Involvement of Neuropeptide Y Signaling in the Antidepressant-Like Effect and Hippocampal Cell Proliferation Induced by Kososan, a Kampo Medicine, in the Stress-Induced Depression-Like Model Mice

• Published in: Biological & pharmaceutical bulletin Vol. 35; no. 10; pp. 1775 - 1783
• Main Authors: Ito, Naoki, Hori, Atsushi, Yabe, Takeshi, Nagai, Takayuki, Oikawa, Tetsuro, Yamada, Haruki, Hanawa, Toshihiko
• Format: Journal Article
• Language: English; Japanese
• Published: Japan The Pharmaceutical Society of Japan 01.10.2012; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: Animals; antidepressant-like effect; Antidepressive Agents - pharmacology; Antidepressive Agents - therapeutic use; Arginine - analogs & derivatives; Arginine - pharmacology; cell proliferation; Cell Proliferation - drug effects; Depression - drug therapy; Depression - metabolism; Disease Models, Animal; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Hippocampus - cytology; Hippocampus - drug effects; Hippocampus - metabolism; Intracellular Signaling Peptides and Proteins - blood; kososan; Male; Medicine, Kampo; Mice; neuropeptide Y; Neuropeptide Y - antagonists & inhibitors; Neuropeptide Y - metabolism; Neuropeptides - blood; orexin A; Orexins; Signal Transduction - drug effects; Stress, Psychological - drug therapy; Stress, Psychological - metabolism

Neuropeptide Y (NPY) and Orexin-A (OX-A), well-known neuropeptides associated with feeding and arousal, show antidepressant-like properties via hippocampal cell proliferation. Previous studies have revealed that kososan, a Kampo (Japanese herbal) medicine, has an antidepressant-like effect in behavi...