Transplantation of Isl1 + cardiac progenitor cells in small intestinal submucosa improves infarcted heart function

Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial infarction. However, the optimal cell types and biomaterials remain elusive. In this study, we seeded Isl1 embryonic cardiac progenitor cells (CPCs) into decellu...

Full description

Saved in:
Bibliographic Details
Published inStem cell research & therapy Vol. 8; no. 1; p. 230
Main Authors Wang, Lingjun, Meier, Elizabeth M, Tian, Shuo, Lei, Ienglam, Liu, Liu, Xian, Shaoxiang, Lam, Mai T, Wang, Zhong
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 16.10.2017
BioMed Central
BMC
Subjects
Biocompatibility
Biomedical materials
Bone marrow
Cardiac progenitor cell
Cardiomyocytes
Collagen
Contraction
Endothelial cells
Extracellular matrix
Health aspects
Heart attack
Heart attacks
Heart diseases
Heart failure
Heart regeneration
Intestine
Myocardial infarction
Myocardium
Risk factors
Small intestinal submucosa
Stem cell transplantation
Stem cells
Studies
Ventricle
Vitamin C
Wound healing
Heart regeneration
Myocardial infarction
Cardiac progenitor cell
Small intestinal submucosa
Online AccessGet full text

Cover

Abstract Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial infarction. However, the optimal cell types and biomaterials remain elusive. In this study, we seeded Isl1 embryonic cardiac progenitor cells (CPCs) into decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM) to assess the therapeutic potential of Isl1 CPCs and the biocompatibility of SIS-ECM with these cells. We observed that SIS-ECM supported the viability and attachment of Isl1 CPCs. Importantly, Isl1 CPCs differentiated into cardiomyocytes and endothelial cells 7 days after seeding into SIS-ECM. In addition, SIS-ECM with CPC-derived cardiomyocytes showed spontaneous contraction and responded to β-adrenergic stimulation. Next, patches of SIS-ECM seeded with CPCs for 7 days were transplanted onto the outer surface of infarcted myocardium in mice. Four weeks after transplantation, the patches were tightly attached to the surface of the host myocardium and remained viable. Transplantation of patches improved cardiac function, decreased the left ventricular myocardial scarring area, and reduced fibrosis and heart failure. Transplantation of Isl1 CPCs seeded in SIS-ECM represents an effective approach for cell-based heart therapy.
AbstractList Abstract Background Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial infarction. However, the optimal cell types and biomaterials remain elusive. Methods In this study, we seeded Isl1+ embryonic cardiac progenitor cells (CPCs) into decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM) to assess the therapeutic potential of Isl1+ CPCs and the biocompatibility of SIS-ECM with these cells. Results We observed that SIS-ECM supported the viability and attachment of Isl1+ CPCs. Importantly, Isl1+ CPCs differentiated into cardiomyocytes and endothelial cells 7 days after seeding into SIS-ECM. In addition, SIS-ECM with CPC-derived cardiomyocytes showed spontaneous contraction and responded to β-adrenergic stimulation. Next, patches of SIS-ECM seeded with CPCs for 7 days were transplanted onto the outer surface of infarcted myocardium in mice. Four weeks after transplantation, the patches were tightly attached to the surface of the host myocardium and remained viable. Transplantation of patches improved cardiac function, decreased the left ventricular myocardial scarring area, and reduced fibrosis and heart failure. Conclusions Transplantation of Isl1+ CPCs seeded in SIS-ECM represents an effective approach for cell-based heart therapy.
Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial infarction. However, the optimal cell types and biomaterials remain elusive. In this study, we seeded Isl1 embryonic cardiac progenitor cells (CPCs) into decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM) to assess the therapeutic potential of Isl1 CPCs and the biocompatibility of SIS-ECM with these cells. We observed that SIS-ECM supported the viability and attachment of Isl1 CPCs. Importantly, Isl1 CPCs differentiated into cardiomyocytes and endothelial cells 7 days after seeding into SIS-ECM. In addition, SIS-ECM with CPC-derived cardiomyocytes showed spontaneous contraction and responded to β-adrenergic stimulation. Next, patches of SIS-ECM seeded with CPCs for 7 days were transplanted onto the outer surface of infarcted myocardium in mice. Four weeks after transplantation, the patches were tightly attached to the surface of the host myocardium and remained viable. Transplantation of patches improved cardiac function, decreased the left ventricular myocardial scarring area, and reduced fibrosis and heart failure. Transplantation of Isl1 CPCs seeded in SIS-ECM represents an effective approach for cell-based heart therapy.
Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial infarction. However, the optimal cell types and biomaterials remain elusive. In this study, we seeded Isl1.sup.+ embryonic cardiac progenitor cells (CPCs) into decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM) to assess the therapeutic potential of Isl1.sup.+ CPCs and the biocompatibility of SIS-ECM with these cells. We observed that SIS-ECM supported the viability and attachment of Isl1.sup.+ CPCs. Importantly, Isl1.sup.+ CPCs differentiated into cardiomyocytes and endothelial cells 7 days after seeding into SIS-ECM. In addition, SIS-ECM with CPC-derived cardiomyocytes showed spontaneous contraction and responded to [beta]-adrenergic stimulation. Next, patches of SIS-ECM seeded with CPCs for 7 days were transplanted onto the outer surface of infarcted myocardium in mice. Four weeks after transplantation, the patches were tightly attached to the surface of the host myocardium and remained viable. Transplantation of patches improved cardiac function, decreased the left ventricular myocardial scarring area, and reduced fibrosis and heart failure. Transplantation of Isl1.sup.+ CPCs seeded in SIS-ECM represents an effective approach for cell-based heart therapy.
BackgroundApplication of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial infarction. However, the optimal cell types and biomaterials remain elusive.MethodsIn this study, we seeded Isl1+ embryonic cardiac progenitor cells (CPCs) into decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM) to assess the therapeutic potential of Isl1+ CPCs and the biocompatibility of SIS-ECM with these cells.ResultsWe observed that SIS-ECM supported the viability and attachment of Isl1+ CPCs. Importantly, Isl1+ CPCs differentiated into cardiomyocytes and endothelial cells 7 days after seeding into SIS-ECM. In addition, SIS-ECM with CPC-derived cardiomyocytes showed spontaneous contraction and responded to β-adrenergic stimulation. Next, patches of SIS-ECM seeded with CPCs for 7 days were transplanted onto the outer surface of infarcted myocardium in mice. Four weeks after transplantation, the patches were tightly attached to the surface of the host myocardium and remained viable. Transplantation of patches improved cardiac function, decreased the left ventricular myocardial scarring area, and reduced fibrosis and heart failure.ConclusionsTransplantation of Isl1+ CPCs seeded in SIS-ECM represents an effective approach for cell-based heart therapy.
Background Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial infarction. However, the optimal cell types and biomaterials remain elusive. Methods In this study, we seeded Isl1.sup.+ embryonic cardiac progenitor cells (CPCs) into decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM) to assess the therapeutic potential of Isl1.sup.+ CPCs and the biocompatibility of SIS-ECM with these cells. Results We observed that SIS-ECM supported the viability and attachment of Isl1.sup.+ CPCs. Importantly, Isl1.sup.+ CPCs differentiated into cardiomyocytes and endothelial cells 7 days after seeding into SIS-ECM. In addition, SIS-ECM with CPC-derived cardiomyocytes showed spontaneous contraction and responded to [beta]-adrenergic stimulation. Next, patches of SIS-ECM seeded with CPCs for 7 days were transplanted onto the outer surface of infarcted myocardium in mice. Four weeks after transplantation, the patches were tightly attached to the surface of the host myocardium and remained viable. Transplantation of patches improved cardiac function, decreased the left ventricular myocardial scarring area, and reduced fibrosis and heart failure. Conclusions Transplantation of Isl1.sup.+ CPCs seeded in SIS-ECM represents an effective approach for cell-based heart therapy. Keywords: Cardiac progenitor cell, Small intestinal submucosa, Heart regeneration, Myocardial infarction
ArticleNumber 230
Audience Academic
Author Lei, Ienglam
Wang, Lingjun
Liu, Liu
Tian, Shuo
Xian, Shaoxiang
Wang, Zhong
Meier, Elizabeth M
Lam, Mai T
Author_xml – sequence: 1
  givenname: Lingjun
  surname: Wang
  fullname: Wang, Lingjun
  organization: Department of Cardiac Surgery, Cardiovascular Center, The University of Michigan, Ann Arbor, MI, 48109, USA
– sequence: 2
  givenname: Elizabeth M
  surname: Meier
  fullname: Meier, Elizabeth M
  organization: Department of Biomedical Engineering, Wayne State University, Detroit, MI, 48201, USA
– sequence: 3
  givenname: Shuo
  surname: Tian
  fullname: Tian, Shuo
  organization: Department of Cardiac Surgery, Cardiovascular Center, The University of Michigan, Ann Arbor, MI, 48109, USA
– sequence: 4
  givenname: Ienglam
  surname: Lei
  fullname: Lei, Ienglam
  organization: Faculty of Health Sciences, University of Macau, Macau SAR, China
– sequence: 5
  givenname: Liu
  surname: Liu
  fullname: Liu, Liu
  organization: Department of Cardiac Surgery, Cardiovascular Center, The University of Michigan, Ann Arbor, MI, 48109, USA
– sequence: 6
  givenname: Shaoxiang
  surname: Xian
  fullname: Xian, Shaoxiang
  organization: The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China
– sequence: 7
  givenname: Mai T
  surname: Lam
  fullname: Lam, Mai T
  organization: Cardiovascular Research Institute, Wayne State University, Detroit, MI, 48201, USA
– sequence: 8
  givenname: Zhong
  surname: Wang
  fullname: Wang, Zhong
  email: zhongw@med.umich.edu
  organization: Department of Cardiac Surgery, Cardiovascular Center, The University of Michigan, Ann Arbor, MI, 48109, USA. zhongw@med.umich.edu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29037258$$D View this record in MEDLINE/PubMed
BookMark eNptkm1r1TAYhotM3Jz7AX6RgiCKdOa97ZfBGL4cGAg6P4ecNDknI02OSTr03_vUM-ep2NI2pNdzP8md-2l1FGIwVfUco3OMO_EuY0q6tkEYHtHyhjyqTnDL20ZwTI4OxsfVWc63CC5KERLsSXVMekRbwruTKt0kFfLOq1BUcTHU0dar7HH9ttYqDU7pepfixgRXYqq18T7XLtR5VN7DoJhcXFC-ztN6nHTMqnYjFNyZGbMq6WKGemtUKrWdgp5bPKseW-WzObv_nlbfPry_ufrUXH_-uLq6vG50S_vSUMEGxlFvWsaQGIwmgnQWK9xSY1ivqbJru1aqw8QgxpmixGItYIauGdaYnlarve4Q1a3cJTeq9FNG5eTviZg2EpbltDey66lCLaHWrhkThnQMddxyw_BgW9R1oHWx19rBPs2gTShJ-YXo8k9wW7mJd5KLefUMBF7fC6T4fQLX5OjybKcKJk5Z4p4TjDpoBujLf9DbOCUweaYExgIT1v6lNgo2AF5H6KtnUXnJMeKihzdQ5_-h4B7M6DQEyjqYXxS8WRQAU8yPslFTznL19cuSfXXAwiH7ss3RT_Mh5yWI96BOMedk7INxGMk5zHIfZglhlnOYJYGaF4eOP1T8iS79BU5u7ws
CitedBy_id crossref_primary_10_1016_j_ebiom_2018_12_003
crossref_primary_10_1016_j_reth_2019_10_001
crossref_primary_10_1186_s13287_021_02259_z
crossref_primary_10_7717_peerj_7160
crossref_primary_10_1093_rb_rbaa014
crossref_primary_10_1038_s41434_020_0148_6
crossref_primary_10_3389_fcell_2021_793605
crossref_primary_10_1016_j_exer_2024_109953
crossref_primary_10_1016_j_lfs_2019_116891
crossref_primary_10_1142_S1793984419410022
crossref_primary_10_1016_j_msec_2020_111603
crossref_primary_10_2217_fca_2021_0017
crossref_primary_10_3390_ani10091561
crossref_primary_10_1038_s41569_018_0013_0
crossref_primary_10_3389_fphar_2024_1408679
crossref_primary_10_1089_ars_2020_8193
crossref_primary_10_1021_acsami_2c16682
crossref_primary_10_1142_S1793984418410088
crossref_primary_10_3389_fcvm_2018_00035
crossref_primary_10_1002_jcb_27925
crossref_primary_10_1007_s12265_018_9851_8
crossref_primary_10_3390_ijms20225760
crossref_primary_10_1016_j_bioactmat_2023_05_015
Cites_doi 10.1038/cr.2014.15
10.1002/1097-4636(20000905)51:3<442::AID-JBM19>3.0.CO;2-4
10.1002/adhm.201500861
10.1089/ten.tea.2012.0480
10.1172/jci.insight.80920
10.1016/j.stem.2010.12.008
10.1088/1758-5082/5/2/025004
10.1016/j.biomaterials.2013.08.017
10.1093/eurheartj/ehp070
10.1038/nature03215
10.1016/S0022-5347(05)64746-5
10.1126/scitranslmed.aad9019
10.1038/nature08191
10.1016/j.actbio.2015.08.017
10.1016/j.biomaterials.2014.04.114
10.1161/CIRCULATIONAHA.106.650903
10.1016/j.jacc.2014.06.1204
10.1016/j.cell.2006.10.029
10.1371/journal.pone.0153412
10.1089/scd.2012.0031
10.1161/01.RES.0000225952.61196.39
10.1016/j.cell.2008.02.002
10.1038/nature02446
10.1016/j.ejcts.2010.02.009
10.1161/CIRCRESAHA.114.303720
10.1016/S1534-5807(03)00363-0
10.1016/j.scr.2007.06.001
10.1016/j.cardiores.2004.10.004
10.1016/j.yjmcc.2012.01.021
10.1016/j.biomaterials.2011.09.078
10.1126/science.1164680
10.1161/JAHA.113.000367
10.1371/journal.pone.0133308
10.1089/ten.teb.2013.0126
10.1056/NEJMoa012081
10.1161/CIR.0000000000000485
10.1002/term.2255
10.1016/S0092-8674(03)00687-1
10.1161/CIRCULATIONAHA.114.015231
10.1111/j.1749-6632.2012.06519.x
10.1006/jmcc.2001.1491
10.1016/j.biomaterials.2012.04.030
ContentType Journal Article
Copyright COPYRIGHT 2017 BioMed Central Ltd.
Copyright BioMed Central 2017
The Author(s). 2017
Copyright_xml – notice: COPYRIGHT 2017 BioMed Central Ltd.
– notice: Copyright BioMed Central 2017
– notice: The Author(s). 2017
DBID NPM
AAYXX
CITATION
ISR
3V.
7X7
7XB
88E
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M7P
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOA
DOI 10.1186/s13287-017-0675-2
DatabaseName PubMed
CrossRef
Gale In Context: Science
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
Biological Science Collection
AUTh Library subscriptions: ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni Edition)
Medical Database
Biological Science Database
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle PubMed
CrossRef
Publicly Available Content Database
ProQuest Central Student
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Medical Library (Alumni)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
PubMed

Publicly Available Content Database



MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1757-6512
EndPage 230
ExternalDocumentID oai_doaj_org_article_893a0723ffb446e284085f5e41df7088
A510569510
10_1186_s13287_017_0675_2
29037258
Genre Journal Article
GrantInformation_xml – fundername: NHLBI NIH HHS
  grantid: R01 HL109054
– fundername: ;
  grantid: 1R01HL109054
– fundername: ;
  grantid: 81373570; 81173438
GroupedDBID ---
-56
-5G
-BR
0R~
3V.
53G
5VS
7X7
88E
8FE
8FH
8FI
8FJ
AAFWJ
AAJSJ
ABDBF
ABUWG
ACGFS
ACIHN
ACJQM
ACPRK
ACRMQ
ADBBV
ADINQ
ADUKV
AEAQA
AENEX
AFKRA
AFPKN
AHBYD
AHMBA
AHYZX
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMTXH
AOIAM
AOIJS
BAPOH
BAWUL
BBNVY
BCNDV
BENPR
BFQNJ
BHPHI
BMC
BPHCQ
BVXVI
C24
C6C
CCPQU
DIK
E3Z
EBD
EBLON
EBS
EJD
EMOBN
ESX
F5P
FYUFA
GROUPED_DOAJ
GX1
H13
HCIFZ
HMCUK
HYE
IAO
IEA
IHR
IHW
INH
INR
ISR
ITC
KQ8
LK8
M1P
M7P
M~E
NPM
O5R
O5S
OK1
P2P
PGMZT
PIMPY
PQQKQ
PROAC
PSQYO
RBZ
ROL
RPM
RSV
SBL
SOJ
SV3
TUS
UKHRP
AAYXX
CITATION
AFGXO
ABVAZ
AFNRJ
7XB
8FK
AHSBF
AZQEC
DWQXO
GNUQQ
K9.
PQEST
PQUKI
PRINS
7X8
5PM
ID FETCH-LOGICAL-c739t-364d4509e74406dec2628f1a173ee49c3afbfbaa812e0454a32f1c6baa3b41c13
IEDL.DBID RPM
ISSN 1757-6512
IngestDate Fri Oct 04 13:10:35 EDT 2024
Tue Sep 17 20:37:08 EDT 2024
Sat Aug 17 03:04:11 EDT 2024
Thu Oct 10 20:40:41 EDT 2024
Fri Feb 23 00:10:11 EST 2024
Fri Feb 02 04:28:14 EST 2024
Thu Aug 01 19:41:35 EDT 2024
Tue Aug 20 22:15:16 EDT 2024
Thu Sep 12 16:30:48 EDT 2024
Wed Oct 16 01:00:23 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Heart regeneration
Myocardial infarction
Cardiac progenitor cell
Small intestinal submucosa
Language English
License Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c739t-364d4509e74406dec2628f1a173ee49c3afbfbaa812e0454a32f1c6baa3b41c13
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644064/
PMID 29037258
PQID 1961161247
PQPubID 2040189
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_893a0723ffb446e284085f5e41df7088
pubmedcentral_primary_oai_pubmedcentral_nih_gov_5644064
proquest_miscellaneous_1952108708
proquest_journals_1961161247
gale_infotracmisc_A510569510
gale_infotracacademiconefile_A510569510
gale_incontextgauss_ISR_A510569510
gale_healthsolutions_A510569510
crossref_primary_10_1186_s13287_017_0675_2
pubmed_primary_29037258
PublicationCentury 2000
PublicationDate 2017-10-16
PublicationDateYYYYMMDD 2017-10-16
PublicationDate_xml – month: 10
  year: 2017
  text: 2017-10-16
  day: 16
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle Stem cell research & therapy
PublicationTitleAlternate Stem Cell Res Ther
PublicationYear 2017
Publisher BioMed Central Ltd
BioMed Central
BMC
Publisher_xml – name: BioMed Central Ltd
– name: BioMed Central
– name: BMC
References 26186362 - PLoS One. 2015 Jul 17;10(7):e0133308
16159807 - Circulation. 2005 Aug 30;112(9 Suppl):I144-9
27525311 - JCI Insight. 2016 Jul 7;1(10):null
28356512 - Sci Transl Med. 2017 Mar 29;9(383):null
11851351 - J Mol Cell Cardiol. 2002 Feb;34(2):107-16
26283164 - Acta Biomater. 2015 Oct;26:105-14
26913710 - Adv Healthc Mater. 2016 May;5(9):1071-9
10880087 - J Biomed Mater Res. 2000 Sep 5;51(3):442-52
22575829 - Biomaterials. 2012 Aug;33(22):5541-51
23072446 - Tissue Eng Part A. 2013 Mar;19(5-6):738-47
25323256 - J Am Coll Cardiol. 2014 Oct 21;64(16):1681-94
28386378 - Am J Transl Res. 2017 Mar 15;9(3):1530-1542
27070546 - PLoS One. 2016 Apr 12;11(4):e0153412
19383383 - Stem Cell Res. 2007 Oct;1(1):9-24
16159808 - Circulation. 2005 Aug 30;112(9 Suppl):I150-6
24503648 - Cell Res. 2014 Apr;24(4):501-4
16690882 - Circ Res. 2006 Jun 9;98(11):1414-21
24862441 - Biomaterials. 2014 Aug;35(25):6850-6858
26304668 - Circulation. 2015 Aug 25;132(8):762-771
17698734 - Circulation. 2007 Sep 4;116(10):1176-84
22548570 - Ann N Y Acad Sci. 2012 Apr;1254:57-65
15703750 - Nature. 2005 Feb 10;433(7026):647-53
28156084 - J Tissue Eng Regen Med. 2017 Dec;11(12 ):3417-3427
23992980 - Biomaterials. 2013 Dec;34(36):9048-55
18295570 - Cell. 2008 Feb 22;132(4):537-43
12131370 - J Urol. 2002 Aug;168(2):798-804
23458889 - Biofabrication. 2013 Jun;5(2):025004
22428725 - Stem Cells Dev. 2012 Aug 10;21(12):2095-110
16820568 - Circulation. 2006 Jul 4;114(1 Suppl):I167-73
17123592 - Cell. 2006 Dec 15;127(6):1151-65
20335044 - Eur J Cardiothorac Surg. 2010 Oct;38(4):450-5
17719065 - J Surg Res. 2007 Oct;142(2):263-7
15034593 - Nature. 2004 Apr 8;428(6983):664-8
24812350 - Circ Res. 2014 May 9;114(10):1564-8
22014942 - Biomaterials. 2012 Jan;33(2):428-43
19342590 - Science. 2009 Apr 3;324(5923):98-102
15639472 - Cardiovasc Res. 2005 Feb 1;65(2):334-44
24113327 - J Am Heart Assoc. 2013 Oct 10;2(5):e000367
23777420 - Tissue Eng Part B Rev. 2014 Feb;20(1):73-83
21295278 - Cell Stem Cell. 2011 Feb 4;8(2):228-40
14667410 - Dev Cell. 2003 Dec;5(6):877-89
28122885 - Circulation. 2017 Mar 7;135(10 ):e146-e603
19571884 - Nature. 2009 Jul 2;460(7251):113-7
19299430 - Eur Heart J. 2009 May;30(10):1180-6
14505575 - Cell. 2003 Sep 19;114(6):763-76
11777997 - N Engl J Med. 2002 Jan 3;346(1):5-15
22326848 - J Mol Cell Cardiol. 2012 May;52(5):1135-44
EJ Benjamin (675_CR1) 2017; 135
HK Lin (675_CR36) 2014; 20
W Hudson (675_CR12) 2007; 142
H Hata (675_CR40) 2010; 38
I Kutschka (675_CR37) 2006; 114
O Bergmann (675_CR6) 2009; 324
K Nakajima (675_CR17) 2015; 10
X Li (675_CR24) 2014; 24
CE Murry (675_CR4) 2004; 428
LW Laake van (675_CR9) 2007; 1
N Hattan (675_CR10) 2005; 65
ET Roche (675_CR13) 2014; 35
A Moretti (675_CR29) 2006; 127
SG Ong (675_CR45) 2015; 132
S Orn (675_CR3) 2009; 30
J Muller-Ehmsen (675_CR8) 2002; 34
C Soler-Botija (675_CR7) 2012; 1254
675_CR31
SW Kim (675_CR44) 2014; 64
DA Feyen (675_CR16) 2016; 5
KL Laugwitz (675_CR27) 2005; 433
Q Liu (675_CR30) 2015; 26
D Kuraitis (675_CR14) 2012; 33
NH Chi (675_CR18) 2012; 33
MT Lam (675_CR33) 2013; 19
AP Beltrami (675_CR22) 2003; 114
PV Kochupura (675_CR41) 2005; 112
L Bu (675_CR26) 2009; 460
CW Chang (675_CR35) 2016; 11
Y Li (675_CR32) 2017; 9
J Liu (675_CR15) 2012; 21
SM Wu (675_CR25) 2008; 132
GA Abraham (675_CR34) 2000; 51
SJ Kattman (675_CR39) 2011; 8
D Hou (675_CR11) 2005; 112
J Endo (675_CR19) 2007; 116
R Uemura (675_CR46) 2006; 98
MV Singh (675_CR2) 2012; 52
675_CR43
675_CR20
CL Cai (675_CR28) 2003; 5
F Quaini (675_CR5) 2002; 346
S Cayan (675_CR38) 2002; 168
RD Levit (675_CR47) 2013; 2
V Serpooshan (675_CR42) 2013; 34
RD Simari (675_CR21) 2014; 114
Y Zhang (675_CR23) 2013; 5
References_xml – volume: 24
  start-page: 501
  issue: 4
  year: 2014
  ident: 675_CR24
  publication-title: Cell Res
  doi: 10.1038/cr.2014.15
  contributor:
    fullname: X Li
– volume: 51
  start-page: 442
  issue: 3
  year: 2000
  ident: 675_CR34
  publication-title: J Biomed Mater Res
  doi: 10.1002/1097-4636(20000905)51:3<442::AID-JBM19>3.0.CO;2-4
  contributor:
    fullname: GA Abraham
– volume: 112
  start-page: I144
  issue: 9 Suppl
  year: 2005
  ident: 675_CR41
  publication-title: Circulation
  contributor:
    fullname: PV Kochupura
– volume: 5
  start-page: 1071
  issue: 9
  year: 2016
  ident: 675_CR16
  publication-title: Adv Healthc Mater
  doi: 10.1002/adhm.201500861
  contributor:
    fullname: DA Feyen
– volume: 19
  start-page: 738
  issue: 5–6
  year: 2013
  ident: 675_CR33
  publication-title: Tissue Eng Part A
  doi: 10.1089/ten.tea.2012.0480
  contributor:
    fullname: MT Lam
– ident: 675_CR31
  doi: 10.1172/jci.insight.80920
– volume: 8
  start-page: 228
  issue: 2
  year: 2011
  ident: 675_CR39
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2010.12.008
  contributor:
    fullname: SJ Kattman
– volume: 5
  start-page: 025004
  issue: 2
  year: 2013
  ident: 675_CR23
  publication-title: Biofabrication
  doi: 10.1088/1758-5082/5/2/025004
  contributor:
    fullname: Y Zhang
– volume: 142
  start-page: 263
  issue: 2
  year: 2007
  ident: 675_CR12
  publication-title: Cardiothoracic
  contributor:
    fullname: W Hudson
– volume: 34
  start-page: 9048
  issue: 36
  year: 2013
  ident: 675_CR42
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2013.08.017
  contributor:
    fullname: V Serpooshan
– volume: 30
  start-page: 1180
  issue: 10
  year: 2009
  ident: 675_CR3
  publication-title: Eur Heart J
  doi: 10.1093/eurheartj/ehp070
  contributor:
    fullname: S Orn
– volume: 433
  start-page: 647
  issue: 7026
  year: 2005
  ident: 675_CR27
  publication-title: Nature
  doi: 10.1038/nature03215
  contributor:
    fullname: KL Laugwitz
– volume: 9
  start-page: 1530
  issue: 3
  year: 2017
  ident: 675_CR32
  publication-title: Am J Transl Res
  contributor:
    fullname: Y Li
– volume: 168
  start-page: 798
  issue: 2
  year: 2002
  ident: 675_CR38
  publication-title: J Urol
  doi: 10.1016/S0022-5347(05)64746-5
  contributor:
    fullname: S Cayan
– ident: 675_CR43
  doi: 10.1126/scitranslmed.aad9019
– volume: 460
  start-page: 113
  issue: 7251
  year: 2009
  ident: 675_CR26
  publication-title: Nature
  doi: 10.1038/nature08191
  contributor:
    fullname: L Bu
– volume: 26
  start-page: 105
  year: 2015
  ident: 675_CR30
  publication-title: Acta Biomater
  doi: 10.1016/j.actbio.2015.08.017
  contributor:
    fullname: Q Liu
– volume: 35
  start-page: 6850
  issue: 25
  year: 2014
  ident: 675_CR13
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2014.04.114
  contributor:
    fullname: ET Roche
– volume: 116
  start-page: 1176
  issue: 10
  year: 2007
  ident: 675_CR19
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.106.650903
  contributor:
    fullname: J Endo
– volume: 64
  start-page: 1681
  issue: 16
  year: 2014
  ident: 675_CR44
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2014.06.1204
  contributor:
    fullname: SW Kim
– volume: 127
  start-page: 1151
  issue: 6
  year: 2006
  ident: 675_CR29
  publication-title: Cell
  doi: 10.1016/j.cell.2006.10.029
  contributor:
    fullname: A Moretti
– volume: 112
  start-page: I150
  issue: 9 Suppl
  year: 2005
  ident: 675_CR11
  publication-title: Circulation
  contributor:
    fullname: D Hou
– volume: 114
  start-page: I167
  issue: 1 Suppl
  year: 2006
  ident: 675_CR37
  publication-title: Circulation
  contributor:
    fullname: I Kutschka
– volume: 11
  start-page: e0153412
  issue: 4
  year: 2016
  ident: 675_CR35
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0153412
  contributor:
    fullname: CW Chang
– volume: 21
  start-page: 2095
  issue: 12
  year: 2012
  ident: 675_CR15
  publication-title: Stem Cells Dev
  doi: 10.1089/scd.2012.0031
  contributor:
    fullname: J Liu
– volume: 98
  start-page: 1414
  issue: 11
  year: 2006
  ident: 675_CR46
  publication-title: Circ Res
  doi: 10.1161/01.RES.0000225952.61196.39
  contributor:
    fullname: R Uemura
– volume: 132
  start-page: 537
  issue: 4
  year: 2008
  ident: 675_CR25
  publication-title: Cell
  doi: 10.1016/j.cell.2008.02.002
  contributor:
    fullname: SM Wu
– volume: 428
  start-page: 664
  issue: 6983
  year: 2004
  ident: 675_CR4
  publication-title: Nature
  doi: 10.1038/nature02446
  contributor:
    fullname: CE Murry
– volume: 38
  start-page: 450
  issue: 4
  year: 2010
  ident: 675_CR40
  publication-title: Eur J Cardiothorac Surg
  doi: 10.1016/j.ejcts.2010.02.009
  contributor:
    fullname: H Hata
– volume: 114
  start-page: 1564
  issue: 10
  year: 2014
  ident: 675_CR21
  publication-title: Circ Res
  doi: 10.1161/CIRCRESAHA.114.303720
  contributor:
    fullname: RD Simari
– volume: 5
  start-page: 877
  issue: 6
  year: 2003
  ident: 675_CR28
  publication-title: Dev Cell
  doi: 10.1016/S1534-5807(03)00363-0
  contributor:
    fullname: CL Cai
– volume: 1
  start-page: 9
  issue: 1
  year: 2007
  ident: 675_CR9
  publication-title: Stem Cell Res
  doi: 10.1016/j.scr.2007.06.001
  contributor:
    fullname: LW Laake van
– volume: 65
  start-page: 334
  issue: 2
  year: 2005
  ident: 675_CR10
  publication-title: Cardiovasc Res
  doi: 10.1016/j.cardiores.2004.10.004
  contributor:
    fullname: N Hattan
– volume: 52
  start-page: 1135
  issue: 5
  year: 2012
  ident: 675_CR2
  publication-title: J Mol Cell Cardiol
  doi: 10.1016/j.yjmcc.2012.01.021
  contributor:
    fullname: MV Singh
– volume: 33
  start-page: 428
  issue: 2
  year: 2012
  ident: 675_CR14
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2011.09.078
  contributor:
    fullname: D Kuraitis
– volume: 324
  start-page: 98
  issue: 5923
  year: 2009
  ident: 675_CR6
  publication-title: Science
  doi: 10.1126/science.1164680
  contributor:
    fullname: O Bergmann
– volume: 2
  start-page: e000367
  issue: 5
  year: 2013
  ident: 675_CR47
  publication-title: J Am Heart Assoc
  doi: 10.1161/JAHA.113.000367
  contributor:
    fullname: RD Levit
– volume: 10
  start-page: e0133308
  issue: 7
  year: 2015
  ident: 675_CR17
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0133308
  contributor:
    fullname: K Nakajima
– volume: 20
  start-page: 73
  issue: 1
  year: 2014
  ident: 675_CR36
  publication-title: Tissue Eng Part B Rev
  doi: 10.1089/ten.teb.2013.0126
  contributor:
    fullname: HK Lin
– volume: 346
  start-page: 5
  issue: 1
  year: 2002
  ident: 675_CR5
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa012081
  contributor:
    fullname: F Quaini
– volume: 135
  start-page: e146
  issue: 10
  year: 2017
  ident: 675_CR1
  publication-title: Circulation
  doi: 10.1161/CIR.0000000000000485
  contributor:
    fullname: EJ Benjamin
– ident: 675_CR20
  doi: 10.1002/term.2255
– volume: 114
  start-page: 763
  issue: 6
  year: 2003
  ident: 675_CR22
  publication-title: Cell
  doi: 10.1016/S0092-8674(03)00687-1
  contributor:
    fullname: AP Beltrami
– volume: 132
  start-page: 762
  issue: 8
  year: 2015
  ident: 675_CR45
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.114.015231
  contributor:
    fullname: SG Ong
– volume: 1254
  start-page: 57
  year: 2012
  ident: 675_CR7
  publication-title: Ann N Y Acad Sci
  doi: 10.1111/j.1749-6632.2012.06519.x
  contributor:
    fullname: C Soler-Botija
– volume: 34
  start-page: 107
  issue: 2
  year: 2002
  ident: 675_CR8
  publication-title: J Mol Cell Cardiol
  doi: 10.1006/jmcc.2001.1491
  contributor:
    fullname: J Muller-Ehmsen
– volume: 33
  start-page: 5541
  issue: 22
  year: 2012
  ident: 675_CR18
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2012.04.030
  contributor:
    fullname: NH Chi
SSID ssj0000330064
Score 2.3239577
Snippet Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial infarction. However,...
Background Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial...
BackgroundApplication of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial...
BACKGROUNDApplication of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial...
Abstract Background Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial...
SourceID doaj
pubmedcentral
proquest
gale
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 230
SubjectTerms Biocompatibility
Biomedical materials
Bone marrow
Cardiac progenitor cell
Cardiomyocytes
Collagen
Contraction
Endothelial cells
Extracellular matrix
Health aspects
Heart attack
Heart attacks
Heart diseases
Heart failure
Heart regeneration
Intestine
Myocardial infarction
Myocardium
Risk factors
Small intestinal submucosa
Stem cell transplantation
Stem cells
Studies
Ventricle
Vitamin C
Wound healing
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lj9MwELbQSkhcEG8CCxiEhASKtn7ETo4LYrUgwQFYaW_WxLHZSiWFTXvg3zNjZ6taHLhwjadtMs9v0vFnxl4q6Awo0dfGt1ATd07d9o2uO98MWC89dIH2O3_6bE7P9Mfz5nzvqC-aCcv0wFlxR1hPYWGlirHHziVgNkWQEJugxRAthkjKvqLZa6ZSDsY2HYvt_DemaM3RhG1XS1OWNO1lm1oWhSjx9f-dlffKUjkyuVeDTm6xmzN45Mf5pm-za2G8w67n4yR_32W_MlP5CvJ2opGvI0eTizfcJz_wnKaxAgXxJac39hNfjnz6AasVJ9oIjHb6-glvgebYgS_TG4dAYhEDAsEppwOwN5yqIf3CPXZ28v7bu9N6PlKh9lZ1m1oZPWjECIF4Ac0QvDSyjQKEVSHoziuIfewBsOwHIucDJaPwBq-oXgsv1H12MK7H8JBxPygDWOrowCvdLZpeBqE9IOQZLATrK_b6Sr_uZ2bOcKnjaI3LxnBoDEfGcLJib8kCO0EivU4X0BXc7AruX65QsWdkP5d3kO5C1x0TiDQEJSv2IkkQ8cVIkzXfYTtN7sPXL4XQq1kortHWHuaNCvjYxJVVSB4WkhiZvly-ciQ3Z4bJYcYTiLKlthV7vlumT9K02xjWW5JBULXATIqP9CD73U4zslsoKxtcsYVHFqorV8blReINbwwZXT_6H7p-zG5IiiWa7TGH7GBzuQ1PEJ5t-qcpEv8AdBk2NA
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: AUTh Library subscriptions: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3da9UwFA-6IfgynF_rnDOKIChlzUeT9kk22ZiCQ6aDvYU0TeaFa7vd3vvgf-85bW63Iuy1Ob237fn6JTn5HULeC1sqK1iVKlfYFLlz0qLKZVq6vIZ86Wzp8bzz9zN1eiG_XeaXccGti2WV65jYB-q6dbhGfgCWwgCdcKk_X9-k2DUKd1djC42HZJMzidu0m0fHZz_Ox1WWDKbrkHTjdiYr1EEH068Cqy2x6kvnKZ8kpJ63___ofCc9TUsn7-SikydkK4JIejhofZs88M1T8mhoK_n3GbkZGMvndjhW1NA2UFA9-0Rdbw-OYlWWR2deUFy57-isod0fO59TpI8Ar8ef7-ARsJ7d0lm_8uBRLIBjAEil2Ah7STEr4j88Jxcnx7--nKaxtULqtCiXqVCyloAVPPIDqto7rngRmGVaeC9LJ2yoQmUtpH-PJH1W8MCcgiuikswx8YJsNG3jdwh1tVAWUh42vpJlllfcM-ksQJ9aW69dQj6uv6-5Hhg0TD_zKJQZlGFAGQaVYXhCjlADoyCSX_cX2sWVib5kAGLZTHMRQgWTWQ8JFnBjyL1kddAQNRPyBvVnhpOkowubQwSTCiFlQt71EkiA0WCFzZVddZ35-vN8IvQhCoUWdO1sPLAAr42cWRPJvYkkeKibDq8NycQI0Zlbe07I23EY78Sqt8a3K5QBcJVBRIVXejnY3fhleJkJzXMY0ROLnHy66Ugz-93zh-cKlS5373-sV-QxRy_B6h21RzaWi5V_DQBsWe1HL_sHoxov9A
  priority: 102
  providerName: ProQuest
Title Transplantation of Isl1 + cardiac progenitor cells in small intestinal submucosa improves infarcted heart function
URI https://www.ncbi.nlm.nih.gov/pubmed/29037258
https://www.proquest.com/docview/1961161247
https://search.proquest.com/docview/1952108708
https://pubmed.ncbi.nlm.nih.gov/PMC5644064
https://doaj.org/article/893a0723ffb446e284085f5e41df7088
Volume 8
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFLe2ISQuaHwubBSDkJBAWevYsZPjOm0aSJumwqSKi-U49qjUJqNpD_z3vOekVSNuXHqIX9rE7-tn9-f3CPnITS4NZ0UsbWZirJ0TZ0Uq4tymJeRLa3KH552vb-TVnfg2Tad7JN2chQmkfVvMTqv54rSa_QrcyoeFHW54YsPb6_MUkjik0uE-2Vec7yzRQ_iFFToMdv9gskwOG1hxZUiwRKKXSmPsYJPkI64SbPS-k45C1f5_Y_NOcuoTJ3cy0eUhedpBSHrWPuozsueq5-Rx21Tyzwvyu61XPjftoaKK1p6C4tkXaoM1WIqcLIeuvKS4b9_QWUWbhZnPKRaPAJ_Hr2_gEZDNbugs7Ds4FPPgFgBRKbbBXlHMifgLL8nd5cWP86u4a6wQW8XzVcylKAUgBYfVAWXpbCKTzDPDFHdO5JYbX_jCGEj-Dkv0GZ54ZiVc4YVglvFX5KCqK3dEqC25NJDwsO2VyEdpkTgmrAHgUyrjlI3I58386oe2foYO645M6lYvGvSiUS86icgYNbAVxNLX4UK9vNedAWgAWGakEu59AUtZB-kVUKNPnWClVxAzI_IO9afbc6RbB9ZnCCUlAsqIfAgSWP6iQn7NvVk3jf76fdIT-tQJ-Rp0bU13XAFeGytm9SRPepLgn7Y_vDEk3cWHRkPcY4C1E6Ei8n47jHci561y9RplAFqNIJ7CK71u7W47MxvzjYjqWWRv6voj4EyhenjnPG_--85j8iRBX0JajzwhB6vl2r0FZLYqBuCPUzUgj8YXN7eTQdjfgM_J-Ocg-OhfFtU8FA
link.rule.ids 230,315,733,786,790,870,891,2115,12083,21416,27955,27956,31752,31753,33777,33778,43343,43838,53825,53827
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagCMEF8SZQqEFISKCo8SN2ckIFUW2h7QFaaW-W49hlpSVpN7sH_j0ziTc0QuIaT3YTz-uzM_6GkLfClsoKVqXKFTZF7py0qHKZli6vIV86W3o873xyqmbn8us8n8cNty6WVW5jYh-o69bhHvk-WAoDdMKl_nh5lWLXKPy6Glto3CS3pBAS7VzP9bjHksFiHVJu_JjJCrXfweKrwFpLrPnSecon6ahn7f83Nl9LTtPCyWuZ6PA-uRchJD0YdP6A3PDNQ3J7aCr5-xG5GvjKl3Y4VNTQNlBQPPtAXW8NjmJNlkdXXlHct-_ooqHdL7tcUiSPAJ_Hn-_gEbCa3dJFv-_gUSyAWwBEpdgGe00xJ-I_PCbnh1_OPs_S2FghdVqU61QoWUtACh7ZAVXtHVe8CMwyLbyXpRM2VKGyFpK_R4o-K3hgTsEVUUnmmHhCdpq28c8IdbVQFhIetr2SZZZX3DPpLACfWluvXULeb-fXXA78GaZfdxTKDMowoAyDyjA8IZ9QA6MgUl_3F9rVhYmeZABg2UxzEUIFS1kP6RVQY8i9ZHXQEDMTsof6M8M50tGBzQFCSYWAMiFvegmkv2iwvubCbrrOHP34PhF6F4VCC7p2Nh5XgNdGxqyJ5O5EEvzTTYe3hmRifOjMX2tOyOtxGO_EmrfGtxuUAWiVQTyFV3o62N04M7zMhOY5jOiJRU6mbjrSLH727OG5QqXL5_9_rD1yZ3Z2cmyOj06_vSB3OXoM1vGoXbKzXm38S4Bi6-pV729_APShMXs
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fb9MwELZgCMQLv38EBjMICQmUprYTO3kcg2oDNk3ApIkXy3HsUdGmpWkf4K_nzkmrBt72Gl8S2T7ffU4-f0fIK2EKaQQrY2lzE6N2TpyXWRoXNqsgX1pTODzvfHwiD8_Sj-fZ-Vapr0Dat-V4UE-mg3r8I3Ar51ObrHliyenxQQZJHFJpMq98cpVcgzXL1dZGPQRh2KeDSfcfk-UyaWDflSPNEuleKouxjg0vhkJxLPe-lZSCdv__EXorRfXpk1v5aHSbfF_3pKWh_BysluXA_vlH5PFSXb1DbnUole63JnfJFVffI9fbupW_75NfrST6xLTnlmo68xR8i72lNjicpUj7chgtFhR_DTR0XNNmaiYTivoUEFbw8Q30Dwnzho7Dpw2HZh5WHqBgipW2lxTTLr7hATkbffh2cBh3tRtiq0SxjIVMqxTAiEMBQlk5yyXPPTNMCefSwgrjS18aA_jCoQqgEdwzK-GKKFNmmXhIdupZ7R4TaishDeRUrKyVFsOs5I6l1gC2qpRxykbkzXry9LyV6NBha5NL3U66hknXOOmaR-QdTu_GENW1w4XZ4kJ3A68Bw5mh4sL7EnbLDjI4AFOfuZRVXkFYjsgeOoduj6puYoTeR7QqEbNG5GWwQIWNGik8F2bVNPro65ee0evOyM_AkazpTkRAt1GUq2e527OEEGD7zWsv1V0IajSEVgZwnqcqIi82zXgn0upqN1uhDaC3IYRs6NKj1qk3I7NeGxFRPXfvDV2_BZw4CJR3Tvvk0nfukRun70f689HJp6fkJsc1iyQiuUt2louVewY4cFk-Dyv-Lx7XXAI
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Transplantation+of+Isl1%2B+cardiac+progenitor+cells+in+small+intestinal+submucosa+improves+infarcted+heart+function&rft.jtitle=Stem+cell+research+%26+therapy&rft.au=Wang%2C+Lingjun&rft.au=Meier%2C+Elizabeth+M.&rft.au=Tian%2C+Shuo&rft.au=Lei%2C+Ienglam&rft.date=2017-10-16&rft.issn=1757-6512&rft.eissn=1757-6512&rft.volume=8&rft.issue=1&rft_id=info:doi/10.1186%2Fs13287-017-0675-2&rft.externalDBID=n%2Fa&rft.externalDocID=10_1186_s13287_017_0675_2
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1757-6512&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1757-6512&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1757-6512&client=summon