Physiologic effect of repeated adrenaline (epinephrine) doses during cardiopulmonary resuscitation in the cath lab setting: A randomised porcine study

• Published in: Resuscitation Vol. 101; no. C; pp. 77 - 83
• Main Authors: Hardig, Bjarne Madsen, Götberg, Michael, Rundgren, Malin, Götberg, Matthias, Zughaft, David, Kopotic, Robert, Wagner, Henrik
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.04.2016; Elsevier
• Subjects: Adrenaline; Anestesi och intensivvård; Anesthesiology and Intensive Care; Animals; Arterial Pressure - drug effects; Carbon Dioxide - blood; Cardiac arrest; Cardiopulmonary Resuscitation - methods; Clinical Medicine; CPR; Emergency; Epinephrine - administration & dosage; Heart Arrest - physiopathology; Heart Arrest - therapy; Klinisk medicin; Medical and Health Sciences; Medicin och hälsovetenskap; Oxygen - blood; Random Allocation; Swine; CPR; Adrenaline; Cardiac arrest

This porcine study was designed to explore the effects of repetitive intravenous adrenaline doses on physiologic parameters during CPR. Thirty-six adult pigs were randomised to four injections of: adrenaline 0.02mg(kgdose)−1, adrenaline 0.03mg(kgdose)−1 or saline control. The effect on systolic, dia...