Cortical folding in Broca's area relates to obstetric complications in schizophrenia patients and healthy controls

• Published in: Psychological medicine Vol. 42; no. 6; pp. 1329 - 1337
• Main Authors: Haukvik, U. K., Schaer, M., Nesvåg, R., McNeil, T., Hartberg, C. B., Jönsson, E. G., Eliez, S., Agartz, I.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.06.2012
• Subjects: Adult; Adult and adolescent clinical studies; Aetiology; Algorithms; Animals; Biological and medical sciences; Birth records; Broca's area; Case-Control Studies; Clinical evaluation; Clinical Medicine; complications; Deviation; Female; Fetal Development - physiology; Frontal lobe; Frontal Lobe - abnormalities; Frontal Lobe - embryology; Functional Laterality; gyrification; Hemispheric laterality; Humans; Image Processing, Computer-Assisted; Klinisk medicin; Linear Models; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Medical and Health Sciences; Medical sciences; Medicin och hälsovetenskap; Mental disorders; Middle Aged; MRI; Neonates; neurodevelopment; NMR; Nuclear magnetic resonance; obstetric; Obstetric Labor Complications - epidemiology; Obstetric Labor Complications - pathology; Obstetrics; Pregnancy; Prevalence; Psychiatry; Psychology; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Psykiatri; Scanning; Schizophrenia; Schizophrenia - epidemiology; Schizophrenia - pathology; Screening; obstetric complications; Broca's area; schizophrenia; neurodevelopment; gyrification; MRI; Human; Healthy subject; Schizophrenia; Nuclear magnetic resonance imaging; Obstetrics; Psychosis; Medical imagery; Complication

The increased occurrence of obstetric complications (OCs) in patients with schizophrenia suggests that alterations in neurodevelopment may be of importance to the aetiology of the illness. Abnormal cortical folding may reflect subtle deviation from normal neurodevelopment during the foetal or neonat...