The Genomic Landscape of Compensatory Evolution

• Published in: PLoS biology Vol. 12; no. 8; p. e1001935
• Main Authors: Szamecz, Béla, Boross, Gábor, Kalapis, Dorottya, Kovács, Károly, Fekete, Gergely, Farkas, Zoltán, Lázár, Viktória, Hrtyan, Mónika, Kemmeren, Patrick, Groot Koerkamp, Marian J. A., Rutkai, Edit, Holstege, Frank C. P., Papp, Balázs, Pál, Csaba
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.08.2014; Public Library of Science (PLoS)
• Subjects: Adaptation, Biological - genetics; Biology and Life Sciences; Compensation; Environment; Epistasis, Genetic; Evolution & development; Evolution, Molecular; Evolutionary genetics; Experiments; Gene Deletion; Gene expression; Gene Expression Regulation, Fungal; Gene mutations; Genetic Fitness; Genetic Pleiotropy; Genetic research; Genetic Variation; Genome, Fungal - genetics; Genomes; Growth rate; Laboratories; Mutation; Phenotype; Saccharomyces cerevisiae - genetics; Studies; Transcriptome - genetics

Adaptive evolution is generally assumed to progress through the accumulation of beneficial mutations. However, as deleterious mutations are common in natural populations, they generate a strong selection pressure to mitigate their detrimental effects through compensatory genetic changes. This proces...