Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle

• Published in: The Journal of clinical investigation Vol. 117; no. 11; pp. 3427 - 3435
• Main Authors: Ling, Charlotte, Poulsen, Pernille, Simonsson, Stina, Rönn, Tina, Holmkvist, Johan, Almgren, Peter, Hagert, Per, Nilsson, Emma, Mabey, Amanda G., Nilsson, Peter, Vaag, Allan, Groop, Leif
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.11.2007
• Subjects: Adult; Age; Age Factors; Aged; Annan klinisk medicin; Biomedical research; Biometrics; Biopsy; Clinical Medicine; Diabetes; Diabetes Mellitus, Type 2 - genetics; DNA methylation; Electron Transport - physiology; Endocrinology and Diabetes; Endokrinologi och diabetes; Epigenesis, Genetic; Epigenetics; Female; Gene expression; Genetic aspects; Genetic Predisposition to Disease; Genotype & phenotype; Glucose Clamp Technique; Humans; Insulin - metabolism; Insulin resistance; Klinisk medicin; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Middle Aged; Muscle, Skeletal - cytology; Muscle, Skeletal - physiology; Muscles; Musculoskeletal system; NADH, NADPH Oxidoreductases - genetics; NADH, NADPH Oxidoreductases - metabolism; Other Clinical Medicine; Phosphorylation; Physical fitness; Polymorphism; Polymorphism, Genetic; Promoter Regions, Genetic; Twins - genetics; Type 2 diabetes

Insulin resistance and type 2 diabetes are associated with decreased expression of genes that regulate oxidative phosphorylation in skeletal muscle. To determine whether this defect might be inherited or acquired, we investigated the association of genetic, epigenetic, and nongenetic factors with ex...