Connectivity derived thalamic segmentation in deep brain stimulation for tremor

• Published in: NeuroImage clinical Vol. 18; pp. 130 - 142
• Main Authors: Akram, Harith, Dayal, Viswas, Mahlknecht, Philipp, Georgiev, Dejan, Hyam, Jonathan, Foltynie, Thomas, Limousin, Patricia, De Vita, Enrico, Jahanshahi, Marjan, Ashburner, John, Behrens, Tim, Hariz, Marwan, Zrinzo, Ludvic
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.01.2018; Elsevier
• Subjects: Aged; Connectivity; DBS; Deep Brain Stimulation; Deep brain stimulation DBS; Dentate nucleus; Dentate nucleus Tremor; Dentato-rubro-thalamic tract; Dentato-rubro-thalamic tract DRT; Diffusion Magnetic Resonance Imaging; Diffusion weighted imaging; Diffusion weighted imaging DWI; DRT; DWI; Essential Tremor - diagnostic imaging; Essential Tremor - physiopathology; Essential Tremor - therapy; Female; Humans; Male; Middle Aged; Parkinson Disease - diagnostic imaging; Parkinson Disease - physiopathology; Parkinson Disease - therapy; Parkinson's disease; Parkinson's disease PD; Radiology; Regular; Thalamus - diagnostic imaging; Thalamus - physiopathology; Tremor; Ventrointermedialis; Ventrointermedialis VIM; Ventrolateral nucleus; Ventrolateral nucleus VL; VIM; IPG; DF; MPRAGE; Parkinson's disease; M1; Dentato-rubro-thalamic tract; Deep brain stimulation; DRT; GLM; FoV; PFC; STN; DBS; HFS; DWI; LEDD; FSL; VBM; AC; SMA; SSEPI; HARDI; NIfTI; EV; MMS; Ventrolateral nucleus; VL; Connectivity; FMRIB; VP; FLIRT; S1; VTA; SAR; BEDPOSTX; MNI; Ventrointermedialis; SD; SE; cZI; SNR; UPDRS; DICOM; Dentate nucleus; NHNN; CON; Tremor; CI; PMC; BET; PC; TFCE; PD; LC; MPTP; TMS; VIM; FNIRT; Diffusion weighted imaging; primary sensory cortex; transcranial magnetic stimulation; anterior commissure; connectivity; mini-mental score; caudal zona incerta; brain extraction tool; field of view; high angular resolution diffusion imaging; neuroimaging informatics technology initiative; standard error; l-DOPA equivalent daily dose; Oxford centre for functional MRI of the brain; magnetization-prepared rapid gradient-echo; unified Parkinson's disease rating scale; single-shot echo planar imaging; primary motor cortex; threshold-free cluster enhancement; ventral posterior; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; signal-to-noise ratio; confidence interval; ventral lateral; high frequency stimulation; diffusion weighted imaging; premotor cortex; digital imaging and communications in medicine; explanatory variable; Montreal neurological institute; deep brain stimulation; general linear model; supplementary motor area; subthalamic nucleus; specific absorption rate; standard deviation; prefrontal cortex; FMRIB's non-linear image registration tool; voxel based morphometry; FMRIB's software library; FMRIB's linear image registration tool; Levodopa challenge; implantable pulse generator; degrees of freedom; posterior commissure; National Hospital for Neurology and Neurosurgery; volume of tissue activated; Bayesian estimation of diffusion parameters obtained using sampling techniques X; CI, confidence interval; DBS, deep brain stimulation; PMC, premotor cortex; TMS, transcranial magnetic stimulation; LEDD, l-DOPA equivalent daily dose; STN, subthalamic nucleus; DICOM, digital imaging and communications in medicine; FLIRT, FMRIB's linear image registration tool; AC, anterior commissure; S1, primary sensory cortex; SMA, supplementary motor area; VL, ventral lateral; DF, degrees of freedom; SAR, specific absorption rate; IPG, implantable pulse generator; SNR, signal-to-noise ratio; PFC, prefrontal cortex; TFCE, threshold-free cluster enhancement; PC, posterior commissure; NIfTI, neuroimaging informatics technology initiative; DWI, diffusion weighted imaging; GLM, general linear model; UPDRS, unified Parkinson's disease rating scale; cZI, caudal zona incerta; MNI, Montreal neurological institute; MMS, mini-mental score; BEDPOSTX, Bayesian estimation of diffusion parameters obtained using sampling techniques X; FNIRT, FMRIB's non-linear image registration tool; SD, standard deviation; EV, explanatory variable; LC, Levodopa challenge; HFS, high frequency stimulation; M1, primary motor cortex; NHNN, National Hospital for Neurology and Neurosurgery; HARDI, high angular resolution diffusion imaging; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; FSL, FMRIB's software library; VTA, volume of tissue activated; VBM, voxel based morphometry; SE, standard error; BET, brain extraction tool; CON, connectivity; FoV, field of view; MPRAGE, magnetization-prepared rapid gradient-echo; VP, ventral posterior; FMRIB, Oxford centre for functional MRI of the brain; SSEPI, single-shot echo planar imaging

The ventral intermediate nucleus (VIM) of the thalamus is an established surgical target for stereotactic ablation and deep brain stimulation (DBS) in the treatment of tremor in Parkinson's disease (PD) and essential tremor (ET). It is centrally placed on a cerebello-thalamo-cortical network co...