Intestinal Microbiota as Modulators of the Immune System and Neuroimmune System: Impact on the Host Health and Homeostasis

Many immune-based intestinal disorders, such as ulcerative colitis and Crohn’s disease, as well as other illnesses, may have the intestines as an initial cause or aggravator in the development of diseases, even apparently not correlating directly to the intestine. Diabetes, obesity, multiple scleros...

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Published inJournal of Immunology Research Vol. 2015; no. 2015; pp. 1 - 14
Main Authors Carmo, Antônio Márcio Resende do, Macedo, Gilson Costa, Silva, Fernando de Sá, Maranduba, Claudinéia Pereira, Rettore, João Vitor Paes, Valente, Maria Anete Santana, da Guia, Francisco Carlos, Rossato, Cristiano, Souza, Gustavo Torres de, De Castro, Sandra Bertelli Ribeiro, Maranduba, Carlos Magno da Costa, Souza, Camila Maurmann de
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2015
John Wiley & Sons, Inc
Wiley
Subjects
Animals
Autoimmune Diseases - etiology
Autoimmune Diseases - metabolism
Bacteria
Biology
Dentistry
Disease Models, Animal
Gastrointestinal Microbiome - immunology
Gastrointestinal Tract - immunology
Gastrointestinal Tract - microbiology
Genetic aspects
Homeostasis
Homeostasis - physiology
Humans
Immune System
Immunology
Metabolic disorders
Microbiota (Symbiotic organisms)
Multiple sclerosis
Nervous System
Neuroimmunomodulation
Nutrition research
Physiological aspects
Physiology
Review
Signal Transduction
Studies
Brazil
Online AccessGet full text
ISSN2314-8861
2314-7156
2314-7156
DOI10.1155/2015/931574

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Abstract Many immune-based intestinal disorders, such as ulcerative colitis and Crohn’s disease, as well as other illnesses, may have the intestines as an initial cause or aggravator in the development of diseases, even apparently not correlating directly to the intestine. Diabetes, obesity, multiple sclerosis, depression, and anxiety are examples of other illnesses discussed in the literature. In parallel, importance of the gut microbiota in intestinal homeostasis and immunologic conflict between tolerance towards commensal microorganisms and combat of pathogens is well known. Recent researches show that the immune system, when altered by the gut microbiota, influences the state in which these diseases are presented in the patient directly and indirectly. At the present moment, a considerable number of investigations about this subject have been performed and published. However, due to difficulties on correlating information, several speculations and hypotheses are generated. Thus, the present review aims at bringing together how these interactions work—gut microbiota, immune system, and their influence in the neuroimmune system.
AbstractList Many immune-based intestinal disorders, such as ulcerative colitis and Crohn's disease, as well as other illnesses, may have the intestines as an initial cause or aggravator in the development of diseases, even apparently not correlating directly to the intestine. Diabetes, obesity, multiple sclerosis, depression, and anxiety are examples of other illnesses discussed in the literature. In parallel, importance of the gut microbiota in intestinal homeostasis and immunologic conflict between tolerance towards commensal microorganisms and combat of pathogens is well known. Recent researches show that the immune system, when altered by the gut microbiota, influences the state in which these diseases are presented in the patient directly and indirectly. At the present moment, a considerable number of investigations about this subject have been performed and published. However, due to difficulties on correlating information, several speculations and hypotheses are generated. Thus, the present review aims at bringing together how these interactions work-gut microbiota, immune system, and their influence in the neuroimmune system.
Many immune-based intestinal disorders, such as ulcerative colitis and Crohn's disease, as well as other illnesses, may have the intestines as an initial cause or aggravator in the development of diseases, even apparently not correlating directly to the intestine. Diabetes, obesity, multiple sclerosis, depression, and anxiety are examples of other illnesses discussed in the literature. In parallel, importance of the gut microbiota in intestinal homeostasis and immunologic conflict between tolerance towards commensal microorganisms and combat of pathogens is well known. Recent researches show that the immune system, when altered by the gut microbiota, influences the state in which these diseases are presented in the patient directly and indirectly. At the present moment, a considerable number of investigations about this subject have been performed and published. However, due to difficulties on correlating information, several speculations and hypotheses are generated. Thus, the present review aims at bringing together how these interactions work-gut microbiota, immune system, and their influence in the neuroimmune system.Many immune-based intestinal disorders, such as ulcerative colitis and Crohn's disease, as well as other illnesses, may have the intestines as an initial cause or aggravator in the development of diseases, even apparently not correlating directly to the intestine. Diabetes, obesity, multiple sclerosis, depression, and anxiety are examples of other illnesses discussed in the literature. In parallel, importance of the gut microbiota in intestinal homeostasis and immunologic conflict between tolerance towards commensal microorganisms and combat of pathogens is well known. Recent researches show that the immune system, when altered by the gut microbiota, influences the state in which these diseases are presented in the patient directly and indirectly. At the present moment, a considerable number of investigations about this subject have been performed and published. However, due to difficulties on correlating information, several speculations and hypotheses are generated. Thus, the present review aims at bringing together how these interactions work-gut microbiota, immune system, and their influence in the neuroimmune system.
Audience Academic
Author Maranduba, Carlos Magno da Costa
Macedo, Gilson Costa
Rossato, Cristiano
Souza, Gustavo Torres de
Carmo, Antônio Márcio Resende do
Valente, Maria Anete Santana
De Castro, Sandra Bertelli Ribeiro
Rettore, João Vitor Paes
Souza, Camila Maurmann de
Maranduba, Claudinéia Pereira
da Guia, Francisco Carlos
Silva, Fernando de Sá
AuthorAffiliation 5 Department of Clinical Dentistry, Federal University of Juiz de Fora, Juiz de Fora, Brazil
1 Department of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil
3 Department of Immunology, University of São Paulo, São Paulo, Brazil
2 Department of Pharmacy, Federal University of Juiz de Fora, Governador Valadares, Brazil
6 Department of Parasitology, Microbiology and Immunology, Federal University of Juiz de Fora, Juiz de Fora, Brazil
7 Department of Dentistry, Federal University of Juiz de Fora, Governador Valadares, Brazil
4 Department of Nutrition, Federal University of Juiz de Fora, Governador Valadares, Brazil
AuthorAffiliation_xml – name: 3 Department of Immunology, University of São Paulo, São Paulo, Brazil
– name: 4 Department of Nutrition, Federal University of Juiz de Fora, Governador Valadares, Brazil
– name: 1 Department of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil
– name: 7 Department of Dentistry, Federal University of Juiz de Fora, Governador Valadares, Brazil
– name: 2 Department of Pharmacy, Federal University of Juiz de Fora, Governador Valadares, Brazil
– name: 5 Department of Clinical Dentistry, Federal University of Juiz de Fora, Juiz de Fora, Brazil
– name: 6 Department of Parasitology, Microbiology and Immunology, Federal University of Juiz de Fora, Juiz de Fora, Brazil
Author_xml – sequence: 1
  fullname: Carmo, Antônio Márcio Resende do
– sequence: 2
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– sequence: 3
  fullname: Silva, Fernando de Sá
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  fullname: Maranduba, Claudinéia Pereira
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  fullname: Rettore, João Vitor Paes
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  fullname: Valente, Maria Anete Santana
– sequence: 7
  fullname: da Guia, Francisco Carlos
– sequence: 8
  fullname: Rossato, Cristiano
– sequence: 9
  fullname: Souza, Gustavo Torres de
– sequence: 10
  fullname: De Castro, Sandra Bertelli Ribeiro
– sequence: 11
  fullname: Maranduba, Carlos Magno da Costa
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  fullname: Souza, Camila Maurmann de
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25759850$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright Copyright © 2015 Carlos Magno da Costa Maranduba et al.
COPYRIGHT 2015 John Wiley & Sons, Inc.
Copyright © 2015 Carlos Magno da Costa Maranduba et al. Carlos Magno da Costa Maranduba et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © 2015 Carlos Magno da Costa Maranduba et al. 2015
Copyright_xml – notice: Copyright © 2015 Carlos Magno da Costa Maranduba et al.
– notice: COPYRIGHT 2015 John Wiley & Sons, Inc.
– notice: Copyright © 2015 Carlos Magno da Costa Maranduba et al. Carlos Magno da Costa Maranduba et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
– notice: Copyright © 2015 Carlos Magno da Costa Maranduba et al. 2015
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Issue 2015
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Snippet Many immune-based intestinal disorders, such as ulcerative colitis and Crohn’s disease, as well as other illnesses, may have the intestines as an initial cause...
Many immune-based intestinal disorders, such as ulcerative colitis and Crohn's disease, as well as other illnesses, may have the intestines as an initial cause...
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StartPage 1
SubjectTerms Animals
Autoimmune Diseases - etiology
Autoimmune Diseases - metabolism
Bacteria
Biology
Dentistry
Disease Models, Animal
Gastrointestinal Microbiome - immunology
Gastrointestinal Tract - immunology
Gastrointestinal Tract - microbiology
Genetic aspects
Homeostasis
Homeostasis - physiology
Humans
Immune System
Immunology
Metabolic disorders
Microbiota (Symbiotic organisms)
Multiple sclerosis
Nervous System
Neuroimmunomodulation
Nutrition research
Physiological aspects
Physiology
Review
Signal Transduction
Studies
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Title Intestinal Microbiota as Modulators of the Immune System and Neuroimmune System: Impact on the Host Health and Homeostasis
URI https://search.emarefa.net/detail/BIM-1068644
https://dx.doi.org/10.1155/2015/931574
https://www.ncbi.nlm.nih.gov/pubmed/25759850
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https://www.proquest.com/docview/1676338295
https://www.proquest.com/docview/1676359325
https://pubmed.ncbi.nlm.nih.gov/PMC4352473
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Volume 2015
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