THC Prevents MDMA Neurotoxicity in Mice

The majority of MDMA (ecstasy) recreational users also consume cannabis. Despite the rewarding effects that both drugs have, they induce several opposite pharmacological responses. MDMA causes hyperthermia, oxidative stress and neuronal damage, especially at warm ambient temperature. However, THC, t...

Full description

Saved in:
Bibliographic Details
Published inPloS one Vol. 5; no. 2; p. e9143
Main Authors Touriño, Clara, Zimmer, Andreas, Valverde, Olga
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 10.02.2010
Public Library of Science (PLoS)
Subjects
Online AccessGet full text

Cover

Loading…
Abstract The majority of MDMA (ecstasy) recreational users also consume cannabis. Despite the rewarding effects that both drugs have, they induce several opposite pharmacological responses. MDMA causes hyperthermia, oxidative stress and neuronal damage, especially at warm ambient temperature. However, THC, the main psychoactive compound of cannabis, produces hypothermic, anti-inflammatory and antioxidant effects. Therefore, THC may have a neuroprotective effect against MDMA-induced neurotoxicity. Mice receiving a neurotoxic regimen of MDMA (20 mg/kg x 4) were pretreated with THC (3 mg/kg x 4) at room (21 degrees C) and at warm (26 degrees C) temperature, and body temperature, striatal glial activation and DA terminal loss were assessed. To find out the mechanisms by which THC may prevent MDMA hyperthermia and neurotoxicity, the same procedure was carried out in animals pretreated with the CB(1) receptor antagonist AM251 and the CB(2) receptor antagonist AM630, as well as in CB(1), CB(2) and CB(1)/CB(2) deficient mice. THC prevented MDMA-induced-hyperthermia and glial activation in animals housed at both room and warm temperature. Surprisingly, MDMA-induced DA terminal loss was only observed in animals housed at warm but not at room temperature, and this neurotoxic effect was reversed by THC administration. However, THC did not prevent MDMA-induced hyperthermia, glial activation, and DA terminal loss in animals treated with the CB(1) receptor antagonist AM251, neither in CB(1) and CB(1)/CB(2) knockout mice. On the other hand, THC prevented MDMA-induced hyperthermia and DA terminal loss, but only partially suppressed glial activation in animals treated with the CB(2) cannabinoid antagonist and in CB(2) knockout animals. Our results indicate that THC protects against MDMA neurotoxicity, and suggest that these neuroprotective actions are primarily mediated by the reduction of hyperthermia through the activation of CB(1) receptor, although CB(2) receptors may also contribute to attenuate neuroinflammation in this process.
AbstractList The majority of MDMA (ecstasy) recreational users also consume cannabis. Despite the rewarding effects that both drugs have, they induce several opposite pharmacological responses. MDMA causes hyperthermia, oxidative stress and neuronal damage, especially at warm ambient temperature. However, THC, the main psychoactive compound of cannabis, produces hypothermic, anti-inflammatory and antioxidant effects. Therefore, THC may have a neuroprotective effect against MDMA-induced neurotoxicity. Mice receiving a neurotoxic regimen of MDMA (20 mg/kg x4) were pretreated with THC (3 mg/kg x4) at room (21°C) and at warm (26°C) temperature, and body temperature, striatal glial activation and DA terminal loss were assessed. To find out the mechanisms by which THC may prevent MDMA hyperthermia and neurotoxicity, the same procedure was carried out in animals pretreated with the CB.sub.1 receptor antagonist AM251 and the CB.sub.2 receptor antagonist AM630, as well as in CB.sub.1, CB.sub.2 and CB.sub.1 /CB.sub.2 deficient mice. THC prevented MDMA-induced-hyperthermia and glial activation in animals housed at both room and warm temperature. Surprisingly, MDMA-induced DA terminal loss was only observed in animals housed at warm but not at room temperature, and this neurotoxic effect was reversed by THC administration. However, THC did not prevent MDMA-induced hyperthermia, glial activation, and DA terminal loss in animals treated with the CB.sub.1 receptor antagonist AM251, neither in CB.sub.1 and CB.sub.1 /CB.sub.2 knockout mice. On the other hand, THC prevented MDMA-induced hyperthermia and DA terminal loss, but only partially suppressed glial activation in animals treated with the CB.sub.2 cannabinoid antagonist and in CB.sub.2 knockout animals. Our results indicate that THC protects against MDMA neurotoxicity, and suggest that these neuroprotective actions are primarily mediated by the reduction of hyperthermia through the activation of CB.sub.1 receptor, although CB.sub.2 receptors may also contribute to attenuate neuroinflammation in this process.
The majority of MDMA (ecstasy) recreational users also consume cannabis. Despite the rewarding effects that both drugs have, they induce several opposite pharmacological responses. MDMA causes hyperthermia, oxidative stress and neuronal damage, especially at warm ambient temperature. However, THC, the main psychoactive compound of cannabis, produces hypothermic, anti-inflammatory and antioxidant effects. Therefore, THC may have a neuroprotective effect against MDMA-induced neurotoxicity. Mice receiving a neurotoxic regimen of MDMA (20 mg/kg ×4) were pretreated with THC (3 mg/kg ×4) at room (21°C) and at warm (26°C) temperature, and body temperature, striatal glial activation and DA terminal loss were assessed. To find out the mechanisms by which THC may prevent MDMA hyperthermia and neurotoxicity, the same procedure was carried out in animals pretreated with the CB1 receptor antagonist AM251 and the CB2 receptor antagonist AM630, as well as in CB1, CB2 and CB1/CB2 deficient mice. THC prevented MDMA-induced-hyperthermia and glial activation in animals housed at both room and warm temperature. Surprisingly, MDMA-induced DA terminal loss was only observed in animals housed at warm but not at room temperature, and this neurotoxic effect was reversed by THC administration. However, THC did not prevent MDMA-induced hyperthermia, glial activation, and DA terminal loss in animals treated with the CB1 receptor antagonist AM251, neither in CB1 and CB1/CB2 knockout mice. On the other hand, THC prevented MDMA-induced hyperthermia and DA terminal loss, but only partially suppressed glial activation in animals treated with the CB2 cannabinoid antagonist and in CB2 knockout animals. Our results indicate that THC protects against MDMA neurotoxicity, and suggest that these neuroprotective actions are primarily mediated by the reduction of hyperthermia through the activation of CB1 receptor, although CB2 receptors may also contribute to attenuate neuroinflammation in this process.
The majority of MDMA (ecstasy) recreational users also consume cannabis. Despite the rewarding effects that both drugs have, they induce several opposite pharmacological responses. MDMA causes hyperthermia, oxidative stress and neuronal damage, especially at warm ambient temperature. However, THC, the main psychoactive compound of cannabis, produces hypothermic, anti-inflammatory and antioxidant effects. Therefore, THC may have a neuroprotective effect against MDMA-induced neurotoxicity. Mice receiving a neurotoxic regimen of MDMA (20 mg/kg ×4) were pretreated with THC (3 mg/kg ×4) at room (21°C) and at warm (26°C) temperature, and body temperature, striatal glial activation and DA terminal loss were assessed. To find out the mechanisms by which THC may prevent MDMA hyperthermia and neurotoxicity, the same procedure was carried out in animals pretreated with the CB 1 receptor antagonist AM251 and the CB 2 receptor antagonist AM630, as well as in CB 1 , CB 2 and CB 1 /CB 2 deficient mice. THC prevented MDMA-induced-hyperthermia and glial activation in animals housed at both room and warm temperature. Surprisingly, MDMA-induced DA terminal loss was only observed in animals housed at warm but not at room temperature, and this neurotoxic effect was reversed by THC administration. However, THC did not prevent MDMA-induced hyperthermia, glial activation, and DA terminal loss in animals treated with the CB 1 receptor antagonist AM251, neither in CB 1 and CB 1 /CB 2 knockout mice. On the other hand, THC prevented MDMA-induced hyperthermia and DA terminal loss, but only partially suppressed glial activation in animals treated with the CB 2 cannabinoid antagonist and in CB 2 knockout animals. Our results indicate that THC protects against MDMA neurotoxicity, and suggest that these neuroprotective actions are primarily mediated by the reduction of hyperthermia through the activation of CB 1 receptor, although CB 2 receptors may also contribute to attenuate neuroinflammation in this process.
The majority of MDMA (ecstasy) recreational users also consume cannabis. Despite the rewarding effects that both drugs have, they induce several opposite pharmacological responses. MDMA causes hyperthermia, oxidative stress and neuronal damage, especially at warm ambient temperature. However, THC, the main psychoactive compound of cannabis, produces hypothermic, anti-inflammatory and antioxidant effects. Therefore, THC may have a neuroprotective effect against MDMA-induced neurotoxicity. Mice receiving a neurotoxic regimen of MDMA (20 mg/kg x 4) were pretreated with THC (3 mg/kg x 4) at room (21 degrees C) and at warm (26 degrees C) temperature, and body temperature, striatal glial activation and DA terminal loss were assessed. To find out the mechanisms by which THC may prevent MDMA hyperthermia and neurotoxicity, the same procedure was carried out in animals pretreated with the CB(1) receptor antagonist AM251 and the CB(2) receptor antagonist AM630, as well as in CB(1), CB(2) and CB(1)/CB(2) deficient mice. THC prevented MDMA-induced-hyperthermia and glial activation in animals housed at both room and warm temperature. Surprisingly, MDMA-induced DA terminal loss was only observed in animals housed at warm but not at room temperature, and this neurotoxic effect was reversed by THC administration. However, THC did not prevent MDMA-induced hyperthermia, glial activation, and DA terminal loss in animals treated with the CB(1) receptor antagonist AM251, neither in CB(1) and CB(1)/CB(2) knockout mice. On the other hand, THC prevented MDMA-induced hyperthermia and DA terminal loss, but only partially suppressed glial activation in animals treated with the CB(2) cannabinoid antagonist and in CB(2) knockout animals. Our results indicate that THC protects against MDMA neurotoxicity, and suggest that these neuroprotective actions are primarily mediated by the reduction of hyperthermia through the activation of CB(1) receptor, although CB(2) receptors may also contribute to attenuate neuroinflammation in this process.
Audience Academic
Author Touriño, Clara
Zimmer, Andreas
Valverde, Olga
AuthorAffiliation Minnesota State University Mankato, United States of America
2 Department of Molecular Psychiatry, University of Bonn, Bonn, Germany
1 Departament de Ciències Experimentals i de la Salut, Grup de Recerca en Neurobiologia del Comportament (GRNC), Universitat Pompeu Fabra, Barcelona, Spain
AuthorAffiliation_xml – name: 2 Department of Molecular Psychiatry, University of Bonn, Bonn, Germany
– name: 1 Departament de Ciències Experimentals i de la Salut, Grup de Recerca en Neurobiologia del Comportament (GRNC), Universitat Pompeu Fabra, Barcelona, Spain
– name: Minnesota State University Mankato, United States of America
Author_xml – sequence: 1
  givenname: Clara
  surname: Touriño
  fullname: Touriño, Clara
  email: clara.tourino@upf.edu
  organization: Departament de Ciències Experimentals i de la Salut, Grup de Recerca en Neurobiologia del Comportament (GRNC), Universitat Pompeu Fabra, Barcelona, Spain. clara.tourino@upf.edu
– sequence: 2
  givenname: Andreas
  surname: Zimmer
  fullname: Zimmer, Andreas
– sequence: 3
  givenname: Olga
  surname: Valverde
  fullname: Valverde, Olga
BackLink https://www.ncbi.nlm.nih.gov/pubmed/20174577$$D View this record in MEDLINE/PubMed
BookMark eNqNkl1r2zAUhsXoWNts_2BshsHGLpLpy5Z9UwjZRwPNOrZut0KRjxIFx8oku7T_fnLjhhg2GEZYOnreI52j9xyd1K4GhF4SPCFMkA8b1_paVZNdDE8wxgXh7Ak6IwWj44xidnI0P0XnIWwwTlmeZc_QKcVE8FSIM_Tu5nKWfPNwC3UTksXHxTT5Cq13jbuz2jb3ia2ThdXwHD01qgrwov-P0M_Pn25ml-Or6y_z2fRqrAVjzZhzUxgMudGUqDwDYMBLXqY6z0GY0oici5TkjAqswOg0ixdhEcOKZIQUmI3Q633eXeWC7GsMktC8oCkhWUfM90Tp1EbuvN0qfy-dsvIh4PxKKt9YXYGkBSwBiF7yJXAjTLc0ojS8zATu-jJCF_1p7XILpY5N8KoaJB3u1HYtV-5W0pzynJKYgOwT6NBq6UGD16p5EB4W3aBYUBn5-CJR86Y_1LvfLYTmH2X21ErFSmxtXLyA3tqg5ZQLVpCsyLpck79Q8Stha3V0hrExPhC8Hwgi08Bds1JtCHL-4_v_s9e_huzbI3YNqmrWwVVtY10dhiDvO-ZdCB7ModsEy87Yj92QnbFlb-woe3X8UgfRo5PZH4aq8ms
CitedBy_id crossref_primary_10_1007_s00213_011_2598_4
crossref_primary_10_1007_s12640_011_9265_8
crossref_primary_10_1371_journal_pone_0098079
crossref_primary_10_1002_hup_2609
crossref_primary_10_1016_j_neubiorev_2015_12_010
crossref_primary_10_1371_journal_pone_0141502
crossref_primary_10_1016_j_expneurol_2021_113894
crossref_primary_10_1016_j_neuropharm_2014_03_014
crossref_primary_10_1016_j_neuroscience_2011_11_040
crossref_primary_10_1080_00952990_2019_1578366
crossref_primary_10_3389_fnmol_2018_00295
crossref_primary_10_3389_fphar_2021_713486
crossref_primary_10_1016_j_pnpbp_2015_09_003
crossref_primary_10_1111_jnc_12060
crossref_primary_10_1371_journal_pone_0225273
crossref_primary_10_1111_jnc_12247
crossref_primary_10_33549_physiolres_935156
crossref_primary_10_1016_j_pbb_2013_03_011
crossref_primary_10_1111_bph_12519
crossref_primary_10_1007_s00204_013_1120_7
crossref_primary_10_1016_j_jocn_2017_08_042
crossref_primary_10_1124_pharmrev_120_000056
crossref_primary_10_1007_s00221_012_3186_5
crossref_primary_10_1002_glia_22773
crossref_primary_10_1007_s00204_013_1147_9
crossref_primary_10_3389_fnins_2015_00445
crossref_primary_10_1016_j_pharmthera_2012_01_008
crossref_primary_10_1016_j_neuropharm_2012_01_013
crossref_primary_10_1007_s12640_016_9633_5
crossref_primary_10_1002_jnr_23452
crossref_primary_10_1111_joim_12049
crossref_primary_10_1016_j_pharmthera_2011_09_002
crossref_primary_10_2174_1573407214666180703130525
crossref_primary_10_1016_j_brainres_2019_146556
crossref_primary_10_1016_j_brainresbull_2017_01_020
crossref_primary_10_1016_j_pharmthera_2017_06_003
crossref_primary_10_1007_s00213_012_2918_3
crossref_primary_10_1016_j_neuro_2016_07_008
crossref_primary_10_1016_j_pbb_2011_06_032
crossref_primary_10_1016_j_neuropharm_2011_07_002
crossref_primary_10_1016_j_lfs_2019_01_050
ContentType Journal Article
Copyright COPYRIGHT 2010 Public Library of Science
2010 Touriño et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Touriño et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5
Touriño et al. 2010
Copyright_xml – notice: COPYRIGHT 2010 Public Library of Science
– notice: 2010 Touriño et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: Touriño et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. info:eu-repo/semantics/openAccess <a href="http://creativecommons.org/licenses/by/2.5/">http://creativecommons.org/licenses/by/2.5/</a>
– notice: Touriño et al. 2010
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
IOV
ISR
3V.
7QG
7QL
7QO
7RV
7SN
7SS
7T5
7TG
7TM
7U9
7X2
7X7
7XB
88E
8AO
8C1
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABJCF
ABUWG
AFKRA
ARAPS
ATCPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
D1I
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
KB.
KB0
KL.
L6V
LK8
M0K
M0S
M1P
M7N
M7P
M7S
NAPCQ
P5Z
P62
P64
PATMY
PDBOC
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
PTHSS
PYCSY
RC3
XX2
5PM
DOA
DOI 10.1371/journal.pone.0009143
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Opposing Viewpoints In Context
Science in Context
ProQuest Central (Corporate)
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Biotechnology Research Abstracts
Nursing & Allied Health Database
Ecology Abstracts
Entomology Abstracts (Full archive)
Immunology Abstracts
Meteorological & Geoastrophysical Abstracts
Nucleic Acids Abstracts
Virology and AIDS Abstracts
Agricultural Science Collection
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Public Health Database
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Materials Science & Engineering Collection
ProQuest Central (Alumni)
ProQuest Central
Advanced Technologies & Aerospace Collection
Agricultural & Environmental Science Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Materials Science Collection
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection (Proquest) (PQ_SDU_P3)
ProQuest Health & Medical Complete (Alumni)
Materials Science Database
Nursing & Allied Health Database (Alumni Edition)
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest Engineering Collection
Biological Sciences
Agriculture Science Database
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Engineering Database
Nursing & Allied Health Premium
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
Environmental Science Database
Materials Science Collection
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Engineering Collection
Environmental Science Collection
Genetics Abstracts
Recercat
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Agricultural Science Database
Publicly Available Content Database
ProQuest Central Student
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
Health Research Premium Collection
Meteorological & Geoastrophysical Abstracts
Natural Science Collection
Biological Science Collection
ProQuest Medical Library (Alumni)
Engineering Collection
Advanced Technologies & Aerospace Collection
Engineering Database
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Agricultural Science Collection
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Environmental Science Collection
Entomology Abstracts
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Environmental Science Database
ProQuest Nursing & Allied Health Source (Alumni)
Engineering Research Database
ProQuest One Academic
Meteorological & Geoastrophysical Abstracts - Academic
Technology Collection
Technology Research Database
Materials Science Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
Genetics Abstracts
ProQuest Engineering Collection
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Agricultural & Environmental Science Collection
AIDS and Cancer Research Abstracts
Materials Science Database
ProQuest Materials Science Collection
ProQuest Public Health
ProQuest Nursing & Allied Health Source
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Animal Behavior Abstracts
Materials Science & Engineering Collection
Immunology Abstracts
ProQuest Central (Alumni)
DatabaseTitleList





MEDLINE
Agricultural Science Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
DocumentTitleAlternate THC Prevents MDMA Toxicity
EISSN 1932-6203
Editor Albertson, Dawn N.
Editor_xml – sequence: 1
  givenname: Dawn N.
  surname: Albertson
  fullname: Albertson, Dawn N.
ExternalDocumentID 1289251160
oai_doaj_org_article_29ebee1cb4be4f7f9ebef7df4d670620
oai_recercat_cat_2072_213193
2897041631
A473916963
10_1371_journal_pone_0009143
20174577
Genre Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations United Kingdom--UK
France
Germany
Spain
GeographicLocations_xml – name: Spain
– name: Germany
– name: United Kingdom--UK
– name: France
GroupedDBID ---
123
29O
2WC
3V.
53G
5VS
7RV
7X2
7X7
7XC
88E
8AO
8C1
8CJ
8FE
8FG
8FH
8FI
8FJ
A8Z
AAFWJ
ABDBF
ABIVO
ABJCF
ABUWG
ACGFO
ACIHN
ACIWK
ACPRK
ADBBV
ADRAZ
AEAQA
AENEX
AFKRA
AFRAH
AHMBA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
APEBS
ARAPS
ATCPS
BAWUL
BBNVY
BBORY
BCNDV
BENPR
BGLVJ
BHPHI
BKEYQ
BPHCQ
BVXVI
BWKFM
CCPQU
CGR
CS3
CUY
CVF
D1I
D1J
D1K
DIK
DU5
E3Z
EAP
EAS
EBD
ECM
EIF
EMOBN
ESTFP
ESX
EX3
F5P
FPL
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
IAO
IEA
IHR
IHW
INH
INR
IOV
IPNFZ
IPY
ISE
ISR
ITC
K6-
KB.
KQ8
L6V
LK5
LK8
M0K
M1P
M48
M7P
M7R
M7S
M~E
NAPCQ
NPM
O5R
O5S
OK1
P2P
P62
PATMY
PDBOC
PIMPY
PQQKQ
PROAC
PSQYO
PTHSS
PYCSY
RIG
RNS
RPM
SV3
TR2
UKHRP
WOQ
WOW
~02
~KM
AAYXX
AFPKN
CITATION
7QG
7QL
7QO
7SN
7SS
7T5
7TG
7TM
7U9
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
KL.
M7N
P64
PQEST
PQUKI
PRINS
RC3
PV9
RZL
XX2
5PM
-
02
AAPBV
ABPTK
ADACO
BBAFP
KM
ID FETCH-LOGICAL-c733t-44f9f0e8fc21a86ee3e4d4d5c88e7fdf78475183270aefc5601736ee0a1611903
IEDL.DBID RPM
ISSN 1932-6203
IngestDate Fri Nov 26 17:14:31 EST 2021
Tue Oct 22 14:56:05 EDT 2024
Tue Sep 17 21:25:37 EDT 2024
Fri Oct 25 12:14:18 EDT 2024
Thu Oct 10 18:00:15 EDT 2024
Thu Feb 22 23:38:47 EST 2024
Fri Feb 02 04:00:39 EST 2024
Thu Aug 01 19:49:02 EDT 2024
Thu Aug 01 20:37:05 EDT 2024
Tue Aug 20 22:01:04 EDT 2024
Fri Aug 23 01:26:40 EDT 2024
Tue Oct 15 23:39:14 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Language English
License This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
Creative Commons Attribution License
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c733t-44f9f0e8fc21a86ee3e4d4d5c88e7fdf78475183270aefc5601736ee0a1611903
Notes Conceived and designed the experiments: CT OV. Performed the experiments: CT. Analyzed the data: CT. Contributed reagents/materials/analysis tools: AZ. Wrote the paper: CT OV.
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824821/
PMID 20174577
PQID 1289251160
PQPubID 1436336
PageCount e9143
ParticipantIDs plos_journals_1289251160
doaj_primary_oai_doaj_org_article_29ebee1cb4be4f7f9ebef7df4d670620
pubmedcentral_primary_oai_pubmedcentral_nih_gov_2824821
csuc_recercat_oai_recercat_cat_2072_213193
proquest_journals_1289251160
gale_infotracmisc_A473916963
gale_infotracacademiconefile_A473916963
gale_incontextgauss_ISR_A473916963
gale_incontextgauss_IOV_A473916963
gale_healthsolutions_A473916963
crossref_primary_10_1371_journal_pone_0009143
pubmed_primary_20174577
PublicationCentury 2000
PublicationDate 2010-02-10
PublicationDateYYYYMMDD 2010-02-10
PublicationDate_xml – month: 02
  year: 2010
  text: 2010-02-10
  day: 10
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: San Francisco
– name: San Francisco, USA
PublicationTitle PloS one
PublicationTitleAlternate PLoS One
PublicationYear 2010
Publisher Public Library of Science
Public Library of Science (PLoS)
Publisher_xml – name: Public Library of Science
– name: Public Library of Science (PLoS)
References 18074122 - Psychopharmacology (Berl). 2008 Apr;197(2):263-78
8071867 - J Pharmacol Exp Ther. 1994 Aug;270(2):741-51
10318961 - Proc Natl Acad Sci U S A. 1999 May 11;96(10):5780-5
3169967 - Inflammation. 1988 Aug;12(4):361-71
17684733 - Psychopharmacology (Berl). 2007 Dec;195(2):255-64
17415074 - Curr Opin Psychiatry. 2007 May;20(3):228-34
7689702 - Nature. 1993 Sep 2;365(6441):61-5
10368032 - Prog Neurobiol. 1999 Jul;58(4):315-48
17520319 - J Neural Transm (Vienna). 2007;114(8):959-68
19005077 - J Neurosci. 2008 Nov 12;28(46):12125-35
17950256 - Biol Psychiatry. 2008 Jun 1;63(11):1030-8
9888857 - Science. 1999 Jan 15;283(5400):401-4
10570211 - Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):14136-41
10869379 - J Pharmacol Exp Ther. 2000 Jun;293(3):807-12
2906000 - Eur J Pharmacol. 1988 Aug 2;152(3):227-34
15464016 - Eur J Pharmacol. 2004 Oct 1;500(1-3):3-13
11077072 - Neuropharmacology. 2001;40(1):65-74
9222545 - Br J Pharmacol. 1997 Jul;121(5):889-900
2433425 - J Pharmacol Exp Ther. 1987 Jan;240(1):1-7
7539115 - Neuropharmacology. 1994 Dec;33(12):1589-95
18047478 - Basic Clin Pharmacol Toxicol. 2008 Jan;102(1):15-24
11470336 - Drug Alcohol Depend. 2001 Sep 1;64(1):9-17
15582925 - J Psychopharmacol. 2004 Dec;18(4):572-5
16375685 - Curr Drug Targets CNS Neurol Disord. 2005 Dec;4(6):677-84
15081792 - Neuropharmacology. 2004 Jun;46(7):954-65
17387458 - Psychopharmacology (Berl). 2007 Jul;193(1):75-84
9653176 - Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8268-73
15189347 - J Neurochem. 2004 Jun;89(6):1445-53
12023525 - J Pharmacol Exp Ther. 2002 Jun;301(3):963-8
17449459 - Neurotox Res. 2007 Apr;11(3-4):183-202
18037916 - Br J Pharmacol. 2008 Jan;153(2):240-51
14561934 - Neuroreport. 2003 Oct 27;14(15):1983-7
12869661 - Pharmacol Rev. 2003 Sep;55(3):463-508
15337264 - Neurosci Lett. 2004 Sep 9;367(3):349-54
16770327 - Br J Pharmacol. 2006 Jul;148(6):778-85
17870248 - Neuroscience. 2007 Oct 12;149(1):112-22
15816011 - Hum Psychopharmacol. 2005 Jun;20(4):249-61
11755802 - J Adolesc Health. 2002 Jan;30(1):64-72
7675958 - Psychopharmacology (Berl). 1995 Jun;119(3):247-60
18635709 - J Psychopharmacol. 2009 Jul;23(5):495-509
9634574 - J Neurosci. 1998 Jul 1;18(13):5086-94
17965659 - Nat Neurosci. 2007 Nov;10(11):1387-94
References_xml
SSID ssj0053866
Score 2.2488525
Snippet The majority of MDMA (ecstasy) recreational users also consume cannabis. Despite the rewarding effects that both drugs have, they induce several opposite...
SourceID plos
doaj
pubmedcentral
csuc
proquest
gale
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage e9143
SubjectTerms Activation
Alcohol
Ambient temperature
Animals
Antioxidants
Astrocytes - drug effects
Astrocytes - metabolism
Body temperature
Body Temperature - drug effects
Brain
Cannabinoid CB1 receptors
Cannabinoid CB2 receptors
Cannabinoides
Cannabis
Dopamine
Drogues
Dronabinol - pharmacology
Drug abuse
Drugs
Ecstasy
Ecstasy (Drug)
Efectes fisiològics
Fever
Fever - chemically induced
Fever - prevention & control
Genetically modified animals
Hallucinogens - toxicity
Hyperthermia
Indoles - pharmacology
Inflammation
Marijuana
MDMA
MDMA (Droga)
Mental Health/Substance Abuse
Mice
Mice, Inbred C57BL
Mice, Knockout
Microglia - drug effects
Microglia - metabolism
N-Methyl-3,4-methylenedioxyamphetamine - toxicity
Neostriatum
Neurological Disorders/Neuropharmacology
Neuroprotection
Neurotoxicity
Neurotoxicity Syndromes - etiology
Neurotoxicity Syndromes - prevention & control
Oxidative stress
Pharmacology
Pharmacology/Drug Interactions
Physiology
Piperidines - pharmacology
Psychotropic Drugs - pharmacology
Pyrazoles - pharmacology
Receptor, Cannabinoid, CB1 - antagonists & inhibitors
Receptor, Cannabinoid, CB1 - genetics
Receptor, Cannabinoid, CB1 - metabolism
Receptor, Cannabinoid, CB2 - antagonists & inhibitors
Receptor, Cannabinoid, CB2 - genetics
Receptor, Cannabinoid, CB2 - metabolism
Receptors
Rodents
Temperature
Temperature effects
Tetrahydrocannabinol
Young adults
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Nb9MwFLdQT1wQg8ECHUQT0gApzHEcOzmWfaggFSTY0G6W49ijEkqrJZX25_Ne7EYNmgQHDj2kfmrln9-n8t7PhLwpDDO1NiwRTOoEUmqdVGlNk6rEWwg458b1Xb5fxPyKf77Or3eu-sKeME8P7IE7YSX8jU1NxSvLnXT46GTteC0kFcxX67TcFlPeB4MVCxEG5TKZnoRz-bBeNRYZC8t-SmcnEE1MuzGBtn9wzpP1r1V7X-b5ZwPlTkS6eEwehVQynvkt7JEHtnlC9oKxtvHbwCj97ik5vpyfxoGsqY0XZ4tZ3JNydKu7pYE0PF428QI8xj65uji_PJ0n4YaExMgs6xLOXemoLZxhqS6EtZnlNa9zUxRWutpJiD05Gq2k2jqD1ZfMQIxqSPQgFciekUkDmByQOM9KAeeCjH4acKaQpmRF7bTkVENE0xFJtnCptSfCUP3bMAkFhN-wQnhVgDci7xFTBX7b3hrdKeSxHh7ww6hkiqXgA0D4IyI__DDK9l-AJqigCepvmhCR13huyg-QDparZlzidDF4mogc9RLIe9FgY82N3rSt-vT1xz8Iff82EjoOQm4FGmB0GGYAAJBPayQ5HUmC9ZrR8gFq2RbCVkG-UGLZJ2A_063m3b_83CvhgBrkcpLnUkZEjtRzBOt4pVn-7CnFofDmBUtf_I9zeEke-hYLBjF-Sibd7cYeQubWVa96I_0Nu-4_5w
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Technology Collection
  dbid: 8FG
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3dj5QwEG90ffHFeH4deioxJqcmeFAKA09mPV1Xk9VE78y9NaW0d5sYWBc28c93Bgoe5mJ82Ae2A-z-Ol-FmV8Ze55prkuleZByUAGm1CooojIMipx2IRBCaNtV-X5Ol6fi01ly5h64Na6scvCJnaMua03PyI_Qj-aUDqfhm83PgHaNorerbguN6-xGxAFIq7PFh8EToy2nqWuXiyE6crPzelNXhngL865X51I4mulmpx15_-iiZ5sfdXNV_vl3GeWluLS4zW65hNKf9xqwx66Z6g7bcybb-C8cr_TLu-zwZHnsO8qmxl-9W839jpqjrX-tNSbj_rryV-g37rHTxfuT42Xg9kkINMRxGwhhcxuazGoeqSw1JjaiFGWis8yALS1gBErIdCFUxmpag0GMYqHCdA8Tgvg-m1WIyT7zkzhPcXaI108JCyEmK3FWWgUiVBjXlMeCAS656ekwZPdODHAZ0f9hSfBKB6_HXhGmEr232WrVSmKzHg_ow0PgkkfoCVD4LSE_Xphkuy_q7bl0hiR5jmpnIl2IwuAvtHRoobSiTCFMeeixpzRvsm8jHe1XzgVQjzH6G4896ySI_aKi8ppztWsa-fHL9_8Q-vZ1InTohGyNGqCVa2lAAIhVayJ5MJFEG9aT4X3SsgHCRv7Rdjxz0Lyrhx_0SjiihhkdiATAYzBRzwms05FqfdERi-PyW2Q8evjvWz5iN_sSCo4x_IDN2u3OPMbMrC2edOb3G5BsNU4
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1db9MwFLVGeeEFMb4WKBAhpAFSJsdx4uQBoTKYClJBghXtzXIce6s0JaVJpe3f797EiQgq0h76kPomSo7vx7FsHxPyJtVMF0qzIGFCBUCpVZCHBQ3yDE8h4Jxr267y_Z7Ml_zbWXy2R_ozWx2A9c6hHZ4ntdxcHl39uf4IAf-hPbVBhP1NR-uqNKhHmAEHuEPuMpTmwsV8fJhXgOhuZy-RtcDb0chtpvvfU0bFaqLrrXbS_kMCn6wvq3oXO_13keVfVevkAbnv6KY_6_xjn-yZ8iHZdwFd-2-d6vS7R-TwdH7sO0Gn2l98Xsz8Vrijqa5WGqi6vyr9BWSVx2R58uX0eB64UxQCLaKoCTi3maUmtZqFKk2MiQwveBHrNDXCFlZAfYoxsAVVxmocoYkIzKgCMgh0IXpCJiVgckD8OMoS6DtU_VPcCgpUJkoLqwSnCqqe8kjQwyXXnViGbGfMBAwyug-WCK908HrkPWIqIbebjVaNRK3r4QJ_jAomWQh5Aow_IfLDg9G2_aPanEsXZpJl4JQm1DnPDbyhxUsrCsuLRFDocI-8wn6T3SbTIbrljAvcgQzZyCOvWwvUxihx8c252ta1_Prj9y2Mfv0cGR06I1uBB2jlNjwAAKi5NbKcjiwhwvWo-QC9rIewlsApMhwaJvA9097zdjc_7ZxwQA34nuCxEB4RI_ccwTpuKVcXrew4DM55ysJntwHoObnXLbNgUOenZNJstuYFsLcmf9kG5A1WYj8K
  priority: 102
  providerName: Scholars Portal
Title THC Prevents MDMA Neurotoxicity in Mice
URI https://www.ncbi.nlm.nih.gov/pubmed/20174577
https://www.proquest.com/docview/1289251160
https://recercat.cat/handle/2072/213193
https://pubmed.ncbi.nlm.nih.gov/PMC2824821
https://doaj.org/article/29ebee1cb4be4f7f9ebef7df4d670620
http://dx.doi.org/10.1371/journal.pone.0009143
Volume 5
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFLe2cuGCGF8rlBIhpAFS2sRx4uTYlZaClDGNDfVmOY69VdrSqmklTvztvJc4EUE7IA6xlPqlSp7fx--1z78Q8i5WVOVSUTeiXLoAqaWb-bnnZgm-hYAxpkzV5XsWLa7Y12W4PCBhsxematpX2WpU3N6NitVN1Vu5uVPjpk9sfJ5OoUxgMfXHh-QQDLQp0evwCw4cRXaPXMD9sV2S0WZdaCQrTAAgIAMwWCILOe-ko54q98qS97chure5XZf34c-_2yj_yEvzx-SRBZTOpL7xI3KgiyfkyLps6by3vNIfnpKTy8XUsZRNpZN-SidORc2xW_9cKQDjzqpwUogbz8jVfHY5Xbj2PQmu4kGwcxkzifF0bBT1ZRxpHWiWszxUcay5yQ2HDBSi63JPaqOwBuMBiHkS4B4AguA56RWgnmPihEESweogr59khnsAVoI4N5IzT0Jek33iNuoSm5oOQ1T_iXEoI-oHFqhpYTXdJx9RpwKit94quRPIZt2e4EE9TgX1IRKA8Clqvv1ilK0-WG-vhV1_QRMwO-2rjGUa7tDgqeG5YXnEvYh6ffIG103U20hb_xUTxnGPMcSbPnlbSSD7RYHtNddyX5biy7cf_yD0_aIjdGKFzBosQEm7pQEUgKxaHclBRxJ8WHWmj9HKGhWWAlBDgsVfBM8zaCzv_ukXtRG2Wmssu094xzw7au3OgJ9VxOLWr17-95WvyMO6u4JCeh-Q3m67168BtO2yIbjqksMYT30c55-H5MHp7Oz8Ylj9DAJjymIcf82GlUP_BsKBRXU
link.rule.ids 230,315,730,783,787,867,888,2109,2228,12070,12237,12779,21402,24332,27938,27939,31735,33282,33389,33760,43326,43595,43616,43821,53808,53810,74083,74352,74373,74640
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELegPMDLxPhaYLAIIQ2QsjmOEydPqBtMHaxDgg71zXIce6uEktKkEn8-d4mbLWhCPPQh9SVpz_fxc3L3MyFvUs10oTQLEiZUAJBaBXlY0CDPcBcCzrm2bZXveTK54J_n8dw9cKtdWeUmJraBuqg0PiM_hDiaIRxO6IflrwB3jcK3q24LjbvkHvJwoYWLeb_gAl9OEtcuF4nw0M3OwbIqDfIWZm2vzo10NNL1Wjvy_j5Ej5Y_q_o2_Pl3GeWNvHTykGw5QOmPOwvYJndM-YhsO5et_beOV_rdY7I_mxz7jrKp9qcfp2O_peZoqt8LDWDcX5T-FOLGE3Jx8ml2PAncPgmBFlHUBJzbzFKTWs1ClSbGRIYXvIh1mhphCysgA8XouoIqYzWuwUQEYlQB3ANAED0loxJ0skP8OMoSmB3k9VPcCgpgJUoLqwSnCvKa8kiwUZdcdnQYsn0nJmAZ0f1hieqVTr0eeY86lRC9zUqrRiKbdX-AH0YFkyyESADCR6j5_sIo235RrS6lcyTJMjA7E-qc5wZ-ocVDKwrLi0TQhFGP7OG8ya6NtPdfOeYCe4wh3njkdSuB7BclltdcqnVdy9OvP_5D6Pu3gdC-E7IVWIBWrqUBFICsWgPJ3YEk-LAeDO-glW1UWMtra4czN5Z3-_Czzgh7rQGiEzwWwiNiYJ4DtQ5HysVVSywOy2-esvD5v2-5R-5PZtMzeXZ6_uUFedCVUzDI57tk1KzW5iWgtCZ_1briHxm-ODI
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELegSIgXxPhaxmARQhoghTqOEydPqHRUHdCBYEN7sxzHHpWmpDSpxJ_PXeKGBU2Ihz6kvn6d7-Pn5u53hLxINdOF0ixImFABQGoV5GFBgzzDKQScc23bKt-TZH7GP5zH567-qXZllduY2AbqotL4H_kY4miGcDihY-vKIr4czd6ufgY4QQrvtLpxGjfJLciKMU4zSKd9uQf4dZK41rlIhGO3U29WVWmQwzBr-3aupKaRrjfaEfn34Xq0uqzq67Do3yWVV3LU7B6568ClP-msYYfcMOV9suPct_ZfOo7pVw_I4el86jv6ptpfHC0mfkvT0VS_lhqAub8s_QXEkIfkbPb-dDoP3MyEQIsoagLObWapSa1moUoTYyLDC17EOk2NsIUVkI1idGNBlbEaz2MiAjGqAPoBOIgekVEJOtklfhxlCewUcvwpbgUF4BKlhVWCUwU5Tnkk2KpLrjpqDNneHxNwpOh-sET1Sqdej7xGnUqI5GatVSOR2bq_wAejgkkWQlQA4Xeo-f6NUbZ9olpfSOdUkmVggibUOc8NfEOLl1YUlheJoAmjHjnAfZNdS2nvy3LCBfYbQ-zxyPNWApkwSrSpC7Wpa3n8-ft_CH37OhA6dEK2AgvQyrU3gAKQYWsguT-QBH_Wg-VdtLKtCmv5x_LhlVvLu375cWeEvdYA3QkeC-ERMTDPgVqHK-XyR0syDkdxnrJw798feUBugxfKT8cnH5-QO11lBYPUvk9GzXpjngJga_JnrSf-BqR6PDI
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=THC+Prevents+MDMA+Neurotoxicity+in+Mice&rft.jtitle=PloS+one&rft.au=Touri%C3%B1o%2C+Clara&rft.au=Zimmer%2C+Andreas&rft.au=Valverde%2C+Olga&rft.date=2010-02-10&rft.pub=Public+Library+of+Science&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=5&rft.issue=2&rft.spage=e9143&rft_id=info:doi/10.1371%2Fjournal.pone.0009143&rft.externalDBID=IOV&rft.externalDocID=A473916963
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon