Icariin Enhances Cytotoxicity of Doxorubicin in Human Multidrug-Resistant Osteosarcoma Cells by Inhibition of ABCB1 and Down-Regulation of the PI3K/Akt Pathway

• Published in: Biological & pharmaceutical bulletin Vol. 38; no. 2; pp. 277 - 284
• Main Authors: Wang, Zhendong, Yang, Lei, Xia, Yuanzheng, Guo, Chao, Kong, Lingyi
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.02.2015; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: Antineoplastic Agents - pharmacology; Apoptosis - drug effects; ATP Binding Cassette Transporter, Sub-Family B - genetics; ATP Binding Cassette Transporter, Sub-Family B - metabolism; ATP Binding Cassette Transporter, Sub-Family G, Member 2; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - metabolism; Cell Line, Tumor; Cell Survival - drug effects; Down-Regulation; Doxorubicin - pharmacology; Drug Resistance, Multiple - drug effects; Drug Resistance, Neoplasm - drug effects; Flavonoids - pharmacology; Humans; icariin; multidrug resistance (MDR); Multidrug Resistance-Associated Proteins - genetics; Multidrug Resistance-Associated Proteins - metabolism; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; osteosarcoma; Osteosarcoma - drug therapy; Osteosarcoma - metabolism; phosphatidyl inositol 3-kinase (PI3K)/Akt pathway; Phosphatidylinositol 3-Kinase - metabolism; Proto-Oncogene Proteins c-akt - metabolism

Multidrug resistance is one of the major causes limiting the efficacy of chemotherapeutic agents used to control osteosarcoma. Multidrug resistance protein 1 (MDR1 or ABCB1) was considered to play a critical role in multidrug resistance. Agents from traditional Chinese medicines (TCMs) have great po...