Impacts and perspectives of prenyltransferases of the DMATS superfamily for use in biotechnology

• Published in: Applied microbiology and biotechnology Vol. 99; no. 18; pp. 7399 - 7415
• Main Authors: Fan, Aili, Winkelblech, Julia, Li, Shu-Ming
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2015; Springer; Springer Nature B.V
• Subjects: Analogs; Analysis; Biocatalysts; Biodiversity; Biomedical and Life Sciences; Biotechnology; Biotechnology - methods; Chemical compounds; Chemical synthesis; Dimethylallyltranstransferase - metabolism; Enzymes; Flavonoids; fungi; genes; Indolocarbazoles; Life Sciences; Metabolites; Microbial Genetics and Genomics; Microbiology; Microorganisms; Mini-Review; Natural products; Peptides; Physiological aspects; Plant metabolites; Prenylation; Prenyltransferases; Proteins - metabolism; Studies; Tryptophan; Tryptophan - metabolism; Tyrosine; xanthone; Xanthones - metabolism; Benin; Prenyltransferase; Prenylated compound; Chemoenzymatic synthesis; Friedel-Crafts alkylation; Dimethylallyltryptophan synthase; Biocatalyst

Prenylated compounds are ubiquitously found in nature and demonstrate interesting biological and pharmacological activities. Prenyltransferases catalyze the attachment of prenyl moieties from different prenyl donors to various acceptors and contribute significantly to the structural and biological d...