The effect of neoadjuvant radiation therapy on perioperative outcomes among patients undergoing resection of retroperitoneal sarcomas
Neoadjuvant radiation therapy (RT) has several theoretical benefits in the treatment of retroperitoneal sarcoma (RPS), but concerns remain about treatment toxicity and perioperative morbidity. There are limited data regarding its effect on perioperative outcomes, most of which come from small, singl...
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| Published in | Surgical oncology Vol. 23; no. 3; pp. 155 - 160 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Ltd
01.09.2014
Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0960-7404 1879-3320 1879-3320 |
| DOI | 10.1016/j.suronc.2014.07.001 |
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| Abstract | Neoadjuvant radiation therapy (RT) has several theoretical benefits in the treatment of retroperitoneal sarcoma (RPS), but concerns remain about treatment toxicity and perioperative morbidity. There are limited data regarding its effect on perioperative outcomes, most of which come from small, single-institution series. The purpose of this study was to evaluate the short-term (30-day) postoperative morbidity and mortality associated with neoadjuvant RT following resection of RPS.
The 2005–2011 National Surgical Quality Improvement Program Participant User File was queried for patients undergoing RPS resection. Subjects were stratified by use of neoadjuvant RT. Perioperative variables and short-term 30-day outcomes were compared. Groups were then propensity matched using a 2:1 nearest-neighbor algorithm and multivariable logistic regression was performed to assess neoadjuvant RT as a predictor of short-term 30-day outcomes.
A total of 785 patients were identified. Neoadjuvant RT was administered to 71 (9.0%). Patients who received neoadjuvant RT were slightly younger (56 vs. 62 years, p < 0.001), but otherwise the groups were similar. After propensity matching, all baseline characteristics were highly similar. Median operative time was longer in the neoadjuvant RT group (279 vs. 219 min, p < 0.01), but there were no differences in mortality (1.4 vs. 2.1%, p = 0.71), major complications (28.2 vs. 25.2%, p = 0.69), overall complications (35.2 vs.33.2%, p = 0.83), early reoperation (5.6 vs. 7.4%, p = 0.81), or length of stay (7 vs. 7 days, p = 0.56). Following further adjustment with logistic regression, we confirmed that there were no differences in 30-day mortality or morbidity between patients who did and did not receive neoadjuvant RT.
Neoadjuvant RT does not appear to increase short-term (30-day) morbidity or mortality following resection of RPS. Continued investigation is needed to better define the role for radiation therapy among patients with this disease.
•We assess short-term postoperative outcomes associated with neoadjuvant RT for RPS.•Currently, approximately 10% of patients with RPS receive neoadjuvant RT.•Operative time is longer among patients who receive neoadjuvant RT.•Neoadjuvant RT does not increase postoperative morbidity following RPS resection. |
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| AbstractList | Neoadjuvant radiation therapy (RT) has several theoretical benefits in the treatment of retroperitoneal sarcoma (RPS), but concerns remain about treatment toxicity and perioperative morbidity. There are limited data regarding its effect on perioperative outcomes, most of which come from small, single-institution series. The purpose of this study was to evaluate the short-term (30-day) postoperative morbidity and mortality associated with neoadjuvant RT following resection of RPS.
The 2005–2011 National Surgical Quality Improvement Program Participant User File was queried for patients undergoing RPS resection. Subjects were stratified by use of neoadjuvant RT. Perioperative variables and short-term 30-day outcomes were compared. Groups were then propensity matched using a 2:1 nearest-neighbor algorithm and multivariable logistic regression was performed to assess neoadjuvant RT as a predictor of short-term 30-day outcomes.
A total of 785 patients were identified. Neoadjuvant RT was administered to 71 (9.0%). Patients who received neoadjuvant RT were slightly younger (56 vs. 62 years, p < 0.001), but otherwise the groups were similar. After propensity matching, all baseline characteristics were highly similar. Median operative time was longer in the neoadjuvant RT group (279 vs. 219 min, p < 0.01), but there were no differences in mortality (1.4 vs. 2.1%, p = 0.71), major complications (28.2 vs. 25.2%, p = 0.69), overall complications (35.2 vs.33.2%, p = 0.83), early reoperation (5.6 vs. 7.4%, p = 0.81), or length of stay (7 vs. 7 days, p = 0.56). Following further adjustment with logistic regression, we confirmed that there were no differences in 30-day mortality or morbidity between patients who did and did not receive neoadjuvant RT.
Neoadjuvant RT does not appear to increase short-term (30-day) morbidity or mortality following resection of RPS. Continued investigation is needed to better define the role for radiation therapy among patients with this disease.
•We assess short-term postoperative outcomes associated with neoadjuvant RT for RPS.•Currently, approximately 10% of patients with RPS receive neoadjuvant RT.•Operative time is longer among patients who receive neoadjuvant RT.•Neoadjuvant RT does not increase postoperative morbidity following RPS resection. Neoadjuvant radiation therapy (RT) has several theoretical benefits in the treatment of retroperitoneal sarcoma (RPS), but concerns remain about treatment toxicity and perioperative morbidity. There are limited data regarding its effect on perioperative outcomes, most of which come from small, single-institution series. The purpose of this study was to evaluate the short-term (30-day) postoperative morbidity and mortality associated with neoadjuvant RT following resection of RPS.BACKGROUNDNeoadjuvant radiation therapy (RT) has several theoretical benefits in the treatment of retroperitoneal sarcoma (RPS), but concerns remain about treatment toxicity and perioperative morbidity. There are limited data regarding its effect on perioperative outcomes, most of which come from small, single-institution series. The purpose of this study was to evaluate the short-term (30-day) postoperative morbidity and mortality associated with neoadjuvant RT following resection of RPS.The 2005-2011 National Surgical Quality Improvement Program Participant User File was queried for patients undergoing RPS resection. Subjects were stratified by use of neoadjuvant RT. Perioperative variables and short-term 30-day outcomes were compared. Groups were then propensity matched using a 2:1 nearest-neighbor algorithm and multivariable logistic regression was performed to assess neoadjuvant RT as a predictor of short-term 30-day outcomes.METHODSThe 2005-2011 National Surgical Quality Improvement Program Participant User File was queried for patients undergoing RPS resection. Subjects were stratified by use of neoadjuvant RT. Perioperative variables and short-term 30-day outcomes were compared. Groups were then propensity matched using a 2:1 nearest-neighbor algorithm and multivariable logistic regression was performed to assess neoadjuvant RT as a predictor of short-term 30-day outcomes.A total of 785 patients were identified. Neoadjuvant RT was administered to 71 (9.0%). Patients who received neoadjuvant RT were slightly younger (56 vs. 62 years, p < 0.001), but otherwise the groups were similar. After propensity matching, all baseline characteristics were highly similar. Median operative time was longer in the neoadjuvant RT group (279 vs. 219 min, p < 0.01), but there were no differences in mortality (1.4 vs. 2.1%, p = 0.71), major complications (28.2 vs. 25.2%, p = 0.69), overall complications (35.2 vs.33.2%, p = 0.83), early reoperation (5.6 vs. 7.4%, p = 0.81), or length of stay (7 vs. 7 days, p = 0.56). Following further adjustment with logistic regression, we confirmed that there were no differences in 30-day mortality or morbidity between patients who did and did not receive neoadjuvant RT.RESULTSA total of 785 patients were identified. Neoadjuvant RT was administered to 71 (9.0%). Patients who received neoadjuvant RT were slightly younger (56 vs. 62 years, p < 0.001), but otherwise the groups were similar. After propensity matching, all baseline characteristics were highly similar. Median operative time was longer in the neoadjuvant RT group (279 vs. 219 min, p < 0.01), but there were no differences in mortality (1.4 vs. 2.1%, p = 0.71), major complications (28.2 vs. 25.2%, p = 0.69), overall complications (35.2 vs.33.2%, p = 0.83), early reoperation (5.6 vs. 7.4%, p = 0.81), or length of stay (7 vs. 7 days, p = 0.56). Following further adjustment with logistic regression, we confirmed that there were no differences in 30-day mortality or morbidity between patients who did and did not receive neoadjuvant RT.Neoadjuvant RT does not appear to increase short-term (30-day) morbidity or mortality following resection of RPS. Continued investigation is needed to better define the role for radiation therapy among patients with this disease.CONCLUSIONSNeoadjuvant RT does not appear to increase short-term (30-day) morbidity or mortality following resection of RPS. Continued investigation is needed to better define the role for radiation therapy among patients with this disease. Background Neoadjuvant radiation therapy (RT) has several theoretical benefits in the treatment of retroperitoneal sarcoma (RPS), but concerns remain about treatment toxicity and perioperative morbidity. There are limited data regarding its effect on perioperative outcomes, most of which come from small, single-institution series. The purpose of this study was to evaluate the short-term (30-day) postoperative morbidity and mortality associated with neoadjuvant RT following resection of RPS. Methods The 2005-2011 National Surgical Quality Improvement Program Participant User File was queried for patients undergoing RPS resection. Subjects were stratified by use of neoadjuvant RT. Perioperative variables and short-term 30-day outcomes were compared. Groups were then propensity matched using a 2:1 nearest-neighbor algorithm and multivariable logistic regression was performed to assess neoadjuvant RT as a predictor of short-term 30-day outcomes. Results A total of 785 patients were identified. Neoadjuvant RT was administered to 71 (9.0%). Patients who received neoadjuvant RT were slightly younger (56 vs. 62 years,p < 0.001), but otherwise the groups were similar. After propensity matching, all baseline characteristics were highly similar. Median operative time was longer in the neoadjuvant RT group (279 vs. 219 min,p < 0.01), but there were no differences in mortality (1.4 vs. 2.1%,p = 0.71), major complications (28.2 vs. 25.2%,p = 0.69), overall complications (35.2 vs.33.2%,p = 0.83), early reoperation (5.6 vs. 7.4%,p = 0.81), or length of stay (7 vs. 7 days,p = 0.56). Following further adjustment with logistic regression, we confirmed that there were no differences in 30-day mortality or morbidity between patients who did and did not receive neoadjuvant RT. Conclusions Neoadjuvant RT does not appear to increase short-term (30-day) morbidity or mortality following resection of RPS. Continued investigation is needed to better define the role for radiation therapy among patients with this disease. Abstract Background Neoadjuvant radiation therapy (RT) has several theoretical benefits in the treatment of retroperitoneal sarcoma (RPS), but concerns remain about treatment toxicity and perioperative morbidity. There are limited data regarding its effect on perioperative outcomes, most of which come from small, single-institution series. The purpose of this study was to evaluate the short-term (30-day) postoperative morbidity and mortality associated with neoadjuvant RT following resection of RPS. Methods The 2005–2011 National Surgical Quality Improvement Program Participant User File was queried for patients undergoing RPS resection. Subjects were stratified by use of neoadjuvant RT. Perioperative variables and short-term 30-day outcomes were compared. Groups were then propensity matched using a 2:1 nearest-neighbor algorithm and multivariable logistic regression was performed to assess neoadjuvant RT as a predictor of short-term 30-day outcomes. Results A total of 785 patients were identified. Neoadjuvant RT was administered to 71 (9.0%). Patients who received neoadjuvant RT were slightly younger (56 vs. 62 years, p < 0.001), but otherwise the groups were similar. After propensity matching, all baseline characteristics were highly similar. Median operative time was longer in the neoadjuvant RT group (279 vs. 219 min, p < 0.01), but there were no differences in mortality (1.4 vs. 2.1%, p = 0.71), major complications (28.2 vs. 25.2%, p = 0.69), overall complications (35.2 vs.33.2%, p = 0.83), early reoperation (5.6 vs. 7.4%, p = 0.81), or length of stay (7 vs. 7 days, p = 0.56). Following further adjustment with logistic regression, we confirmed that there were no differences in 30-day mortality or morbidity between patients who did and did not receive neoadjuvant RT. Conclusions Neoadjuvant RT does not appear to increase short-term (30-day) morbidity or mortality following resection of RPS. Continued investigation is needed to better define the role for radiation therapy among patients with this disease. Neoadjuvant radiation therapy (RT) has several theoretical benefits in the treatment of retroperitoneal sarcoma (RPS), but concerns remain about treatment toxicity and perioperative morbidity. There are limited data regarding its effect on perioperative outcomes, most of which come from small, single-institution series. The purpose of this study was to evaluate the short-term (30-day) postoperative morbidity and mortality associated with neoadjuvant RT following resection of RPS. The 2005-2011 National Surgical Quality Improvement Program Participant User File was queried for patients undergoing RPS resection. Subjects were stratified by use of neoadjuvant RT. Perioperative variables and short-term 30-day outcomes were compared. Groups were then propensity matched using a 2:1 nearest-neighbor algorithm and multivariable logistic regression was performed to assess neoadjuvant RT as a predictor of short-term 30-day outcomes. A total of 785 patients were identified. Neoadjuvant RT was administered to 71 (9.0%). Patients who received neoadjuvant RT were slightly younger (56 vs. 62 years, p < 0.001), but otherwise the groups were similar. After propensity matching, all baseline characteristics were highly similar. Median operative time was longer in the neoadjuvant RT group (279 vs. 219 min, p < 0.01), but there were no differences in mortality (1.4 vs. 2.1%, p = 0.71), major complications (28.2 vs. 25.2%, p = 0.69), overall complications (35.2 vs.33.2%, p = 0.83), early reoperation (5.6 vs. 7.4%, p = 0.81), or length of stay (7 vs. 7 days, p = 0.56). Following further adjustment with logistic regression, we confirmed that there were no differences in 30-day mortality or morbidity between patients who did and did not receive neoadjuvant RT. Neoadjuvant RT does not appear to increase short-term (30-day) morbidity or mortality following resection of RPS. Continued investigation is needed to better define the role for radiation therapy among patients with this disease. |
| Author | Speicher, Paul J. Ganapathi, Asvin M. Gulack, Brian C. Blazer, Dan G. Keenan, Jeffrey E. Tyler, Douglas S. Kirsch, David G. Stinnett, Sandra S. Nussbaum, Daniel P. |
| AuthorAffiliation | b Duke University, Department of Biostatistics and Bioinformatics, USA a Duke University, Department of Surgery, USA c Duke University, Department of Radiation Oncology and Department of Pharmacology & Cancer Biology, USA |
| AuthorAffiliation_xml | – name: c Duke University, Department of Radiation Oncology and Department of Pharmacology & Cancer Biology, USA – name: a Duke University, Department of Surgery, USA – name: b Duke University, Department of Biostatistics and Bioinformatics, USA |
| Author_xml | – sequence: 1 givenname: Daniel P. orcidid: 0000-0003-3070-6605 surname: Nussbaum fullname: Nussbaum, Daniel P. email: daniel.nussbaum@duke.edu organization: Duke University, Department of Surgery, USA – sequence: 2 givenname: Paul J. surname: Speicher fullname: Speicher, Paul J. organization: Duke University, Department of Surgery, USA – sequence: 3 givenname: Brian C. surname: Gulack fullname: Gulack, Brian C. organization: Duke University, Department of Surgery, USA – sequence: 4 givenname: Asvin M. surname: Ganapathi fullname: Ganapathi, Asvin M. organization: Duke University, Department of Surgery, USA – sequence: 5 givenname: Jeffrey E. surname: Keenan fullname: Keenan, Jeffrey E. organization: Duke University, Department of Surgery, USA – sequence: 6 givenname: Sandra S. surname: Stinnett fullname: Stinnett, Sandra S. organization: Duke University, Department of Biostatistics and Bioinformatics, USA – sequence: 7 givenname: David G. surname: Kirsch fullname: Kirsch, David G. organization: Duke University, Department of Radiation Oncology and Department of Pharmacology & Cancer Biology, USA – sequence: 8 givenname: Douglas S. surname: Tyler fullname: Tyler, Douglas S. organization: Duke University, Department of Surgery, USA – sequence: 9 givenname: Dan G. surname: Blazer fullname: Blazer, Dan G. organization: Duke University, Department of Surgery, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25085344$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1200/JCO.2000.18.19.3378 10.1245/s10434-006-9248-9 10.1007/BF02573869 10.1097/CCO.0b013e328122d757 10.1245/s10434-013-2868-y 10.1097/SLA.0b013e3181b4148f 10.1245/s10434-006-9139-0 10.1097/00000658-199809000-00008 10.1097/01.coc.0000158441.96455.31 10.1016/j.radonc.2013.10.041 10.1200/JCO.2012.44.3747 10.1002/jso.23534 10.1186/1748-717X-7-214 10.1245/ASO.2006.05.035 10.7785/tcrt.2012.500371 10.1111/j.1445-2197.2012.06211.x 10.1245/s10434-007-9382-z 10.1245/s10434-012-2797-1 |
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| Keywords | NSQIP RT Sarcoma CPT EORTC Neoadjuvant Radiation therapy Radiotherapy 30-day outcomes Outcomes ICD-9 RPS Retroperitoneal sarcoma Preoperative Short-term outcomes Current Procedural Terminology International Classification of Diseases Ninth Revision European Organisation for Research and Treatment of Cancer National Surgical Quality Improvement Program |
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| References | ACS-NSQIP (bib11) 2013 Jones, Catton, O'Sullivan, Couture, Heisler, Kandel (bib13) May 2002; 9 Baldini, Lapidus, Wang, Manola, Orgill, Pomahac (bib14) May 2013; 20 Meric, Milas, Hunt, Hess, Pisters, Hildebrandt (bib10) Oct 1 2000; 18 Bonvalot S, Litiere S, Nzokirantevye A, Marreaud S, Kirkpatrick A. A phase III randomized study of preoperative radiotherapy plus surgery versus surgery alone for patients with retroperitoneal sarcomas Brussels. Belgium: European Organisation for Research and Treatment of Cancer. Available at Smith, Ridgway, Catton, Cannell, O'Sullivan, Mikula (bib21) Jan 7 2014; 110 El-Bared, Taussky, Mehiri, Patocskai, Roberge, Donath (bib20) Aug 2 2013; 13 White, Biberdorf, DiFrancesco, Kurien, Temple (bib17) Feb 2007; 14 Zagar, Shenk, Kim, Harpp, Kunos, Abdul-Karim (bib15) 2008; 2008 Gronchi, Miceli, Shurell, Eilber, Eilber, Anaya (bib2) May 1 2013; 31 Pisters (bib8) Jun 2007; 14 . Hall, Hamilton, Richards, Bilimoria, Cohen, Ko (bib12) Sep 2009; 250 Lewis, Leung, Woodruff, Brennan (bib1) Sep 1998; 228 McBride, Raut, Lapidus, Devlin, Marcus, Bertagnolli (bib7) Jul 2013; 20 Sargos, Dejean, de Figueiredo, Brouste, Nguyen Bui, Italiano (bib19) 2012; 7 Alford, Choong, Chander, Henderson, Powell, Ngan (bib16) May 2013; 83 Bartlett, Roses, Meise, Fraker, Kelz, Karakousis (bib18) Dec 30 2013; 109 Caudle, Tepper, Calvo, Meyers, Goyal, Cance (bib3) Feb 2007; 14 Pawlik, Ahuja, Herman (bib4) Jul 2007; 19 Pawlik, Pisters, Mikula, Feig, Hunt, Cormier (bib5) Apr 2006; 13 Zlotecki, Katz, Morris, Lind, Hochwald (bib6) Jun 2005; 28 Zagar (10.1016/j.suronc.2014.07.001_bib15) 2008; 2008 Meric (10.1016/j.suronc.2014.07.001_bib10) 2000; 18 White (10.1016/j.suronc.2014.07.001_bib17) 2007; 14 El-Bared (10.1016/j.suronc.2014.07.001_bib20) 2013; 13 Smith (10.1016/j.suronc.2014.07.001_bib21) 2014; 110 Pisters (10.1016/j.suronc.2014.07.001_bib8) 2007; 14 Sargos (10.1016/j.suronc.2014.07.001_bib19) 2012; 7 Alford (10.1016/j.suronc.2014.07.001_bib16) 2013; 83 Baldini (10.1016/j.suronc.2014.07.001_bib14) 2013; 20 Hall (10.1016/j.suronc.2014.07.001_bib12) 2009; 250 Jones (10.1016/j.suronc.2014.07.001_bib13) 2002; 9 Lewis (10.1016/j.suronc.2014.07.001_bib1) 1998; 228 10.1016/j.suronc.2014.07.001_bib9 ACS-NSQIP (10.1016/j.suronc.2014.07.001_bib11) 2013 Caudle (10.1016/j.suronc.2014.07.001_bib3) 2007; 14 Pawlik (10.1016/j.suronc.2014.07.001_bib4) 2007; 19 McBride (10.1016/j.suronc.2014.07.001_bib7) 2013; 20 Gronchi (10.1016/j.suronc.2014.07.001_bib2) 2013; 31 Pawlik (10.1016/j.suronc.2014.07.001_bib5) 2006; 13 Bartlett (10.1016/j.suronc.2014.07.001_bib18) 2013; 109 Zlotecki (10.1016/j.suronc.2014.07.001_bib6) 2005; 28 11986186 - Ann Surg Oncol. 2002 May;9(4):346-54 23245199 - Radiat Oncol. 2012;7:214 9742918 - Ann Surg. 1998 Sep;228(3):355-65 17094026 - Ann Surg Oncol. 2007 Feb;14(2):583-90 19277103 - J Oncol. 2008;2008:824036 16491338 - Ann Surg Oncol. 2006 Apr;13(4):508-17 24374652 - J Surg Oncol. 2014 May;109(6):606-11 19644350 - Ann Surg. 2009 Sep;250(3):363-76 23392853 - Ann Surg Oncol. 2013 Jul;20(7):2140-7 17406946 - Ann Surg Oncol. 2007 Jun;14(6):1787-9 23530096 - J Clin Oncol. 2013 May 1;31(13):1649-55 24411227 - Radiother Oncol. 2014 Jan;110(1):165-71 17119868 - Ann Surg Oncol. 2007 Feb;14(2):577-82 15923806 - Am J Clin Oncol. 2005 Jun;28(3):310-6 23919397 - Technol Cancer Res Treat. 2014 Jun;13(3):211-6 11013278 - J Clin Oncol. 2000 Oct 1;18(19):3378-83 23242820 - Ann Surg Oncol. 2013 May;20(5):1494-9 17545800 - Curr Opin Oncol. 2007 Jul;19(4):359-66 22943678 - ANZ J Surg. 2013 May;83(5):336-41 |
| References_xml | – volume: 20 start-page: 1494 year: May 2013 end-page: 1499 ident: bib14 article-title: Predictors for major wound complications following preoperative radiotherapy and surgery for soft-tissue sarcoma of the extremities and trunk: importance of tumor proximity to skin surface publication-title: Ann Surg Oncol – reference: Bonvalot S, Litiere S, Nzokirantevye A, Marreaud S, Kirkpatrick A. A phase III randomized study of preoperative radiotherapy plus surgery versus surgery alone for patients with retroperitoneal sarcomas Brussels. Belgium: European Organisation for Research and Treatment of Cancer. Available at: – volume: 19 start-page: 359 year: Jul 2007 end-page: 366 ident: bib4 article-title: The role of radiation in retroperitoneal sarcomas: a surgical perspective publication-title: Curr Opin Oncol – volume: 7 start-page: 214 year: 2012 ident: bib19 article-title: High-dose pre-operative helical tomotherapy (54 Gy) for retroperitoneal liposarcoma publication-title: Radiat Oncol – volume: 13 start-page: 211 year: Aug 2 2013 end-page: 216 ident: bib20 article-title: Preoperative intensity modulated radiation therapy for retroperitoneal sarcoma publication-title: Technol Cancer Res Treat – volume: 2008 start-page: 824036 year: 2008 ident: bib15 article-title: Radiation therapy in addition to gross total resection of retroperitoneal sarcoma results in prolonged survival: results from a single institutional study publication-title: J Oncol – volume: 28 start-page: 310 year: Jun 2005 end-page: 316 ident: bib6 article-title: Adjuvant radiation therapy for resectable retroperitoneal soft tissue sarcoma: the University of Florida experience publication-title: Am J Clin Oncol – volume: 14 start-page: 1787 year: Jun 2007 end-page: 1789 ident: bib8 article-title: Retroperitoneal sarcomas–an SOS to colleagues in Europe publication-title: Ann Surg Oncol – volume: 13 start-page: 508 year: Apr 2006 end-page: 517 ident: bib5 article-title: Long-term results of two prospective trials of preoperative external beam radiotherapy for localized intermediate- or high-grade retroperitoneal soft tissue sarcoma publication-title: Ann Surg Oncol – reference: . – year: 2013 ident: bib11 article-title: Home | ACS NSQIPACS NSQIP | surgical quality improvement – volume: 31 start-page: 1649 year: May 1 2013 end-page: 1655 ident: bib2 article-title: Outcome prediction in primary resected retroperitoneal soft tissue sarcoma: histology-specific overall survival and disease-free survival nomograms built on major sarcoma center data sets publication-title: J Clin Oncol – volume: 20 start-page: 2140 year: Jul 2013 end-page: 2147 ident: bib7 article-title: Locoregional recurrence after preoperative radiation therapy for retroperitoneal sarcoma: adverse impact of multifocal disease and potential implications of dose escalation publication-title: Ann Surg Oncol – volume: 110 start-page: 165 year: Jan 7 2014 end-page: 171 ident: bib21 article-title: Combined management of retroperitoneal sarcoma with dose intensification radiotherapy and resection: long-term results of a prospective trial publication-title: Radiother Oncol J Eur Soc Ther Radiol Oncol – volume: 14 start-page: 577 year: Feb 2007 end-page: 582 ident: bib3 article-title: Complications associated with neoadjuvant radiotherapy in the multidisciplinary treatment of retroperitoneal sarcomas publication-title: Ann Surg Oncol – volume: 109 start-page: 606 year: Dec 30 2013 end-page: 611 ident: bib18 article-title: Preoperative radiation for retroperitoneal sarcoma is not associated with increased early postoperative morbidity publication-title: J Surg Oncol – volume: 83 start-page: 336 year: May 2013 end-page: 341 ident: bib16 article-title: Outcomes of preoperative radiotherapy and resection of retroperitoneal sarcoma publication-title: ANZ J Surg – volume: 228 start-page: 355 year: Sep 1998 end-page: 365 ident: bib1 article-title: Retroperitoneal soft-tissue sarcoma: analysis of 500 patients treated and followed at a single institution publication-title: Ann Surg – volume: 250 start-page: 363 year: Sep 2009 end-page: 376 ident: bib12 article-title: Does surgical quality improve in the American college of surgeons national surgical quality improvement program: an evaluation of all participating hospitals publication-title: Ann Surg – volume: 18 start-page: 3378 year: Oct 1 2000 end-page: 3383 ident: bib10 article-title: Impact of neoadjuvant chemotherapy on postoperative morbidity in soft tissue sarcomas publication-title: J Clin Oncol Off J Am Soc Clin Oncol – volume: 9 start-page: 346 year: May 2002 end-page: 354 ident: bib13 article-title: Initial results of a trial of preoperative external-beam radiation therapy and postoperative brachytherapy for retroperitoneal sarcoma publication-title: Ann Surg Oncol – volume: 14 start-page: 583 year: Feb 2007 end-page: 590 ident: bib17 article-title: Use of tissue expanders and pre-operative external beam radiotherapy in the treatment of retroperitoneal sarcoma publication-title: Ann Surg Oncol – volume: 18 start-page: 3378 issue: 19 year: 2000 ident: 10.1016/j.suronc.2014.07.001_bib10 article-title: Impact of neoadjuvant chemotherapy on postoperative morbidity in soft tissue sarcomas publication-title: J Clin Oncol Off J Am Soc Clin Oncol doi: 10.1200/JCO.2000.18.19.3378 – year: 2013 ident: 10.1016/j.suronc.2014.07.001_bib11 – volume: 14 start-page: 577 issue: 2 year: 2007 ident: 10.1016/j.suronc.2014.07.001_bib3 article-title: Complications associated with neoadjuvant radiotherapy in the multidisciplinary treatment of retroperitoneal sarcomas publication-title: Ann Surg Oncol doi: 10.1245/s10434-006-9248-9 – volume: 9 start-page: 346 issue: 4 year: 2002 ident: 10.1016/j.suronc.2014.07.001_bib13 article-title: Initial results of a trial of preoperative external-beam radiation therapy and postoperative brachytherapy for retroperitoneal sarcoma publication-title: Ann Surg Oncol doi: 10.1007/BF02573869 – volume: 19 start-page: 359 issue: 4 year: 2007 ident: 10.1016/j.suronc.2014.07.001_bib4 article-title: The role of radiation in retroperitoneal sarcomas: a surgical perspective publication-title: Curr Opin Oncol doi: 10.1097/CCO.0b013e328122d757 – volume: 20 start-page: 2140 issue: 7 year: 2013 ident: 10.1016/j.suronc.2014.07.001_bib7 article-title: Locoregional recurrence after preoperative radiation therapy for retroperitoneal sarcoma: adverse impact of multifocal disease and potential implications of dose escalation publication-title: Ann Surg Oncol doi: 10.1245/s10434-013-2868-y – volume: 250 start-page: 363 issue: 3 year: 2009 ident: 10.1016/j.suronc.2014.07.001_bib12 article-title: Does surgical quality improve in the American college of surgeons national surgical quality improvement program: an evaluation of all participating hospitals publication-title: Ann Surg doi: 10.1097/SLA.0b013e3181b4148f – volume: 14 start-page: 583 issue: 2 year: 2007 ident: 10.1016/j.suronc.2014.07.001_bib17 article-title: Use of tissue expanders and pre-operative external beam radiotherapy in the treatment of retroperitoneal sarcoma publication-title: Ann Surg Oncol doi: 10.1245/s10434-006-9139-0 – volume: 228 start-page: 355 issue: 3 year: 1998 ident: 10.1016/j.suronc.2014.07.001_bib1 article-title: Retroperitoneal soft-tissue sarcoma: analysis of 500 patients treated and followed at a single institution publication-title: Ann Surg doi: 10.1097/00000658-199809000-00008 – volume: 28 start-page: 310 issue: 3 year: 2005 ident: 10.1016/j.suronc.2014.07.001_bib6 article-title: Adjuvant radiation therapy for resectable retroperitoneal soft tissue sarcoma: the University of Florida experience publication-title: Am J Clin Oncol doi: 10.1097/01.coc.0000158441.96455.31 – volume: 110 start-page: 165 issue: 1 year: 2014 ident: 10.1016/j.suronc.2014.07.001_bib21 article-title: Combined management of retroperitoneal sarcoma with dose intensification radiotherapy and resection: long-term results of a prospective trial publication-title: Radiother Oncol J Eur Soc Ther Radiol Oncol doi: 10.1016/j.radonc.2013.10.041 – volume: 31 start-page: 1649 issue: 13 year: 2013 ident: 10.1016/j.suronc.2014.07.001_bib2 article-title: Outcome prediction in primary resected retroperitoneal soft tissue sarcoma: histology-specific overall survival and disease-free survival nomograms built on major sarcoma center data sets publication-title: J Clin Oncol doi: 10.1200/JCO.2012.44.3747 – ident: 10.1016/j.suronc.2014.07.001_bib9 – volume: 2008 start-page: 824036 year: 2008 ident: 10.1016/j.suronc.2014.07.001_bib15 article-title: Radiation therapy in addition to gross total resection of retroperitoneal sarcoma results in prolonged survival: results from a single institutional study publication-title: J Oncol – volume: 109 start-page: 606 issue: 6 year: 2013 ident: 10.1016/j.suronc.2014.07.001_bib18 article-title: Preoperative radiation for retroperitoneal sarcoma is not associated with increased early postoperative morbidity publication-title: J Surg Oncol doi: 10.1002/jso.23534 – volume: 7 start-page: 214 year: 2012 ident: 10.1016/j.suronc.2014.07.001_bib19 article-title: High-dose pre-operative helical tomotherapy (54 Gy) for retroperitoneal liposarcoma publication-title: Radiat Oncol doi: 10.1186/1748-717X-7-214 – volume: 13 start-page: 508 issue: 4 year: 2006 ident: 10.1016/j.suronc.2014.07.001_bib5 article-title: Long-term results of two prospective trials of preoperative external beam radiotherapy for localized intermediate- or high-grade retroperitoneal soft tissue sarcoma publication-title: Ann Surg Oncol doi: 10.1245/ASO.2006.05.035 – volume: 13 start-page: 211 issue: 3 year: 2013 ident: 10.1016/j.suronc.2014.07.001_bib20 article-title: Preoperative intensity modulated radiation therapy for retroperitoneal sarcoma publication-title: Technol Cancer Res Treat doi: 10.7785/tcrt.2012.500371 – volume: 83 start-page: 336 issue: 5 year: 2013 ident: 10.1016/j.suronc.2014.07.001_bib16 article-title: Outcomes of preoperative radiotherapy and resection of retroperitoneal sarcoma publication-title: ANZ J Surg doi: 10.1111/j.1445-2197.2012.06211.x – volume: 14 start-page: 1787 issue: 6 year: 2007 ident: 10.1016/j.suronc.2014.07.001_bib8 article-title: Retroperitoneal sarcomas–an SOS to colleagues in Europe publication-title: Ann Surg Oncol doi: 10.1245/s10434-007-9382-z – volume: 20 start-page: 1494 issue: 5 year: 2013 ident: 10.1016/j.suronc.2014.07.001_bib14 article-title: Predictors for major wound complications following preoperative radiotherapy and surgery for soft-tissue sarcoma of the extremities and trunk: importance of tumor proximity to skin surface publication-title: Ann Surg Oncol doi: 10.1245/s10434-012-2797-1 – reference: 23245199 - Radiat Oncol. 2012;7:214 – reference: 23919397 - Technol Cancer Res Treat. 2014 Jun;13(3):211-6 – reference: 11013278 - J Clin Oncol. 2000 Oct 1;18(19):3378-83 – reference: 11986186 - Ann Surg Oncol. 2002 May;9(4):346-54 – reference: 17094026 - Ann Surg Oncol. 2007 Feb;14(2):583-90 – reference: 15923806 - Am J Clin Oncol. 2005 Jun;28(3):310-6 – reference: 23530096 - J Clin Oncol. 2013 May 1;31(13):1649-55 – reference: 19277103 - J Oncol. 2008;2008:824036 – reference: 17119868 - Ann Surg Oncol. 2007 Feb;14(2):577-82 – reference: 23242820 - Ann Surg Oncol. 2013 May;20(5):1494-9 – reference: 24374652 - J Surg Oncol. 2014 May;109(6):606-11 – reference: 16491338 - Ann Surg Oncol. 2006 Apr;13(4):508-17 – reference: 19644350 - Ann Surg. 2009 Sep;250(3):363-76 – reference: 17406946 - Ann Surg Oncol. 2007 Jun;14(6):1787-9 – reference: 22943678 - ANZ J Surg. 2013 May;83(5):336-41 – reference: 9742918 - Ann Surg. 1998 Sep;228(3):355-65 – reference: 24411227 - Radiother Oncol. 2014 Jan;110(1):165-71 – reference: 23392853 - Ann Surg Oncol. 2013 Jul;20(7):2140-7 – reference: 17545800 - Curr Opin Oncol. 2007 Jul;19(4):359-66 |
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| Snippet | Neoadjuvant radiation therapy (RT) has several theoretical benefits in the treatment of retroperitoneal sarcoma (RPS), but concerns remain about treatment... Abstract Background Neoadjuvant radiation therapy (RT) has several theoretical benefits in the treatment of retroperitoneal sarcoma (RPS), but concerns remain... Background Neoadjuvant radiation therapy (RT) has several theoretical benefits in the treatment of retroperitoneal sarcoma (RPS), but concerns remain about... |
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| SubjectTerms | 30-day outcomes Aged Alcohol use Body mass index Cardiovascular disease Classification Codes Coronary vessels Cysts Diabetes Female Heart attacks Hematology, Oncology and Palliative Medicine Hemophilia Humans Length of Stay Male Middle Aged Morbidity Mortality Neoadjuvant Neoadjuvant Therapy - adverse effects Operative Time Outcomes Postoperative Complications Postoperative Period Preoperative Radiation therapy Radiotherapy Radiotherapy, Adjuvant - adverse effects Retroperitoneal Neoplasms - mortality Retroperitoneal Neoplasms - radiotherapy Retroperitoneal Neoplasms - surgery Retroperitoneal sarcoma Retrospective Studies Sarcoma Sarcoma - mortality Sarcoma - radiotherapy Sarcoma - surgery Sepsis Short-term outcomes Surgery Surgical outcomes Tobacco Treatment Outcome Tumors Variables |
| Title | The effect of neoadjuvant radiation therapy on perioperative outcomes among patients undergoing resection of retroperitoneal sarcomas |
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