Icariin Enhances Cytotoxicity of Doxorubicin in Human Multidrug-Resistant Osteosarcoma Cells by Inhibition of ABCB1 and Down-Regulation of the PI3K/Akt Pathway - Wang, Zhendong; Yang, Lei; Xia, Yuanzheng; Guo, Chao; Kong, Lingyi (Biological & pharmaceutical bulletin, 2015)
Keywords: Antineoplastic Agents - pharmacology; Apoptosis - drug effects; ATP Binding Cassette Transporter, Sub-Family B - genetics; ATP Binding Cassette Transporter, Sub-Family B - metabolism; ATP Binding Cassette Transporter, Sub-Family G, Member 2; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - metabolism; Cell Line, Tumor; Cell Survival - drug effects; Down-Regulation; Doxorubicin - pharmacology; Drug Resistance, Multiple - drug effects; Drug Resistance, Neoplasm - drug effects; Flavonoids - pharmacology; Humans; icariin; multidrug resistance (MDR); Multidrug Resistance-Associated Proteins - genetics; Multidrug Resistance-Associated Proteins - metabolism; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; osteosarcoma; Osteosarcoma - drug therapy; Osteosarcoma - metabolism; phosphatidyl inositol 3-kinase (PI3K)/Akt pathway; Phosphatidylinositol 3-Kinase - metabolism; Proto-Oncogene Proteins c-akt - metabolism