Release from UNC93B1 reinforces the compartmentalized activation of select TLRs

• Published in: Nature (London) Vol. 575; no. 7782; pp. 371 - 374
• Main Authors: Majer, Olivia, Liu, Bo, Woo, Brian J., Kreuk, Lieselotte S. M., Van Dis, Erik, Barton, Gregory M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2019; Nature Publishing Group
• Subjects: 13; 13/106; 631/250/262/2106/2108; 631/250/38; 64/60; 82/1; 82/80; 96/31; 96/63; 96/95; Activation; Amino acids; Animals; Cell Line; Control; Deoxyribonucleic acid; DNA; Endosomes; Genomes; Humanities and Social Sciences; Humans; Influence; Intracellular; Ligands; Localization; Lupus; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Membrane proteins; Membrane Transport Proteins - genetics; Membrane Transport Proteins - metabolism; Methods; Mice; Mice, Inbred C57BL; Microorganisms; Molecular modelling; multidisciplinary; Mutation; Nucleic acids; Protein Binding; Protein Transport; Radioactivation analysis; Receptors; Recognition; Ribonucleic acid; RNA; Science; Science (multidisciplinary); Signal Transduction; TLR3 protein; TLR7 protein; TLR9 protein; Toll-Like Receptor 3 - genetics; Toll-Like Receptor 3 - metabolism; Toll-Like Receptor 7 - genetics; Toll-Like Receptor 7 - metabolism; Toll-Like Receptor 9 - genetics; Toll-Like Receptor 9 - metabolism; Toll-like receptors; United States

Nucleic acid-sensing Toll-like receptors (TLRs) are subject to complex regulation to facilitate the recognition of microbial DNA and RNA while limiting the recognition of an organism’s own nucleic acids 1 . Failure to properly regulate these TLRs can lead to autoimmune and autoinflammatory diseases...