Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity

• Published in: PLoS pathogens Vol. 6; no. 8; p. e1001062
• Main Authors: Ylinen, Laura M J, Price, Amanda J, Rasaiyaah, Jane, Hué, Stéphane, Rose, Nicola J, Marzetta, Flavia, James, Leo C, Towers, Greg J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.08.2010; Public Library of Science (PLoS)
• Subjects: Amino Acid Sequence; Animals; Crystallography, X-Ray; Cyclophilin A - genetics; Cyclophilin A - metabolism; Development and progression; Evolution, Molecular; Evolutionary Biology/Animal Genetics; Gene mutations; Genetic aspects; HIV Infections - genetics; Human immunodeficiency virus 1; Human immunodeficiency virus 2; Immunology/Innate Immunity; Infectious Diseases/HIV Infection and AIDS; Lentivirus; Lentivirus Infections - genetics; Macaca - genetics; Macaca - metabolism; Macaca fascicularis; Macaca mulatta; Macaques; Medical research; Molecular Sequence Data; Mutant Chimeric Proteins - genetics; Mutant Chimeric Proteins - metabolism; Mutation; Pan troglodytes; Phylogeny; Primates; Protein Structure, Quaternary; Proteins; Proteins - genetics; Proteins - metabolism; Retrovirus; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Ubiquitin-Protein Ligases; Viral infections; Virology/Animal Models of Infection; Virology/Host Antiviral Responses; Virology/Immunodeficiency Viruses; Virology/Virion Structure, Assembly, and Egress; Virology/Virulence Factors and Mechanisms

TRIMCyps are anti-retroviral proteins that have arisen independently in New World and Old World primates. All TRIMCyps comprise a CypA domain fused to the tripartite domains of TRIM5alpha but they have distinct lentiviral specificities, conferring HIV-1 restriction in New World owl monkeys and HIV-2...