Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity
TRIMCyps are anti-retroviral proteins that have arisen independently in New World and Old World primates. All TRIMCyps comprise a CypA domain fused to the tripartite domains of TRIM5alpha but they have distinct lentiviral specificities, conferring HIV-1 restriction in New World owl monkeys and HIV-2...
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Published in | PLoS pathogens Vol. 6; no. 8; p. e1001062 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Public Library of Science
01.08.2010
Public Library of Science (PLoS) |
Subjects | |
Online Access | Get full text |
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