Carcinogenicity of multi-walled carbon nanotubes : challenging issue on hazard assessment

• Published in: Journal of Occupational Health Vol. 60; no. 1; pp. 10 - 30
• Main Authors: Fukushima, Shoji, Kasai, Tatsuya, Umeda, Yumi, Ohnishi, Makoto, Sasaki, Toshiaki, Matsumoto, Michiharu
• Format: Journal Article
• Language: English
• Published: Australia JAPAN SOCIETY FOR OCCUPATIONAL HEALTH 01.01.2018; Oxford University Press; Japan Society for Occupational Health
• Subjects: Animals; Cancer; Carcinogenesis; Carcinogenesis - drug effects; Carcinogenicity; Carcinogens; Carcinoma - chemically induced; Exposure limits; Fibers; Gastric cancer; Hazard assessment; Humans; Inhalation; Inhalation Exposure; Injection; Lung - drug effects; Lung burden; Lung carcinogenicity; Lung carcinoma; Lung Neoplasms - chemically induced; Macrophages; Maximum Allowable Concentration; Mesothelioma; Mesothelioma - chemically induced; Mesothelioma, Malignant; Mice; Mode of action; Multi wall carbon nanotubes; Multi‐walled carbon nanotube; MWCNT; Nanotechnology; Nanotubes; Nanotubes, Carbon - toxicity; Occupational exposure; Occupational Exposure - standards; Occupational health; Peritoneal Neoplasms - chemically induced; Peritoneum; Phagocytosis; Phagocytosis - drug effects; Pleural Neoplasms - chemically induced; Rats; Respiration; Review; Rodents; Shape effects; Trachea; Mesothelioma; Lung burden; MWCNT; Inhalation exposure; Multi-walled carbon nanotube; Lung carcinogenicity

[Abstract]: [Objectives]: This report reviews the carcinogenicity of multi-walled carbon nanotubes (MWCNTs) in experimental animals, concentrating on MWNT-7, a straight fibrous MWCNT. [Methods]: MWCNTs were administered to mice and rats by intraperitoneal injection, intrascrotal injection, subcutane...