Anti-inflammatory Activity of Crude Extract and Fractions of Nectandra falcifolia Leaves
The present study evaluated the effect of the crude extract of the leaves of Nectandra falcifolia (NEES) Castiglioni and its fractions in different experimental models of inflammation (paw edema, pleurisy, and ear edema). Carrageenan-induced edema of the paw and pleurisy were evaluated in Wistar rat...
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| Published in | Biological & Pharmaceutical Bulletin Vol. 29; no. 11; pp. 2241 - 2245 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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Japan
The Pharmaceutical Society of Japan
01.11.2006
Pharmaceutical Society of Japan Japan Science and Technology Agency |
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| Abstract | The present study evaluated the effect of the crude extract of the leaves of Nectandra falcifolia (NEES) Castiglioni and its fractions in different experimental models of inflammation (paw edema, pleurisy, and ear edema). Carrageenan-induced edema of the paw and pleurisy were evaluated in Wistar rats (180—220 g), which were treated with different doses of the total extract (250, 500 mg·kg−1). Edema of the ear, induced by croton oil, and determination of myeloperoxidase activity were evaluated in Swiss mice (25—35 g). In this experiment, the crude extract of Nectandra falcifolia (Nf) (1.25, 2.5, 5.0, 7.5 mg) and the hexane, chloroform, ethyl-acetate and hydromethanol fractions (5.0 mg) were applied topically, immediately after application of the oil. The crude extract of Nf (500 mg·kg−1) significantly reduced edema of the paw compared to the control group. Similarly, at doses of 250 and 500 mg·kg−1 it significantly reduced the volume of pleural inflammatory exudate compared to the control animals. However, it did not change the number of migrated cells. At doses of 2.5, 5.0 and 7.5 mg, the crude extract significantly inhibited edema of the ear and the influx of neutrophils. The fractions from Nectandra falcifolia (hexane, chloroform, ethyl acetate and hydromethanol) also inhibited edema of the ear. Taken together, the results demonstrated that the crude extract and its fractions administered to animals orally or topically showed an anti-inflammatory effect. |
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| AbstractList | The present study evaluated the effect of the crude extract of the leaves of Nectandra falcifolia (NEES) Castiglioni and its fractions in different experimental models of inflammation (paw edema, pleurisy, and ear edema). Carrageenan-induced edema of the paw and pleurisy were evaluated in Wistar rats (180-220 g), which were treated with different doses of the total extract (250, 500mg・kg-1). Edema of the ear, induced by croton oil, and determination of myeloperoxidase activity were evaluated in Swiss mice (25-35 g). In this experiment, the crude extract of Nectandra falcifolia (Nf) (1.25, 2.5, 5.0, 7.5 mg) and the hexane, chloroform, ethyl-acetate and hy-dromethanol fractions (5.0 mg) were applied topically, immediately after application of the oil. The crude extract of Nf (500mg・kg-1) significantly reduced edema of the paw compared to the control group. Similarly, at doses of 250 and 500mg*・kg-1 it significantly reduced the volume of pleural inflammatory exudate compared to the control animals. However, it did not change the number of migrated cells. At doses of 2.5, 5.0 and 7.5 mg, the crude extract significantly inhibited edema of the ear and the influx of neutrophils. The fractions from Nectandra falcifolia (hexane, chloroform, ethyl acetate and hydromethanol) also inhibited edema of the ear. Taken together, the results demonstrated that the crude extract and its fractions administered to animals orally or topically showed an anti-inflammatory effect. The present study evaluated the effect of the crude extract of the leaves of Nectandra falcifolia (NEES) Castiglioni and its fractions in different experimental models of inflammation (paw edema, pleurisy, and ear edema). Carrageenan-induced edema of the paw and pleurisy were evaluated in Wistar rats (180--220 g), which were treated with different doses of the total extract (250, 500 mg·kg-1). Edema of the ear, induced by croton oil, and determination of myeloperoxidase activity were evaluated in Swiss mice (25--35 g). In this experiment, the crude extract of Nectandra falcifolia (Nf) (1.25, 2.5, 5.0, 7.5 mg) and the hexane, chloroform, ethyl-acetate and hydromethanol fractions (5.0 mg) were applied topically, immediately after application of the oil. The crude extract of Nf (500 mg·kg-1) significantly reduced edema of the paw compared to the control group. Similarly, at doses of 250 and 500 mg·kg-1 it significantly reduced the volume of pleural inflammatory exudate compared to the control animals. However, it did not change the number of migrated cells. At doses of 2.5, 5.0 and 7.5 mg, the crude extract significantly inhibited edema of the ear and the influx of neutrophils. The fractions from Nectandra falcifolia (hexane, chloroform, ethyl acetate and hydromethanol) also inhibited edema of the ear. Taken together, the results demonstrated that the crude extract and its fractions administered to animals orally or topically showed an anti-inflammatory effect. The present study evaluated the effect of the crude extract of the leaves of Nectandra falcifolia (NEES) Castiglioni and its fractions in different experimental models of inflammation (paw edema, pleurisy, and ear edema). Carrageenan-induced edema of the paw and pleurisy were evaluated in Wistar rats (180-220 g), which were treated with different doses of the total extract (250, 500 mg.kg-1). Edema of the ear, induced by croton oil, and determination of myeloperoxidase activity were evaluated in Swiss mice (25-35 g). In this experiment, the crude extract of Nectandra falcifolia (Nf) (1.25, 2.5, 5.0, 7.5 mg) and the hexane, chloroform, ethyl-acetate and hydromethanol fractions (5.0 mg) were applied topically, immediately after application of the oil. The crude extract of Nf (500 mg.kg-1) significantly reduced edema of the paw compared to the control group. Similarly, at doses of 250 and 500 mg.kg-1 it significantly reduced the volume of pleural inflammatory exudate compared to the control animals. However, it did not change the number of migrated cells. At doses of 2.5, 5.0 and 7.5 mg, the crude extract significantly inhibited edema of the ear and the influx of neutrophils. The fractions from Nectandra falcifolia (hexane, chloroform, ethyl acetate and hydromethanol) also inhibited edema of the ear. Taken together, the results demonstrated that the crude extract and its fractions administered to animals orally or topically showed an anti-inflammatory effect. The present study evaluated the effect of the crude extract of the leaves of Nectandra falcifolia (NEES) Castiglioni and its fractions in different experimental models of inflammation (paw edema, pleurisy, and ear edema). Carrageenan-induced edema of the paw and pleurisy were evaluated in Wistar rats (180—220 g), which were treated with different doses of the total extract (250, 500 mg·kg−1). Edema of the ear, induced by croton oil, and determination of myeloperoxidase activity were evaluated in Swiss mice (25—35 g). In this experiment, the crude extract of Nectandra falcifolia (Nf) (1.25, 2.5, 5.0, 7.5 mg) and the hexane, chloroform, ethyl-acetate and hydromethanol fractions (5.0 mg) were applied topically, immediately after application of the oil. The crude extract of Nf (500 mg·kg−1) significantly reduced edema of the paw compared to the control group. Similarly, at doses of 250 and 500 mg·kg−1 it significantly reduced the volume of pleural inflammatory exudate compared to the control animals. However, it did not change the number of migrated cells. At doses of 2.5, 5.0 and 7.5 mg, the crude extract significantly inhibited edema of the ear and the influx of neutrophils. The fractions from Nectandra falcifolia (hexane, chloroform, ethyl acetate and hydromethanol) also inhibited edema of the ear. Taken together, the results demonstrated that the crude extract and its fractions administered to animals orally or topically showed an anti-inflammatory effect. |
| Author | Bersani-Amado, Ciomar Aparecida Maria da Conceição Torrado Truiti Dantas, Jailson Araujo Muscará, Marcelo Nicolás Melo, Juliana Oliveira de Caparroz-Assef, Silvana Martins Cuman, Roberto Kenji Nakamura Bolonheis, Simone Marques |
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| Cites_doi | 10.1111/1523-1747.ep12506462 10.1016/S0196-9781(99)00086-8 10.1016/S0076-6879(96)68026-4 10.1016/0031-9422(94)00609-W 10.1111/j.2042-7158.1971.tb08661.x 10.1016/S0378-8741(98)00225-6 10.1021/np50009a006 10.1016/0006-291X(80)90767-6 10.1016/S0006-2952(97)00530-3 10.1021/np9902791 10.1016/S0031-9422(00)97906-8 10.3181/00379727-143-37397 10.1002/cpt1974165part2900 10.1021/np960195h 10.3181/00379727-111-27849 10.1016/S0378-8741(99)00148-8 10.1054/plef.2002.0387 10.1016/S0024-3205(99)00120-4 10.1016/S1043-6618(03)00225-1 10.1007/BF00920477 10.1590/S0100-46702002000200004 10.1111/1523-1747.ep12275349 |
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| SubjectTerms | Administration, Oral Animals anti-inflammatory Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Carrageenan - administration & dosage Carrageenan - toxicity Croton Oil - administration & dosage Croton Oil - toxicity Drug Evaluation, Preclinical - methods Ear - pathology ear edema Edema - chemically induced Edema - metabolism Edema - prevention & control Hindlimb - drug effects Hindlimb - pathology Indomethacin - pharmacology Indomethacin - therapeutic use Inflammation - chemically induced Inflammation - metabolism Inflammation - prevention & control Injections, Intradermal Lauraceae - chemistry Male Nectandra falcifolia Nitric Oxide - metabolism paw edema Peroxidase - metabolism Phytotherapy - methods Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Leaves - chemistry pleurisy Pleurisy - chemically induced Pleurisy - metabolism Pleurisy - prevention & control Rats Rats, Wistar Solvents - chemistry |
| Title | Anti-inflammatory Activity of Crude Extract and Fractions of Nectandra falcifolia Leaves |
| URI | https://www.jstage.jst.go.jp/article/bpb/29/11/29_11_2241/_article/-char/en http://mol.medicalonline.jp/en/journal/download?GoodsID=cs7biolo/2006/002911/015&name=2241-2245e https://www.ncbi.nlm.nih.gov/pubmed/17077521 https://www.proquest.com/docview/1449345684 |
| Volume | 29 |
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| ispartofPNX | Biological and Pharmaceutical Bulletin, 2006, Vol.29(11), pp.2241-2245 |
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