Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill
The north-west coast of Spain was heavily contaminated by the Prestige oil spill, in 2002. Individuals who participated in the clean-up tasks showed increased chromosome damage two years after exposure. Long-term clinical implications of chromosome damage are still unknown. To realize a follow-up ge...
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| Published in | PloS one Vol. 10; no. 7; p. e0132413 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
29.07.2015
Public Library of Science (PLoS) |
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| Abstract | The north-west coast of Spain was heavily contaminated by the Prestige oil spill, in 2002. Individuals who participated in the clean-up tasks showed increased chromosome damage two years after exposure. Long-term clinical implications of chromosome damage are still unknown.
To realize a follow-up genotoxic study to detect whether the chromosome damage persisted six years after exposure to the oil.
Follow-up study.
Fishermen cooperatives in coastal villages.
Local fishermen who were highly exposed (n = 52) and non-exposed (n = 23) to oil seven years after the spill.
Chromosome damage in circulating lymphocytes.
Chromosome damage in exposed individuals persists six years after oil exposure, with a similar incidence than those previously detected four years before. A surprising increase in chromosome damage in non-exposed individual was found six years after Prestige spill vs. those detected two years after the exposure.
The sample size and the possibility of some kind of selection bias should be considered. Genotoxic results cannot be extrapolated to the approximately 300,000 individuals who participated occasionally in clean-up tasks.
The persistence of chromosome damage detected in exposed individuals six years after oil exposure seems to indicate that the cells of the bone marrow are affected. A surprising increase in chromosome damage in non-exposed individuals detected in the follow-up study suggests an indirect exposition of these individuals to some oil compounds or to other toxic agents during the last four years. More long-term studies are needed to confirm the presence of chromosome damage in exposed and non-exposed fishermen due to the association between increased chromosomal damage and increased risk of cancer. Understanding and detecting chromosome damage is important for detecting cancer in its early stages. The present work is the first follow-up cytogenetic study carried out in lymphocytes to determine genotoxic damage evolution between two and six years after oil exposure in same individuals. |
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| AbstractList | The north-west coast of Spain was heavily contaminated by the Prestige oil spill, in 2002. Individuals who participated in the clean-up tasks showed increased chromosome damage two years after exposure. Long-term clinical implications of chromosome damage are still unknown. To realize a follow-up genotoxic study to detect whether the chromosome damage persisted six years after exposure to the oil. Follow-up study. Fishermen cooperatives in coastal villages. Local fishermen who were highly exposed (n = 52) and non-exposed (n = 23) to oil seven years after the spill. Chromosome damage in circulating lymphocytes. Chromosome damage in exposed individuals persists six years after oil exposure, with a similar incidence than those previously detected four years before. A surprising increase in chromosome damage in non-exposed individual was found six years after Prestige spill vs. those detected two years after the exposure. The persistence of chromosome damage detected in exposed individuals six years after oil exposure seems to indicate that the cells of the bone marrow are affected. A surprising increase in chromosome damage in non-exposed individuals detected in the follow-up study suggests an indirect exposition of these individuals to some oil compounds or to other toxic agents during the last four years. More long-term studies are needed to confirm the presence of chromosome damage in exposed and non-exposed fishermen due to the association between increased chromosomal damage and increased risk of cancer. Understanding and detecting chromosome damage is important for detecting cancer in its early stages. The present work is the first follow-up cytogenetic study carried out in lymphocytes to determine genotoxic damage evolution between two and six years after oil exposure in same individuals. Background The north-west coast of Spain was heavily contaminated by the Prestige oil spill, in 2002. Individuals who participated in the clean-up tasks showed increased chromosome damage two years after exposure. Long-term clinical implications of chromosome damage are still unknown. Objective To realize a follow-up genotoxic study to detect whether the chromosome damage persisted six years after exposure to the oil. Design Follow-up study. Setting Fishermen cooperatives in coastal villages. Participants Local fishermen who were highly exposed (n = 52) and non-exposed (n = 23) to oil seven years after the spill. Measurements Chromosome damage in circulating lymphocytes. Results Chromosome damage in exposed individuals persists six years after oil exposure, with a similar incidence than those previously detected four years before. A surprising increase in chromosome damage in non-exposed individual was found six years after Prestige spill vs. those detected two years after the exposure. Limitations The sample size and the possibility of some kind of selection bias should be considered. Genotoxic results cannot be extrapolated to the approximately 300,000 individuals who participated occasionally in clean-up tasks. Conclusion The persistence of chromosome damage detected in exposed individuals six years after oil exposure seems to indicate that the cells of the bone marrow are affected. A surprising increase in chromosome damage in non-exposed individuals detected in the follow-up study suggests an indirect exposition of these individuals to some oil compounds or to other toxic agents during the last four years. More long-term studies are needed to confirm the presence of chromosome damage in exposed and non-exposed fishermen due to the association between increased chromosomal damage and increased risk of cancer. Understanding and detecting chromosome damage is important for detecting cancer in its early stages. The present work is the first follow-up cytogenetic study carried out in lymphocytes to determine genotoxic damage evolution between two and six years after oil exposure in same individuals. Background The north-west coast of Spain was heavily contaminated by the Prestige oil spill, in 2002. Individuals who participated in the clean-up tasks showed increased chromosome damage two years after exposure. Long-term clinical implications of chromosome damage are still unknown. Objective To realize a follow-up genotoxic study to detect whether the chromosome damage persisted six years after exposure to the oil. Design Follow-up study. Setting Fishermen cooperatives in coastal villages. Participants Local fishermen who were highly exposed (n = 52) and non-exposed (n = 23) to oil seven years after the spill. Measurements Chromosome damage in circulating lymphocytes. Results Chromosome damage in exposed individuals persists six years after oil exposure, with a similar incidence than those previously detected four years before. A surprising increase in chromosome damage in non-exposed individual was found six years after Prestige spill vs. those detected two years after the exposure. Limitations The sample size and the possibility of some kind of selection bias should be considered. Genotoxic results cannot be extrapolated to the approximately 300,000 individuals who participated occasionally in clean-up tasks. Conclusion The persistence of chromosome damage detected in exposed individuals six years after oil exposure seems to indicate that the cells of the bone marrow are affected. A surprising increase in chromosome damage in non-exposed individuals detected in the follow-up study suggests an indirect exposition of these individuals to some oil compounds or to other toxic agents during the last four years. More long-term studies are needed to confirm the presence of chromosome damage in exposed and non-exposed fishermen due to the association between increased chromosomal damage and increased risk of cancer. Understanding and detecting chromosome damage is important for detecting cancer in its early stages. The present work is the first follow-up cytogenetic study carried out in lymphocytes to determine genotoxic damage evolution between two and six years after oil exposure in same individuals. The north-west coast of Spain was heavily contaminated by the Prestige oil spill, in 2002. Individuals who participated in the clean-up tasks showed increased chromosome damage two years after exposure. Long-term clinical implications of chromosome damage are still unknown.To realize a follow-up genotoxic study to detect whether the chromosome damage persisted six years after exposure to the oil.Follow-up study.Fishermen cooperatives in coastal villages.Local fishermen who were highly exposed (n = 52) and non-exposed (n = 23) to oil seven years after the spill.Chromosome damage in circulating lymphocytes.Chromosome damage in exposed individuals persists six years after oil exposure, with a similar incidence than those previously detected four years before. A surprising increase in chromosome damage in non-exposed individual was found six years after Prestige spill vs. those detected two years after the exposure.The sample size and the possibility of some kind of selection bias should be considered. Genotoxic results cannot be extrapolated to the approximately 300,000 individuals who participated occasionally in clean-up tasks.The persistence of chromosome damage detected in exposed individuals six years after oil exposure seems to indicate that the cells of the bone marrow are affected. A surprising increase in chromosome damage in non-exposed individuals detected in the follow-up study suggests an indirect exposition of these individuals to some oil compounds or to other toxic agents during the last four years. More long-term studies are needed to confirm the presence of chromosome damage in exposed and non-exposed fishermen due to the association between increased chromosomal damage and increased risk of cancer. Understanding and detecting chromosome damage is important for detecting cancer in its early stages. The present work is the first follow-up cytogenetic study carried out in lymphocytes to determine genotoxic damage evolution between two and six years after oil exposure in same individuals. The north-west coast of Spain was heavily contaminated by the Prestige oil spill, in 2002. Individuals who participated in the clean-up tasks showed increased chromosome damage two years after exposure. Long-term clinical implications of chromosome damage are still unknown. To realize a follow-up genotoxic study to detect whether the chromosome damage persisted six years after exposure to the oil. Follow-up study. Fishermen cooperatives in coastal villages. Local fishermen who were highly exposed (n = 52) and non-exposed (n = 23) to oil seven years after the spill. Chromosome damage in circulating lymphocytes. Chromosome damage in exposed individuals persists six years after oil exposure, with a similar incidence than those previously detected four years before. A surprising increase in chromosome damage in non-exposed individual was found six years after Prestige spill vs. those detected two years after the exposure. The sample size and the possibility of some kind of selection bias should be considered. Genotoxic results cannot be extrapolated to the approximately 300,000 individuals who participated occasionally in clean-up tasks. The persistence of chromosome damage detected in exposed individuals six years after oil exposure seems to indicate that the cells of the bone marrow are affected. A surprising increase in chromosome damage in non-exposed individuals detected in the follow-up study suggests an indirect exposition of these individuals to some oil compounds or to other toxic agents during the last four years. More long-term studies are needed to confirm the presence of chromosome damage in exposed and non-exposed fishermen due to the association between increased chromosomal damage and increased risk of cancer. Understanding and detecting chromosome damage is important for detecting cancer in its early stages. The present work is the first follow-up cytogenetic study carried out in lymphocytes to determine genotoxic damage evolution between two and six years after oil exposure in same individuals. |
| Audience | Academic |
| Author | Barberà, Joan Albert Fuster, Carme Frances, Alexandra Zock, Jan-Paul Hildur, Kristin Gómez, Federico P Souto, Ana Templado, Cristina Antó, Josep M Monyarch, Gemma Rodriguez-Rodriguez, Emma Pozo-Rodríguez, Francisco Giraldo, Jesús Rodríguez-Trigo, Gema |
| AuthorAffiliation | 9 Departamento de Medicina Respiratoria, Complexo Hospitalario Universitario A Coruña, A Coruña, Spain 2 Centre de Recerca en Epidemiologia Ambiental (CREAL), Barcelona, Spain 6 Departamento de Medicina Respiratoria, Unidad Epidemiologia Clínica, Hospital 12 de Octubre, Madrid, Spain 4 CIBER Epidemiologia i Salut Pública (CIBERESP), Barcelona, Spain 8 Departamento de Medicina Respiratoria, Hospital Clínico San Carlos, Madrid, Spain 5 Unitat de Bioestadística and Institut de Neurociències, Facultat de Medicina, UAB, Bellaterra, Spain University at Buffalo, UNITED STATES 7 CIBER Enfermedades Respiratorias (CIBERES), Bunyola, Mallorca, Spain 1 Unitat de Biologia Cel·lular i Genètica Mèdica, Facultat de Medicina, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain 3 Hospital del Mar Medical Research Institute, Barcelona, Spain 10 Departament de Medicina Respiratòria, Hospital Clínic-Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain 11 Universitat Pompeu Fabra |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26221948$$D View this record in MEDLINE/PubMed |
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| Copyright | COPYRIGHT 2015 Public Library of Science 2015 Hildur et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. cc-by (c) Hildur, K. et al., 2015 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/3.0/es 2015 Hildur et al 2015 Hildur et al |
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| Editor | Ren, Xuefeng |
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| Issue | 7 |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License |
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| Notes | Conceived and designed the experiments: GRT JPZ FPG JAA FPR JAB CF. Performed the experiments: KH GM AF CT CF. Analyzed the data: JG JPZ. Contributed reagents/materials/analysis tools: ERR AS. Wrote the paper: KH JG JPZ GRT FPG JAA FPR JAB CT CF. Competing Interests: The authors have declared that no competing interests exist. |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519162/ |
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| Snippet | The north-west coast of Spain was heavily contaminated by the Prestige oil spill, in 2002. Individuals who participated in the clean-up tasks showed increased... Background The north-west coast of Spain was heavily contaminated by the Prestige oil spill, in 2002. Individuals who participated in the clean-up tasks showed... BACKGROUND: The north-west coast of Spain was heavily contaminated by the Prestige oil spill, in 2002. Individuals who participated in the clean-up tasks... Background The north-west coast of Spain was heavily contaminated by the Prestige oil spill, in 2002. Individuals who participated in the clean-up tasks showed... |
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| SubjectTerms | Adult Aged Biomarkers Bone marrow Bone Marrow Cells - metabolism Bone Marrow Cells - pathology Cancer Catàstrofe del Prestige, Espanya, 2002 Chromosome Aberrations Chromosomes Citogenètica Coastal environments Crude oil Cytogenetics Càncer Damage detection Deoxyribonucleic acid DNA DNA Damage Environmental cleanup Environmental Exposure - adverse effects Exposure Female Fishers (Persons) Follow-Up Studies Genetic aspects Genetic toxicology Genotoxicity Health aspects Health risks Humans Hydrocarbons Lymphocytes Lymphocytes - metabolism Lymphocytes - pathology Male Medical research Middle Aged Mollusks Mutació (Biologia) Mutation (Biology) Mytilus Occupational exposure Occupational Exposure - adverse effects Oil pollution Oil spills Petroleum Pollution - adverse effects Prestige oil spill, Spain, 2002 Spain Studies Time Factors Toxicologia genètica VOCs Volatile organic compounds |
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| Title | Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/26221948 https://www.proquest.com/docview/1700107793/abstract/ https://recercat.cat/handle/2072/260897 https://pubmed.ncbi.nlm.nih.gov/PMC4519162 https://doaj.org/article/0e79e48d0bd547d7b3098ca6742a332b http://dx.doi.org/10.1371/journal.pone.0132413 |
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