Ceruloplasmin Is a Novel Adipokine Which Is Overexpressed in Adipose Tissue of Obese Subjects and in Obesity-Associated Cancer Cells

• Published in: PloS one Vol. 9; no. 3; p. e80274
• Main Authors: Arner, Erik, Forrest, Alistair R. R., Ehrlund, Anna, Mejhert, Niklas, Itoh, Masayoshi, Kawaji, Hideya, Lassmann, Timo, Laurencikiene, Jurga, Rydén, Mikael, Arner, Peter
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 27.03.2014; Public Library of Science (PLoS)
• Subjects: Adipocytes; Adipocytes - metabolism; Adipokines - genetics; Adipokines - metabolism; Adipose tissue; Adipose Tissue - metabolism; Adult; Analysis; Angiogenesis; Biology and Life Sciences; Body fat; Body mass index; Cancer; Cancer cells; Case-Control Studies; Cell Line, Tumor; Ceruloplasmin; Ceruloplasmin - genetics; Ceruloplasmin - metabolism; Committees; Computational Biology - methods; Computer and Information Sciences; Consortia; Copper; Databases, Genetic; Development and progression; Diabetes; Ethics; Female; Gastrointestinal surgery; Gene Expression; Gene Expression Profiling; Genes; Genetic Loci; Genomics - methods; Health aspects; Health care; Health risks; Humans; Kidney cancer; Life sciences; Male; Medicine and Health Sciences; Middle Aged; Neoplasms - etiology; Obesity; Obesity - complications; Obesity - genetics; Preventive medicine; Proteins; Secretion; Sweden; Tissues; Tumor cell lines; Tumor cells; Tumors; Type 2 diabetes; Sweden; Japan

Obesity confers an increased risk of developing specific cancer forms. Although the mechanisms are unclear, increased fat cell secretion of specific proteins (adipokines) may promote/facilitate development of malignant tumors in obesity via cross-talk between adipose tissue(s) and the tissues prone...