The contribution of bone to whole-organism physiology

The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism a...

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Published inNature (London) Vol. 481; no. 7381; pp. 314 - 320
Main Authors Karsenty, Gérard, Ferron, Mathieu
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 19.01.2012
Nature Publishing Group
Subjects
631/208/200
631/443/319/333/1465
692/699/2743/316
Animals
Appetite - physiology
Biological and medical sciences
Biology
Bone and Bones - pathology
Bone and Bones - physiology
Bone Diseases - metabolism
Bone Diseases - pathology
Energy Metabolism
Evolution
Fundamental and applied biological sciences. Psychology
Gene expression
Genes
Homeostasis
Humanities and Social Sciences
Humans
Leptin - metabolism
multidisciplinary
Organ Specificity
Osteocalcin - metabolism
Osteoporosis
Physiological aspects
Physiological Phenomena
Physiology
Proteins
review-article
Science
Science (multidisciplinary)
Serotonin
Skeleton and joints
Tumors
Vertebrates: osteoarticular system, musculoskeletal system
United States
Pancreatic hormone
Energy metabolism
Osteocalcin
Serotonin
Rodentia
Review
Insulin
Osteoarticular system
Vertebrata
Mammalia
Bone mass
Mouse
Fertility
Leptin
Hormonal regulation
Neurotransmitter
Physiology
Skeleton
Bone
Online AccessGet full text

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Abstract The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiology can broaden the functions of a given organ, reveal connections of this organ with others such as the brain, pancreas and gut, and shed new light on the pathogenesis of degenerative diseases affecting multiple organs.
AbstractList The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiology can broaden the functions of a given organ, reveal connections of this organ with others such as the brain, pancreas and gut, and shed new light on the pathogenesis of degenerative diseases affecting multiple organs.
The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiology can broaden the functions of a given organ, reveal connections of this organ with others such as the brain, pancreas and gut, and shed new light on the pathogenesis of degenerative diseases affecting multiple organs.The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiology can broaden the functions of a given organ, reveal connections of this organ with others such as the brain, pancreas and gut, and shed new light on the pathogenesis of degenerative diseases affecting multiple organs.
The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiology can broaden the functions of a given organ, reveal connections of this organ with others such as the brain, pancreas and gut, and shed new light on the pathogenesis of degenerative diseases affecting multiple organs. [PUBLICATION ABSTRACT]
Audience Academic
Author Ferron, Mathieu
Karsenty, Gérard
AuthorAffiliation 1 Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
AuthorAffiliation_xml – name: 1 Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Author_xml – sequence: 1
  givenname: Gérard
  surname: Karsenty
  fullname: Karsenty, Gérard
  email: gk2172@columbia.edu
  organization: Department of Genetics and Development, College of Physicians and Surgeons, Columbia University
– sequence: 2
  givenname: Mathieu
  surname: Ferron
  fullname: Ferron, Mathieu
  organization: Department of Genetics and Development, College of Physicians and Surgeons, Columbia University
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25380617$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/22258610$$D View this record in MEDLINE/PubMed
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Cites_doi 10.2337/db08-0913
10.1084/jem.20101940
10.1016/j.jbspin.2004.07.011
10.1038/nm.2388
10.1016/S0092-8674(01)00571-2
10.1016/j.bone.2005.01.007
10.1359/jbmr.060709
10.1002/jbmr.44
10.1101/gad.1977210
10.1074/jbc.M505186200
10.1016/j.cell.2011.02.004
10.1016/S0092-8674(02)01049-8
10.1086/338450
10.1016/j.bone.2007.01.006
10.1126/science.289.5484.1504
10.1016/S0092-8674(00)81558-5
10.1001/archpsyc.1992.01820060022003
10.1097/00000441-193212000-00028
10.1359/jbmr.1998.13.5.763
10.1016/0169-6009(90)90062-K
10.1101/SQB.1961.026.01.048
10.1038/nm1640
10.1159/000323771
10.1016/j.cmet.2011.03.016
10.1056/NEJM198606263142605
10.1073/pnas.0711119105
10.1016/j.cmet.2006.10.010
10.1016/j.abb.2010.07.030
10.1128/MCB.00959-07
10.1016/j.neuron.2005.12.021
10.1016/S0006-3223(98)00195-4
10.1038/35035117
10.1016/j.devcel.2005.02.017
10.1002/jbmr.439
10.1038/nm.2098
10.1038/27376
10.1124/jpet.107.132670
10.1172/JCI30688
10.1210/jc.2010-2731
10.1111/j.1365-2265.2009.03680.x
10.1038/ng0396-318
10.1016/S1097-2765(00)80062-3
10.1210/jc.2010-0861
10.1016/S1534-5807(02)00199-5
10.1677/joe.0.1750405
10.1056/NEJMoa013444
10.1016/0014-4827(88)90191-7
10.1083/jcb.200809113
10.1016/S1534-5807(03)00063-7
10.1126/science.1078197
10.1016/j.cell.2010.06.003
10.1038/1971015a0
10.1371/journal.pone.0008415
10.1359/jbmr.090721
10.1016/j.cell.2009.06.051
10.1073/pnas.0308744101
10.1073/pnas.0808701106
10.1002/jbmr.376
10.1002/jbmr.406
10.1152/physrev.1989.69.3.990
10.1021/jm800338j
10.1016/S0092-8674(04)00344-7
10.1038/nm.1963
10.1016/j.cell.2007.05.047
10.1083/jcb.200201089
10.1126/science.7624777
10.1016/j.bone.2009.12.031
10.1128/MCB.01428-09
10.1038/nature03319
10.1038/372425a0
10.1126/science.283.5407.1544
10.1016/j.neuron.2004.06.004
10.1038/81664
10.1016/S1097-2765(00)80155-0
10.1001/jama.1960.73020340003013
10.1038/nature03398
10.1016/j.cell.2009.07.047
10.1016/j.cell.2008.09.059
10.1016/j.cell.2010.03.055
10.1210/en.2010-0800
10.3748/wjg.v16.i44.5536
10.3748/wjg.v13.i46.6156
10.1074/jbc.M413274200
10.1016/S0021-9258(17)37935-8
10.1074/jbc.M411999200
10.1126/science.289.5484.1501
10.1210/jc.2004-0376
10.1016/j.cell.2010.06.002
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Keywords Pancreatic hormone
Energy metabolism
Osteocalcin
Serotonin
Rodentia
Review
Insulin
Osteoarticular system
Vertebrata
Mammalia
Bone mass
Mouse
Fertility
Leptin
Hormonal regulation
Neurotransmitter
Physiology
Skeleton
Bone
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References BluherMAdipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intoleranceDev. Cell2002325381:CAS:528:DC%2BD38XlsFSms7s%3D1211016510.1016/S1534-5807(02)00199-5
DhillonHLeptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasisNeuron2006491912031:CAS:528:DC%2BD28Xht1SrtbY%3D10.1016/j.neuron.2005.12.02116423694
KatoMCbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptorJ. Cell Biol.20021573033141:CAS:528:DC%2BD38XivFKktLk%3D11956231219926310.1083/jcb.200201089
FrostMLevels of serotonin, sclerostin, bone turnover markers as well as bone density and microarchitecture in patients with high bone mass phenotype due to a mutation in Lrp5J. Bone Miner. Res.201126172117281:CAS:528:DC%2BC3MXhtVejtL7E2135114810.1002/jbmr.376
MonodJJacobFTeleonomic mechanisms in cellular metabolism, growth, and differentiationCold Spring Harb. Symp. Quant. Biol.1961263894011:STN:280:DyaF38%2Fns1yquw%3D%3D1447541510.1101/SQB.1961.026.01.048
RiggsBLKhoslaSMeltonLJA unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging menJ. Bone Miner. Res.1998137637731:STN:280:DyaK1c3nt1aksg%3D%3D961073910.1359/jbmr.1998.13.5.763
DucyPLeptin inhibits bone formation through a hypothalamic relay: a central control of bone massCell20001001972071:CAS:528:DC%2BD3cXotFChsw%3D%3D1066004310.1016/S0092-8674(00)81558-5
GurneyCWErythropoietin, erythropoiesis, and the kidneyJ. Am. Med. Assoc.1960173182818291:STN:280:DyaF3c7ltVyltQ%3D%3D10.1001/jama.1960.73020340003013
GlassDACanonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiationDev. Cell200587517641:CAS:528:DC%2BD2MXkslenur4%3D1586616510.1016/j.devcel.2005.02.017
YadavVKPharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosisNature Med.2010163083121:CAS:528:DC%2BC3cXhs1Olsr4%3D2013999110.1038/nm.2098
FrostMPatients with high-bone-mass phenotype owing to Lrp5-T253I mutation have low plasma levels of serotoninJ. Bone Miner. Res.2010256736751:CAS:528:DC%2BC3cXksl2lu78%3D2020096010.1002/jbmr.44
GongYLDL receptor-related protein 5 (LRP5) affects bone accrual and eye developmentCell20011075135231:CAS:528:DC%2BD3MXovVCnsb4%3D1171919110.1016/S0092-8674(01)00571-2
CannonWBThe Wisdom of the Body193210.1097/00000441-193212000-00028
ElefteriouFLeptin regulation of bone resorption by the sympathetic nervous system and CARTNature20054345145202005Natur.434..514E1:CAS:528:DC%2BD2MXisFeit70%3D1572414910.1038/nature03398
VilacaTYamamotoRMCarvalhoABLazaretti-CastroMNeuroendocrine tumor associated with severe osteoporosis in a male patientEndocr Rev201132P3-123
TolwinskiNSWg/Wnt signal can be transmitted through Arrow/LRP5,6 and Axin independently of Zw3/Gsk3β activityDev. Cell200344074181:CAS:528:DC%2BD3sXisVekurs%3D1263692110.1016/S1534-5807(03)00063-7
FriedmanJMHalaasJLLeptin and the regulation of body weight in mammalsNature19983957637701998Natur.395..763F1:CAS:528:DyaK1cXmvFOmsL0%3D979681110.1038/27376
MotylKJMcCabeLRSchwartzAVBone and glucose metabolism: a two-way streetArch. Biochem. Biophys.20105032101:CAS:528:DC%2BC3cXhtFygtLvE20682281294684510.1016/j.abb.2010.07.030
YadavVKA serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditureCell20091389769891:CAS:528:DC%2BD1MXhsVCjs7zP19737523276858210.1016/j.cell.2009.06.051
SilverIAMurrillsRJEtheringtonDJMicroelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclastsExp. Cell Res.19881752662761:CAS:528:DyaL1cXitF2ru7o%3D336005610.1016/0014-4827(88)90191-7
BaldockPANeuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to body weightPLoS ONE20094e84152009PLoSO...4.8415B20027231279453310.1371/journal.pone.00084151:CAS:528:DC%2BC3cXhvVem
InoseHEfficacy of serotonin inhibition in mouse models of bone lossJ. Bone Miner. Res.201126200220111:CAS:528:DC%2BC3MXht1CjsrvO2160803310.1002/jbmr.439
OuryFEndocrine regulation of male fertility by the skeletonCell20111447968091:CAS:528:DC%2BC3MXjsFeqt7k%3D21333348305278710.1016/j.cell.2011.02.004
MannJJRelationship between central and peripheral serotonin indexes in depressed and suicidal psychiatric inpatientsArch. Gen. Psychiatry1992494424461:STN:280:DyaK383os12hsg%3D%3D137610610.1001/archpsyc.1992.01820060022003
TamaiKLDL-receptor-related proteins in Wnt signal transductionNature20004075305352000Natur.407..530T1:STN:280:DC%2BD3cvnslKgtQ%3D%3D1102900710.1038/35035117
LeeNKEndocrine regulation of energy metabolism by the skeletonCell20071304564691:CAS:528:DC%2BD2sXptlyntbs%3D17693256201374610.1016/j.cell.2007.05.047
BliziotesMUpdate in serotonin and boneJ. Clin. Endocrinol. Metab.201095412441321:CAS:528:DC%2BC3cXht1Wms77F20823465293606510.1210/jc.2010-0861
MerleBDelmasPDNormal carboxylation of circulating osteocalcin (bone Gla-protein) in Paget's disease of boneBone Miner.1990112372451:STN:280:DyaK3M%2FpvVeksg%3D%3D217655910.1016/0169-6009(90)90062-K
KramerIOsteocyte Wnt/β-catenin signaling is required for normal bone homeostasisMol. Cell. Biol.201030307130851:CAS:528:DC%2BC3cXotFGqsLo%3D20404086287668510.1128/MCB.01428-09
HalaasJLWeight-reducing effects of the plasma protein encoded by the obese geneScience19952695435461995Sci...269..543H1:CAS:528:DyaK2MXntF2ktr8%3D762477710.1126/science.7624777
CornishJLeptin directly regulates bone cell function in vitro and reduces bone fragility in vivoJ. Endocrinol.20021754054151:CAS:528:DC%2BD38Xptlaktbc%3D1242903810.1677/joe.0.1750405
OuryFCREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neuronsGenes Dev.2010242330234227700711:CAS:528:DC%2BC3cXhtlyqt7vO20952540295621110.1101/gad.1977210
RaiszLGStimulation of bone resorption by parathyroid hormone in tissue cultureNature1963197101510161963Natur.197.1015R1:CAS:528:DyaF3sXkt12ktb4%3D1399053410.1038/1971015a0
ElefteriouFSerum leptin level is a regulator of bone massProc. Natl Acad. Sci. USA2004101325832632004PNAS..101.3258E1:CAS:528:DC%2BD2cXitlWhurs%3D1497827110.1073/pnas.0308744101365777
YadavVKLeptin-dependent serotonin control of appetite: temporal specificity, transcriptional regulation, and therapeutic implicationsJ. Exp. Med.201120841521:CAS:528:DC%2BC3MXhtlCgsbY%3D21187319302313210.1084/jem.20101940
BalthasarNLeptin receptor signaling in POMC neurons is required for normal body weight homeostasisNeuron2004429839911:CAS:528:DC%2BD2cXlsleisrw%3D1520724210.1016/j.neuron.2004.06.004
FulzeleKInsulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body compositionCell20101423093191:CAS:528:DC%2BC3cXpsVahsr8%3D20655471292515510.1016/j.cell.2010.06.002
ShiZCModulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disordersJ. Med. Chem.200851368436871:CAS:528:DC%2BD1cXnt1WitLw%3D1855760910.1021/jm800338j
HauschkaPVLianJBColeDEGundbergCMOsteocalcin and matrix Gla protein: vitamin K-dependent proteins in bonePhysiol. Rev.19896999010471:CAS:528:DyaL1MXlslWntL0%3D266482810.1152/physrev.1989.69.3.990
YeXNorrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularizationCell20091392852981:CAS:528:DC%2BD1MXhsFWht7zJ19837032277970710.1016/j.cell.2009.07.047
ADHR Consortium. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23 . Nature Genet.26, 345–348 (2000).10.1038/81664
HoriMShimizuYFukumotoSFibroblast growth factor 23 in phosphate homeostasis and bone metabolismEndocrinology20111524101:CAS:528:DC%2BC3MXitVCju7c%3D2108444510.1210/en.2010-0800
ElefteriouFATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiaeCell Metab.200644414511:CAS:528:DC%2BD2sXmslU%3D17141628275671310.1016/j.cmet.2006.10.010
BernardCIntroduction à l'Etude de la Médecine Expérimentale1865
DelibegovicMLiver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stressDiabetes2009585905991:CAS:528:DC%2BD1MXjt1Wksbg%3D19074988264605710.2337/db08-0913
YadavVKLrp5 controls bone formation by inhibiting serotonin synthesis in the duodenumCell20081358258371:CAS:528:DC%2BD1cXhsV2jtr%2FP19041748261433210.1016/j.cell.2008.09.059
SchinkeTImpaired gastric acidification negatively affects calcium homeostasis and bone massNature Med.2009156746811:CAS:528:DC%2BD1MXmtVOrtLk%3D1944863510.1038/nm.1963
WaltherDJSynthesis of serotonin by a second tryptophan hydroxylase isoformScience2003299761:CAS:528:DC%2BD3sXptVWqug%3D%3D1251164310.1126/science.1078197
DelibegovicMImproved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1BMol. Cell. Biol.200727772777341:CAS:528:DC%2BD2sXht1Glt7%2FE17724080216906310.1128/MCB.00959-07
ShiYDissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivoProc. Natl Acad. Sci. USA200810520529205332008PNAS..10520529S1:CAS:528:DC%2BD1MXhtlChtw%3D%3D1907428210.1073/pnas.08087011062629309
RiggsBLMeltonLJInvolutional osteoporosisN. Engl. J. Med.1986314167616861:STN:280:DyaL283jtVOntw%3D%3D352032110.1056/NEJM198606263142605
PollockNKLower uncarboxylated osteocalcin concentrations in children with prediabetes is associated with beta-cell functionJ. Clin. Endocrinol. Metab.201196E1092E109921508147313518810.1210/jc.2010-2731
BonnetNProtective effect of beta blockers in postmenopausal women: influence on fractures, bone density, micro and macroarchitectureBone200740120912161:CAS:528:DC%2BD2sXktF2nsro%3D1732464810.1016/j.bone.2007.01.006
PiMIdentification of a novel extracellular cation-sensing G-protein-coupled receptorJ. Biol. Chem.200528040201402091:CAS:528:DC%2BD2MXht1
J Monod (BFnature10763_CR6) 1961; 26
SM Bartell (BFnature10763_CR29) 2011; 26
DA Glass (BFnature10763_CR78) 2005; 8
C Bernard (BFnature10763_CR1) 1865
M Delibegovic (BFnature10763_CR59) 2007; 27
FF Chehab (BFnature10763_CR18) 1996; 12
L Rodriguez-Bores (BFnature10763_CR62) 2007; 13
JC Bruning (BFnature10763_CR54) 1998; 2
K Tamai (BFnature10763_CR71) 2000; 407
B Merle (BFnature10763_CR49) 1990; 11
M Bjornholm (BFnature10763_CR24) 2007; 117
T Vilaca (BFnature10763_CR85) 2011; 32
M Kato (BFnature10763_CR70) 2002; 157
BL Riggs (BFnature10763_CR11) 1998; 13
H Dhillon (BFnature10763_CR33) 2006; 49
NK Pollock (BFnature10763_CR47) 2011; 96
F Elefteriou (BFnature10763_CR63) 2006; 4
Y Zhang (BFnature10763_CR16) 1994; 372
E Hinoi (BFnature10763_CR60) 2008; 183
P Ducy (BFnature10763_CR19) 2000; 100
M Delibegovic (BFnature10763_CR58) 2009; 58
PA Baldock (BFnature10763_CR26) 2009; 4
H Inose (BFnature10763_CR89) 2011; 26
M Frost (BFnature10763_CR83) 2010; 25
WT Gibson (BFnature10763_CR22) 2004; 89
JM Friedman (BFnature10763_CR3) 1998; 395
VK Yadav (BFnature10763_CR31) 2009; 138
I Legroux-Gerot (BFnature10763_CR9) 2005; 72
M Pi (BFnature10763_CR48) 2005; 280
F Elefteriou (BFnature10763_CR21) 2004; 101
Y Gong (BFnature10763_CR67) 2001; 107
JL Halaas (BFnature10763_CR17) 1995; 269
N Bonnet (BFnature10763_CR43) 2007; 40
JJ Mann (BFnature10763_CR37) 1992; 49
W Kaye (BFnature10763_CR36) 1998; 44
KJ Motyl (BFnature10763_CR46) 2010; 503
VK Yadav (BFnature10763_CR76) 2008; 135
SL Teitelbaum (BFnature10763_CR7) 2000; 289
SK Chen (BFnature10763_CR4) 2010; 141
S Sato (BFnature10763_CR27) 2007; 13
NS Tolwinski (BFnature10763_CR73) 2003; 4
X Li (BFnature10763_CR74) 2005; 280
RD Little (BFnature10763_CR68) 2002; 70
F Oury (BFnature10763_CR14) 2011; 144
LM Boyden (BFnature10763_CR69) 2002; 346
A Saarinen (BFnature10763_CR82) 2010; 72
P Pogoda (BFnature10763_CR20) 2006; 21
C Bjorbaek (BFnature10763_CR23) 1998; 1
N Balthasar (BFnature10763_CR32) 2004; 42
M Bluher (BFnature10763_CR53) 2002; 3
P Miheller (BFnature10763_CR61) 2010; 16
S Takeda (BFnature10763_CR30) 2002; 111
BL Riggs (BFnature10763_CR12) 1986; 314
T Schinke (BFnature10763_CR66) 2009; 15
M Bliziotes (BFnature10763_CR35) 2010; 95
Y Cui (BFnature10763_CR81) 2011; 17
F Elefteriou (BFnature10763_CR42) 2005; 434
E Hay (BFnature10763_CR72) 2005; 280
X Yang (BFnature10763_CR64) 2004; 117
WB Cannon (BFnature10763_CR5) 1932
M Misra (BFnature10763_CR10) 2011; 93
NK Lee (BFnature10763_CR15) 2007; 130
LG Raisz (BFnature10763_CR65) 1963; 197
DJ Walther (BFnature10763_CR38) 2003; 299
K Fulzele (BFnature10763_CR52) 2010; 142
IA Silver (BFnature10763_CR55) 1988; 175
P Ducy (BFnature10763_CR8) 2000; 289
Y Shi (BFnature10763_CR25) 2008; 105
J Cornish (BFnature10763_CR28) 2002; 175
VK Yadav (BFnature10763_CR40) 2011; 208
VK Yadav (BFnature10763_CR90) 2010; 16
BFnature10763_CR44
M Ferron (BFnature10763_CR51) 2010; 142
M Frost (BFnature10763_CR84) 2011; 26
ZC Shi (BFnature10763_CR87) 2008; 51
SJ Warden (BFnature10763_CR34) 2010; 46
X Ye (BFnature10763_CR75) 2009; 139
F Oury (BFnature10763_CR39) 2010; 24
DD Lam (BFnature10763_CR41) 2011; 13
T Reya (BFnature10763_CR80) 2005; 434
M Hori (BFnature10763_CR45) 2011; 152
JW Poser (BFnature10763_CR56) 1979; 254
CW Gurney (BFnature10763_CR2) 1960; 173
UI Modder (BFnature10763_CR86) 2010; 25
PV Hauschka (BFnature10763_CR13) 1989; 69
Q Liu (BFnature10763_CR88) 2008; 325
M Ferron (BFnature10763_CR50) 2008; 105
I Kramer (BFnature10763_CR79) 2010; 30
M Elchebly (BFnature10763_CR57) 1999; 283
A Jackson (BFnature10763_CR77) 2005; 36
References_xml – reference: YadavVKLrp5 controls bone formation by inhibiting serotonin synthesis in the duodenumCell20081358258371:CAS:528:DC%2BD1cXhsV2jtr%2FP19041748261433210.1016/j.cell.2008.09.059
– reference: ADHR Consortium. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23 . Nature Genet.26, 345–348 (2000).10.1038/81664
– reference: MotylKJMcCabeLRSchwartzAVBone and glucose metabolism: a two-way streetArch. Biochem. Biophys.20105032101:CAS:528:DC%2BC3cXhtFygtLvE20682281294684510.1016/j.abb.2010.07.030
– reference: DhillonHLeptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasisNeuron2006491912031:CAS:528:DC%2BD28Xht1SrtbY%3D10.1016/j.neuron.2005.12.02116423694
– reference: FulzeleKInsulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body compositionCell20101423093191:CAS:528:DC%2BC3cXpsVahsr8%3D20655471292515510.1016/j.cell.2010.06.002
– reference: YangXATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin–Lowry syndromeCell20041173873981:CAS:528:DC%2BD2cXjvFemtro%3D1510949810.1016/S0092-8674(04)00344-7
– reference: HayEInteraction between LRP5 and Frat1 mediates the activation of the Wnt canonical pathwayJ. Biol. Chem.200528013616136231:CAS:528:DC%2BD2MXivV2ktLw%3D1569904610.1074/jbc.M411999200
– reference: FrostMLevels of serotonin, sclerostin, bone turnover markers as well as bone density and microarchitecture in patients with high bone mass phenotype due to a mutation in Lrp5J. Bone Miner. Res.201126172117281:CAS:528:DC%2BC3MXhtVejtL7E2135114810.1002/jbmr.376
– reference: GibsonWTCongenital leptin deficiency due to homozygosity for the Δ133G mutation: report of another case and evaluation of response to four years of leptin therapyJ. Clin. Endocrinol. Metab.200489482148261:CAS:528:DC%2BD2cXovVenurw%3D1547216910.1210/jc.2004-0376
– reference: OuryFCREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neuronsGenes Dev.2010242330234227700711:CAS:528:DC%2BC3cXhtlyqt7vO20952540295621110.1101/gad.1977210
– reference: ZhangYPositional cloning of the mouse obese gene and its human homologueNature19943724254321994Natur.372..425Z1:CAS:528:DyaK2MXisVGqsbs%3D10.1038/372425a07984236
– reference: YadavVKA serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditureCell20091389769891:CAS:528:DC%2BD1MXhsVCjs7zP19737523276858210.1016/j.cell.2009.06.051
– reference: RaiszLGStimulation of bone resorption by parathyroid hormone in tissue cultureNature1963197101510161963Natur.197.1015R1:CAS:528:DyaF3sXkt12ktb4%3D1399053410.1038/1971015a0
– reference: CuiYLrp5 functions in bone to regulate bone massNature Med.2011176846911:CAS:528:DC%2BC3MXmsVGmsLY%3D2160280210.1038/nm.2388
– reference: BliziotesMUpdate in serotonin and boneJ. Clin. Endocrinol. Metab.201095412441321:CAS:528:DC%2BC3cXht1Wms77F20823465293606510.1210/jc.2010-0861
– reference: DucyPSchinkeTKarsentyGThe osteoblast: a sophisticated fibroblast under central surveillanceScience2000289150115042000Sci...289.1501D1:CAS:528:DC%2BD3cXmt1KgsLg%3D10.1126/science.289.5484.150110968779
– reference: ShiYDissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivoProc. Natl Acad. Sci. USA200810520529205332008PNAS..10520529S1:CAS:528:DC%2BD1MXhtlChtw%3D%3D1907428210.1073/pnas.08087011062629309
– reference: Rodriguez-BoresLBarahona-GarridoJYamamoto-FurushoJKBasic and clinical aspects of osteoporosis in inflammatory bowel diseaseWorld J. Gastroenterol.200713615661651:CAS:528:DC%2BD1cXhtVOhtLk%3D18069754417122410.3748/wjg.v13.i46.6156
– reference: CannonWBThe Wisdom of the Body193210.1097/00000441-193212000-00028
– reference: PollockNKLower uncarboxylated osteocalcin concentrations in children with prediabetes is associated with beta-cell functionJ. Clin. Endocrinol. Metab.201196E1092E109921508147313518810.1210/jc.2010-2731
– reference: LeeNKEndocrine regulation of energy metabolism by the skeletonCell20071304564691:CAS:528:DC%2BD2sXptlyntbs%3D17693256201374610.1016/j.cell.2007.05.047
– reference: BernardCIntroduction à l'Etude de la Médecine Expérimentale1865
– reference: FriedmanJMHalaasJLLeptin and the regulation of body weight in mammalsNature19983957637701998Natur.395..763F1:CAS:528:DyaK1cXmvFOmsL0%3D979681110.1038/27376
– reference: FrostMPatients with high-bone-mass phenotype owing to Lrp5-T253I mutation have low plasma levels of serotoninJ. Bone Miner. Res.2010256736751:CAS:528:DC%2BC3cXksl2lu78%3D2020096010.1002/jbmr.44
– reference: CornishJLeptin directly regulates bone cell function in vitro and reduces bone fragility in vivoJ. Endocrinol.20021754054151:CAS:528:DC%2BD38Xptlaktbc%3D1242903810.1677/joe.0.1750405
– reference: LittleRDA mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass traitAm. J. Hum. Genet.20027011191:CAS:528:DC%2BD38XlvVKhtw%3D%3D1174119310.1086/338450
– reference: BruningJCA muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose toleranceMol. Cell199825595691:CAS:528:DyaK1MXhtV2muw%3D%3D984462910.1016/S1097-2765(00)80155-0
– reference: ElefteriouFATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiaeCell Metab.200644414511:CAS:528:DC%2BD2sXmslU%3D17141628275671310.1016/j.cmet.2006.10.010
– reference: InoseHEfficacy of serotonin inhibition in mouse models of bone lossJ. Bone Miner. Res.201126200220111:CAS:528:DC%2BC3MXht1CjsrvO2160803310.1002/jbmr.439
– reference: GongYLDL receptor-related protein 5 (LRP5) affects bone accrual and eye developmentCell20011075135231:CAS:528:DC%2BD3MXovVCnsb4%3D1171919110.1016/S0092-8674(01)00571-2
– reference: HoriMShimizuYFukumotoSFibroblast growth factor 23 in phosphate homeostasis and bone metabolismEndocrinology20111524101:CAS:528:DC%2BC3MXitVCju7c%3D2108444510.1210/en.2010-0800
– reference: PogodaPLeptin inhibits bone formation not only in rodents, but also in sheepJ. Bone Miner. Res.200621159115991:CAS:528:DC%2BD28XhtFekt7zJ1699581410.1359/jbmr.060709
– reference: TamaiKLDL-receptor-related proteins in Wnt signal transductionNature20004075305352000Natur.407..530T1:STN:280:DC%2BD3cvnslKgtQ%3D%3D1102900710.1038/35035117
– reference: GurneyCWErythropoietin, erythropoiesis, and the kidneyJ. Am. Med. Assoc.1960173182818291:STN:280:DyaF3c7ltVyltQ%3D%3D10.1001/jama.1960.73020340003013
– reference: SaarinenALow density lipoprotein receptor-related protein 5 (LRP5) mutations and osteoporosis, impaired glucose metabolism and hypercholesterolaemiaClin. Endocrinol.2010724814881:CAS:528:DC%2BC3cXksFCrs74%3D10.1111/j.1365-2265.2009.03680.x
– reference: BoydenLMHigh bone density due to a mutation in LDL-receptor-related protein 5N. Engl. J. Med.2002346151315211:CAS:528:DC%2BD38Xjs1Smurs%3D1201539010.1056/NEJMoa013444
– reference: FerronMInsulin signaling in osteoblasts integrates bone remodeling and energy metabolismCell20101422963081:CAS:528:DC%2BC3cXpsVahsr4%3D20655470291041110.1016/j.cell.2010.06.003
– reference: KatoMCbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptorJ. Cell Biol.20021573033141:CAS:528:DC%2BD38XivFKktLk%3D11956231219926310.1083/jcb.200201089
– reference: ChenSKHematopoietic origin of pathological grooming in Hoxb8 mutant miceCell20101417757851:CAS:528:DC%2BC3cXnsFKms7c%3D20510925289457310.1016/j.cell.2010.03.055
– reference: DelibegovicMImproved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1BMol. Cell. Biol.200727772777341:CAS:528:DC%2BD2sXht1Glt7%2FE17724080216906310.1128/MCB.00959-07
– reference: HauschkaPVLianJBColeDEGundbergCMOsteocalcin and matrix Gla protein: vitamin K-dependent proteins in bonePhysiol. Rev.19896999010471:CAS:528:DyaL1MXlslWntL0%3D266482810.1152/physrev.1989.69.3.990
– reference: PiMIdentification of a novel extracellular cation-sensing G-protein-coupled receptorJ. Biol. Chem.200528040201402091:CAS:528:DC%2BD2MXht1Gjs7rN1619953210.1074/jbc.M505186200
– reference: BluherMAdipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intoleranceDev. Cell2002325381:CAS:528:DC%2BD38XlsFSms7s%3D1211016510.1016/S1534-5807(02)00199-5
– reference: ElcheblyMIncreased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B geneScience1999283154415481999Sci...283.1544E1:CAS:528:DyaK1MXhs1ymtrs%3D10.1126/science.283.5407.154410066179
– reference: BaldockPANeuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to body weightPLoS ONE20094e84152009PLoSO...4.8415B20027231279453310.1371/journal.pone.00084151:CAS:528:DC%2BC3cXhvVem
– reference: BonnetNProtective effect of beta blockers in postmenopausal women: influence on fractures, bone density, micro and macroarchitectureBone200740120912161:CAS:528:DC%2BD2sXktF2nsro%3D1732464810.1016/j.bone.2007.01.006
– reference: BartellSMCentral (ICV) leptin injection increases bone formation, bone mineral density, muscle mass, serum IGF-1, and the expression of osteogenic genes in leptin-deficient ob/ob miceJ. Bone Miner. Res.201126171017201:CAS:528:DC%2BC3MXhtVejtL7L2152027510.1002/jbmr.406
– reference: ChehabFFLimMELuRCorrection of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptinNature Genet.1996123183201:CAS:528:DyaK28XhvVSgtb0%3D858972610.1038/ng0396-318
– reference: JacksonAGene array analysis of Wnt-regulated genes in C3H10T1/2 cellsBone2005365855981:CAS:528:DC%2BD2MXjs1Krt7c%3D1577774410.1016/j.bone.2005.01.007
– reference: BjorbaekCElmquistJKFrantzJDShoelsonSEFlierJSIdentification of SOCS-3 as a potential mediator of central leptin resistanceMol. Cell199816196251:CAS:528:DyaK1cXit1Gisbk%3D966094610.1016/S1097-2765(00)80062-3
– reference: ReyaTCleversHWnt signalling in stem cells and cancerNature20054348438502005Natur.434..843R1:CAS:528:DC%2BD2MXjtFOmsrw%3D1582995310.1038/nature03319
– reference: LiuQDiscovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tractJ. Pharmacol. Exp. Ther.200832547551:CAS:528:DC%2BD1cXktFGjt7o%3D1819249910.1124/jpet.107.132670
– reference: BjornholmMMice lacking inhibitory leptin receptor signals are lean with normal endocrine functionJ. Clin. Invest.2007117135413601:CAS:528:DC%2BD2sXlt1OmtLY%3D17415414183892510.1172/JCI30688
– reference: Legroux-GerotIVignauJCollierFCortetBBone loss associated with anorexia nervosaJoint Bone Spine2005724894951624237310.1016/j.jbspin.2004.07.011
– reference: MannJJRelationship between central and peripheral serotonin indexes in depressed and suicidal psychiatric inpatientsArch. Gen. Psychiatry1992494424461:STN:280:DyaK383os12hsg%3D%3D137610610.1001/archpsyc.1992.01820060022003
– reference: MonodJJacobFTeleonomic mechanisms in cellular metabolism, growth, and differentiationCold Spring Harb. Symp. Quant. Biol.1961263894011:STN:280:DyaF38%2Fns1yquw%3D%3D1447541510.1101/SQB.1961.026.01.048
– reference: MisraMKlibanskiAThe neuroendocrine basis of anorexia nervosa and its impact on bone metabolismNeuroendocrinology20119365731:CAS:528:DC%2BC3MXivFCns74%3D21228564321492910.1159/000323771
– reference: OuryFEndocrine regulation of male fertility by the skeletonCell20111447968091:CAS:528:DC%2BC3MXjsFeqt7k%3D21333348305278710.1016/j.cell.2011.02.004
– reference: BalthasarNLeptin receptor signaling in POMC neurons is required for normal body weight homeostasisNeuron2004429839911:CAS:528:DC%2BD2cXlsleisrw%3D1520724210.1016/j.neuron.2004.06.004
– reference: FerronMHinoiEKarsentyGDucyPOsteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type miceProc. Natl Acad. Sci. USA2008105526652702008PNAS..105.5266F1:CAS:528:DC%2BD1cXksVOns7Y%3D1836235910.1073/pnas.07111191052278202
– reference: TakedaSLeptin regulates bone formation via the sympathetic nervous systemCell20021113053171:CAS:528:DC%2BD38XovVakurk%3D1241924210.1016/S0092-8674(02)01049-8
– reference: RiggsBLMeltonLJInvolutional osteoporosisN. Engl. J. Med.1986314167616861:STN:280:DyaL283jtVOntw%3D%3D352032110.1056/NEJM198606263142605
– reference: WaltherDJSynthesis of serotonin by a second tryptophan hydroxylase isoformScience2003299761:CAS:528:DC%2BD3sXptVWqug%3D%3D1251164310.1126/science.1078197
– reference: SchinkeTImpaired gastric acidification negatively affects calcium homeostasis and bone massNature Med.2009156746811:CAS:528:DC%2BD1MXmtVOrtLk%3D1944863510.1038/nm.1963
– reference: YadavVKLeptin-dependent serotonin control of appetite: temporal specificity, transcriptional regulation, and therapeutic implicationsJ. Exp. Med.201120841521:CAS:528:DC%2BC3MXhtlCgsbY%3D21187319302313210.1084/jem.20101940
– reference: ModderUIRelation of serum serotonin levels to bone density and structural parameters in womenJ. Bone Miner. Res.2010254154221:CAS:528:DC%2BC3cXksl2ksLk%3D1959429710.1359/jbmr.090721
– reference: WardenSJPsychotropic drugs have contrasting skeletal effects that are independent of their effects on physical activity levelsBone2010469859921:CAS:528:DC%2BC3cXjs1akt7o%3D20060080284244610.1016/j.bone.2009.12.031
– reference: MihellerPLorinczyKLakatosPLClinical relevance of changes in bone metabolism in inflammatory bowel diseaseWorld J. Gastroenterol.2010165536554221105186299267110.3748/wjg.v16.i44.5536
– reference: TolwinskiNSWg/Wnt signal can be transmitted through Arrow/LRP5,6 and Axin independently of Zw3/Gsk3β activityDev. Cell200344074181:CAS:528:DC%2BD3sXisVekurs%3D1263692110.1016/S1534-5807(03)00063-7
– reference: TeitelbaumSLBone resorption by osteoclastsScience2000289150415082000Sci...289.1504T1:CAS:528:DC%2BD3cXmt1KgsLk%3D1096878010.1126/science.289.5484.1504
– reference: SatoSCentral control of bone remodeling by neuromedin UNature Med.200713123412401:CAS:528:DC%2BD2sXhtFagsb3I1787388110.1038/nm1640
– reference: KayeWGendallKStroberMSerotonin neuronal function and selective serotonin reuptake inhibitor treatment in anorexia and bulimia nervosaBiol. Psychiatry1998448258381:CAS:528:DyaK1cXnsFGrtro%3D980763810.1016/S0006-3223(98)00195-4
– reference: SilverIAMurrillsRJEtheringtonDJMicroelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclastsExp. Cell Res.19881752662761:CAS:528:DyaL1cXitF2ru7o%3D336005610.1016/0014-4827(88)90191-7
– reference: HalaasJLWeight-reducing effects of the plasma protein encoded by the obese geneScience19952695435461995Sci...269..543H1:CAS:528:DyaK2MXntF2ktr8%3D762477710.1126/science.7624777
– reference: LamDDLeptin does not directly affect CNS serotonin neurons to influence appetiteCell Metab.2011135845911:CAS:528:DC%2BC3MXlsFals7c%3D21531340308714710.1016/j.cmet.2011.03.016
– reference: YeXNorrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularizationCell20091392852981:CAS:528:DC%2BD1MXhsFWht7zJ19837032277970710.1016/j.cell.2009.07.047
– reference: YadavVKPharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosisNature Med.2010163083121:CAS:528:DC%2BC3cXhs1Olsr4%3D2013999110.1038/nm.2098
– reference: GlassDACanonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiationDev. Cell200587517641:CAS:528:DC%2BD2MXkslenur4%3D1586616510.1016/j.devcel.2005.02.017
– reference: PoserJWPricePAA method for decarboxylation of γ-carboxyglutamic acid in proteins. Properties of the decarboxylated γ-carboxyglutamic acid protein from calf boneJ. Biol. Chem.19792544314361:CAS:528:DyaE1MXpvFKlsw%3D%3D76207010.1016/S0021-9258(17)37935-8
– reference: ElefteriouFSerum leptin level is a regulator of bone massProc. Natl Acad. Sci. USA2004101325832632004PNAS..101.3258E1:CAS:528:DC%2BD2cXitlWhurs%3D1497827110.1073/pnas.0308744101365777
– reference: LiXSclerostin binds to LRP5/6 and antagonizes canonical Wnt signalingJ. Biol. Chem.200528019883198871:CAS:528:DC%2BD2MXktFylsbs%3D1577850310.1074/jbc.M413274200
– reference: VilacaTYamamotoRMCarvalhoABLazaretti-CastroMNeuroendocrine tumor associated with severe osteoporosis in a male patientEndocr Rev201132P3-123
– reference: DucyPLeptin inhibits bone formation through a hypothalamic relay: a central control of bone massCell20001001972071:CAS:528:DC%2BD3cXotFChsw%3D%3D1066004310.1016/S0092-8674(00)81558-5
– reference: RiggsBLKhoslaSMeltonLJA unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging menJ. Bone Miner. Res.1998137637731:STN:280:DyaK1c3nt1aksg%3D%3D961073910.1359/jbmr.1998.13.5.763
– reference: DelibegovicMLiver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stressDiabetes2009585905991:CAS:528:DC%2BD1MXjt1Wksbg%3D19074988264605710.2337/db08-0913
– reference: KramerIOsteocyte Wnt/β-catenin signaling is required for normal bone homeostasisMol. Cell. Biol.201030307130851:CAS:528:DC%2BC3cXotFGqsLo%3D20404086287668510.1128/MCB.01428-09
– reference: MerleBDelmasPDNormal carboxylation of circulating osteocalcin (bone Gla-protein) in Paget's disease of boneBone Miner.1990112372451:STN:280:DyaK3M%2FpvVeksg%3D%3D217655910.1016/0169-6009(90)90062-K
– reference: HinoiEThe sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivityJ. Cell Biol.2008183123512421:CAS:528:DC%2BD1MXlsVOgug%3D%3D19103808260696210.1083/jcb.200809113
– reference: ShiZCModulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disordersJ. Med. Chem.200851368436871:CAS:528:DC%2BD1cXnt1WitLw%3D1855760910.1021/jm800338j
– reference: ElefteriouFLeptin regulation of bone resorption by the sympathetic nervous system and CARTNature20054345145202005Natur.434..514E1:CAS:528:DC%2BD2MXisFeit70%3D1572414910.1038/nature03398
– volume: 58
  start-page: 590
  year: 2009
  ident: BFnature10763_CR58
  publication-title: Diabetes
  doi: 10.2337/db08-0913
– volume: 208
  start-page: 41
  year: 2011
  ident: BFnature10763_CR40
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20101940
– volume: 72
  start-page: 489
  year: 2005
  ident: BFnature10763_CR9
  publication-title: Joint Bone Spine
  doi: 10.1016/j.jbspin.2004.07.011
– volume: 17
  start-page: 684
  year: 2011
  ident: BFnature10763_CR81
  publication-title: Nature Med.
  doi: 10.1038/nm.2388
– volume: 107
  start-page: 513
  year: 2001
  ident: BFnature10763_CR67
  publication-title: Cell
  doi: 10.1016/S0092-8674(01)00571-2
– volume: 36
  start-page: 585
  year: 2005
  ident: BFnature10763_CR77
  publication-title: Bone
  doi: 10.1016/j.bone.2005.01.007
– volume: 21
  start-page: 1591
  year: 2006
  ident: BFnature10763_CR20
  publication-title: J. Bone Miner. Res.
  doi: 10.1359/jbmr.060709
– volume: 25
  start-page: 673
  year: 2010
  ident: BFnature10763_CR83
  publication-title: J. Bone Miner. Res.
  doi: 10.1002/jbmr.44
– volume: 24
  start-page: 2330
  year: 2010
  ident: BFnature10763_CR39
  publication-title: Genes Dev.
  doi: 10.1101/gad.1977210
– volume: 280
  start-page: 40201
  year: 2005
  ident: BFnature10763_CR48
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M505186200
– volume: 144
  start-page: 796
  year: 2011
  ident: BFnature10763_CR14
  publication-title: Cell
  doi: 10.1016/j.cell.2011.02.004
– volume: 111
  start-page: 305
  year: 2002
  ident: BFnature10763_CR30
  publication-title: Cell
  doi: 10.1016/S0092-8674(02)01049-8
– volume: 70
  start-page: 11
  year: 2002
  ident: BFnature10763_CR68
  publication-title: Am. J. Hum. Genet.
  doi: 10.1086/338450
– volume: 40
  start-page: 1209
  year: 2007
  ident: BFnature10763_CR43
  publication-title: Bone
  doi: 10.1016/j.bone.2007.01.006
– volume: 289
  start-page: 1504
  year: 2000
  ident: BFnature10763_CR7
  publication-title: Science
  doi: 10.1126/science.289.5484.1504
– volume: 100
  start-page: 197
  year: 2000
  ident: BFnature10763_CR19
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81558-5
– volume: 49
  start-page: 442
  year: 1992
  ident: BFnature10763_CR37
  publication-title: Arch. Gen. Psychiatry
  doi: 10.1001/archpsyc.1992.01820060022003
– volume-title: The Wisdom of the Body
  year: 1932
  ident: BFnature10763_CR5
  doi: 10.1097/00000441-193212000-00028
– volume: 13
  start-page: 763
  year: 1998
  ident: BFnature10763_CR11
  publication-title: J. Bone Miner. Res.
  doi: 10.1359/jbmr.1998.13.5.763
– volume: 11
  start-page: 237
  year: 1990
  ident: BFnature10763_CR49
  publication-title: Bone Miner.
  doi: 10.1016/0169-6009(90)90062-K
– volume: 26
  start-page: 389
  year: 1961
  ident: BFnature10763_CR6
  publication-title: Cold Spring Harb. Symp. Quant. Biol.
  doi: 10.1101/SQB.1961.026.01.048
– volume: 13
  start-page: 1234
  year: 2007
  ident: BFnature10763_CR27
  publication-title: Nature Med.
  doi: 10.1038/nm1640
– volume: 93
  start-page: 65
  year: 2011
  ident: BFnature10763_CR10
  publication-title: Neuroendocrinology
  doi: 10.1159/000323771
– volume: 13
  start-page: 584
  year: 2011
  ident: BFnature10763_CR41
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2011.03.016
– volume: 314
  start-page: 1676
  year: 1986
  ident: BFnature10763_CR12
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM198606263142605
– volume: 105
  start-page: 5266
  year: 2008
  ident: BFnature10763_CR50
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0711119105
– volume: 4
  start-page: 441
  year: 2006
  ident: BFnature10763_CR63
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2006.10.010
– volume: 503
  start-page: 2
  year: 2010
  ident: BFnature10763_CR46
  publication-title: Arch. Biochem. Biophys.
  doi: 10.1016/j.abb.2010.07.030
– volume: 27
  start-page: 7727
  year: 2007
  ident: BFnature10763_CR59
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.00959-07
– volume: 49
  start-page: 191
  year: 2006
  ident: BFnature10763_CR33
  publication-title: Neuron
  doi: 10.1016/j.neuron.2005.12.021
– volume: 44
  start-page: 825
  year: 1998
  ident: BFnature10763_CR36
  publication-title: Biol. Psychiatry
  doi: 10.1016/S0006-3223(98)00195-4
– volume: 407
  start-page: 530
  year: 2000
  ident: BFnature10763_CR71
  publication-title: Nature
  doi: 10.1038/35035117
– volume: 8
  start-page: 751
  year: 2005
  ident: BFnature10763_CR78
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2005.02.017
– volume: 26
  start-page: 2002
  year: 2011
  ident: BFnature10763_CR89
  publication-title: J. Bone Miner. Res.
  doi: 10.1002/jbmr.439
– volume: 16
  start-page: 308
  year: 2010
  ident: BFnature10763_CR90
  publication-title: Nature Med.
  doi: 10.1038/nm.2098
– volume: 395
  start-page: 763
  year: 1998
  ident: BFnature10763_CR3
  publication-title: Nature
  doi: 10.1038/27376
– volume: 325
  start-page: 47
  year: 2008
  ident: BFnature10763_CR88
  publication-title: J. Pharmacol. Exp. Ther.
  doi: 10.1124/jpet.107.132670
– volume: 117
  start-page: 1354
  year: 2007
  ident: BFnature10763_CR24
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI30688
– volume: 96
  start-page: E1092
  year: 2011
  ident: BFnature10763_CR47
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2010-2731
– volume: 72
  start-page: 481
  year: 2010
  ident: BFnature10763_CR82
  publication-title: Clin. Endocrinol.
  doi: 10.1111/j.1365-2265.2009.03680.x
– volume: 12
  start-page: 318
  year: 1996
  ident: BFnature10763_CR18
  publication-title: Nature Genet.
  doi: 10.1038/ng0396-318
– volume: 1
  start-page: 619
  year: 1998
  ident: BFnature10763_CR23
  publication-title: Mol. Cell
  doi: 10.1016/S1097-2765(00)80062-3
– volume: 95
  start-page: 4124
  year: 2010
  ident: BFnature10763_CR35
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2010-0861
– volume: 3
  start-page: 25
  year: 2002
  ident: BFnature10763_CR53
  publication-title: Dev. Cell
  doi: 10.1016/S1534-5807(02)00199-5
– volume: 175
  start-page: 405
  year: 2002
  ident: BFnature10763_CR28
  publication-title: J. Endocrinol.
  doi: 10.1677/joe.0.1750405
– volume: 346
  start-page: 1513
  year: 2002
  ident: BFnature10763_CR69
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa013444
– volume: 175
  start-page: 266
  year: 1988
  ident: BFnature10763_CR55
  publication-title: Exp. Cell Res.
  doi: 10.1016/0014-4827(88)90191-7
– volume: 183
  start-page: 1235
  year: 2008
  ident: BFnature10763_CR60
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200809113
– volume: 4
  start-page: 407
  year: 2003
  ident: BFnature10763_CR73
  publication-title: Dev. Cell
  doi: 10.1016/S1534-5807(03)00063-7
– volume: 299
  start-page: 76
  year: 2003
  ident: BFnature10763_CR38
  publication-title: Science
  doi: 10.1126/science.1078197
– volume: 142
  start-page: 296
  year: 2010
  ident: BFnature10763_CR51
  publication-title: Cell
  doi: 10.1016/j.cell.2010.06.003
– volume: 32
  start-page: P3-123
  year: 2011
  ident: BFnature10763_CR85
  publication-title: Endocr Rev
– volume: 197
  start-page: 1015
  year: 1963
  ident: BFnature10763_CR65
  publication-title: Nature
  doi: 10.1038/1971015a0
– volume: 4
  start-page: e8415
  year: 2009
  ident: BFnature10763_CR26
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0008415
– volume: 25
  start-page: 415
  year: 2010
  ident: BFnature10763_CR86
  publication-title: J. Bone Miner. Res.
  doi: 10.1359/jbmr.090721
– volume: 138
  start-page: 976
  year: 2009
  ident: BFnature10763_CR31
  publication-title: Cell
  doi: 10.1016/j.cell.2009.06.051
– volume: 101
  start-page: 3258
  year: 2004
  ident: BFnature10763_CR21
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0308744101
– volume: 105
  start-page: 20529
  year: 2008
  ident: BFnature10763_CR25
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0808701106
– volume: 26
  start-page: 1721
  year: 2011
  ident: BFnature10763_CR84
  publication-title: J. Bone Miner. Res.
  doi: 10.1002/jbmr.376
– volume: 26
  start-page: 1710
  year: 2011
  ident: BFnature10763_CR29
  publication-title: J. Bone Miner. Res.
  doi: 10.1002/jbmr.406
– volume: 69
  start-page: 990
  year: 1989
  ident: BFnature10763_CR13
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.1989.69.3.990
– volume: 51
  start-page: 3684
  year: 2008
  ident: BFnature10763_CR87
  publication-title: J. Med. Chem.
  doi: 10.1021/jm800338j
– volume: 117
  start-page: 387
  year: 2004
  ident: BFnature10763_CR64
  publication-title: Cell
  doi: 10.1016/S0092-8674(04)00344-7
– volume: 15
  start-page: 674
  year: 2009
  ident: BFnature10763_CR66
  publication-title: Nature Med.
  doi: 10.1038/nm.1963
– volume: 130
  start-page: 456
  year: 2007
  ident: BFnature10763_CR15
  publication-title: Cell
  doi: 10.1016/j.cell.2007.05.047
– volume: 157
  start-page: 303
  year: 2002
  ident: BFnature10763_CR70
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200201089
– volume: 269
  start-page: 543
  year: 1995
  ident: BFnature10763_CR17
  publication-title: Science
  doi: 10.1126/science.7624777
– volume: 46
  start-page: 985
  year: 2010
  ident: BFnature10763_CR34
  publication-title: Bone
  doi: 10.1016/j.bone.2009.12.031
– volume: 30
  start-page: 3071
  year: 2010
  ident: BFnature10763_CR79
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.01428-09
– volume: 434
  start-page: 843
  year: 2005
  ident: BFnature10763_CR80
  publication-title: Nature
  doi: 10.1038/nature03319
– volume-title: Introduction à l'Etude de la Médecine Expérimentale
  year: 1865
  ident: BFnature10763_CR1
– volume: 372
  start-page: 425
  year: 1994
  ident: BFnature10763_CR16
  publication-title: Nature
  doi: 10.1038/372425a0
– volume: 283
  start-page: 1544
  year: 1999
  ident: BFnature10763_CR57
  publication-title: Science
  doi: 10.1126/science.283.5407.1544
– volume: 42
  start-page: 983
  year: 2004
  ident: BFnature10763_CR32
  publication-title: Neuron
  doi: 10.1016/j.neuron.2004.06.004
– ident: BFnature10763_CR44
  doi: 10.1038/81664
– volume: 2
  start-page: 559
  year: 1998
  ident: BFnature10763_CR54
  publication-title: Mol. Cell
  doi: 10.1016/S1097-2765(00)80155-0
– volume: 173
  start-page: 1828
  year: 1960
  ident: BFnature10763_CR2
  publication-title: J. Am. Med. Assoc.
  doi: 10.1001/jama.1960.73020340003013
– volume: 434
  start-page: 514
  year: 2005
  ident: BFnature10763_CR42
  publication-title: Nature
  doi: 10.1038/nature03398
– volume: 139
  start-page: 285
  year: 2009
  ident: BFnature10763_CR75
  publication-title: Cell
  doi: 10.1016/j.cell.2009.07.047
– volume: 135
  start-page: 825
  year: 2008
  ident: BFnature10763_CR76
  publication-title: Cell
  doi: 10.1016/j.cell.2008.09.059
– volume: 141
  start-page: 775
  year: 2010
  ident: BFnature10763_CR4
  publication-title: Cell
  doi: 10.1016/j.cell.2010.03.055
– volume: 152
  start-page: 4
  year: 2011
  ident: BFnature10763_CR45
  publication-title: Endocrinology
  doi: 10.1210/en.2010-0800
– volume: 16
  start-page: 5536
  year: 2010
  ident: BFnature10763_CR61
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v16.i44.5536
– volume: 13
  start-page: 6156
  year: 2007
  ident: BFnature10763_CR62
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v13.i46.6156
– volume: 280
  start-page: 19883
  year: 2005
  ident: BFnature10763_CR74
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M413274200
– volume: 254
  start-page: 431
  year: 1979
  ident: BFnature10763_CR56
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(17)37935-8
– volume: 280
  start-page: 13616
  year: 2005
  ident: BFnature10763_CR72
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M411999200
– volume: 289
  start-page: 1501
  year: 2000
  ident: BFnature10763_CR8
  publication-title: Science
  doi: 10.1126/science.289.5484.1501
– volume: 89
  start-page: 4821
  year: 2004
  ident: BFnature10763_CR22
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2004-0376
– volume: 142
  start-page: 309
  year: 2010
  ident: BFnature10763_CR52
  publication-title: Cell
  doi: 10.1016/j.cell.2010.06.002
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Snippet The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a...
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SubjectTerms 631/208/200
631/443/319/333/1465
692/699/2743/316
Animals
Appetite - physiology
Biological and medical sciences
Biology
Bone and Bones - pathology
Bone and Bones - physiology
Bone Diseases - metabolism
Bone Diseases - pathology
Energy Metabolism
Evolution
Fundamental and applied biological sciences. Psychology
Gene expression
Genes
Homeostasis
Humanities and Social Sciences
Humans
Leptin - metabolism
multidisciplinary
Organ Specificity
Osteocalcin - metabolism
Osteoporosis
Physiological aspects
Physiological Phenomena
Physiology
Proteins
review-article
Science
Science (multidisciplinary)
Serotonin
Skeleton and joints
Tumors
Vertebrates: osteoarticular system, musculoskeletal system
Title The contribution of bone to whole-organism physiology
URI https://link.springer.com/article/10.1038/nature10763
https://www.ncbi.nlm.nih.gov/pubmed/22258610
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Volume 481
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