Thalamic dopamine D2-receptor availability in schizophrenia: a study on antipsychotic-naive patients with first-episode psychosis and a meta-analysis
Pharmacological and genetic evidence support a role for an involvement of the dopamine D2-receptor (D2-R) in the pathophysiology of schizophrenia. Previous molecular imaging studies have suggested lower levels of D2-R in thalamus, but results are inconclusive. The objective of the present study was...
Saved in:
| Published in | Molecular psychiatry Vol. 27; no. 2; pp. 1233 - 1240 |
|---|---|
| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.02.2022
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Pharmacological and genetic evidence support a role for an involvement of the dopamine D2-receptor (D2-R) in the pathophysiology of schizophrenia. Previous molecular imaging studies have suggested lower levels of D2-R in thalamus, but results are inconclusive. The objective of the present study was to use improved methodology to compare D2-R density in whole thalamus and thalamic subregions between first-episode psychosis patients and healthy controls. Differences in thalamocortical connectivity was explored based on the D2-R results. 19 antipsychotic-naive first-episode psychosis patients and 19 age- and sex-matched healthy controls were examined using high-resolution Positron Emission Tomography (PET) and the high-affinity D2-R radioligand [
11
C]FLB457. The main outcome was D2-R binding potential (BP
ND
) in thalamus, and it was predicted that patients would have lower binding. Diffusion tensor imaging (DTI) was performed in a subgroup of 11 patients and 15 controls. D2-R binding in whole thalamus was lower in patients compared with controls (Cohen’s dz = −0.479,
p
= 0.026, Bayes Factor (BF) > 4). Among subregions, lower BP
ND
was observed in the ROI representing thalamic connectivity to the frontal cortex (Cohen’s dz = −0.527,
p
= 0.017, BF > 6). A meta-analysis, including the sample of this study, confirmed significantly lower thalamic D2-R availability in patients. Exploratory analyses suggested that patients had lower fractional anisotropy values compared with controls (Cohen’s
d
= −0.692,
p
= 0.036) in the inferior thalamic radiation. The findings support the hypothesis of a dysregulation of thalamic dopaminergic neurotransmission in schizophrenia, and it is hypothesized that this could underlie a disturbance of thalamocortical connectivity. |
|---|---|
| AbstractList | Pharmacological and genetic evidence support a role for an involvement of the dopamine D2-receptor (D2-R) in the pathophysiology of schizophrenia. Previous molecular imaging studies have suggested lower levels of D2-R in thalamus, but results are inconclusive. The objective of the present study was to use improved methodology to compare D2-R density in whole thalamus and thalamic subregions between first-episode psychosis patients and healthy controls. Differences in thalamocortical connectivity was explored based on the D2-R results. 19 antipsychotic-naive first-episode psychosis patients and 19 age- and sex-matched healthy controls were examined using high-resolution Positron Emission Tomography (PET) and the high-affinity D2-R radioligand [11C]FLB457. The main outcome was D2-R binding potential (BPND) in thalamus, and it was predicted that patients would have lower binding. Diffusion tensor imaging (DTI) was performed in a subgroup of 11 patients and 15 controls. D2-R binding in whole thalamus was lower in patients compared with controls (Cohen’s dz = −0.479, p = 0.026, Bayes Factor (BF) > 4). Among subregions, lower BPND was observed in the ROI representing thalamic connectivity to the frontal cortex (Cohen’s dz = −0.527, p = 0.017, BF > 6). A meta-analysis, including the sample of this study, confirmed significantly lower thalamic D2-R availability in patients. Exploratory analyses suggested that patients had lower fractional anisotropy values compared with controls (Cohen’s d = −0.692, p = 0.036) in the inferior thalamic radiation. The findings support the hypothesis of a dysregulation of thalamic dopaminergic neurotransmission in schizophrenia, and it is hypothesized that this could underlie a disturbance of thalamocortical connectivity. Abstract Pharmacological and genetic evidence support a role for an involvement of the dopamine D2-receptor (D2-R) in the pathophysiology of schizophrenia. Previous molecular imaging studies have suggested lower levels of D2-R in thalamus, but results are inconclusive. The objective of the present study was to use improved methodology to compare D2-R density in whole thalamus and thalamic subregions between first-episode psychosis patients and healthy controls. Differences in thalamocortical connectivity was explored based on the D2-R results. 19 antipsychotic-naive first-episode psychosis patients and 19 age- and sex-matched healthy controls were examined using high-resolution Positron Emission Tomography (PET) and the high-affinity D2-R radioligand [ 11 C]FLB457. The main outcome was D2-R binding potential (BP ND ) in thalamus, and it was predicted that patients would have lower binding. Diffusion tensor imaging (DTI) was performed in a subgroup of 11 patients and 15 controls. D2-R binding in whole thalamus was lower in patients compared with controls (Cohen’s dz = −0.479, p = 0.026, Bayes Factor (BF) > 4). Among subregions, lower BP ND was observed in the ROI representing thalamic connectivity to the frontal cortex (Cohen’s dz = −0.527, p = 0.017, BF > 6). A meta-analysis, including the sample of this study, confirmed significantly lower thalamic D2-R availability in patients. Exploratory analyses suggested that patients had lower fractional anisotropy values compared with controls (Cohen’s d = −0.692, p = 0.036) in the inferior thalamic radiation. The findings support the hypothesis of a dysregulation of thalamic dopaminergic neurotransmission in schizophrenia, and it is hypothesized that this could underlie a disturbance of thalamocortical connectivity. Pharmacological and genetic evidence support a role for an involvement of the dopamine D2-receptor (D2-R) in the pathophysiology of schizophrenia. Previous molecular imaging studies have suggested lower levels of D2-R in thalamus, but results are inconclusive. The objective of the present study was to use improved methodology to compare D2-R density in whole thalamus and thalamic subregions between first-episode psychosis patients and healthy controls. Differences in thalamocortical connectivity was explored based on the D2-R results. 19 antipsychotic-naive first-episode psychosis patients and 19 age- and sex-matched healthy controls were examined using high-resolution Positron Emission Tomography (PET) and the high-affinity D2-R radioligand [11C]FLB457. The main outcome was D2-R binding potential (BPND) in thalamus, and it was predicted that patients would have lower binding. Diffusion tensor imaging (DTI) was performed in a subgroup of 11 patients and 15 controls. D2-R binding in whole thalamus was lower in patients compared with controls (Cohen's dz = -0.479, p = 0.026, Bayes Factor (BF) > 4). Among subregions, lower BPND was observed in the ROI representing thalamic connectivity to the frontal cortex (Cohen's dz = -0.527, p = 0.017, BF > 6). A meta-analysis, including the sample of this study, confirmed significantly lower thalamic D2-R availability in patients. Exploratory analyses suggested that patients had lower fractional anisotropy values compared with controls (Cohen's d = -0.692, p = 0.036) in the inferior thalamic radiation. The findings support the hypothesis of a dysregulation of thalamic dopaminergic neurotransmission in schizophrenia, and it is hypothesized that this could underlie a disturbance of thalamocortical connectivity.Pharmacological and genetic evidence support a role for an involvement of the dopamine D2-receptor (D2-R) in the pathophysiology of schizophrenia. Previous molecular imaging studies have suggested lower levels of D2-R in thalamus, but results are inconclusive. The objective of the present study was to use improved methodology to compare D2-R density in whole thalamus and thalamic subregions between first-episode psychosis patients and healthy controls. Differences in thalamocortical connectivity was explored based on the D2-R results. 19 antipsychotic-naive first-episode psychosis patients and 19 age- and sex-matched healthy controls were examined using high-resolution Positron Emission Tomography (PET) and the high-affinity D2-R radioligand [11C]FLB457. The main outcome was D2-R binding potential (BPND) in thalamus, and it was predicted that patients would have lower binding. Diffusion tensor imaging (DTI) was performed in a subgroup of 11 patients and 15 controls. D2-R binding in whole thalamus was lower in patients compared with controls (Cohen's dz = -0.479, p = 0.026, Bayes Factor (BF) > 4). Among subregions, lower BPND was observed in the ROI representing thalamic connectivity to the frontal cortex (Cohen's dz = -0.527, p = 0.017, BF > 6). A meta-analysis, including the sample of this study, confirmed significantly lower thalamic D2-R availability in patients. Exploratory analyses suggested that patients had lower fractional anisotropy values compared with controls (Cohen's d = -0.692, p = 0.036) in the inferior thalamic radiation. The findings support the hypothesis of a dysregulation of thalamic dopaminergic neurotransmission in schizophrenia, and it is hypothesized that this could underlie a disturbance of thalamocortical connectivity. Pharmacological and genetic evidence support a role for an involvement of the dopamine D2-receptor (D2-R) in the pathophysiology of schizophrenia. Previous molecular imaging studies have suggested lower levels of D2-R in thalamus, but results are inconclusive. The objective of the present study was to use improved methodology to compare D2-R density in whole thalamus and thalamic subregions between first-episode psychosis patients and healthy controls. Differences in thalamocortical connectivity was explored based on the D2-R results. 19 antipsychotic-naive first-episode psychosis patients and 19 age- and sex-matched healthy controls were examined using high-resolution Positron Emission Tomography (PET) and the high-affinity D2-R radioligand [ 11 C]FLB457. The main outcome was D2-R binding potential (BP ND ) in thalamus, and it was predicted that patients would have lower binding. Diffusion tensor imaging (DTI) was performed in a subgroup of 11 patients and 15 controls. D2-R binding in whole thalamus was lower in patients compared with controls (Cohen’s dz = −0.479, p = 0.026, Bayes Factor (BF) > 4). Among subregions, lower BP ND was observed in the ROI representing thalamic connectivity to the frontal cortex (Cohen’s dz = −0.527, p = 0.017, BF > 6). A meta-analysis, including the sample of this study, confirmed significantly lower thalamic D2-R availability in patients. Exploratory analyses suggested that patients had lower fractional anisotropy values compared with controls (Cohen’s d = −0.692, p = 0.036) in the inferior thalamic radiation. The findings support the hypothesis of a dysregulation of thalamic dopaminergic neurotransmission in schizophrenia, and it is hypothesized that this could underlie a disturbance of thalamocortical connectivity. Pharmacological and genetic evidence support a role for an involvement of the dopamine D2-receptor (D2-R) in the pathophysiology of schizophrenia. Previous molecular imaging studies have suggested lower levels of D2-R in thalamus, but results are inconclusive. The objective of the present study was to use improved methodology to compare D2-R density in whole thalamus and thalamic subregions between first-episode psychosis patients and healthy controls. Differences in thalamocortical connectivity was explored based on the D2-R results. 19 antipsychotic-naive first-episode psychosis patients and 19 age- and sex-matched healthy controls were examined using high-resolution Positron Emission Tomography (PET) and the high-affinity D2-R radioligand [ 11 C]FLB457. The main outcome was D2-R binding potential (BP ND ) in thalamus, and it was predicted that patients would have lower binding. Diffusion tensor imaging (DTI) was performed in a subgroup of 11 patients and 15 controls. D2-R binding in whole thalamus was lower in patients compared with controls (Cohen's dz = -0.479, p = 0.026, Bayes Factor (BF) > 4). Among subregions, lower BP ND was observed in the ROI representing thalamic connectivity to the frontal cortex (Cohen's dz = -0.527, p = 0.017, BF > 6). A meta-analysis, including the sample of this study, confirmed significantly lower thalamic D2-R availability in patients. Exploratory analyses suggested that patients had lower fractional anisotropy values compared with controls (Cohen's d = -0.692, p = 0.036) in the inferior thalamic radiation. The findings support the hypothesis of a dysregulation of thalamic dopaminergic neurotransmission in schizophrenia, and it is hypothesized that this could underlie a disturbance of thalamocortical connectivity. Pharmacological and genetic evidence support a role for an involvement of the dopamine D2-receptor (D2-R) in the pathophysiology of schizophrenia. Previous molecular imaging studies have suggested lower levels of D2-R in thalamus, but results are inconclusive. The objective of the present study was to use improved methodology to compare D2-R density in whole thalamus and thalamic subregions between first-episode psychosis patients and healthy controls. Differences in thalamocortical connectivity was explored based on the D2-R results. 19 antipsychotic-naive first-episode psychosis patients and 19 age- and sex-matched healthy controls were examined using high-resolution Positron Emission Tomography (PET) and the high-affinity D2-R radioligand [11C]FLB457. The main outcome was D2-R binding potential (BPND) in thalamus, and it was predicted that patients would have lower binding. Diffusion tensor imaging (DTI) was performed in a subgroup of 11 patients and 15 controls. D2-R binding in whole thalamus was lower inpatients compared with controls (Cohen’s dz = −0.479, p = 0.026, Bayes Factor (BF) > 4). Among subregions, lower BPND was observed in the ROI representing thalamic connectivity to the frontal cortex (Cohen’s dz = −0.527, p = 0.017, BF > 6). A meta-analysis, including the sample of this study, confirmed significantly lower thalamic D2-R availability in patients. Exploratory analyses suggested that patients had lower fractional anisotropy values compared with controls (Cohen’s d = −0.692, p = 0.036) in the inferior thalamic radiation. The findings support the hypothesis of a dysregulation of thalamic dopaminergic neurotransmission in schizophrenia, and it is hypothesized that this could underlie a disturbance of thalamocortical connectivity. Pharmacological and genetic evidence support a role for an involvement of the dopamine D2-receptor (D2-R) in the pathophysiology of schizophrenia. Previous molecular imaging studies have suggested lower levels of D2-R in thalamus, but results are inconclusive. The objective of the present study was to use improved methodology to compare D2-R density in whole thalamus and thalamic subregions between first-episode psychosis patients and healthy controls. Differences in thalamocortical connectivity was explored based on the D2-R results. 19 antipsychotic-naive first-episode psychosis patients and 19 age- and sex-matched healthy controls were examined using high-resolution Positron Emission Tomography (PET) and the high-affinity D2-R radioligand [ C]FLB457. The main outcome was D2-R binding potential (BP ) in thalamus, and it was predicted that patients would have lower binding. Diffusion tensor imaging (DTI) was performed in a subgroup of 11 patients and 15 controls. D2-R binding in whole thalamus was lower in patients compared with controls (Cohen's dz = -0.479, p = 0.026, Bayes Factor (BF) > 4). Among subregions, lower BP was observed in the ROI representing thalamic connectivity to the frontal cortex (Cohen's dz = -0.527, p = 0.017, BF > 6). A meta-analysis, including the sample of this study, confirmed significantly lower thalamic D2-R availability in patients. Exploratory analyses suggested that patients had lower fractional anisotropy values compared with controls (Cohen's d = -0.692, p = 0.036) in the inferior thalamic radiation. The findings support the hypothesis of a dysregulation of thalamic dopaminergic neurotransmission in schizophrenia, and it is hypothesized that this could underlie a disturbance of thalamocortical connectivity. |
| Author | Santillo, Alexander Ikonen Victorsson, Pauliina Agartz, Ingrid Matheson, Granville J. Sellgren, Carl M. Erhardt, Sophie Halldin, Christer Lee, Maria Plavén-Sigray, Pontus Collste, Karin Fatouros-Bergman, Helena Cervenka, Simon Farde, Lars |
| Author_xml | – sequence: 1 givenname: Pontus surname: Plavén-Sigray fullname: Plavén-Sigray, Pontus organization: Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm, Neurobiology Research Unit, Copenhagen University Hospital – sequence: 2 givenname: Pauliina surname: Ikonen Victorsson fullname: Ikonen Victorsson, Pauliina organization: Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm – sequence: 3 givenname: Alexander surname: Santillo fullname: Santillo, Alexander organization: Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm, Clinical Memory Research Unit, Department of Clinical Sciences, Lund University – sequence: 4 givenname: Granville J. surname: Matheson fullname: Matheson, Granville J. organization: Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm, Molecular Imaging and Neuropathology Division, Columbia University, Department of Biostatistics, Columbia University – sequence: 5 givenname: Maria orcidid: 0000-0003-4080-4030 surname: Lee fullname: Lee, Maria organization: Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm – sequence: 6 givenname: Karin surname: Collste fullname: Collste, Karin organization: Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm – sequence: 7 givenname: Helena surname: Fatouros-Bergman fullname: Fatouros-Bergman, Helena organization: Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm – sequence: 8 givenname: Carl M. surname: Sellgren fullname: Sellgren, Carl M. organization: Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm, Department of Physiology and Pharmacology, Karolinska Institutet – sequence: 9 givenname: Sophie orcidid: 0000-0001-7359-5250 surname: Erhardt fullname: Erhardt, Sophie organization: Department of Physiology and Pharmacology, Karolinska Institutet – sequence: 10 givenname: Ingrid surname: Agartz fullname: Agartz, Ingrid organization: Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm, Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Department of Psychiatric Research, Diakonhjemmet Hospital – sequence: 11 givenname: Christer surname: Halldin fullname: Halldin, Christer organization: Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm – sequence: 12 givenname: Lars orcidid: 0000-0003-1297-0816 surname: Farde fullname: Farde, Lars organization: Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm – sequence: 13 givenname: Simon orcidid: 0000-0001-8103-6977 surname: Cervenka fullname: Cervenka, Simon email: simon.cervenka@neuro.uu.se organization: Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm, Department of Neuroscience, Psychiatry, Uppsala University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34759359$$D View this record in MEDLINE/PubMed https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-460424$$DView record from Swedish Publication Index https://lup.lub.lu.se/record/fe1bb843-4ba0-4cfc-b52b-b95ae3f2801b$$DView record from Swedish Publication Index oai:portal.research.lu.se:publications/fe1bb843-4ba0-4cfc-b52b-b95ae3f2801b$$DView record from Swedish Publication Index http://kipublications.ki.se/Default.aspx?queryparsed=id:148029709$$DView record from Swedish Publication Index |
| BookMark | eNqNk0tv1DAQxyNURB_wBThAJC4cCDjxIzEHpKrlJVXiUrhaE8dpXLJ2sJ1tl-_B92W2uwVaqRUHy5bnN_-Z8Xj2sx3nncmypyV5XRLavImspA0pSFUWpKRMFpcPsr2S1aLgvG528Ey5LFjZsN1sP8ZzQtZG_ijbpazmEo172a_TAUZYWJ13fsLdmfy4KoLRZko-5LAEO0JrR5tWuXV51IP96achGGfhbQ55THO3yr3LwSU7xZUefLK6cGCXJp8gWeNSzC9sGvLehpgKM9noO7RdsdFG9OxQaGESFOBgXOHd4-xhD2M0T7b7Qfb1w_vTo0_FyZePn48OTwpd0yoVtdRcUAOScFH1IKjmWpRUUKhb0XJd9XVd9hWRpKYCREcI6xrDiZCMcAmEHmTFRjdemGlu1RTsAsJKebBqe_UdT0YxjkoSebiTn3xIMKpgooGgBzXOa0ekRqvxHbyLqjdl2zaMKtYCUUz3WrW8alUrORjaVw0pW4xxcmeMcZ5wtVvt_5R7dafcsf12qHw4U_OsmCCsYoi_2-DILkynsX0Bq7pR6A2Ls4M680uFPWCCNyjwfCOgg43JOuV8AFWShleqkUysQ7zchgj-x2xiUgsbtRlHcMbPUVVcCsYpdgjRF7fQcz8H_CRICS5kXQts7UH27N-c_yR7_csRaK5z8jEG0ytt01VPsAQ7YnZqPVBqM1AKB0pdDZS6RNfqluu1-r1OdPvmCLszE_6mfY_Xb_5rOFk |
| CitedBy_id | crossref_primary_10_3390_ma16031091 crossref_primary_10_1002_jmri_29471 crossref_primary_10_3389_fncir_2024_1522421 crossref_primary_10_1016_j_jpsychires_2023_09_021 crossref_primary_10_1038_s41398_022_01990_2 crossref_primary_10_1016_j_cpet_2024_09_005 crossref_primary_10_1016_j_schres_2023_04_008 crossref_primary_10_1093_schbul_sbad039 crossref_primary_10_1007_s40336_024_00646_z crossref_primary_10_1016_j_schres_2023_05_012 crossref_primary_10_1038_s41380_024_02873_2 crossref_primary_10_1016_j_nicl_2024_103578 |
| Cites_doi | 10.1016/j.neuroscience.2012.04.044 10.1016/j.neuroimage.2011.09.015 10.1001/archgenpsychiatry.2012.169 10.1001/jamapsychiatry.2014.2414 10.1109/TMI.2009.2035616 10.1503/jpn.150030 10.1523/JNEUROSCI.0067-17.2017 10.1016/j.schres.2016.08.007 10.1016/j.tics.2015.09.009 10.1007/s00213-018-4916-6 10.1016/j.neuroimage.2017.04.031 10.1038/npp.2008.199 10.1016/j.biopsych.2006.01.010 10.1176/appi.ajp.161.6.1016 10.1007/s002130000532 10.1176/appi.ajp.2008.07101562 10.1016/j.apradiso.2008.09.010 10.1073/pnas.052023499 10.1016/j.biopsych.2008.12.029 10.1038/s41467-019-14122-0 10.1186/s13550-020-00664-8 10.1016/j.neuroimage.2004.02.002 10.1016/j.schres.2010.03.043 10.1038/mp.2017.170 10.1017/S1461145703003699 10.1503/jpn.110181 10.1016/0893-133X(87)90004-2 10.1111/j.1755-5949.2010.00222.x 10.1192/bjp.bp.113.132308 10.1038/nn1075 10.1007/s00406-006-0649-3 10.1016/j.neuroimage.2009.11.075 10.1017/CBO9781139087759 10.1016/j.neuroimage.2020.117523 10.1001/archpsyc.1992.01820070032005 10.1002/hbm.1058 10.1038/sj.jcbfm.9600340 10.1016/j.biopsych.2010.05.027 10.1007/s00401-008-0404-0 10.3389/fpsyg.2015.00223 10.1002/syn.20926 10.1016/j.cortex.2015.02.004 10.1016/j.neuroimage.2019.116143 10.3171/JNS/2008/108/4/0775 10.1016/j.pscychresns.2009.04.006 10.1016/j.pscychresns.2006.05.009 10.1002/(SICI)1096-9861(19971103)387:4<588::AID-CNE8>3.0.CO;2-Z 10.1016/S0006-3223(98)00281-9 10.1038/nature13595 10.1371/journal.pone.0233684 10.1038/s41593-018-0334-7 10.1001/archpsyc.59.1.25 10.3389/fpsyt.2018.00522 10.1002/mrm.21890 10.1093/schbul/sbs118 10.1080/01621459.1995.10476572 10.1001/archpsyc.1990.01810230039007 10.1038/s41380-018-0041-5 10.1038/jcbfm.1990.127 10.1093/acprof:oso/9780195104233.001.0001 10.1016/0969-8051(94)00117-3 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2021 2021. The Author(s). The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. info:eu-repo/semantics/openAccess |
| Copyright_xml | – notice: The Author(s) 2021 – notice: 2021. The Author(s). – notice: The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: info:eu-repo/semantics/openAccess |
| CorporateAuthor | MultiPark: Multidisciplinary research focused on Parkinson's disease Lunds universitet Profile areas and other strong research environments Department of Clinical Sciences, Malmö Lund University Strategiska forskningsområden (SFO) Faculty of Medicine Strategic research areas (SRA) Clinical Memory Research Klinisk minnesforskning Medicinska fakulteten Profilområden och andra starka forskningsmiljöer Institutionen för kliniska vetenskaper, Malmö |
| CorporateAuthor_xml | – name: Faculty of Medicine – name: Medicinska fakulteten – name: Strategiska forskningsområden (SFO) – name: Institutionen för kliniska vetenskaper, Malmö – name: Clinical Memory Research – name: Strategic research areas (SRA) – name: Lunds universitet – name: Klinisk minnesforskning – name: Profilområden och andra starka forskningsmiljöer – name: Lund University – name: Profile areas and other strong research environments – name: MultiPark: Multidisciplinary research focused on Parkinson's disease – name: Department of Clinical Sciences, Malmö |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7TK 7X7 7XB 88E 88G 8AO 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2M M7P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ Q9U 7X8 3HK 5PM ACNBI ADTPV AOWAS D8T DF2 ZZAVC AGCHP D95 |
| DOI | 10.1038/s41380-021-01349-x |
| DatabaseName | Springer Nature OA Free Journals (Selected full-text) CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Neurosciences Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Psychology Database (Alumni) ProQuest Pharma Collection ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection (via ProQuest) ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection ProQuest Health & Medical Collection Medical Database Psychology Database Biological Science Database ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic MEDLINE - Academic NORA - Norwegian Open Research Archives PubMed Central (Full Participant titles) SWEPUB Uppsala universitet full text SwePub SwePub Articles SWEPUB Freely available online SWEPUB Uppsala universitet SwePub Articles full text SWEPUB Lunds universitet full text SWEPUB Lunds universitet |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Psychology ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic ProQuest One Psychology CrossRef MEDLINE |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Nature OA Free Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1476-5578 |
| EndPage | 1240 |
| ExternalDocumentID | oai_swepub_ki_se_457719 oai_portal_research_lu_se_publications_fe1bb843_4ba0_4cfc_b52b_b95ae3f2801b oai_lup_lub_lu_se_fe1bb843_4ba0_4cfc_b52b_b95ae3f2801b oai_DiVA_org_uu_460424 PMC9054658 10852_89464 34759359 10_1038_s41380_021_01349_x |
| Genre | Research Support, Non-U.S. Gov't Meta-Analysis Journal Article |
| GrantInformation_xml | – fundername: Karolinska Institutet and Stockholm County Council – fundername: Svenska Sällskapet för Medicinsk Forskning (Swedish Society for Medical Research) funderid: https://doi.org/10.13039/501100003748 – fundername: Lundbeck Foundation – fundername: Benthe Rexhed Gersteds Foundation – fundername: Vetenskapsrådet (Swedish Research Council) grantid: 523-2014-3467; 2017-00875; K2015-62X-15077-12-3, 2017-00949; 09114 funderid: https://doi.org/10.13039/501100004359 – fundername: ; – fundername: ; grantid: 523-2014-3467; 2017-00875; K2015-62X-15077-12-3, 2017-00949; 09114 |
| GroupedDBID | --- -Q- 0R~ 123 29M 2WC 36B 39C 3V. 4.4 406 53G 70F 7X7 88E 8AO 8FI 8FJ 8R4 8R5 AACDK AANZL AASML AATNV AAYZH AAZLF ABAKF ABAWZ ABDBF ABIVO ABJNI ABLJU ABUWG ABZZP ACAOD ACGFS ACKTT ACPRK ACRQY ACUHS ACZOJ ADBBV ADHDB AEFQL AEJRE AEMSY AENEX AEVLU AEXYK AFBBN AFKRA AFRAH AFSHS AGAYW AGHAI AGQEE AHMBA AHSBF AIGIU AILAN AJRNO ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMYLF AXYYD AZQEC B0M BAWUL BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI C6C CAG CCPQU COF CS3 DIK DNIVK DPUIP DU5 DWQXO E3Z EAD EAP EBC EBD EBLON EBS EE. EIOEI EJD EMB EMK EMOBN EPL EPS ESX F5P FDQFY FEDTE FERAY FIGPU FIZPM FSGXE FYUFA GNUQQ HCIFZ HMCUK HVGLF HZ~ IAO IHR INH INR IPY ITC IWAJR JSO JZLTJ KQ8 M1P M2M M7P NAO NQJWS O9- OK1 OVD P2P PQQKQ PROAC PSQYO PSYQQ Q2X RNS RNT RNTTT ROL SNX SNYQT SOHCF SOJ SRMVM SV3 SWTZT TAOOD TBHMF TDRGL TEORI TR2 TSG TUS UKHRP ~8M AAYXX ABBRH ABDBE ABFSG ACSTC AEZWR AFDZB AFHIU AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT CGR CUY CVF ECM EIF NPM 7TK 7XB 8FE 8FH 8FK ABRTQ K9. LK8 PJZUB PKEHL PPXIY PQEST PQGLB PQUKI PRINS Q9U 7X8 3HK AADWK AAPBV AAWBL AAYJO ABPTK ABTEG ACBMV ACBRV ACBYP ACIGE ACTTH ACVWB ADMDM ADQMX ADYYL AEDAW AEFTE AGEZK AGGBP AJDOV AMRJV N95 NYICJ W2D ZA5 5PM ACNBI ADTPV AOWAS D8T DF2 ZZAVC AGCHP D95 PUEGO |
| ID | FETCH-LOGICAL-c732t-79c563ea90562fa63c5c61363a7b6b5c2f771f2090736a6d004d8e50694059a03 |
| IEDL.DBID | 7X7 |
| ISSN | 1359-4184 1476-5578 |
| IngestDate | Mon Aug 25 03:22:10 EDT 2025 Wed Aug 27 04:08:06 EDT 2025 Thu Jul 03 04:42:42 EDT 2025 Thu Aug 21 06:49:43 EDT 2025 Thu Aug 21 14:08:31 EDT 2025 Sat Apr 29 05:41:29 EDT 2023 Fri Jul 11 07:07:18 EDT 2025 Sat Aug 23 14:13:08 EDT 2025 Wed Feb 19 02:24:41 EST 2025 Thu Apr 24 23:06:34 EDT 2025 Tue Jul 01 00:21:56 EDT 2025 Fri Feb 21 02:39:26 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| License | 2021. The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c732t-79c563ea90562fa63c5c61363a7b6b5c2f771f2090736a6d004d8e50694059a03 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-3 ObjectType-Evidence Based Healthcare-1 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0003-1297-0816 0000-0003-4080-4030 0000-0001-7359-5250 0000-0001-8103-6977 |
| OpenAccessLink | https://www.nature.com/articles/s41380-021-01349-x |
| PMID | 34759359 |
| PQID | 2656977607 |
| PQPubID | 44096 |
| PageCount | 8 |
| ParticipantIDs | swepub_primary_oai_swepub_ki_se_457719 swepub_primary_oai_portal_research_lu_se_publications_fe1bb843_4ba0_4cfc_b52b_b95ae3f2801b swepub_primary_oai_lup_lub_lu_se_fe1bb843_4ba0_4cfc_b52b_b95ae3f2801b swepub_primary_oai_DiVA_org_uu_460424 pubmedcentral_primary_oai_pubmedcentral_nih_gov_9054658 cristin_nora_10852_89464 proquest_miscellaneous_2596453059 proquest_journals_2656977607 pubmed_primary_34759359 crossref_citationtrail_10_1038_s41380_021_01349_x crossref_primary_10_1038_s41380_021_01349_x springer_journals_10_1038_s41380_021_01349_x |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2022-02-01 |
| PublicationDateYYYYMMDD | 2022-02-01 |
| PublicationDate_xml | – month: 02 year: 2022 text: 2022-02-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England – name: New York |
| PublicationTitle | Molecular psychiatry |
| PublicationTitleAbbrev | Mol Psychiatry |
| PublicationTitleAlternate | Mol Psychiatry |
| PublicationYear | 2022 |
| Publisher | Nature Publishing Group UK Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
| References | Kambeitz, Abi-Dargham, Kapur, Howes (CR17) 2014; 204 Andersson, Truong, Halldin (CR24) 2009; 67 Kessler, Woodward, Riccardi, Li, Ansari, Anderson (CR11) 2009; 65 Matheson, Stenkrona, Cselényi, Plavén-Sigray, Halldin, Farde (CR23) 2017; 155 Perezgonzalez (CR37) 2015; 6 Seeman, Bzowej, Guan, Bergeron, Reynolds, Bird (CR46) 1987; 1 Nichols, Holmes (CR34) 2002; 15 Behrens, Johansen-Berg, Woolrich, Smith, Wheeler-Kingshott, Boulby (CR22) 2003; 6 Olsson, Halldin, Farde (CR61) 2004; 22 Sellgren, Gracias, Watmuff, Biag, Thanos, Whittredge (CR58) 2019; 22 Hwang, Bertolero, Liu, D’Esposito (CR5) 2017; 37 Svensson, Schain, Plavén-Sigray, Cervenka, Tiger, Nord (CR43) 2019; 202 Ellison-Wright, Glahn, Laird, Thelen, Bullmore (CR52) 2008; 165 Talvik, Nordström, Okubo, Olsson, Borg, Halldin (CR38) 2006; 148 Byne, Hazlett, Buchsbaum, Kemether (CR18) 2009; 117 Glausier, Lewis (CR55) 2013; 251 Tjerkaski, Cervenka, Farde, Matheson (CR26) 2020; 10 CR8 Glenthoj, Mackeprang, Svarer, Rasmussen, Pinborg, Friberg (CR39) 2006; 60 Roiser, Stephan, den Ouden, Friston, Joyce (CR54) 2010; 50 Halldin, Farde, Hogberg, Mohell, Hall, Suhara (CR7) 1995; 36 Cannon (CR50) 2015; 19 Onwordi, Halff, Whitehurst, Mansur, Cotel, Wells (CR57) 2020; 11 Osimo, Beck, Reis Marques, Howes (CR56) 2019; 24 Ebdrup, Raghava, Nielsen, Rostrup, Glenthøj (CR51) 2016; 41 Asselin, Montgomery, Grasby, Hume (CR60) 2007; 27 Kelly, Jahanshad, Zalesky, Kochunov, Agartz, Alloza (CR35) 2018; 23 Selemon, Goldman-Rakic (CR48) 1999; 45 Leemans, Jones (CR30) 2009; 61 Graff-Guerrero, Mizrahi, Agid, Marcon, Barsoum, Rusjan (CR41) 2009; 34 Wang, Sun, Li, Liu (CR28) 2008; 108 Morel, Magnin, Jeanmonod (CR47) 1997; 387 Barth, Lonning, Gurholt, Andreassen, Myhre, Agartz (CR36) 2020; 15 Lehrer, Christian, Kirbas, Chiang, Sidhu, Short (CR9) 2010; 122 Ripke, Neale, Corvin, Walters, Farh, Holmans (CR3) 2014; 511 Veselinović, Vernaleken, Janouschek, Cumming, Paulzen, Mottaghy (CR15) 2018; 235 Niida, Yamagata, Niida, Uechi, Matsuda, Mimura (CR29) 2018; 9 Howes, Kambeitz, Kim, Stahl, Slifstein, Abi-Dargham (CR4) 2012; 69 Freiburghaus, Svensson, Matheson, Plavén-Sigray, Lundberg, Farde (CR44) 2021; 226 Dorph-Petersen, Lewis (CR20) 2017; 180 Narendran, Mason, Chen, Himes, Keating, May (CR59) 2011; 65 Wagner, De la Cruz, Schachtzabel, Güllmar, Schultz, Schlösser (CR6) 2015; 66 Yasuno, Suhara, Okubo, Sudo, Inoue, Ichimiya (CR10) 2004; 161 Klein, Staring, Murphy, Viergever, Pluim (CR31) 2010; 29 Silvestri, Seeman, Negrete, Houle, Shammi, Remington (CR45) 2000; 152 CR27 CR25 Tuppurainen, Kuikka, Laakso, Viinamaki, Husso, Tiihonen (CR40) 2006; 256 Lee, Wagenmakers (CR33) 2014 Farde, Nordström, Wiesel, Pauli, Halldin, Sedvall (CR2) 1992; 49 Cannon, Thompson, Van Erp, Toga, Poutanen, Huttunen (CR49) 2002; 99 Kass, Raftery (CR32) 1995; 90 Talvik, Nordström, Olsson, Halldin, Farde (CR12) 2003; 6 Slifstein, van de Giessen, Van Snellenberg, Thompson, Narendran, Gil (CR13) 2015; 72 Haijma, Van Haren, Cahn, Koolschijn, Hulshoff Pol, Kahn (CR53) 2013; 39 Nord, Farde (CR1) 2011; 17 Pakkenberg (CR19) 1990; 47 Suridjan, Rusjan, Addington, Wilson, Houle, Mizrahi (CR42) 2013; 38 Vilkman, Kajander, Aalto, Vahlberg, Någren, Allonen (CR62) 2009; 174 Kegeles, Slifstein, Xu, Urban, Thompson, Moadel (CR16) 2010; 68 Suhara, Okubo, Yasuno, Sudo, Inoue, Ichimiya (CR14) 2002; 59 Jenkinson, Beckmann, Behrens, Woolrich, Smith (CR21) 2012; 62 JP Roiser (1349_CR54) 2010; 50 R Niida (1349_CR29) 2018; 9 B Pakkenberg (1349_CR19) 1990; 47 M Nord (1349_CR1) 2011; 17 A Graff-Guerrero (1349_CR41) 2009; 34 BY Glenthoj (1349_CR39) 2006; 60 T Freiburghaus (1349_CR44) 2021; 226 I Ellison-Wright (1349_CR52) 2008; 165 LD Selemon (1349_CR48) 1999; 45 BH Ebdrup (1349_CR51) 2016; 41 EC Onwordi (1349_CR57) 2020; 11 H Vilkman (1349_CR62) 2009; 174 1349_CR8 M Talvik (1349_CR12) 2003; 6 OD Howes (1349_CR4) 2012; 69 K Hwang (1349_CR5) 2017; 37 A Leemans (1349_CR30) 2009; 61 F Yasuno (1349_CR10) 2004; 161 TD Cannon (1349_CR49) 2002; 99 M Jenkinson (1349_CR21) 2012; 62 F Wang (1349_CR28) 2008; 108 W Byne (1349_CR18) 2009; 117 CM Sellgren (1349_CR58) 2019; 22 A Morel (1349_CR47) 1997; 387 EF Osimo (1349_CR56) 2019; 24 T Veselinović (1349_CR15) 2018; 235 KA Dorph-Petersen (1349_CR20) 2017; 180 M Slifstein (1349_CR13) 2015; 72 GJ Matheson (1349_CR23) 2017; 155 TE Nichols (1349_CR34) 2002; 15 S Ripke (1349_CR3) 2014; 511 TEJ Behrens (1349_CR22) 2003; 6 J Andersson (1349_CR24) 2009; 67 LS Kegeles (1349_CR16) 2010; 68 JD Perezgonzalez (1349_CR37) 2015; 6 P Seeman (1349_CR46) 1987; 1 C Barth (1349_CR36) 2020; 15 M Talvik (1349_CR38) 2006; 148 DS Lehrer (1349_CR9) 2010; 122 H Olsson (1349_CR61) 2004; 22 J Tjerkaski (1349_CR26) 2020; 10 G Wagner (1349_CR6) 2015; 66 JR Glausier (1349_CR55) 2013; 251 M Lee (1349_CR33) 2014 RE Kass (1349_CR32) 1995; 90 C Halldin (1349_CR7) 1995; 36 RM Kessler (1349_CR11) 2009; 65 SV Haijma (1349_CR53) 2013; 39 1349_CR27 L Farde (1349_CR2) 1992; 49 S Klein (1349_CR31) 2010; 29 S Kelly (1349_CR35) 2018; 23 1349_CR25 H Tuppurainen (1349_CR40) 2006; 256 JE Svensson (1349_CR43) 2019; 202 TD Cannon (1349_CR50) 2015; 19 MC Asselin (1349_CR60) 2007; 27 R Narendran (1349_CR59) 2011; 65 T Suhara (1349_CR14) 2002; 59 J Kambeitz (1349_CR17) 2014; 204 S Silvestri (1349_CR45) 2000; 152 I Suridjan (1349_CR42) 2013; 38 |
| References_xml | – volume: 251 start-page: 90 year: 2013 end-page: 107 ident: CR55 article-title: Dendritic spine pathology in schizophrenia publication-title: Neuroscience doi: 10.1016/j.neuroscience.2012.04.044 – volume: 62 start-page: 782 year: 2012 end-page: 90 ident: CR21 article-title: Review FSL publication-title: Neuroimage doi: 10.1016/j.neuroimage.2011.09.015 – volume: 69 start-page: 776 year: 2012 end-page: 86 ident: CR4 article-title: The nature of dopamine dysfunction in schizophrenia and what this means for treatment publication-title: Arch Gen Psychiatry doi: 10.1001/archgenpsychiatry.2012.169 – volume: 72 start-page: 316 year: 2015 end-page: 24 ident: CR13 article-title: Deficits in prefrontal cortical and extrastriatal dopamine release in schizophrenia: a positron emission tomographic functional magnetic resonance imaging study publication-title: JAMA Psychiatry doi: 10.1001/jamapsychiatry.2014.2414 – volume: 29 start-page: 196 year: 2010 end-page: 205 ident: CR31 article-title: elastix: a toolbox for intensity-based medical image registration publication-title: IEEE Trans Med Imaging. doi: 10.1109/TMI.2009.2035616 – volume: 41 start-page: 133 year: 2016 end-page: 41 ident: CR51 article-title: Frontal fasciculi and psychotic symptoms in antipsychotic-naive patients with schizophrenia before and after 6 weeks of selective dopamine D2/3 receptor blockade publication-title: J Psychiatry Neurosci doi: 10.1503/jpn.150030 – volume: 37 start-page: 5594 year: 2017 end-page: 607 ident: CR5 article-title: The human thalamus is an integrative hub for functional brain networks publication-title: J Neurosci doi: 10.1523/JNEUROSCI.0067-17.2017 – volume: 180 start-page: 28 year: 2017 end-page: 35 ident: CR20 article-title: Postmortem structural studies of the thalamus in schizophrenia publication-title: Schizophr Res doi: 10.1016/j.schres.2016.08.007 – volume: 19 start-page: 744 year: 2015 end-page: 56 ident: CR50 article-title: How schizophrenia develops: cognitive and brain mechanisms underlying onset of psychosis publication-title: Trends Cogn Sci doi: 10.1016/j.tics.2015.09.009 – volume: 235 start-page: 2221 year: 2018 end-page: 32 ident: CR15 article-title: The role of striatal dopamine D 2/3 receptors in cognitive performance in drug-free patients with schizophrenia publication-title: Psychopharmacology doi: 10.1007/s00213-018-4916-6 – volume: 155 start-page: 344 year: 2017 end-page: 53 ident: CR23 article-title: Reliability of volumetric and surface-based normalisation and smoothing techniques for PET analysis of the cortex: A test-retest analysis using [11C]SCH-23390 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2017.04.031 – volume: 34 start-page: 1078 year: 2009 end-page: 86 ident: CR41 article-title: The Dopamine D2 Receptors in High-Affinity State and D3 Receptors in Schizophrenia: A Clinical [11C]-(+)-PHNO PET Study publication-title: Neuropsychopharmacology doi: 10.1038/npp.2008.199 – volume: 60 start-page: 621 year: 2006 end-page: 9 ident: CR39 article-title: Frontal dopamine D(2/3) receptor binding in drug-naive first-episode schizophrenic patients correlates with positive psychotic symptoms and gender publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2006.01.010 – ident: CR8 – ident: CR25 – volume: 161 start-page: 1016 year: 2004 end-page: 22 ident: CR10 article-title: Low dopamine d(2) receptor binding in subregions of the thalamus in schizophrenia publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.161.6.1016 – volume: 152 start-page: 174 year: 2000 end-page: 80 ident: CR45 article-title: Increased dopamine D2 receptor binding after long-term treatment with antipsychotics in humans: A clinical PET study publication-title: Psychopharmacology doi: 10.1007/s002130000532 – volume: 165 start-page: 1015 year: 2008 end-page: 23 ident: CR52 article-title: The anatomy of first-episode and chronic schizophrenia: An anatomical likelihood estimation meta-analysis publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.2008.07101562 – volume: 67 start-page: 106 year: 2009 end-page: 10 ident: CR24 article-title: In-target produced [11C]methane: Increased specific radioactivity publication-title: Appl Radiat Isot doi: 10.1016/j.apradiso.2008.09.010 – volume: 99 start-page: 3228 year: 2002 end-page: 33 ident: CR49 article-title: Cortex mapping reveals regionally specific patterns of genetic and disease-specific gray-matter deficits in twins discordant for schizophrenia publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.052023499 – volume: 65 start-page: 1024 year: 2009 end-page: 31 ident: CR11 article-title: Dopamine D2 Receptor Levels in Striatum, Thalamus, Substantia Nigra, Limbic Regions, and Cortex in Schizophrenic Subjects publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2008.12.029 – volume: 11 year: 2020 ident: CR57 article-title: Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats publication-title: Nat Commun doi: 10.1038/s41467-019-14122-0 – volume: 10 year: 2020 ident: CR26 article-title: Kinfitr—an open source tool for reproducible PET modelling: validation and evaluation of test-retest reliability publication-title: EJNMMI Res. doi: 10.1186/s13550-020-00664-8 – volume: 22 start-page: 794 year: 2004 end-page: 803 ident: CR61 article-title: Differentiation of extrastriatal dopamine D2 receptor density and affinity in the human brain using PET publication-title: Neuroimage. doi: 10.1016/j.neuroimage.2004.02.002 – volume: 122 start-page: 43 year: 2010 end-page: 52 ident: CR9 article-title: 18F-Fallypride binding potential in patients with schizophrenia compared to healthy controls publication-title: Schizophr Res doi: 10.1016/j.schres.2010.03.043 – volume: 23 start-page: 1261 year: 2018 end-page: 9 ident: CR35 article-title: Widespread white matter microstructural differences in schizophrenia across 4322 individuals: Results from the ENIGMA Schizophrenia DTI Working Group publication-title: Mol Psychiatry doi: 10.1038/mp.2017.170 – volume: 6 start-page: 361 year: 2003 end-page: 70 ident: CR12 article-title: Decreased thalamic D2/D3 receptor binding in drug-naive patients with schizophrenia: A PET study with [11C]FLB 457 publication-title: Int J Neuropsychopharmacol doi: 10.1017/S1461145703003699 – volume: 38 start-page: 98 year: 2013 end-page: 106 ident: CR42 article-title: Dopamine D2 and D3 binding in people at clinical high risk for schizophrenia, antipsychotic-naive patients and healthy controls while performing a cognitive task publication-title: J Psychiatry Neurosci doi: 10.1503/jpn.110181 – volume: 1 start-page: 5 year: 1987 end-page: 15 ident: CR46 article-title: Human brain D1 and D2 dopamine receptors in schizophrenia, Alzheimer’s, Parkinson’s, and Huntington’s diseases publication-title: Neuropsychopharmacology. doi: 10.1016/0893-133X(87)90004-2 – volume: 17 start-page: 97 year: 2011 end-page: 103 ident: CR1 article-title: Antipsychotic occupancy of dopamine receptors in schizophrenia publication-title: CNS Neurosci Ther doi: 10.1111/j.1755-5949.2010.00222.x – volume: 204 start-page: 420 year: 2014 end-page: 9 ident: CR17 article-title: Alterations in cortical and extrastriatal subcortical dopamine function in schizophrenia: systematic review and meta-analysis of imaging studies publication-title: Br J Psychiatry doi: 10.1192/bjp.bp.113.132308 – volume: 6 start-page: 750 year: 2003 end-page: 7 ident: CR22 article-title: Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging publication-title: Nat Neurosci doi: 10.1038/nn1075 – volume: 256 start-page: 382 year: 2006 end-page: 7 ident: CR40 article-title: Midbrain dopamine D2/3 receptor binding in schizophrenia publication-title: Eur Arch Psychiatry Clin Neurosci doi: 10.1007/s00406-006-0649-3 – volume: 50 start-page: 657 year: 2010 end-page: 64 ident: CR54 article-title: Adaptive and aberrant reward prediction signals in the human brain publication-title: Neuroimage doi: 10.1016/j.neuroimage.2009.11.075 – year: 2014 ident: CR33 publication-title: Bayesian cognitive modeling: A practical course. doi: 10.1017/CBO9781139087759 – volume: 226 start-page: 1 year: 2021 end-page: 21 ident: CR44 article-title: Low convergent validity of [11C]raclopride binding in extrastriatal brain regions: A PET study of within-subject correlations with [11C]FLB 457 publication-title: Neuroimage. doi: 10.1016/j.neuroimage.2020.117523 – volume: 49 start-page: 538 year: 1992 end-page: 44 ident: CR2 article-title: Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine: relation to extrapyramidal side effects publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.1992.01820070032005 – volume: 15 start-page: 1 year: 2002 end-page: 25 ident: CR34 article-title: Nonparametric permutation tests for functional neuroimaging: a primer with examples publication-title: Hum Brain Mapp. doi: 10.1002/hbm.1058 – volume: 27 start-page: 378 year: 2007 end-page: 92 ident: CR60 article-title: Quantification of PET studies with the very high-affinity dopamine D2/D3 receptor ligand [11C]FLB 457: re-evaluation of the validity of using a cerebellar reference region publication-title: J Cereb Blood Flow Metab. doi: 10.1038/sj.jcbfm.9600340 – volume: 68 start-page: 634 year: 2010 end-page: 41 ident: CR16 article-title: Striatal and Extrastriatal Dopamine D2/D3 Receptors in Schizophrenia Evaluated With [18F]fallypride Positron Emission Tomography publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2010.05.027 – volume: 117 start-page: 347 year: 2009 end-page: 68 ident: CR18 article-title: The thalamus and schizophrenia: current status of research publication-title: Acta Neuropathol doi: 10.1007/s00401-008-0404-0 – volume: 6 start-page: 1 year: 2015 end-page: 11 ident: CR37 article-title: Fisher, Neyman-Pearson or NHST? A tutorial for teaching data testing publication-title: Front Psychol doi: 10.3389/fpsyg.2015.00223 – volume: 36 start-page: 1275 year: 1995 end-page: 81 ident: CR7 article-title: Carbon-11-FLB 457: A radioligand for extrastriatal D2 dopamine receptors publication-title: J Nucl Med – volume: 65 start-page: 991 year: 2011 end-page: 7 ident: CR59 article-title: Evaluation of dopamine D2/3 specific binding in the cerebellum for the positron emission tomography radiotracer [¹¹C]FLB 457: implications for measuring cortical dopamine release publication-title: Synapse. doi: 10.1002/syn.20926 – volume: 66 start-page: 35 year: 2015 end-page: 45 ident: CR6 article-title: Structural and functional dysconnectivity of thefronto-thalamic system in schizophrenia: ADCM-DTI study publication-title: Cortex doi: 10.1016/j.cortex.2015.02.004 – ident: CR27 – volume: 202 start-page: 116143 year: 2019 ident: CR43 article-title: Validity and reliability of extrastriatal [11C]raclopride binding quantification in the living human brain publication-title: Neuroimage. doi: 10.1016/j.neuroimage.2019.116143 – volume: 108 start-page: 775 year: 2008 end-page: 81 ident: CR28 article-title: Diffusion tensor tractography of the temporal stem on the inferior limiting sulcus: Laboratory investigation publication-title: J Neurosurg doi: 10.3171/JNS/2008/108/4/0775 – volume: 174 start-page: 130 year: 2009 end-page: 7 ident: CR62 article-title: The effects of lorazepam on extrastriatal dopamine D2/3-receptors-A double-blind randomized placebo-controlled PET study publication-title: Psychiatry Res - Neuroimaging doi: 10.1016/j.pscychresns.2009.04.006 – volume: 148 start-page: 165 year: 2006 end-page: 73 ident: CR38 article-title: Dopamine D2 receptor binding in drug-naïve patients with schizophrenia examined with raclopride-C11 and positron emission tomography publication-title: Psychiatry Res doi: 10.1016/j.pscychresns.2006.05.009 – volume: 387 start-page: 588 year: 1997 end-page: 630 ident: CR47 article-title: Multiarchitectonic and stereotactic atlas of the human thalamus publication-title: J Comp Neurol doi: 10.1002/(SICI)1096-9861(19971103)387:4<588::AID-CNE8>3.0.CO;2-Z – volume: 45 start-page: 17 year: 1999 end-page: 25 ident: CR48 article-title: The reduced neuropil hypothesis: a circuit based model of schizophrenia publication-title: Biol Psychiatry doi: 10.1016/S0006-3223(98)00281-9 – volume: 511 start-page: 421 year: 2014 end-page: 7 ident: CR3 article-title: Biological insights from 108 schizophreniaassociated genetic loci publication-title: Nature. doi: 10.1038/nature13595 – volume: 15 start-page: e0233684 year: 2020 ident: CR36 article-title: Exploring white matter microstructure and the impact of antipsychotics in adolescent-onset psychosis publication-title: PLoS ONE doi: 10.1371/journal.pone.0233684 – volume: 22 start-page: 374 year: 2019 end-page: 85 ident: CR58 article-title: Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning publication-title: Nat Neurosci. doi: 10.1038/s41593-018-0334-7 – volume: 59 start-page: 25 year: 2002 end-page: 30 ident: CR14 article-title: Decreased dopamine D2 receptor binding in the anterior cingulate cortex in schizophrenia publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.59.1.25 – volume: 9 start-page: 1 year: 2018 end-page: 7 ident: CR29 article-title: Aberrant anterior thalamic radiation structure in bipolar disorder: A diffusion tensor tractography study publication-title: Front Psychiatry doi: 10.3389/fpsyt.2018.00522 – volume: 61 start-page: 1336 year: 2009 end-page: 49 ident: CR30 article-title: The -matrix must be rotated when correcting for subject motion in DTI data publication-title: Magn Reson Med doi: 10.1002/mrm.21890 – volume: 39 start-page: 1129 year: 2013 end-page: 38 ident: CR53 article-title: Brain volumes in schizophrenia: a meta-analysis in over 18 000 subjects publication-title: Schizophr Bull doi: 10.1093/schbul/sbs118 – volume: 90 start-page: 773 year: 1995 end-page: 95 ident: CR32 article-title: Bayes factors publication-title: J Am Stat Assoc doi: 10.1080/01621459.1995.10476572 – volume: 47 start-page: 1023 year: 1990 end-page: 8 ident: CR19 article-title: Pronounced Reduction of Total Neuron Number in Mediodorsal Thalamic Nucleus and Nucleus Accumbens in Schizophrenics publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.1990.01810230039007 – volume: 24 start-page: 549 year: 2019 end-page: 61 ident: CR56 article-title: Synaptic loss in schizophrenia: a meta-analysis and systematic review of synaptic protein and mRNA measures publication-title: Mol Psychiatry doi: 10.1038/s41380-018-0041-5 – volume: 45 start-page: 17 year: 1999 ident: 1349_CR48 publication-title: Biol Psychiatry doi: 10.1016/S0006-3223(98)00281-9 – volume: 148 start-page: 165 year: 2006 ident: 1349_CR38 publication-title: Psychiatry Res doi: 10.1016/j.pscychresns.2006.05.009 – volume: 24 start-page: 549 year: 2019 ident: 1349_CR56 publication-title: Mol Psychiatry doi: 10.1038/s41380-018-0041-5 – volume: 29 start-page: 196 year: 2010 ident: 1349_CR31 publication-title: IEEE Trans Med Imaging. doi: 10.1109/TMI.2009.2035616 – volume: 152 start-page: 174 year: 2000 ident: 1349_CR45 publication-title: Psychopharmacology doi: 10.1007/s002130000532 – volume: 19 start-page: 744 year: 2015 ident: 1349_CR50 publication-title: Trends Cogn Sci doi: 10.1016/j.tics.2015.09.009 – volume: 47 start-page: 1023 year: 1990 ident: 1349_CR19 publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.1990.01810230039007 – ident: 1349_CR25 doi: 10.1038/jcbfm.1990.127 – volume: 256 start-page: 382 year: 2006 ident: 1349_CR40 publication-title: Eur Arch Psychiatry Clin Neurosci doi: 10.1007/s00406-006-0649-3 – volume: 49 start-page: 538 year: 1992 ident: 1349_CR2 publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.1992.01820070032005 – volume: 122 start-page: 43 year: 2010 ident: 1349_CR9 publication-title: Schizophr Res doi: 10.1016/j.schres.2010.03.043 – volume: 67 start-page: 106 year: 2009 ident: 1349_CR24 publication-title: Appl Radiat Isot doi: 10.1016/j.apradiso.2008.09.010 – ident: 1349_CR27 doi: 10.1093/acprof:oso/9780195104233.001.0001 – volume: 161 start-page: 1016 year: 2004 ident: 1349_CR10 publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.161.6.1016 – volume: 72 start-page: 316 year: 2015 ident: 1349_CR13 publication-title: JAMA Psychiatry doi: 10.1001/jamapsychiatry.2014.2414 – volume: 34 start-page: 1078 year: 2009 ident: 1349_CR41 publication-title: Neuropsychopharmacology doi: 10.1038/npp.2008.199 – volume: 165 start-page: 1015 year: 2008 ident: 1349_CR52 publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.2008.07101562 – volume: 50 start-page: 657 year: 2010 ident: 1349_CR54 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2009.11.075 – volume: 65 start-page: 991 year: 2011 ident: 1349_CR59 publication-title: Synapse. doi: 10.1002/syn.20926 – volume: 387 start-page: 588 year: 1997 ident: 1349_CR47 publication-title: J Comp Neurol doi: 10.1002/(SICI)1096-9861(19971103)387:4<588::AID-CNE8>3.0.CO;2-Z – volume: 226 start-page: 1 year: 2021 ident: 1349_CR44 publication-title: Neuroimage. doi: 10.1016/j.neuroimage.2020.117523 – volume: 6 start-page: 750 year: 2003 ident: 1349_CR22 publication-title: Nat Neurosci doi: 10.1038/nn1075 – volume: 15 start-page: e0233684 year: 2020 ident: 1349_CR36 publication-title: PLoS ONE doi: 10.1371/journal.pone.0233684 – volume: 99 start-page: 3228 year: 2002 ident: 1349_CR49 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.052023499 – volume: 180 start-page: 28 year: 2017 ident: 1349_CR20 publication-title: Schizophr Res doi: 10.1016/j.schres.2016.08.007 – volume: 204 start-page: 420 year: 2014 ident: 1349_CR17 publication-title: Br J Psychiatry doi: 10.1192/bjp.bp.113.132308 – volume: 65 start-page: 1024 year: 2009 ident: 1349_CR11 publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2008.12.029 – volume: 108 start-page: 775 year: 2008 ident: 1349_CR28 publication-title: J Neurosurg doi: 10.3171/JNS/2008/108/4/0775 – volume: 11 year: 2020 ident: 1349_CR57 publication-title: Nat Commun doi: 10.1038/s41467-019-14122-0 – volume: 202 start-page: 116143 year: 2019 ident: 1349_CR43 publication-title: Neuroimage. doi: 10.1016/j.neuroimage.2019.116143 – volume: 235 start-page: 2221 year: 2018 ident: 1349_CR15 publication-title: Psychopharmacology doi: 10.1007/s00213-018-4916-6 – volume: 117 start-page: 347 year: 2009 ident: 1349_CR18 publication-title: Acta Neuropathol doi: 10.1007/s00401-008-0404-0 – volume: 17 start-page: 97 year: 2011 ident: 1349_CR1 publication-title: CNS Neurosci Ther doi: 10.1111/j.1755-5949.2010.00222.x – volume: 511 start-page: 421 year: 2014 ident: 1349_CR3 publication-title: Nature. doi: 10.1038/nature13595 – volume: 61 start-page: 1336 year: 2009 ident: 1349_CR30 publication-title: Magn Reson Med doi: 10.1002/mrm.21890 – volume: 62 start-page: 782 year: 2012 ident: 1349_CR21 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2011.09.015 – volume: 60 start-page: 621 year: 2006 ident: 1349_CR39 publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2006.01.010 – volume: 23 start-page: 1261 year: 2018 ident: 1349_CR35 publication-title: Mol Psychiatry doi: 10.1038/mp.2017.170 – volume: 1 start-page: 5 year: 1987 ident: 1349_CR46 publication-title: Neuropsychopharmacology. doi: 10.1016/0893-133X(87)90004-2 – volume: 22 start-page: 794 year: 2004 ident: 1349_CR61 publication-title: Neuroimage. doi: 10.1016/j.neuroimage.2004.02.002 – volume: 36 start-page: 1275 year: 1995 ident: 1349_CR7 publication-title: J Nucl Med – volume: 174 start-page: 130 year: 2009 ident: 1349_CR62 publication-title: Psychiatry Res - Neuroimaging doi: 10.1016/j.pscychresns.2009.04.006 – volume: 6 start-page: 361 year: 2003 ident: 1349_CR12 publication-title: Int J Neuropsychopharmacol doi: 10.1017/S1461145703003699 – volume: 66 start-page: 35 year: 2015 ident: 1349_CR6 publication-title: Cortex doi: 10.1016/j.cortex.2015.02.004 – volume: 251 start-page: 90 year: 2013 ident: 1349_CR55 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2012.04.044 – volume: 90 start-page: 773 year: 1995 ident: 1349_CR32 publication-title: J Am Stat Assoc doi: 10.1080/01621459.1995.10476572 – volume: 39 start-page: 1129 year: 2013 ident: 1349_CR53 publication-title: Schizophr Bull doi: 10.1093/schbul/sbs118 – volume: 59 start-page: 25 year: 2002 ident: 1349_CR14 publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.59.1.25 – volume: 10 year: 2020 ident: 1349_CR26 publication-title: EJNMMI Res. doi: 10.1186/s13550-020-00664-8 – volume: 38 start-page: 98 year: 2013 ident: 1349_CR42 publication-title: J Psychiatry Neurosci doi: 10.1503/jpn.110181 – volume: 9 start-page: 1 year: 2018 ident: 1349_CR29 publication-title: Front Psychiatry doi: 10.3389/fpsyt.2018.00522 – volume: 155 start-page: 344 year: 2017 ident: 1349_CR23 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2017.04.031 – volume-title: Bayesian cognitive modeling: A practical course. year: 2014 ident: 1349_CR33 doi: 10.1017/CBO9781139087759 – volume: 27 start-page: 378 year: 2007 ident: 1349_CR60 publication-title: J Cereb Blood Flow Metab. doi: 10.1038/sj.jcbfm.9600340 – volume: 68 start-page: 634 year: 2010 ident: 1349_CR16 publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2010.05.027 – volume: 69 start-page: 776 year: 2012 ident: 1349_CR4 publication-title: Arch Gen Psychiatry doi: 10.1001/archgenpsychiatry.2012.169 – volume: 6 start-page: 1 year: 2015 ident: 1349_CR37 publication-title: Front Psychol doi: 10.3389/fpsyg.2015.00223 – volume: 22 start-page: 374 year: 2019 ident: 1349_CR58 publication-title: Nat Neurosci. doi: 10.1038/s41593-018-0334-7 – volume: 41 start-page: 133 year: 2016 ident: 1349_CR51 publication-title: J Psychiatry Neurosci doi: 10.1503/jpn.150030 – volume: 37 start-page: 5594 year: 2017 ident: 1349_CR5 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.0067-17.2017 – ident: 1349_CR8 doi: 10.1016/0969-8051(94)00117-3 – volume: 15 start-page: 1 year: 2002 ident: 1349_CR34 publication-title: Hum Brain Mapp. doi: 10.1002/hbm.1058 |
| SSID | ssj0014765 |
| Score | 2.4657617 |
| SecondaryResourceType | review_article |
| Snippet | Pharmacological and genetic evidence support a role for an involvement of the dopamine D2-receptor (D2-R) in the pathophysiology of schizophrenia. Previous... Abstract Pharmacological and genetic evidence support a role for an involvement of the dopamine D2-receptor (D2-R) in the pathophysiology of schizophrenia.... |
| SourceID | swepub pubmedcentral cristin proquest pubmed crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1233 |
| SubjectTerms | 59/57 59/78 631/45 692/699/476/1799 Anisotropy Antipsychotic Agents - therapeutic use Antipsychotics Bayes Theorem Bayesian analysis Behavioral Sciences Biological Psychology Clinical Medicine Cortex (frontal) Diffusion Tensor Imaging Dopamine Dopamine - metabolism Dopamine D2 receptors Genetic analysis Humans Klinisk medicin Magnetic resonance imaging Medical and Health Sciences Medicin och hälsovetenskap Medicine Medicine & Public Health Mental disorders Meta-analysis Neural networks Neuroimaging Neurologi Neurology Neurosciences Neurotransmission Pharmacotherapy Positron emission tomography Positron-Emission Tomography - methods Psychiatry Psychosis Psychotic Disorders - metabolism Psychotropic drugs Psykiatri Receptors, Dopamine D3 - metabolism Schizophrenia Schizophrenia - metabolism Thalamus Thalamus - metabolism |
| SummonAdditionalLinks | – databaseName: Springer Nature OA Free Journals (Selected full-text) dbid: C6C link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELaqIhAXBOXRQEFGAi5g4cSPJNyqbasKCU4tqrhYtuOwEdtk1ewi-kP4v4wdb-jSVQWHXGJnEmfGk28y488IveIls67OLfFwlHBWaFJIYwg1OcTPaQ0gIRTIfpbHp_zjmTjbQtlqLUwo2g-UlsFNr6rD3vfgbAtKfEEB9Yx6BHDjLU_d7gOuiZyMmQOeh-0jUyZ8hrPgcaEMZcUGGQB6bZhL7fpn6RrWvF4yOeZN_-IYDd-lo_voXgSUeH8YwgO05doddHvYYvJyB935FJPnD9Gvk6me-e3ncQWR8jmcwwcZAY_n5hB4Y_1DN7OBtfsSNy3ur5bjfcAaByZa3LUYlNHE1VuNJa0Gh4kjP2uP_Y9dXDcAKombN31XQVvo2zc9XFmBoHO30ERHNpRH6PTo8GRyTOKuDMTmLFuQvLRCMqdLD51qLZkVFjCBZDo30gib1Xme1hmFqJtJLSuYhVXhhF9gC1BOU_YYbbdd63YRdhV1Toi8zFLDdZVqSisH1sNAiwWMPkG7UT2qhQnhyUxFpoqSS56gdKUvZSObud9UY6ZCVp0VatC2Am2roG31M0Fvx2vmA5fHjb33Vmag4rzuVQbwFxCzpHmCXo7NMCN9mkW3rltCH1FKLsCPlgl6MljNeDvm6RWZb8nX7Gns4Nm-11vaZhpYv-F9c4CLCXq3srw_j3XTKF4P1rl2h4Pmy77qLr6p5VJx6bPfCTrc0G-2nMNh4FC9U7VLjSk4U9xoqritrTIiM8qUQjtWZwB2TIK-bpAzhJIq8ldNo7z5lR_T_yj8zQbh8dT3xsvkAqyvfPp_L-kZupv5VS2hGH8PbS8ulu45YM2FeRGcy29Ox31X priority: 102 providerName: Springer Nature |
| Title | Thalamic dopamine D2-receptor availability in schizophrenia: a study on antipsychotic-naive patients with first-episode psychosis and a meta-analysis |
| URI | https://link.springer.com/article/10.1038/s41380-021-01349-x https://www.ncbi.nlm.nih.gov/pubmed/34759359 https://www.proquest.com/docview/2656977607 https://www.proquest.com/docview/2596453059 http://hdl.handle.net/10852/89464 https://pubmed.ncbi.nlm.nih.gov/PMC9054658 https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-460424 https://lup.lub.lu.se/record/fe1bb843-4ba0-4cfc-b52b-b95ae3f2801b oai:portal.research.lu.se:publications/fe1bb843-4ba0-4cfc-b52b-b95ae3f2801b http://kipublications.ki.se/Default.aspx?queryparsed=id:148029709 |
| Volume | 27 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELdgExIviO8FxmQk4AWsJfFHEl5Q27WaeKgQ2lDFi2U7Do3o0rC0aPtD-H85J263sqniIaoUO07SO19-5zv_DqE3LKPGFokhDo4SRlNFUqE1CXUC_nNUAEhoE2TH4viUfZ7wiV9wa3xa5comtoY6nxu3Rn4YA_AArCLC5FP9i7iqUS666kto3EW7jrrMaXUyWTtcEUvaUpIR5S7amTK_aSak6WEDxjsNiUtQCB1DH7kAAGzaeVVtfqJu4M6b6ZPrGOo_fKPtN2r0ED3w4BL3Om14hO7Y6jG615WbvHyC_pxM1czVn8c5uMpngC_xUUzA5NkaPG-sfqty1tF2X-Kyws31fLyPWOGWihbPKwzSKP32rdKQSoHFxJ6gtcFuZRcXJaBKYuuymefQ1vZtygauzGGgM7tQRHk6lKfodDQ8GRwTX5aBmITGC5JkhgtqVeawU6EENdwAKBBUJVpobuIiSaIiDsHtpkKJHKZhnlrudtgCllMhfYZ2qnll9xC2eWgt50kWR5qpPFJhmFtQHwqiS-HtA7TnZSIrmBGOzZTHMs2YYAGKVkKSxtOZu6oaM9mG1WkqOxFLELFsRSwvAvR-fU3dkXls7b2_kr30E7uRV2oYoNfrZpiSLs6iKjtfQh-eCcbBkGYBet6pyvp21PErUteSbCjRuoOj-95sqcppS_sN_zcDvBigDyt1u3qsbW_xtlPJjTscld96cn7-Qy6XkgkX_g7Q8JZ-s2UNh4ZDNlYWNtI6ZVQyrULJTGGk5rGWOuPK0iIGtKMD9P2WcTpfUnoCq6kfr762Mv2fg7-7ZXB_6mfpxmQctC97sV12L9H92G1jabPv99HO4nxpXwG4XOiD1oIcoN3eqN8fw29_OP7yFc4OxOAv9Pl_8w |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELZKEYIL4t1AASNRLmA1ie08kBCq2FZbWnraohUXYzsOG7FNQrML3R_C3-A3Ms5j26WrFZceclk7k2RnMv4mM_4GoZcsptqkoSYWjhJGI0miQCniqhDiZy8FkFAXyB4F_WP2cciHa-hPtxfGllV2PrF21Emh7TfybR-AB2CVwA3flz-I7Rpls6tdC43GLA7M7BeEbNW7_R7od8v393YHH_qk7SpAdEj9CQljzQNqZGyX_lQGVHMNa1pAZagCxbWfhqGX-i5EjTSQQQJWlESG2w2iAEWkS0HuNXQdFl7XBnvhcB7geSysW1d6lNvsasTaTToujbYrWCwil9iCCNcyApIzANy6fo_zxSXxEs69XK45z9n-w29ar4l7d9DtFszincb67qI1k99DN5r2lrP76PdgJMe23z1OIDQ_ATyLez4BF2tKiPSx_CmzcUMTPsNZjquL9X9vscQ19S0ucgzaz9rtYpkmuQQPjVtC2ArbL8k4zQDFElNmVZHAWD23yio4MwFBJ2YiiWzpVx6g4ytR2EO0nhe52UDYJK4xnIex7ykmE0-6bmLAXCmoLoKnd9BGqxORwxto2VO5L6KYBcxBXqckoVv6dNvFYyzqND6NRKNiASoWtYrFmYNez88pG_KQlbM3O92L1pFU4tzsHfRiPgwuwOZ1ZG6KKczhccA4OO7YQY8aU5lfjlo-R2pHwgUjmk-w9OKLI3k2qmnG4f9mgE8d9KYzt_PbWvUUW41JLlyhl33eEcXpNzGdChbYdLuDdpfMG09LOBQcojIiNZ5SEaOCKekKplMtFPeVUDGXhqY-oCvloC9L5DSxq2gJs0atvPLCl_D_FP5qifD2p--Zlck4WF_8eLXunqOb_cGnQ3G4f3TwBN3y7RaauvJ_E61PTqfmKQDbiXpWexOMvl61-_oLnNO2XQ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3NbtQwELZKKxAXxH8DBYxEuYDVJLbzg4RQYbtqKVpVqEVVL8Z2HBrRJqHZhfZBeBmejnHiTbu0qrj0kMvamSQ74_E3nvFnhF6wlGqTx5pYOEoYTSRJIqWIr2KIn4McQEJbIDuK1nfYx12-O4f-TPfC2LLKqU9sHXVWabtGvhIC8ACsEvnxSu7KIrYGw3f1D2JPkLKZ1ulxGp2JbJqTXxC-NW83BqDr5TAcrm1_WCfuhAGiYxqOSZxqHlEjUwsDchlRzTXMbxGVsYoU12Eex0Ee-hBB0khGGVhUlhhuN4sCLJE-BbnX0EJso6J5tPB-bbT1uc9hsLg9yDKg3OZaE-a27Pg0WWlg6kh8YssjfMsPSI4Bfut2VJezE-Q51Hu-eLPP4P7DdtrOkMPb6JaDtni1s8U7aM6Ud9H17rDLk3vo9_a-BPMrNM4gUD8EdIsHIQGHa2qI-7H8KYuDjjT8BBclbs5WA77BErdEuLgqMdhC4TaPFZqUEvw1dvSwDbbryjgvANMSUxdNlUFb27cpGrgzA0GHZiyJdGQs99HOlajsAZovq9IsImwy3xjO4zQMFJNZIH0_M2C8FFSXwNd7aNHpRJQwHi2XKg9FkrKIeSiYKkloR6Zuz_Q4EG1SnyaiU7EAFYtWxeLYQ6_6e-qOSuTS3ktT3QvnVhpxOgg89LxvBodgszyyNNUE-vA0YhzceOqhh52p9I-jlt2R2pZ4xoj6DpZsfLalLPZb0nH4vxmgVQ-9nprb6Wtd9hXLnUnOPGFQfFkV1dE3MZkIFtnku4fWLuh3MKnhUnCJxojcBEoljAqmpC-YzrVQPFRCpVwamoeAtZSH9i6Q00WywtFn7Tt59Zl18f8U_vIC4e6n74WVyThYX_roct09QzfAdYlPG6PNx-hmaPfTtNsAltD8-GhingDKHaunzp1g9PWqPdhfnsK7-A |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Thalamic+dopamine+D2-receptor+availability+in+schizophrenia%3A+a+study+on+antipsychotic-naive+patients+with+first-episode+psychosis+and+a+meta-analysis&rft.jtitle=Molecular+psychiatry&rft.au=Plav%C3%A9n-Sigray%2C+Pontus&rft.au=Ikonen+Victorsson%2C+Pauliina&rft.au=Santillo%2C+Alexander&rft.au=Matheson%2C+Granville+J.&rft.date=2022-02-01&rft.pub=Nature+Publishing+Group+UK&rft.issn=1359-4184&rft.eissn=1476-5578&rft.volume=27&rft.issue=2&rft.spage=1233&rft.epage=1240&rft_id=info:doi/10.1038%2Fs41380-021-01349-x&rft_id=info%3Apmid%2F34759359&rft.externalDocID=PMC9054658 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1359-4184&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1359-4184&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1359-4184&client=summon |