Anti-inflammatory Activity of Crude Extract and Fractions of Nectandra falcifolia Leaves

• Published in: Biological & Pharmaceutical Bulletin Vol. 29; no. 11; pp. 2241 - 2245
• Main Authors: Melo, Juliana Oliveira de, Maria da Conceição Torrado Truiti, Muscará, Marcelo Nicolás, Bolonheis, Simone Marques, Dantas, Jailson Araujo, Caparroz-Assef, Silvana Martins, Cuman, Roberto Kenji Nakamura, Bersani-Amado, Ciomar Aparecida
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.11.2006; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: Administration, Oral; Animals; anti-inflammatory; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Carrageenan - administration & dosage; Carrageenan - toxicity; Croton Oil - administration & dosage; Croton Oil - toxicity; Drug Evaluation, Preclinical - methods; Ear - pathology; ear edema; Edema - chemically induced; Edema - metabolism; Edema - prevention & control; Hindlimb - drug effects; Hindlimb - pathology; Indomethacin - pharmacology; Indomethacin - therapeutic use; Inflammation - chemically induced; Inflammation - metabolism; Inflammation - prevention & control; Injections, Intradermal; Lauraceae - chemistry; Male; Nectandra falcifolia; Nitric Oxide - metabolism; paw edema; Peroxidase - metabolism; Phytotherapy - methods; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Plant Leaves - chemistry; pleurisy; Pleurisy - chemically induced; Pleurisy - metabolism; Pleurisy - prevention & control; Rats; Rats, Wistar; Solvents - chemistry

The present study evaluated the effect of the crude extract of the leaves of Nectandra falcifolia (NEES) Castiglioni and its fractions in different experimental models of inflammation (paw edema, pleurisy, and ear edema). Carrageenan-induced edema of the paw and pleurisy were evaluated in Wistar rat...