Selective MicroRNA-Offset RNA Expression in Human Embryonic Stem Cells

• Published in: PloS one Vol. 10; no. 3; p. e0116668
• Main Authors: Asikainen, Suvi, Heikkinen, Liisa, Juhila, Juuso, Holm, Frida, Weltner, Jere, Trokovic, Ras, Mikkola, Milla, Toivonen, Sanna, Balboa, Diego, Lampela, Riina, Icay, Katherine, Tuuri, Timo, Otonkoski, Timo, Wong, Garry, Hovatta, Outi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 30.03.2015; Public Library of Science (PLoS)
• Subjects: Analysis; Base Sequence; Binding Sites; Cancer; Cell cycle; Cell Line; Cell proliferation; Coding; Computational Biology; Embryo cells; Embryogenesis; Embryonic stem cells; Embryos; Fibroblasts; Gene Expression; Gene Expression Profiling; Gene Library; Genomes; High-Throughput Nucleotide Sequencing; Human Embryonic Stem Cells - metabolism; Humans; Isoforms; Loci; MicroRNA; MicroRNAs; MicroRNAs - chemistry; MicroRNAs - genetics; miRNA; Molecular chains; Molecular Sequence Annotation; Molecular Sequence Data; Neurology; Non-coding RNA; Pluripotency; Ribonucleic acid; RNA; RNA, Small Untranslated - chemistry; RNA, Small Untranslated - genetics; Science; Sequence Alignment; Stem cell transplantation; Stem cells; Sweden; Macao; Finland

Small RNA molecules, including microRNAs (miRNAs), play critical roles in regulating pluripotency, proliferation and differentiation of embryonic stem cells. miRNA-offset RNAs (moRNAs) are similar in length to miRNAs, align to miRNA precursor (pre-miRNA) loci and are therefore believed to derive fro...