Vector-based genetically modified vaccines: Exploiting Jenner’s legacy

• Published in: Vaccine Vol. 34; no. 50; pp. 6436 - 6448
• Main Authors: Ramezanpour, Bahar, Haan, Ingrid, Osterhaus, Ab, Claassen, Eric
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 07.12.2016; Elsevier Limited; The Author(s). Published by Elsevier Ltd
• Subjects: Adenoviridae; Adenoviridae - genetics; Allergy and Immunology; Antigens; Candidates; Clinical trials; Drug Carriers; Drug Discovery - trends; Encephalitis; Flavivirus; Flavivirus - genetics; genetic engineering; Genetic Vectors; Genetically modified techniques; Genetically modifies vaccines; Hepatitis; HIV; Human immunodeficiency virus; Human papillomavirus; Humans; Infectious diseases; Malaria; markets; Medical libraries; Medical Subject Headings-MeSH; Molecular Biology - methods; Novel vaccine platforms; people; Poxviruses and adenoviruses; Respiratory diseases; Search strategies; Technology, Pharmaceutical - methods; Tuberculosis; vaccine development; Vaccines; Vaccines, Synthetic - genetics; Vaccines, Synthetic - immunology; Vaccinia virus; Vaccinia virus - genetics; Vector-based vaccines; Vector-borne diseases; Vectors; Vectors (Biology); Viral Vaccines - genetics; Viral Vaccines - immunology; Viruses; Vector-based vaccines; Vectors; Poxviruses and adenoviruses; Genetically modified techniques; Novel vaccine platforms; Genetically modifies vaccines

The global vaccine market is diverse while facing a plethora of novel developments. Genetic modification (GM) techniques facilitate the design of ’smarter’ vaccines. For many of the major infectious diseases of humans, like AIDS and malaria, but also for most human neoplastic disorders, still no vac...