Genomewide association for schizophrenia in the CATIE study: results of stage 1

• Published in: Molecular psychiatry Vol. 13; no. 6; pp. 570 - 584
• Main Authors: Sullivan, P F, Lin, D, Tzeng, J-Y, van den Oord, E, Perkins, D, Stroup, T S, Wagner, M, Lee, S, Wright, F A, Zou, F, Liu, W, Downing, A M, Lieberman, J, Close, S L
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2008; Nature Publishing Group
• Subjects: Adult and adolescent clinical studies; Antipsychotic Agents - therapeutic use; Antipsychotics; Behavioral Sciences; Biological and medical sciences; Biological Psychology; Bipolar disorder; Body mass index; Care and treatment; Case-Control Studies; Collaboration; Computational Biology; Diabetes; Diagnosis; DNA - genetics; DNA - isolation & purification; Epidemiology; Genetic Markers; Genetic Variation; Genetics; Genome, Human; Genomes; Genomics; Genotype; Genotype & phenotype; Genotyping; Humans; Identification and classification; immediate-communication; Management; Medical sciences; Medicine; Medicine & Public Health; Mental disorders; Methods; National Institute of Mental Health (U.S.); Neurosciences; Nucleotide sequence; Pharmacotherapy; Pharmacy; Phenotypes; Polymorphism, Single Nucleotide; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Psychotropic drugs; Quality control; Research institutes; Risk factors; Schizophrenia; Schizophrenia - drug therapy; Schizophrenia - genetics; Single-nucleotide polymorphism; United States; United States; United States > US; Indianapolis Indiana; CATIE; genomewide association; schizophrenia; Psychosis; Schizophrenia
• ISSN: 1359-4184; 1476-5578; 1476-5578
• DOI: 10.1038/mp.2008.25

Little is known for certain about the genetics of schizophrenia. The advent of genomewide association has been widely anticipated as a promising means to identify reproducible DNA sequence variation associated with this important and debilitating disorder. A total of 738 cases with DSM-IV schizophrenia (all participants in the CATIE study) and 733 group-matched controls were genotyped for 492 900 single-nucleotide polymorphisms (SNPs) using the Affymetrix 500K two-chip genotyping platform plus a custom 164K fill-in chip. Following multiple quality control steps for both subjects and SNPs, logistic regression analyses were used to assess the evidence for association of all SNPs with schizophrenia. We identified a number of promising SNPs for follow-up studies, although no SNP or multimarker combination of SNPs achieved genomewide statistical significance. Although a few signals coincided with genomic regions previously implicated in schizophrenia, chance could not be excluded. These data do not provide evidence for the involvement of any genomic region with schizophrenia detectable with moderate sample size. However, a planned genomewide association study for response phenotypes and inclusion of individual phenotype and genotype data from this study in meta-analyses hold promise for eventual identification of susceptibility and protective variants.