206r 10.1016/S0021-5198(19)57776-9 10.1016/S0040-4020(99)00984-9 10.1038/nature12959 10.1038/ja.2008.39 10.1021/ol501664b |
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| References | 13) Kobayashi J., Madono T., Shigemori H., Tetrahedron, 51, 10867–10874 (1995). 7) Takahashi Y., Kubota T., Fromont J., Kobayashi J., Org. Lett., 11, 21–24 (2009). 12) Kusama T., Tanaka N., Sakai K., Gonoi T., Fromont J., Kashiwada Y., Kobayashi J., Org. Lett., 16, 3916–3918 (2014). 1) Kobayashi J., J. Antibiot., 61, 271–284 (2008), and references therein. 24) Kazami S., Muroi M., Kawatani M., Kubota T., Usui T., Kobayashi J., Osada H., Biosci. Biotechnol. Biochem., 70, 1364–1370 (2006). 8) Yamada M., Takahashi Y., Kubota T., Fromont J., Ishiyama A., Otoguro K., Yamada H., Ōmura S., Kobayashi J., Tetrahedron, 65, 2313–2317 (2009). 6) Kobayashi J., Watanabe D., Kawasaki N., Tsuda M., J. Org. Chem., 62, 9236–9239 (1997). 22) Tsuda M., Nozawa K., Shimbo K., Ishiyama H., Fukushi E., Kawabata J., Kobayashi J., Tetrahedron Lett., 44, 1395–1399 (2003). 32) Komatsu K., Shigemori H., Shiro M., Kobayashi J., Tetrahedron, 56, 8841–8844 (2000). 14) Kobayashi J., Itagaki F., Shigemori H., Ishibashi M., Takahashi K., Ogura M., Nagasawa S., Nakamura T., Hirota H., Ohta T., Nozoe S., J. Am. Chem. Soc., 113, 7812–7813 (1991). 10) Kobayashi J., Ohizumi Y., Nakamura H., Hirata Y., Wakamatsu K., Miyazawa T., Experientia, 42, 1064–1065 (1986). 28) Seino A., Momose K., Kobayashi M., Ishibashi M., Nakamura H., Kobayashi J., Ohizumi Y., Jpn. J. Pharmacol., 46, 312 (1988). 20) Kobayashi J., Cheng J.-F., Ohta T., Nakamura H., Nozoe S., Hirata Y., Ohizumi Y., Sasaki T., J. Org. Chem., 53, 6147–6150 (1988). 23) Nozawa K., Tsuda M., Ishiyama H., Sasaki T., Tsuruo T., Kobayashi J., Bioorg. Med. Chem., 14, 1063–1067 (2006). 33) Nakamura H., Kobayashi J., Ohizumi Y., Hirata Y., Experientia, 39, 590–591 (1983). 31) Shigemori H., Komatsu K., Mikami Y., Kobayashi J., Tetrahedron, 55, 14925–14930 (1999). 5) Kondo K., Shigemori H., Kikuchi Y., Ishibashi M., Sasaki T., Kobayashi J., J. Org. Chem., 57, 2480–2483 (1992). 17) Perpelescu M., Tsuda M., Suzuki M., Yoshida S., Kobayashi J., Natural Medicines, 58, 86 (2004). 26) Rinehart K. L. Jr., Kobayashi J., Harbour G. C., Hughes R. G. Jr., Mizsak S. A., Scahill T. H., J. Am. Chem. Soc., 106, 1524–1526 (1984). 4) Usui T., Kazami S., Dohmae N., Mashimo Y., Kondo H., Tsuda M., Terasaki G. A., Ohashi K., Kobayashi J., Osada H., Chem. Biol., 11, 1269–1277 (2004). 11) Kobayashi J., Nakamura H., Ohizumi Y., Experientia, 44, 86–87 (1988). 18) Tanaka N., Asai M., Takahashi-Nakaguchi A., Gonoi T., Fromont J., Kobayashi J., Org. Lett., 15, 2518–2521 (2013). 2) Kobayashi J., Shigemori H., Ishibashi M., Yamasu T., Hirota H., Sasaki T., J. Org. Chem., 56, 5221–5224 (1991). 21) Kikuchi Y., Ishibashi M., Sasaki T., Kobayashi J., Tetrahedron Lett., 32, 797–798 (1991). 27) Rinehart K. L. Jr., Kobayashi J., Harbour G. C., Gilmore J., Mascal M., Holt T. G., Shield L. S., Lafargue F., J. Am. Chem. Soc., 109, 3378–3387 (1987). 19) Ishiyama H., Ishibashi M., Ogawa A., Yoshida S., Kobayashi J., J. Org. Chem., 62, 3831–3836 (1997). 15) Wilson M. C., Mori T., Rückert C., Uria A. R., Helf M. J., Takada K., Gernert C., Steffens U. A. E., Heycke N., Schmitt S., Rinke C., Helfrich E. J. N., Brachmann A. O., Gurgui C., Wakimoto T., Kracht M., Crüsemann M., Hentschel U., Abe I., Matsunaga S., Kalinowski J., Takeyama H., Piel J., Nature (London), 506, 58–62 (2014). 16) Tsukamoto S., Takeuchi S., Ishibashi M., Kobayashi J., J. Org. Chem., 57, 5255–5260 (1992). 9) Kubota T., Kamijyo Y., Takahashi-Nakaguchi A., Fromont J., Gonoi T., Kobayashi J., Org. Lett., 15, 610–612 (2013). 25) Kazami S., Takaine M., Itoh H., Kubota T., Kobayashi J., Usui T., Biol. Pharm. Bull., 37, 1944–1947 (2014). 29) Ohshita K., Ishiyama H., Oyanagi K., Nakata H., Kobayashi J., Bioorg. Med. Chem., 15, 3235–3240 (2007). 3) Kobayashi J., Shimbo K., Sato M., Shiro M., Tsuda M., Org. Lett., 2, 2805–2807 (2000). 30) Shigemori H., Bae M.-A., Yazawa K., Sasaki T., Kobayashi J., J. Org. Chem., 57, 4317–4320 (1992). 22 23 24 25 26 27 28 29 30 31 10 32 11 33 12 13 14 15 16 17 18 19 1 2 3 4 5 6 7 8 9 20 21 |
| References_xml | – reference: 15) Wilson M. C., Mori T., Rückert C., Uria A. R., Helf M. J., Takada K., Gernert C., Steffens U. A. E., Heycke N., Schmitt S., Rinke C., Helfrich E. J. N., Brachmann A. O., Gurgui C., Wakimoto T., Kracht M., Crüsemann M., Hentschel U., Abe I., Matsunaga S., Kalinowski J., Takeyama H., Piel J., Nature (London), 506, 58–62 (2014). – reference: 4) Usui T., Kazami S., Dohmae N., Mashimo Y., Kondo H., Tsuda M., Terasaki G. A., Ohashi K., Kobayashi J., Osada H., Chem. Biol., 11, 1269–1277 (2004). – reference: 23) Nozawa K., Tsuda M., Ishiyama H., Sasaki T., Tsuruo T., Kobayashi J., Bioorg. Med. Chem., 14, 1063–1067 (2006). – reference: 25) Kazami S., Takaine M., Itoh H., Kubota T., Kobayashi J., Usui T., Biol. Pharm. Bull., 37, 1944–1947 (2014). – reference: 16) Tsukamoto S., Takeuchi S., Ishibashi M., Kobayashi J., J. Org. Chem., 57, 5255–5260 (1992). – reference: 2) Kobayashi J., Shigemori H., Ishibashi M., Yamasu T., Hirota H., Sasaki T., J. Org. Chem., 56, 5221–5224 (1991). – reference: 28) Seino A., Momose K., Kobayashi M., Ishibashi M., Nakamura H., Kobayashi J., Ohizumi Y., Jpn. J. Pharmacol., 46, 312 (1988). – reference: 8) Yamada M., Takahashi Y., Kubota T., Fromont J., Ishiyama A., Otoguro K., Yamada H., Ōmura S., Kobayashi J., Tetrahedron, 65, 2313–2317 (2009). – reference: 31) Shigemori H., Komatsu K., Mikami Y., Kobayashi J., Tetrahedron, 55, 14925–14930 (1999). – reference: 10) Kobayashi J., Ohizumi Y., Nakamura H., Hirata Y., Wakamatsu K., Miyazawa T., Experientia, 42, 1064–1065 (1986). – reference: 13) Kobayashi J., Madono T., Shigemori H., Tetrahedron, 51, 10867–10874 (1995). – reference: 7) Takahashi Y., Kubota T., Fromont J., Kobayashi J., Org. Lett., 11, 21–24 (2009). – reference: 30) Shigemori H., Bae M.-A., Yazawa K., Sasaki T., Kobayashi J., J. Org. Chem., 57, 4317–4320 (1992). – reference: 33) Nakamura H., Kobayashi J., Ohizumi Y., Hirata Y., Experientia, 39, 590–591 (1983). – reference: 5) Kondo K., Shigemori H., Kikuchi Y., Ishibashi M., Sasaki T., Kobayashi J., J. Org. Chem., 57, 2480–2483 (1992). – reference: 12) Kusama T., Tanaka N., Sakai K., Gonoi T., Fromont J., Kashiwada Y., Kobayashi J., Org. Lett., 16, 3916–3918 (2014). – reference: 18) Tanaka N., Asai M., Takahashi-Nakaguchi A., Gonoi T., Fromont J., Kobayashi J., Org. Lett., 15, 2518–2521 (2013). – reference: 26) Rinehart K. L. Jr., Kobayashi J., Harbour G. C., Hughes R. G. Jr., Mizsak S. A., Scahill T. H., J. Am. Chem. Soc., 106, 1524–1526 (1984). – reference: 11) Kobayashi J., Nakamura H., Ohizumi Y., Experientia, 44, 86–87 (1988). – reference: 24) Kazami S., Muroi M., Kawatani M., Kubota T., Usui T., Kobayashi J., Osada H., Biosci. Biotechnol. Biochem., 70, 1364–1370 (2006). – reference: 17) Perpelescu M., Tsuda M., Suzuki M., Yoshida S., Kobayashi J., Natural Medicines, 58, 86 (2004). – reference: 27) Rinehart K. L. Jr., Kobayashi J., Harbour G. C., Gilmore J., Mascal M., Holt T. G., Shield L. S., Lafargue F., J. Am. Chem. Soc., 109, 3378–3387 (1987). – reference: 9) Kubota T., Kamijyo Y., Takahashi-Nakaguchi A., Fromont J., Gonoi T., Kobayashi J., Org. Lett., 15, 610–612 (2013). – reference: 6) Kobayashi J., Watanabe D., Kawasaki N., Tsuda M., J. Org. Chem., 62, 9236–9239 (1997). – reference: 29) Ohshita K., Ishiyama H., Oyanagi K., Nakata H., Kobayashi J., Bioorg. Med. Chem., 15, 3235–3240 (2007). – reference: 32) Komatsu K., Shigemori H., Shiro M., Kobayashi J., Tetrahedron, 56, 8841–8844 (2000). – reference: 19) Ishiyama H., Ishibashi M., Ogawa A., Yoshida S., Kobayashi J., J. Org. Chem., 62, 3831–3836 (1997). – reference: 22) Tsuda M., Nozawa K., Shimbo K., Ishiyama H., Fukushi E., Kawabata J., Kobayashi J., Tetrahedron Lett., 44, 1395–1399 (2003). – reference: 20) Kobayashi J., Cheng J.-F., Ohta T., Nakamura H., Nozoe S., Hirata Y., Ohizumi Y., Sasaki T., J. Org. Chem., 53, 6147–6150 (1988). – reference: 1) Kobayashi J., J. Antibiot., 61, 271–284 (2008), and references therein. – reference: 3) Kobayashi J., Shimbo K., Sato M., Shiro M., Tsuda M., Org. Lett., 2, 2805–2807 (2000). – reference: 21) Kikuchi Y., Ishibashi M., Sasaki T., Kobayashi J., Tetrahedron Lett., 32, 797–798 (1991). – reference: 14) Kobayashi J., Itagaki F., Shigemori H., Ishibashi M., Takahashi K., Ogura M., Nagasawa S., Nakamura T., Hirota H., Ohta T., Nozoe S., J. Am. Chem. Soc., 113, 7812–7813 (1991). – ident: 10 doi: 10.1007/BF01940735 – ident: 2 doi: 10.1021/jo00017a044 – ident: 23 doi: 10.1016/j.bmc.2005.09.033 – ident: 4 doi: 10.1016/j.chembiol.2004.07.014 – ident: 5 doi: 10.1021/jo00034a052 – ident: 32 doi: 10.1016/S0040-4020(00)00838-3 – ident: 29 doi: 10.1016/j.bmc.2007.02.043 – ident: 30 doi: 10.1021/jo00041a053 – ident: 26 doi: 10.1021/ja00317a079 – ident: 24 doi: 10.1271/bbb.50644 – ident: 20 doi: 10.1021/jo00261a040 – ident: 21 doi: 10.1016/S0040-4039(00)74889-1 – ident: 6 doi: 10.1021/jo9715377 – ident: 33 doi: 10.1007/BF01971110 – ident: 13 doi: 10.1016/0040-4020(95)00661-Q – ident: 11 doi: 10.1007/BF01960260 – ident: 22 doi: 10.1016/S0040-4039(02)02869-1 – ident: 9 doi: 10.1021/ol3034274 – ident: 7 doi: 10.1021/ol802251q – ident: 25 doi: 10.1248/bpb.b14-00548 – ident: 17 – ident: 18 doi: 10.1021/ol4009975 – ident: 3 doi: 10.1021/ol006223b – ident: 8 doi: 10.1016/j.tet.2009.01.032 – ident: 16 doi: 10.1021/jo00045a048 – ident: 14 doi: 10.1021/ja00020a081 – ident: 27 doi: 10.1021/ja00245a031 – ident: 19 doi: 10.1021/jo970206r – ident: 28 doi: 10.1016/S0021-5198(19)57776-9 – ident: 31 doi: 10.1016/S0040-4020(99)00984-9 – ident: 15 doi: 10.1038/nature12959 – ident: 1 doi: 10.1038/ja.2008.39 – ident: 12 doi: 10.1021/ol501664b |
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| SubjectTerms | Animal Shells - chemistry Animals Bacteria - chemistry bioactive natural product Biological Products - chemistry dinoflagellate Dinoflagellida - chemistry Drug Discovery Fungi - chemistry marine bacteria marine sponge marine-derived fungi Porifera tunicate Urochordata |
| Title | Search for New Bioactive Marine Natural Products and Application to Drug Development |
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