Non-Steroidal Anti-Inflammatory Drug Use and Genomic DNA Methylation in Blood

Non-steroidal anti-inflammatory drug (NSAID) use is associated with decreased risk of some cancers. NSAID use modulates the epigenetic profile of normal colonic epithelium and may reduce risk of colon cancer through this pathway; however, the effect of NSAID use on the DNA methylation profile of oth...

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Published inPloS one Vol. 10; no. 9; p. e0138920
Main Authors Wilson, Lauren E, Kim, Sangmi, Xu, Zongli, Harlid, Sophia, Sandler, Dale P, Taylor, Jack A
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 22.09.2015
Public Library of Science (PLoS)
Subjects
Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Blood
Breast cancer
Cancer prevention
Colon
Colon cancer
CpG islands
CpG Islands - genetics
Deoxyribonucleic acid
DNA
DNA - blood
DNA - genetics
DNA Methylation
Epigenetic inheritance
Epigenetics
Epithelium
Genome, Human - genetics
Genomes
Genomics
Health aspects
Health risk assessment
Health risks
Humans
Inflammation
Linear Models
Methylation
Middle Aged
Nonsteroidal anti-inflammatory agents
Nonsteroidal anti-inflammatory drugs
Replication
Risk reduction
Statistical analysis
Time Factors
North Carolina
United States > US
Georgia
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Abstract Non-steroidal anti-inflammatory drug (NSAID) use is associated with decreased risk of some cancers. NSAID use modulates the epigenetic profile of normal colonic epithelium and may reduce risk of colon cancer through this pathway; however, the effect of NSAID use on the DNA methylation profile of other tissues including whole blood has not yet been examined. Using the Sister Study cohort, we examined the association between NSAID usage and whole genome methylation patterns in blood DNA. Blood DNA methylation status across 27,589 CpG sites was evaluated for 871 women using the Illumina Infinium HumanMethylation27 Beadchip, and in a non-overlapping replication sample of 187 women at 485,512 CpG sites using the Infinium HumanMethylation450 Beadchip. We identified a number of CpG sites that were differentially methylated in regular, long-term users of NSAIDs in the discovery group, but none of these sites were statistically significant in our replication group. We found no replicable methylation differences in blood related to NSAID usage. If NSAID use does effect blood DNA methylation patterns, differences are likely small.
AbstractList Non-steroidal anti-inflammatory drug (NSAID) use is associated with decreased risk of some cancers. NSAID use modulates the epigenetic profile of normal colonic epithelium and may reduce risk of colon cancer through this pathway; however, the effect of NSAID use on the DNA methylation profile of other tissues including whole blood has not yet been examined. Using the Sister Study cohort, we examined the association between NSAID usage and whole genome methylation patterns in blood DNA. Blood DNA methylation status across 27,589 CpG sites was evaluated for 871 women using the Illumina Infinium HumanMethylation27 Beadchip, and in a non-overlapping replication sample of 187 women at 485,512 CpG sites using the Infinium HumanMethylation450 Beadchip. We identified a number of CpG sites that were differentially methylated in regular, long-term users of NSAIDs in the discovery group, but none of these sites were statistically significant in our replication group. We found no replicable methylation differences in blood related to NSAID usage. If NSAID use does effect blood DNA methylation patterns, differences are likely small.
Background Non-steroidal anti-inflammatory drug (NSAID) use is associated with decreased risk of some cancers. NSAID use modulates the epigenetic profile of normal colonic epithelium and may reduce risk of colon cancer through this pathway; however, the effect of NSAID use on the DNA methylation profile of other tissues including whole blood has not yet been examined. Findings Using the Sister Study cohort, we examined the association between NSAID usage and whole genome methylation patterns in blood DNA. Blood DNA methylation status across 27,589 CpG sites was evaluated for 871 women using the Illumina Infinium HumanMethylation27 Beadchip, and in a non-overlapping replication sample of 187 women at 485,512 CpG sites using the Infinium HumanMethylation450 Beadchip. We identified a number of CpG sites that were differentially methylated in regular, long-term users of NSAIDs in the discovery group, but none of these sites were statistically significant in our replication group. Conclusions We found no replicable methylation differences in blood related to NSAID usage. If NSAID use does effect blood DNA methylation patterns, differences are likely small.
Non-steroidal anti-inflammatory drug (NSAID) use is associated with decreased risk of some cancers. NSAID use modulates the epigenetic profile of normal colonic epithelium and may reduce risk of colon cancer through this pathway; however, the effect of NSAID use on the DNA methylation profile of other tissues including whole blood has not yet been examined. Using the Sister Study cohort, we examined the association between NSAID usage and whole genome methylation patterns in blood DNA. Blood DNA methylation status across 27,589 CpG sites was evaluated for 871 women using the Illumina Infinium HumanMethylation27 Beadchip, and in a non-overlapping replication sample of 187 women at 485,512 CpG sites using the Infinium HumanMethylation450 Beadchip. We identified a number of CpG sites that were differentially methylated in regular, long-term users of NSAIDs in the discovery group, but none of these sites were statistically significant in our replication group. We found no replicable methylation differences in blood related to NSAID usage. If NSAID use does effect blood DNA methylation patterns, differences are likely small.
Background Non-steroidal anti-inflammatory drug (NSAID) use is associated with decreased risk of some cancers. NSAID use modulates the epigenetic profile of normal colonic epithelium and may reduce risk of colon cancer through this pathway; however, the effect of NSAID use on the DNA methylation profile of other tissues including whole blood has not yet been examined. Findings Using the Sister Study cohort, we examined the association between NSAID usage and whole genome methylation patterns in blood DNA. Blood DNA methylation status across 27,589 CpG sites was evaluated for 871 women using the Illumina Infinium HumanMethylation27 Beadchip, and in a non-overlapping replication sample of 187 women at 485,512 CpG sites using the Infinium HumanMethylation450 Beadchip. We identified a number of CpG sites that were differentially methylated in regular, long-term users of NSAIDs in the discovery group, but none of these sites were statistically significant in our replication group. Conclusions We found no replicable methylation differences in blood related to NSAID usage. If NSAID use does effect blood DNA methylation patterns, differences are likely small.
BACKGROUND: Non-steroidal anti-inflammatory drug (NSAID) use is associated with decreased risk of some cancers. NSAID use modulates the epigenetic profile of normal colonic epithelium and may reduce risk of colon cancer through this pathway; however, the effect of NSAID use on the DNA methylation profile of other tissues including whole blood has not yet been examined. FINDINGS: Using the Sister Study cohort, we examined the association between NSAID usage and whole genome methylation patterns in blood DNA. Blood DNA methylation status across 27,589 CpG sites was evaluated for 871 women using the Illumina Infinium HumanMethylation27 Beadchip, and in a non-overlapping replication sample of 187 women at 485,512 CpG sites using the Infinium HumanMethylation450 Beadchip. We identified a number of CpG sites that were differentially methylated in regular, long-term users of NSAIDs in the discovery group, but none of these sites were statistically significant in our replication group. CONCLUSIONS: We found no replicable methylation differences in blood related to NSAID usage. If NSAID use does effect blood DNA methylation patterns, differences are likely small.
Audience Academic
Author Xu, Zongli
Harlid, Sophia
Taylor, Jack A
Kim, Sangmi
Wilson, Lauren E
Sandler, Dale P
AuthorAffiliation 2 Section of Hematology/Oncology, Department of Medicine, Georgia Regents University Cancer Center; Medical College of Georgia, Augusta, Georgia, United States of America
Emory University, UNITED STATES
1 Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
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Notes Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: LEW SK SH DPS JAT. Performed the experiments: LEW ZX. Analyzed the data: LEW ZX. Contributed reagents/materials/analysis tools: SK SH DPS JAT. Wrote the paper: LEW SK ZX SH DPS JAT.
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Snippet Non-steroidal anti-inflammatory drug (NSAID) use is associated with decreased risk of some cancers. NSAID use modulates the epigenetic profile of normal...
Background Non-steroidal anti-inflammatory drug (NSAID) use is associated with decreased risk of some cancers. NSAID use modulates the epigenetic profile of...
BACKGROUND: Non-steroidal anti-inflammatory drug (NSAID) use is associated with decreased risk of some cancers. NSAID use modulates the epigenetic profile of...
Background Non-steroidal anti-inflammatory drug (NSAID) use is associated with decreased risk of some cancers. NSAID use modulates the epigenetic profile of...
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StartPage e0138920
SubjectTerms Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Blood
Breast cancer
Cancer prevention
Colon
Colon cancer
CpG islands
CpG Islands - genetics
Deoxyribonucleic acid
DNA
DNA - blood
DNA - genetics
DNA Methylation
Epigenetic inheritance
Epigenetics
Epithelium
Genome, Human - genetics
Genomes
Genomics
Health aspects
Health risk assessment
Health risks
Humans
Inflammation
Linear Models
Methylation
Middle Aged
Nonsteroidal anti-inflammatory agents
Nonsteroidal anti-inflammatory drugs
Replication
Risk reduction
Statistical analysis
Time Factors
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Title Non-Steroidal Anti-Inflammatory Drug Use and Genomic DNA Methylation in Blood
URI https://www.ncbi.nlm.nih.gov/pubmed/26393518
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https://pubmed.ncbi.nlm.nih.gov/PMC4578936
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http://dx.doi.org/10.1371/journal.pone.0138920
Volume 10
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