IgG4 inhibits peanut-induced basophil and mast cell activation in peanut-tolerant children sensitized to peanut major allergens

• Published in: Journal of allergy and clinical immunology Vol. 135; no. 5; pp. 1249 - 1256
• Main Authors: Santos, Alexandra F., James, Louisa K., Bahnson, Henry T., Shamji, Mohammed H., Couto-Francisco, Natália C., Islam, Sabita, Houghton, Sally, Clark, Andrew T., Stephens, Alick, Turcanu, Victor, Durham, Stephen R., Gould, Hannah J., Lack, Gideon
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2015; Mosby
• Subjects: Allergens - immunology; Allergy and Immunology; Antibody Specificity; Antigens, Plant; Ara h 2; Arachis - adverse effects; Arachis hypogaea; basophil; basophil activation test; Basophils - immunology; blocking antibodies; Child; Child, Preschool; Female; Food, Drug, Insect Sting Allergy, and Anaphylaxis; Humans; IgE inhibition; IgG4; Immune Tolerance; Immunoglobulin E - immunology; Immunoglobulin G - immunology; Male; mast cells; Mast Cells - immunology; peanut; peanut allergy; Peanut Hypersensitivity - immunology; tolerance; P-sIgE; PS; IgG4; basophil; IgE inhibition; mast cells; Ara h 2; POIT; peanut allergy; PA; P-sIgG4; NA; SPT; HSA; basophil activation test; blocking antibodies; peanut; tolerance; Peanut-specific IgG 4; Human serum albumin; Skin prick test; IgG 4; Peanut oral immunotherapy; Non–peanut-sensitized nonallergic; P-sIgG 4; Peanut-sensitized but tolerant; Peanut-specific IgE; IgG

Most children with detectable peanut-specific IgE (P-sIgE) are not allergic to peanut. We addressed 2 non–mutually exclusive hypotheses for the discrepancy between allergy and sensitization: (1) differences in P-sIgE levels between children with peanut allergy (PA) and peanut-sensitized but tolerant...