Assessment of antibody dynamics and neutralizing activity using serological assay after SARS-CoV-2 infection and vaccination

• Published in: PloS one Vol. 18; no. 9; p. e0291670
• Main Authors: Takahashi, Toshihiro, Ai, Tomohiko, Saito, Kaori, Nojiri, Shuko, Takahashi, Maika, Igawa, Gene, Yamamoto, Takamasa, Khasawneh, Abdullah, Paran, Faith Jessica, Takei, Satomi, Horiuchi, Yuki, Kanno, Takayuki, Tobiume, Minoru, Hiki, Makoto, Wakita, Mitsuru, Miida, Takashi, Okuzawa, Atsushi, Suzuki, Tadaki, Takahashi, Kazuhisa, Naito, Toshio, Tabe, Yoko
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 19.09.2023; Public Library of Science (PLoS)
• Subjects: Antibodies; Assaying; Biology and life sciences; COVID-19; COVID-19 vaccines; Enzymes; Ethics; Evaluation; Health aspects; Immune response; Immune response (humoral); Immunoassay; Immunoglobulin G; Infections; Infectious diseases; Medical personnel; Medicine and health sciences; Neutralization; Neutralizing; Pneumonia; Prophylaxis; Proteins; Research and Analysis Methods; Serology; Severe acute respiratory syndrome coronavirus 2; Vaccination; Variance analysis; Viral antibodies; Viral diseases; Viruses; Japan; United States > US

The COVID-19 antibody test was developed to investigate the humoral immune response to SARS-CoV-2 infection. In this study, we examined whether S antibody titers measured using the anti-SARS-CoV-2 IgG II Quant assay (S-IgG), a high-throughput test method, reflects the neutralizing capacity acquired...