Transmission of influenza A viruses

• Published in: Virology (New York, N.Y.) Vol. 479-480; pp. 234 - 246
• Main Authors: Neumann, Gabriele, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2015
• Subjects: Animals; Gain-of-function; genes; Hemagglutinin Glycoproteins, Influenza Virus - genetics; Hemagglutinin Glycoproteins, Influenza Virus - metabolism; hemagglutinins; Host-Pathogen Interactions; hosts; Humans; immunity; Infectious Disease; Influenza A virus; Influenza A virus - enzymology; Influenza A virus - genetics; Influenza A virus - growth & development; Influenza virus; Influenza, Human - transmission; Influenza, Human - virology; Orthomyxoviridae Infections - transmission; Orthomyxoviridae Infections - veterinary; Orthomyxoviridae Infections - virology; pandemic; PB2; Receptor-binding; respiratory tract diseases; RNA-Dependent RNA Polymerase - genetics; RNA-Dependent RNA Polymerase - metabolism; Transmission; Viral Proteins - genetics; Viral Proteins - metabolism; Virus lineage; virus transmission; viruses; Zoonoses - transmission; Zoonoses - virology; Virus lineage; PB2; NA; Influenza virus; Transmission; Receptor-binding; HA; Gain-of-function

Influenza A viruses cause respiratory infections that range from asymptomatic to deadly in humans. Widespread outbreaks (pandemics) are attributable to ‘novel’ viruses that possess a viral hemagglutinin (HA) gene to which humans lack immunity. After a pandemic, these novel viruses form stable virus...