Hypothyroidism in hibernating brown bears

• Published in: Thyroid research Vol. 16; no. 1; pp. 3 - 8
• Main Authors: Frøbert, Anne Mette, Nielsen, Claus G., Brohus, Malene, Kindberg, Jonas, Fröbert, Ole, Overgaard, Michael T.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.02.2023; BioMed Central; BMC
• Subjects: Albumin; Bears; Binding proteins; Bradycardia; Brief Report; Comparative analysis; Energy conservation; Energy consumption; Globulins; Grizzly bear; Hibernation; Hormones; Hypothermia; Hypothyroidism; Immunoassay; Liver; Läkemedelskemi; Males; Medicinal Chemistry; Metabolic rate; Metabolism; mRNA; Physiological aspects; Protein binding; Proteins; RNA; RNA sequencing; Statistical analysis; Thyroid gland; Thyroid hormone; Thyroid hormones; Thyroxine; Thyroxine-binding globulin (TBG); Transthyretin; Triiodothyronine; Ursus arctos; Zoologi; Zoology; Ursus arctos; Thyroxine-binding globulin (TBG); Hibernation; Thyroxine; Thyroid hormone; Triiodothyronine; Hypothyroidism; Metabolism

Brown bears hibernate throughout half of the year as a survival strategy to reduce energy consumption during prolonged periods with scarcity of food and water. Thyroid hormones are the major endocrine regulators of basal metabolic rate in humans. Therefore, we aimed to determine regulations in serum...