A mutation in the FAM83G gene in dogs with hereditary footpad hyperkeratosis (HFH)

• Published in: PLoS genetics Vol. 10; no. 5; p. e1004370
• Main Authors: Drögemüller, Michaela, Jagannathan, Vidhya, Becker, Doreen, Drögemüller, Cord, Schelling, Claude, Plassais, Jocelyn, Kaerle, Cécile, Dufaure de Citres, Caroline, Thomas, Anne, Müller, Eliane J, Welle, Monika M, Roosje, Petra, Leeb, Tosso
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.05.2014; Public Library of Science (PLoS)
• Subjects: Animals; Biology and Life Sciences; Breeding; Diseases; Dog Diseases - genetics; Dog Diseases - pathology; Dogs; Gene mutations; Genes; Genetic aspects; Genetic research; Genetics; Genome-Wide Association Study; Genomics; Haplotypes; Intracellular Signaling Peptides and Proteins - genetics; Keratosis; Life Sciences; Male; Medicine and Health Sciences; Mutation; Pedigree; Proteins - genetics; Zoological research; PALMOPLANTAR KERATODERMA; IRISH TERRIERS; KERATIN-16; DISORDERS; SEQUENCING DATA; INHERITANCE; ASSOCIATION; GENOME; PACHYONYCHIA-CONGENITA; TOOL

Hereditary footpad hyperkeratosis (HFH) represents a palmoplantar hyperkeratosis, which is inherited as a monogenic autosomal recessive trait in several dog breeds, such as e.g. Kromfohrländer and Irish Terriers. We performed genome-wide association studies (GWAS) in both breeds. In Kromfohrländer w...