Putative endogenous filovirus VP35-like protein potentially functions as an IFN antagonist but not a polymerase cofactor

• Published in: PloS one Vol. 12; no. 10; p. e0186450
• Main Authors: Kondoh, Tatsunari, Manzoor, Rashid, Nao, Naganori, Maruyama, Junki, Furuyama, Wakako, Miyamoto, Hiroko, Shigeno, Asako, Kuroda, Makoto, Matsuno, Keita, Fujikura, Daisuke, Kajihara, Masahiro, Yoshida, Reiko, Igarashi, Manabu, Takada, Ayato
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.10.2017; Public Library of Science (PLoS)
• Subjects: Amino Acid Sequence; Amino acids; Animals; Bats; Biology and life sciences; Chiroptera; Chiroptera - virology; Collaboration; Double-stranded RNA; Ebola virus; Ebolavirus; Ebolavirus - genetics; Ebolavirus - isolation & purification; Ebolavirus - metabolism; Education; Epidemiology; Gene Expression; Gene sequencing; Genes, Reporter; Genomes; HEK293 Cells; Host-Pathogen Interactions; Humans; Infections; Interferon; Interferon-beta - antagonists & inhibitors; Interferon-beta - genetics; Interferon-beta - immunology; Kinases; Luciferases - genetics; Luciferases - metabolism; Multiple sclerosis; Myotis lucifugus; Nucleocapsid Proteins; Nucleoproteins - genetics; Nucleoproteins - metabolism; Polymers; Promoter Regions, Genetic; Protein Binding; Proteins; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Replication; Reporter gene; Research and analysis methods; Ribonucleic acid; RNA; RNA viruses; RNA, Double-Stranded - genetics; RNA, Double-Stranded - metabolism; Sequence Alignment; Sequence Homology, Amino Acid; Transcription; Veterinary medicine; Viral Core Proteins - genetics; Viral Core Proteins - metabolism; Viral infections; Virus Replication; Viruses; Zoonoses; Japan

It has been proposed that some non-retroviral RNA virus genes are integrated into vertebrate genomes. Endogenous filovirus-like elements (EFLs) have been discovered in some mammalian genomes. However, their potential roles in ebolavirus infection are unclear. A filovirus VP35-like element (mlEFL35)...