Development of multi-drug resistance to anticancer drugs in HepG2 cells due to MRP2 upregulation on exposure to menthol

• Published in: PloS one Vol. 18; no. 9; p. e0291822
• Main Authors: Nagai, Katsuhito, Tamura, Mayuko, Murayama, Ryuga, Fukuno, Shuhei, Ito, Takuya, Konishi, Hiroki
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 21.09.2023; Public Library of Science (PLoS)
• Subjects: ABC transporters; Accumulation; AKT protein; Antibacterial agents; Antimitotic agents; Antineoplastic agents; Antineoplastic drugs; Antitumor agents; Biology and Life Sciences; Care and treatment; Cell viability; Chromatography; Cisplatin; Cytotoxicity; Diagnosis; Drug development; Drug resistance; Drug resistance in microorganisms; Epirubicin; Exposure; Functional foods; Functional foods & nutraceuticals; Gene expression; Health aspects; Hepatocellular carcinoma; Hepatoma; High performance liquid chromatography; Inflammation; Intracellular; Liquid chromatography; Liver cancer; Medicine and Health Sciences; Menthol; mRNA; Multidrug resistance; Research and Analysis Methods; Ribonucleic acid; RNA; Verapamil; Japan; United States > US

Background Menthol exerts relaxing, antibacterial, and anti-inflammatory activities, and is marketed as a functional food and therapeutic drug. Aim In the present study, the effects of menthol on the expression of multidrug resistance associated protein 2 (MRP2) and its association with the cytotoxi...