Degenerative Changes in the Cervical Spine Are More Common in Middle-Aged Individuals with Thalidomide Embryopathy than in Healthy Controls

• Published in: PloS one Vol. 11; no. 5; p. e0155493
• Main Authors: Ghassemi Jahani, Shadi A., Danielsson, Aina, Ab-Fawaz, Rana, Hebelka, Hanna, Danielson, Barbro, Brisby, Helena
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.05.2016; Public Library of Science (PLoS)
• Subjects: ABNORMALITIES; Adult; ASYMPTOMATIC SUBJECTS; Biocompatibility; Biology and Life Sciences; Biomedical materials; Case-Control Studies; Cervical Vertebrae - pathology; Children; Complications and side effects; Compression; Compression tests; Constriction, Pathologic; Control methods; Degeneration; Demography; Development and progression; Diagnosis; Dosage and administration; Female; Fetal diseases; Fetal Diseases - pathology; Gender; Hand - pathology; Humans; INTERVERTEBRAL DISC; Intervertebral Disc Degeneration - complications; Intervertebral Disc Degeneration - pathology; Intervertebral discs; Leg - pathology; Limb malformations; Magnetic Resonance Imaging; Male; MALFORMATIONS; Medicine and Health Sciences; Middle age; Middle Aged; Neck pain; Observer Variation; Orthopaedics; Ortopedi; Osteophyte - complications; Osteophyte - pathology; Osteophytes; Pathology; Patients; Pregnancy; Research and Analysis Methods; Risk factors; Scoliosis; Spine; Spine (cervical); Studies; Thalidomide; Thalidomide - adverse effects; Sweden

Thalidomide was used as a sedative drug for pregnant women in the 1950-60:s and resulted in children born with thalidomide embryopathy (TE), including upper limb malformations. These may alter the motion pattern of the cervical spine by the use of head/shoulder and mouth grip. To compare degenerativ...