Improved Anti-Tumor Effect of Liposomal Doxorubicin After Targeted Blood-Brain Barrier Disruption by MRI-Guided Focused Ultrasound in Rat Glioma - Treat, Lisa H.; McDannold, Nathan; Zhang, Yongzhi; Vykhodtseva, Natalia; Hynynen, Kullervo (Ultrasound in medicine & biology, 2012)
Keywords: 9L gliosarcoma; Animals; Antineoplastic Agents - administration & dosage; Biological and medical sciences; Blood-brain barrier; Blood-Brain Barrier - radiation effects; brain; Brain Neoplasms - diagnosis; Brain Neoplasms - drug therapy; Brain Neoplasms - physiopathology; Cell Line, Tumor; Doxorubicin; Doxorubicin - administration & dosage; drug therapy; Focused ultrasound; Gliosarcoma - diagnosis; Gliosarcoma - drug therapy; Gliosarcoma - physiopathology; Investigative techniques, diagnostic techniques (general aspects); Liposomes - administration & dosage; Liposomes - chemistry; magnetic resonance imaging; Magnetic Resonance Imaging, Interventional - methods; Male; Medical sciences; microbubbles; Microbubbles - therapeutic use; Neurology; Radiology; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Rats; Rats, Sprague-Dawley; Sonication - methods; Survival; Treatment Outcome; Tumors of the nervous system. Phacomatoses; ultrasonics; Focused ultrasound; 9L gliosarcoma; Blood-brain barrier; Doxorubicin; Survival; Antineoplastic agent; Nuclear medicine; Rat; Central nervous system; Blood brain barrier; Encephalon; Isomerases; Gliosarcoma; Biomedical engineering; Sonography; DNA topoisomerase (ATP-hydrolysing); Nervous system diseases; Sarcoma; Enzyme; Interventional ultrasonography; Rodentia; Ultrasonic treatment; Enzyme inhibitor; Liposome; Instrumentation therapy; Topoisomerase II inhibitor; Malignant tumor; Nuclear magnetic resonance imaging; Guidance; Vertebrata; Antibiotic; Mammalia; Glioma; Animal; Central nervous system disease; Radiology; Medical imagery; Anthracyclins; Cancer