Reduced cerebrospinal fluid concentration of interleukin-12/23 subunit p40 in patients with cognitive impairment

• Published in: PloS one Vol. 12; no. 5; p. e0176760
• Main Authors: Johansson, Per, Almqvist, Erik G., Wallin, Anders, Johansson, Jan-Ove, Andreasson, Ulf, Blennow, Kaj, Zetterberg, Henrik, Svensson, Johan
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 02.05.2017; Public Library of Science (PLoS)
• Subjects: Abuse; Activation; Activation analysis; Advertisements; Aged; Aged, 80 and over; Aging; Aging (artificial); Alcohols; Alzheimer Disease - blood; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - immunology; Alzheimer Inflammation Cognitive impairment Cerebrospinal fluid Interleukin Cytokine Chemokin Steroid homone; Alzheimer's disease; Amyloid beta-Peptides - cerebrospinal fluid; Analysis; Animal models; Annan klinisk medicin; Annan medicin och hälsovetenskap; Anti-inflammatory agents; Arches; Astrocytes; Attitude control; Autocrine signalling; Biology and Life Sciences; Biomarkers; Biomarkers - blood; Biomarkers - cerebrospinal fluid; Blood; Blood circulation; Body mass; Body Mass Index; Brain; Cerebrospinal fluid; Chemokines; Cholinesterase; Cholinesterase inhibitors; Clinical Medicine; Cognitive ability; Cognitive disorders; Cognitive Dysfunction - blood; Cognitive Dysfunction - cerebrospinal fluid; Cognitive Dysfunction - immunology; Cohort Studies; Cytokines; Dementia; Dementia disorders; Diabetes mellitus; Drug abuse; Drugs; Dura mater; Endocrinology; Evaluation; Family physicians; Female; Glucocorticoids; Growth factors; Health aspects; Hip; Hospitals; Humans; Immune system; Inactivation; Inflammation; Inhibitors; Interferon; Interleukin 1; Interleukin 6; Interleukin-12 Subunit p40 - blood; Interleukin-12 Subunit p40 - cerebrospinal fluid; Klinisk medicin; Male; Markers; Mathematical models; Medicine; Medicine and Health Sciences; Mental disorders; Mental Status Schedule; Mice; Microglia; Migration; Multiplexing; Myocardial infarction; Necrosis; Nervous system; Neurochemistry; Neurodegenerative diseases; Neurologi; Neurology; Neurons; Neurosciences; Nonsteroidal anti-inflammatory drugs; Other Clinical Medicine; Other Medical and Health Sciences; Pathogenesis; Peptide Fragments - cerebrospinal fluid; Phosphorylation; Physiology; Proteins; Psychiatry; Psykiatri; Risk; Sweden; tau Proteins - cerebrospinal fluid; Tumor necrosis factor-TNF; White People; Womens health; β-Amyloid; Sweden

The role of inflammation in Alzheimer's disease (AD) and other cognitive disorders is unclear. In a well-defined mono-center population, we measured cytokines and chemokines in paired serum and cerebrospinal fluid (CSF) samples. Consecutive patients with AD (n = 30), stable mild cognitive impai...