Transplantation of Isl1 + cardiac progenitor cells in small intestinal submucosa improves infarcted heart function
Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial infarction. However, the optimal cell types and biomaterials remain elusive. In this study, we seeded Isl1 embryonic cardiac progenitor cells (CPCs) into decellu...
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Published in | Stem cell research & therapy Vol. 8; no. 1; p. 230 |
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16.10.2017
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Abstract | Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial infarction. However, the optimal cell types and biomaterials remain elusive.
In this study, we seeded Isl1
embryonic cardiac progenitor cells (CPCs) into decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM) to assess the therapeutic potential of Isl1
CPCs and the biocompatibility of SIS-ECM with these cells.
We observed that SIS-ECM supported the viability and attachment of Isl1
CPCs. Importantly, Isl1
CPCs differentiated into cardiomyocytes and endothelial cells 7 days after seeding into SIS-ECM. In addition, SIS-ECM with CPC-derived cardiomyocytes showed spontaneous contraction and responded to β-adrenergic stimulation. Next, patches of SIS-ECM seeded with CPCs for 7 days were transplanted onto the outer surface of infarcted myocardium in mice. Four weeks after transplantation, the patches were tightly attached to the surface of the host myocardium and remained viable. Transplantation of patches improved cardiac function, decreased the left ventricular myocardial scarring area, and reduced fibrosis and heart failure.
Transplantation of Isl1
CPCs seeded in SIS-ECM represents an effective approach for cell-based heart therapy. |
---|---|
AbstractList | Abstract Background Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial infarction. However, the optimal cell types and biomaterials remain elusive. Methods In this study, we seeded Isl1+ embryonic cardiac progenitor cells (CPCs) into decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM) to assess the therapeutic potential of Isl1+ CPCs and the biocompatibility of SIS-ECM with these cells. Results We observed that SIS-ECM supported the viability and attachment of Isl1+ CPCs. Importantly, Isl1+ CPCs differentiated into cardiomyocytes and endothelial cells 7 days after seeding into SIS-ECM. In addition, SIS-ECM with CPC-derived cardiomyocytes showed spontaneous contraction and responded to β-adrenergic stimulation. Next, patches of SIS-ECM seeded with CPCs for 7 days were transplanted onto the outer surface of infarcted myocardium in mice. Four weeks after transplantation, the patches were tightly attached to the surface of the host myocardium and remained viable. Transplantation of patches improved cardiac function, decreased the left ventricular myocardial scarring area, and reduced fibrosis and heart failure. Conclusions Transplantation of Isl1+ CPCs seeded in SIS-ECM represents an effective approach for cell-based heart therapy. Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial infarction. However, the optimal cell types and biomaterials remain elusive. In this study, we seeded Isl1 embryonic cardiac progenitor cells (CPCs) into decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM) to assess the therapeutic potential of Isl1 CPCs and the biocompatibility of SIS-ECM with these cells. We observed that SIS-ECM supported the viability and attachment of Isl1 CPCs. Importantly, Isl1 CPCs differentiated into cardiomyocytes and endothelial cells 7 days after seeding into SIS-ECM. In addition, SIS-ECM with CPC-derived cardiomyocytes showed spontaneous contraction and responded to β-adrenergic stimulation. Next, patches of SIS-ECM seeded with CPCs for 7 days were transplanted onto the outer surface of infarcted myocardium in mice. Four weeks after transplantation, the patches were tightly attached to the surface of the host myocardium and remained viable. Transplantation of patches improved cardiac function, decreased the left ventricular myocardial scarring area, and reduced fibrosis and heart failure. Transplantation of Isl1 CPCs seeded in SIS-ECM represents an effective approach for cell-based heart therapy. Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial infarction. However, the optimal cell types and biomaterials remain elusive. In this study, we seeded Isl1.sup.+ embryonic cardiac progenitor cells (CPCs) into decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM) to assess the therapeutic potential of Isl1.sup.+ CPCs and the biocompatibility of SIS-ECM with these cells. We observed that SIS-ECM supported the viability and attachment of Isl1.sup.+ CPCs. Importantly, Isl1.sup.+ CPCs differentiated into cardiomyocytes and endothelial cells 7 days after seeding into SIS-ECM. In addition, SIS-ECM with CPC-derived cardiomyocytes showed spontaneous contraction and responded to [beta]-adrenergic stimulation. Next, patches of SIS-ECM seeded with CPCs for 7 days were transplanted onto the outer surface of infarcted myocardium in mice. Four weeks after transplantation, the patches were tightly attached to the surface of the host myocardium and remained viable. Transplantation of patches improved cardiac function, decreased the left ventricular myocardial scarring area, and reduced fibrosis and heart failure. Transplantation of Isl1.sup.+ CPCs seeded in SIS-ECM represents an effective approach for cell-based heart therapy. BackgroundApplication of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial infarction. However, the optimal cell types and biomaterials remain elusive.MethodsIn this study, we seeded Isl1+ embryonic cardiac progenitor cells (CPCs) into decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM) to assess the therapeutic potential of Isl1+ CPCs and the biocompatibility of SIS-ECM with these cells.ResultsWe observed that SIS-ECM supported the viability and attachment of Isl1+ CPCs. Importantly, Isl1+ CPCs differentiated into cardiomyocytes and endothelial cells 7 days after seeding into SIS-ECM. In addition, SIS-ECM with CPC-derived cardiomyocytes showed spontaneous contraction and responded to β-adrenergic stimulation. Next, patches of SIS-ECM seeded with CPCs for 7 days were transplanted onto the outer surface of infarcted myocardium in mice. Four weeks after transplantation, the patches were tightly attached to the surface of the host myocardium and remained viable. Transplantation of patches improved cardiac function, decreased the left ventricular myocardial scarring area, and reduced fibrosis and heart failure.ConclusionsTransplantation of Isl1+ CPCs seeded in SIS-ECM represents an effective approach for cell-based heart therapy. Background Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial infarction. However, the optimal cell types and biomaterials remain elusive. Methods In this study, we seeded Isl1.sup.+ embryonic cardiac progenitor cells (CPCs) into decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM) to assess the therapeutic potential of Isl1.sup.+ CPCs and the biocompatibility of SIS-ECM with these cells. Results We observed that SIS-ECM supported the viability and attachment of Isl1.sup.+ CPCs. Importantly, Isl1.sup.+ CPCs differentiated into cardiomyocytes and endothelial cells 7 days after seeding into SIS-ECM. In addition, SIS-ECM with CPC-derived cardiomyocytes showed spontaneous contraction and responded to [beta]-adrenergic stimulation. Next, patches of SIS-ECM seeded with CPCs for 7 days were transplanted onto the outer surface of infarcted myocardium in mice. Four weeks after transplantation, the patches were tightly attached to the surface of the host myocardium and remained viable. Transplantation of patches improved cardiac function, decreased the left ventricular myocardial scarring area, and reduced fibrosis and heart failure. Conclusions Transplantation of Isl1.sup.+ CPCs seeded in SIS-ECM represents an effective approach for cell-based heart therapy. Keywords: Cardiac progenitor cell, Small intestinal submucosa, Heart regeneration, Myocardial infarction |
ArticleNumber | 230 |
Audience | Academic |
Author | Lei, Ienglam Wang, Lingjun Liu, Liu Tian, Shuo Xian, Shaoxiang Wang, Zhong Meier, Elizabeth M Lam, Mai T |
Author_xml | – sequence: 1 givenname: Lingjun surname: Wang fullname: Wang, Lingjun organization: Department of Cardiac Surgery, Cardiovascular Center, The University of Michigan, Ann Arbor, MI, 48109, USA – sequence: 2 givenname: Elizabeth M surname: Meier fullname: Meier, Elizabeth M organization: Department of Biomedical Engineering, Wayne State University, Detroit, MI, 48201, USA – sequence: 3 givenname: Shuo surname: Tian fullname: Tian, Shuo organization: Department of Cardiac Surgery, Cardiovascular Center, The University of Michigan, Ann Arbor, MI, 48109, USA – sequence: 4 givenname: Ienglam surname: Lei fullname: Lei, Ienglam organization: Faculty of Health Sciences, University of Macau, Macau SAR, China – sequence: 5 givenname: Liu surname: Liu fullname: Liu, Liu organization: Department of Cardiac Surgery, Cardiovascular Center, The University of Michigan, Ann Arbor, MI, 48109, USA – sequence: 6 givenname: Shaoxiang surname: Xian fullname: Xian, Shaoxiang organization: The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China – sequence: 7 givenname: Mai T surname: Lam fullname: Lam, Mai T organization: Cardiovascular Research Institute, Wayne State University, Detroit, MI, 48201, USA – sequence: 8 givenname: Zhong surname: Wang fullname: Wang, Zhong email: zhongw@med.umich.edu organization: Department of Cardiac Surgery, Cardiovascular Center, The University of Michigan, Ann Arbor, MI, 48109, USA. zhongw@med.umich.edu |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29037258$$D View this record in MEDLINE/PubMed |
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Keywords | Heart regeneration Myocardial infarction Cardiac progenitor cell Small intestinal submucosa |
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Snippet | Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial infarction. However,... Background Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial... BackgroundApplication of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial... BACKGROUNDApplication of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial... Abstract Background Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial... |
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SubjectTerms | Biocompatibility Biomedical materials Bone marrow Cardiac progenitor cell Cardiomyocytes Collagen Contraction Endothelial cells Extracellular matrix Health aspects Heart attack Heart attacks Heart diseases Heart failure Heart regeneration Intestine Myocardial infarction Myocardium Risk factors Small intestinal submucosa Stem cell transplantation Stem cells Studies Ventricle Vitamin C Wound healing |
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Title | Transplantation of Isl1 + cardiac progenitor cells in small intestinal submucosa improves infarcted heart function |
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