Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries

• Published in: Carcinogenesis (New York) Vol. 29; no. 6; pp. 1178 - 1183
• Main Authors: Bonassi, Stefano, Norppa, Hannu, Ceppi, Marcello, Strömberg, Ulf, Vermeulen, Roel, Znaor, Ariana, Cebulska-Wasilewska, Antonina, Fabianova, Eleonora, Fucic, Alexandra, Gundy, Sarolta, Hansteen, Inger-Lise, Knudsen, Lisbeth E., Lazutka, Juozas, Rossner, Pavel, Sram, Radim J., Boffetta, Paolo
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.06.2008; Oxford Publishing Limited (England)
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Cancer and Oncology; Cancer och onkologi; Carcinogenesis, carcinogens and anticarcinogens; Chromosome Aberrations; Clinical Medicine; Cohort Studies; Female; Genetic Predisposition to Disease; Humans; Incidence; Klinisk medicin; Lymphocytes; Male; Medical and Health Sciences; Medical sciences; Medicin och hälsovetenskap; Middle Aged; Molecular Epidemiology; Neoplasms - epidemiology; Neoplasms - genetics; Risk Assessment; Risk Factors; Tumors; Chromosomal aberration; Human; Toxicity; Countries; Genotoxicity; Risk; Malignant tumor; Cohort study; Risk factor; Frequency; Predictive factor; Lymphocyte; Cancer

Mechanistic evidence linking chromosomal aberration (CA) to early stages of cancer has been recently supported by the results of epidemiological studies that associated CA frequency in peripheral lymphocytes of healthy individuals to future cancer incidence. To overcome the limitations of single stu...