The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia

• Published in: Nature medicine Vol. 23; no. 3; pp. 301 - 313
• Main Authors: Fenouille, Nina, Bassil, Christopher F, Ben-Sahra, Issam, Benajiba, Lina, Alexe, Gabriela, Ramos, Azucena, Pikman, Yana, Conway, Amy S, Burgess, Michael R, Li, Qing, Luciano, Frédéric, Auberger, Patrick, Galinsky, Ilene, DeAngelo, Daniel J, Stone, Richard M, Zhang, Yi, Perkins, Archibald S, Shannon, Kevin, Hemann, Michael T, Puissant, Alexandre, Stegmaier, Kimberly
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.03.2017; Nature Publishing Group
• Subjects: 13/31; 59/5; 692/699/67/1990/283/1897; 692/699/67/2327; 96; 96/1; 96/34; 96/35; Acute myelocytic leukemia; Adult; Aged; Aged, 80 and over; Analysis; ATP; Biomedicine; Blotting, Western; Cancer; Cancer Research; Care and treatment; Cell cycle; Cell metabolism; Computer Simulation; Core Binding Factor Alpha 2 Subunit - genetics; Core Binding Factor Alpha 2 Subunit - metabolism; Creatine Kinase - genetics; Creatine Kinase - metabolism; Dehydrogenases; Development and progression; DNA-Binding Proteins - genetics; Female; Flow Cytometry; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic - genetics; Genetic aspects; Genome-Wide Association Study; Health aspects; Humans; Infectious Diseases; Kinases; Leukemia; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - metabolism; Male; MDS1 and EVI1 Complex Locus Protein; Medicine; Metabolic Diseases; Metabolic Networks and Pathways; Metabolism; Metabolites; Metabolomics; Middle Aged; Mitochondria; Molecular Medicine; Mutation; Neurosciences; Oncogenes; Oncology; Physiological aspects; Proteins; Proto-Oncogenes - genetics; RNA, Small Interfering; Transcription factors; Transcription Factors - genetics; New York; San Francisco California; California; United States > US; Massachusetts

Transcriptomic and metabolic profiling reveals that the creatine kinase pathway is essential for growth of acute myeloid leukemias expressing the transcription factor EVI1. Expression of the MECOM (also known as EVI1 ) proto-oncogene is deregulated by chromosomal translocations in some cases of acut...