Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity

• Published in: Nature communications Vol. 8; no. 1; pp. 1214 - 13
• Main Authors: Palmqvist, Sebastian, Schöll, Michael, Strandberg, Olof, Mattsson, Niklas, Stomrud, Erik, Zetterberg, Henrik, Blennow, Kaj, Landau, Susan, Jagust, William, Hansson, Oskar
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 31.10.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 631/1647/245/2092; 631/378/1689/1283; 692/308/53/2421; Accumulation; Aged; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - pathology; Alzheimer Disease - physiopathology; Alzheimer's disease; Amyloid beta-Peptides - cerebrospinal fluid; Amyloid beta-Peptides - metabolism; Atrophy; Basic Medicine; Brain; Brain - metabolism; Brain - pathology; Brain - physiopathology; Cerebrospinal fluid; Cohort Studies; Cortex (parietal); Female; Fibrils; Glucose - metabolism; Humanities and Social Sciences; Humans; Hypometabolism; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinska och farmaceutiska grundvetenskaper; multidisciplinary; Nerve Net - metabolism; Nerve Net - pathology; Nerve Net - physiopathology; Neural networks; Neurochemistry; Neurodegeneration; Neurodegenerative diseases; Neurologi; Neurology; Neurosciences; Neurovetenskaper; Organ Size; Positron emission; Positron emission tomography; Radiologi och bildbehandling; Radiology and Medical Imaging; Reproducibility of Results; Science; Science (multidisciplinary); Tomography; β-Amyloid

It is not known exactly where amyloid-β (Aβ) fibrils begin to accumulate in individuals with Alzheimer’s disease (AD). Recently, we showed that abnormal levels of Aβ42 in cerebrospinal fluid (CSF) can be detected before abnormal amyloid can be detected using PET in individuals with preclinical AD. U...