Reduced cerebrospinal fluid concentration of interleukin-12/23 subunit p40 in patients with cognitive impairment
The role of inflammation in Alzheimer's disease (AD) and other cognitive disorders is unclear. In a well-defined mono-center population, we measured cytokines and chemokines in paired serum and cerebrospinal fluid (CSF) samples. Consecutive patients with AD (n = 30), stable mild cognitive impai...
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| Published in | PloS one Vol. 12; no. 5; p. e0176760 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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Public Library of Science
02.05.2017
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| Abstract | The role of inflammation in Alzheimer's disease (AD) and other cognitive disorders is unclear. In a well-defined mono-center population, we measured cytokines and chemokines in paired serum and cerebrospinal fluid (CSF) samples.
Consecutive patients with AD (n = 30), stable mild cognitive impairment (SMCI, n = 11), other dementias (n = 11), and healthy controls (n = 18) were included. None of the subjects was treated with glucocorticoids, cholinesterase inhibitors, or non-steroidal anti-inflammatory drugs. Serum and CSF concentrations of interleukin-6 (IL-6), IL-8, IL-12/23 p40, IL-15, IL-16, vascular endothelial growth factor-A (VEGF-A), and three chemokines were measured using a multiplex panel.
After correction for multiple comparisons, only CSF IL-12/23 p40 concentration differed significantly between the total patient group (n = 52) and controls (n = 18; p = 0.002). Further analyses showed that CSF IL-12/23 p40 concentration was decreased in all patient subgroups (AD, other dementias, and SMCI) compared to healthy controls (p < 0.01, p < 0.05, and p < 0.05, respectively). In the total study population (n = 70), CSF IL-12/23 p40 concentrations correlated positively with CSF concentrations of β-amyloid1-42 (Aβ1-42) and phosphorylated tau protein (P-tau) whereas in AD patients (n = 30), CSF IL-12/23 p40 only correlated positively with CSF P-Tau (r = 0.46, p = 0.01).
Most cytokines and chemokines were similar in patients and controls, but CSF IL-12/23 subunit p40 concentration was decreased in patients with cognitive impairment, and correlated with markers of AD disease status. Further studies are needed to evaluate the role of CSF IL-12/23 p40 in other dementias and SMCI. |
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| AbstractList | The role of inflammation in Alzheimer's disease (AD) and other cognitive disorders is unclear. In a well-defined mono-center population, we measured cytokines and chemokines in paired serum and cerebrospinal fluid (CSF) samples.BACKGROUNDThe role of inflammation in Alzheimer's disease (AD) and other cognitive disorders is unclear. In a well-defined mono-center population, we measured cytokines and chemokines in paired serum and cerebrospinal fluid (CSF) samples.Consecutive patients with AD (n = 30), stable mild cognitive impairment (SMCI, n = 11), other dementias (n = 11), and healthy controls (n = 18) were included. None of the subjects was treated with glucocorticoids, cholinesterase inhibitors, or non-steroidal anti-inflammatory drugs. Serum and CSF concentrations of interleukin-6 (IL-6), IL-8, IL-12/23 p40, IL-15, IL-16, vascular endothelial growth factor-A (VEGF-A), and three chemokines were measured using a multiplex panel.METHODSConsecutive patients with AD (n = 30), stable mild cognitive impairment (SMCI, n = 11), other dementias (n = 11), and healthy controls (n = 18) were included. None of the subjects was treated with glucocorticoids, cholinesterase inhibitors, or non-steroidal anti-inflammatory drugs. Serum and CSF concentrations of interleukin-6 (IL-6), IL-8, IL-12/23 p40, IL-15, IL-16, vascular endothelial growth factor-A (VEGF-A), and three chemokines were measured using a multiplex panel.After correction for multiple comparisons, only CSF IL-12/23 p40 concentration differed significantly between the total patient group (n = 52) and controls (n = 18; p = 0.002). Further analyses showed that CSF IL-12/23 p40 concentration was decreased in all patient subgroups (AD, other dementias, and SMCI) compared to healthy controls (p < 0.01, p < 0.05, and p < 0.05, respectively). In the total study population (n = 70), CSF IL-12/23 p40 concentrations correlated positively with CSF concentrations of β-amyloid1-42 (Aβ1-42) and phosphorylated tau protein (P-tau) whereas in AD patients (n = 30), CSF IL-12/23 p40 only correlated positively with CSF P-Tau (r = 0.46, p = 0.01).RESULTSAfter correction for multiple comparisons, only CSF IL-12/23 p40 concentration differed significantly between the total patient group (n = 52) and controls (n = 18; p = 0.002). Further analyses showed that CSF IL-12/23 p40 concentration was decreased in all patient subgroups (AD, other dementias, and SMCI) compared to healthy controls (p < 0.01, p < 0.05, and p < 0.05, respectively). In the total study population (n = 70), CSF IL-12/23 p40 concentrations correlated positively with CSF concentrations of β-amyloid1-42 (Aβ1-42) and phosphorylated tau protein (P-tau) whereas in AD patients (n = 30), CSF IL-12/23 p40 only correlated positively with CSF P-Tau (r = 0.46, p = 0.01).Most cytokines and chemokines were similar in patients and controls, but CSF IL-12/23 subunit p40 concentration was decreased in patients with cognitive impairment, and correlated with markers of AD disease status. Further studies are needed to evaluate the role of CSF IL-12/23 p40 in other dementias and SMCI.CONCLUSIONSMost cytokines and chemokines were similar in patients and controls, but CSF IL-12/23 subunit p40 concentration was decreased in patients with cognitive impairment, and correlated with markers of AD disease status. Further studies are needed to evaluate the role of CSF IL-12/23 p40 in other dementias and SMCI. The role of inflammation in Alzheimer's disease (AD) and other cognitive disorders is unclear. In a well-defined mono-center population, we measured cytokines and chemokines in paired serum and cerebrospinal fluid (CSF) samples. Consecutive patients with AD (n = 30), stable mild cognitive impairment (SMCI, n = 11), other dementias (n = 11), and healthy controls (n = 18) were included. None of the subjects was treated with glucocorticoids, cholinesterase inhibitors, or non-steroidal anti-inflammatory drugs. Serum and CSF concentrations of interleukin-6 (IL-6), IL-8, IL-12/23 p40, IL-15, IL-16, vascular endothelial growth factor-A (VEGF-A), and three chemokines were measured using a multiplex panel. After correction for multiple comparisons, only CSF IL-12/23 p40 concentration differed significantly between the total patient group (n = 52) and controls (n = 18; p = 0.002). Further analyses showed that CSF IL-12/23 p40 concentration was decreased in all patient subgroups (AD, other dementias, and SMCI) compared to healthy controls (p < 0.01, p < 0.05, and p < 0.05, respectively). In the total study population (n = 70), CSF IL-12/23 p40 concentrations correlated positively with CSF concentrations of [beta]-amyloid.sub.1-42 (A[beta].sub.1-42) and phosphorylated tau protein (P-tau) whereas in AD patients (n = 30), CSF IL-12/23 p40 only correlated positively with CSF P-Tau (r = 0.46, p = 0.01). Most cytokines and chemokines were similar in patients and controls, but CSF IL-12/23 subunit p40 concentration was decreased in patients with cognitive impairment, and correlated with markers of AD disease status. Further studies are needed to evaluate the role of CSF IL-12/23 p40 in other dementias and SMCI. Background The role of inflammation in Alzheimer’s disease (AD) and other cognitive disorders is unclear. In a well-defined mono-center population, we measured cytokines and chemokines in paired serum and cerebrospinal fluid (CSF) samples. Methods Consecutive patients with AD (n = 30), stable mild cognitive impairment (SMCI, n = 11), other dementias (n = 11), and healthy controls (n = 18) were included. None of the subjects was treated with glucocorticoids, cholinesterase inhibitors, or non-steroidal anti-inflammatory drugs. Serum and CSF concentrations of interleukin-6 (IL-6), IL-8, IL-12/23 p40, IL-15, IL-16, vascular endothelial growth factor-A (VEGF-A), and three chemokines were measured using a multiplex panel. Results After correction for multiple comparisons, only CSF IL-12/23 p40 concentration differed significantly between the total patient group (n = 52) and controls (n = 18; p = 0.002). Further analyses showed that CSF IL-12/23 p40 concentration was decreased in all patient subgroups (AD, other dementias, and SMCI) compared to healthy controls (p < 0.01, p < 0.05, and p < 0.05, respectively). In the total study population (n = 70), CSF IL-12/23 p40 concentrations correlated positively with CSF concentrations of β-amyloid 1-42 (Aβ 1–42 ) and phosphorylated tau protein (P-tau) whereas in AD patients (n = 30), CSF IL-12/23 p40 only correlated positively with CSF P-Tau (r = 0.46, p = 0.01). Conclusions Most cytokines and chemokines were similar in patients and controls, but CSF IL-12/23 subunit p40 concentration was decreased in patients with cognitive impairment, and correlated with markers of AD disease status. Further studies are needed to evaluate the role of CSF IL-12/23 p40 in other dementias and SMCI. Background The role of inflammation in Alzheimer's disease (AD) and other cognitive disorders is unclear. In a well-defined mono-center population, we measured cytokines and chemokines in paired serum and cerebrospinal fluid (CSF) samples. Methods Consecutive patients with AD (n = 30), stable mild cognitive impairment (SMCI, n = 11), other dementias (n = 11), and healthy controls (n = 18) were included. None of the subjects was treated with glucocorticoids, cholinesterase inhibitors, or non-steroidal anti-inflammatory drugs. Serum and CSF concentrations of interleukin-6 (IL-6), IL-8, IL-12/23 p40, IL-15, IL-16, vascular endothelial growth factor-A (VEGF-A), and three chemokines were measured using a multiplex panel. Results After correction for multiple comparisons, only CSF IL-12/23 p40 concentration differed significantly between the total patient group (n = 52) and controls (n = 18; p = 0.002). Further analyses showed that CSF IL-12/23 p40 concentration was decreased in all patient subgroups (AD, other dementias, and SMCI) compared to healthy controls (p < 0.01, p < 0.05, and p < 0.05, respectively). In the total study population (n = 70), CSF IL-12/23 p40 concentrations correlated positively with CSF concentrations of [beta]-amyloid.sub.1-42 (A[beta].sub.1-42) and phosphorylated tau protein (P-tau) whereas in AD patients (n = 30), CSF IL-12/23 p40 only correlated positively with CSF P-Tau (r = 0.46, p = 0.01). Conclusions Most cytokines and chemokines were similar in patients and controls, but CSF IL-12/23 subunit p40 concentration was decreased in patients with cognitive impairment, and correlated with markers of AD disease status. Further studies are needed to evaluate the role of CSF IL-12/23 p40 in other dementias and SMCI. BackgroundThe role of inflammation in Alzheimer's disease (AD) and other cognitive disorders is unclear. In a well-defined mono-center population, we measured cytokines and chemokines in paired serum and cerebrospinal fluid (CSF) samples.MethodsConsecutive patients with AD (n = 30), stable mild cognitive impairment (SMCI, n = 11), other dementias (n = 11), and healthy controls (n = 18) were included. None of the subjects was treated with glucocorticoids, cholinesterase inhibitors, or non-steroidal anti-inflammatory drugs. Serum and CSF concentrations of interleukin-6 (IL-6), IL-8, IL-12/23 p40, IL-15, IL-16, vascular endothelial growth factor-A (VEGF-A), and three chemokines were measured using a multiplex panel.ResultsAfter correction for multiple comparisons, only CSF IL-12/23 p40 concentration differed significantly between the total patient group (n = 52) and controls (n = 18; p = 0.002). Further analyses showed that CSF IL-12/23 p40 concentration was decreased in all patient subgroups (AD, other dementias, and SMCI) compared to healthy controls (p < 0.01, p < 0.05, and p < 0.05, respectively). In the total study population (n = 70), CSF IL-12/23 p40 concentrations correlated positively with CSF concentrations of β-amyloid1-42 (Aβ1-42) and phosphorylated tau protein (P-tau) whereas in AD patients (n = 30), CSF IL-12/23 p40 only correlated positively with CSF P-Tau (r = 0.46, p = 0.01).ConclusionsMost cytokines and chemokines were similar in patients and controls, but CSF IL-12/23 subunit p40 concentration was decreased in patients with cognitive impairment, and correlated with markers of AD disease status. Further studies are needed to evaluate the role of CSF IL-12/23 p40 in other dementias and SMCI. Background The role of inflammation in Alzheimer’s disease (AD) and other cognitive disorders is unclear. In a well-defined mono-center population, we measured cytokines and chemokines in paired serum and cerebrospinal fluid (CSF) samples. Methods Consecutive patients with AD (n = 30), stable mild cognitive impairment (SMCI, n = 11), other dementias (n = 11), and healthy controls (n = 18) were included. None of the subjects was treated with glucocorticoids, cholinesterase inhibitors, or non-steroidal anti-inflammatory drugs. Serum and CSF concentrations of interleukin-6 (IL-6), IL-8, IL-12/23 p40, IL-15, IL-16, vascular endothelial growth factor-A (VEGF-A), and three chemokines were measured using a multiplex panel. Results After correction for multiple comparisons, only CSF IL-12/23 p40 concentration differed significantly between the total patient group (n = 52) and controls (n = 18; p = 0.002). Further analyses showed that CSF IL-12/23 p40 concentration was decreased in all patient subgroups (AD, other dementias, and SMCI) compared to healthy controls (p < 0.01, p < 0.05, and p < 0.05, respectively). In the total study population (n = 70), CSF IL-12/23 p40 concentrations correlated positively with CSF concentrations of β-amyloid1-42 (Aβ1–42) and phosphorylated tau protein (P-tau) whereas in AD patients (n = 30), CSF IL-12/23 p40 only correlated positively with CSF P-Tau (r = 0.46, p = 0.01). Conclusions Most cytokines and chemokines were similar in patients and controls, but CSF IL-12/23 subunit p40 concentration was decreased in patients with cognitive impairment, and correlated with markers of AD disease status. Further studies are needed to evaluate the role of CSF IL-12/23 p40 in other dementias and SMCI. The role of inflammation in Alzheimer's disease (AD) and other cognitive disorders is unclear. In a well-defined mono-center population, we measured cytokines and chemokines in paired serum and cerebrospinal fluid (CSF) samples. Consecutive patients with AD (n = 30), stable mild cognitive impairment (SMCI, n = 11), other dementias (n = 11), and healthy controls (n = 18) were included. None of the subjects was treated with glucocorticoids, cholinesterase inhibitors, or non-steroidal anti-inflammatory drugs. Serum and CSF concentrations of interleukin-6 (IL-6), IL-8, IL-12/23 p40, IL-15, IL-16, vascular endothelial growth factor-A (VEGF-A), and three chemokines were measured using a multiplex panel. After correction for multiple comparisons, only CSF IL-12/23 p40 concentration differed significantly between the total patient group (n = 52) and controls (n = 18; p = 0.002). Further analyses showed that CSF IL-12/23 p40 concentration was decreased in all patient subgroups (AD, other dementias, and SMCI) compared to healthy controls (p < 0.01, p < 0.05, and p < 0.05, respectively). In the total study population (n = 70), CSF IL-12/23 p40 concentrations correlated positively with CSF concentrations of β-amyloid1-42 (Aβ1-42) and phosphorylated tau protein (P-tau) whereas in AD patients (n = 30), CSF IL-12/23 p40 only correlated positively with CSF P-Tau (r = 0.46, p = 0.01). Most cytokines and chemokines were similar in patients and controls, but CSF IL-12/23 subunit p40 concentration was decreased in patients with cognitive impairment, and correlated with markers of AD disease status. Further studies are needed to evaluate the role of CSF IL-12/23 p40 in other dementias and SMCI. The role of inflammation in Alzheimer's disease (AD) and other cognitive disorders is unclear. In a well-defined mono-center population, we measured cytokines and chemokines in paired serum and cerebrospinal fluid (CSF) samples.Consecutive patients with AD (n = 30), stable mild cognitive impairment (SMCI, n = 11), other dementias (n = 11), and healthy controls (n = 18) were included. None of the subjects was treated with glucocorticoids, cholinesterase inhibitors, or non-steroidal anti-inflammatory drugs. Serum and CSF concentrations of interleukin-6 (IL-6), IL-8, IL-12/23 p40, IL-15, IL-16, vascular endothelial growth factor-A (VEGF-A), and three chemokines were measured using a multiplex panel.After correction for multiple comparisons, only CSF IL-12/23 p40 concentration differed significantly between the total patient group (n = 52) and controls (n = 18; p = 0.002). Further analyses showed that CSF IL-12/23 p40 concentration was decreased in all patient subgroups (AD, other dementias, and SMCI) compared to healthy controls (p < 0.01, p < 0.05, and p < 0.05, respectively). In the total study population (n = 70), CSF IL-12/23 p40 concentrations correlated positively with CSF concentrations of β-amyloid1-42 (Aβ1-42) and phosphorylated tau protein (P-tau) whereas in AD patients (n = 30), CSF IL-12/23 p40 only correlated positively with CSF P-Tau (r = 0.46, p = 0.01).Most cytokines and chemokines were similar in patients and controls, but CSF IL-12/23 subunit p40 concentration was decreased in patients with cognitive impairment, and correlated with markers of AD disease status. Further studies are needed to evaluate the role of CSF IL-12/23 p40 in other dementias and SMCI. |
| Audience | Academic |
| Author | Johansson, Jan-Ove Andreasson, Ulf Svensson, Johan Blennow, Kaj Zetterberg, Henrik Almqvist, Erik G. Johansson, Per Wallin, Anders |
| AuthorAffiliation | 1 Department of Neuropsychiatry, Skaraborg Central Hospital, Falköping, Sweden Nathan S Kline Institute, UNITED STATES 2 Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden 3 Department of Endocrinology, Skaraborg Central Hospital, Skövde, Sweden 5 UCL Institute of Neurology, Queen Square, London, United Kingdom 4 Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden |
| AuthorAffiliation_xml | – name: 1 Department of Neuropsychiatry, Skaraborg Central Hospital, Falköping, Sweden – name: Nathan S Kline Institute, UNITED STATES – name: 2 Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden – name: 4 Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden – name: 5 UCL Institute of Neurology, Queen Square, London, United Kingdom – name: 3 Department of Endocrinology, Skaraborg Central Hospital, Skövde, Sweden |
| Author_xml | – sequence: 1 givenname: Per surname: Johansson fullname: Johansson, Per – sequence: 2 givenname: Erik G. surname: Almqvist fullname: Almqvist, Erik G. – sequence: 3 givenname: Anders surname: Wallin fullname: Wallin, Anders – sequence: 4 givenname: Jan-Ove surname: Johansson fullname: Johansson, Jan-Ove – sequence: 5 givenname: Ulf surname: Andreasson fullname: Andreasson, Ulf – sequence: 6 givenname: Kaj surname: Blennow fullname: Blennow, Kaj – sequence: 7 givenname: Henrik surname: Zetterberg fullname: Zetterberg, Henrik – sequence: 8 givenname: Johan orcidid: 0000-0002-4487-6405 surname: Svensson fullname: Svensson, Johan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28464009$$D View this record in MEDLINE/PubMed https://gup.ub.gu.se/publication/253387$$DView record from Swedish Publication Index |
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| Cites_doi | 10.1177/1533317514542644 10.1016/j.jns.2006.05.063 10.1007/BF02815140 10.1016/j.jalz.2016.02.010 10.1212/01.wnl.0000311269.57716.63 10.3233/JAD-2011-101878 10.1038/nri1001 10.1093/gerona/gls187 10.1001/archneur.63.4.538 10.1523/JNEUROSCI.4361-12.2013 10.1016/S0197-0186(99)00031-5 10.1096/fj.09-141754 10.1017/S1041610211000810 10.1159/000089137 10.1016/S0304-3940(00)01036-3 10.1016/S0197-4580(01)00285-8 10.1016/j.imlet.2007.09.002 10.1016/j.jneuroim.2014.03.013 10.1007/s11910-015-0531-7 10.1016/j.neulet.2013.06.031 10.1016/S0165-5728(00)00285-X 10.1212/WNL.34.7.939 10.1186/1471-2318-5-2 10.1007/s10072-006-0562-6 10.1038/nm.2965 10.1016/j.neulet.2005.03.051 10.1002/eji.200737772 10.1007/s00415-008-0737-6 10.1159/000329568 10.1212/WNL.43.2.250 10.1177/1533317512467680 10.1016/j.jneuroim.2014.06.026 10.1159/000161560 10.3109/13506120009146438 10.1159/000322092 10.1523/JNEUROSCI.23-20-07504.2003 10.1016/j.jneuroim.2013.01.002 10.1111/j.1468-1331.2006.01637.x 10.1016/j.biopsych.2010.06.012 10.1016/j.cytogfr.2014.07.017 10.1021/acschemneuro.5b00265 10.1371/journal.pone.0062679 10.1371/journal.pone.0030525 10.3233/JAD-141506 10.1016/j.neurobiolaging.2015.10.021 10.1177/0891988706286226 10.1111/j.1365-2796.2004.01388.x 10.1186/1471-2377-11-51 10.3233/JAD-131148 10.1016/j.jneuroim.2007.10.020 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2017 Public Library of Science 2017 Johansson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2017 Johansson et al 2017 Johansson et al |
| Copyright_xml | – notice: COPYRIGHT 2017 Public Library of Science – notice: 2017 Johansson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2017 Johansson et al 2017 Johansson et al |
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| DOI | 10.1371/journal.pone.0176760 |
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| References | S Kim (ref31) 2011; 11 P Gupta (ref10) 2015; 30 Y Liu (ref47) 2014; 271 J Wang (ref11) 2015; 44 M Rentzos (ref50) 2006; 249 A Chen (ref14) 2016; 38 E Vanmechelen (ref25) 2000; 285 A Yip (ref8) 2005; 5 A Helmy (ref28) 2012; 9 G McKhann (ref18) 1984; 34 M Motta (ref34) 2007; 114 S Rasmuson (ref27) 2011; 23 G Román (ref19) 1993; 43 I Blasko (ref33) 2006; 21 C Dinarello (ref1) 2007; 37 D Galimberti (ref37) 2006; 63 E Tarkowski (ref36) 2002; 23 G Kovacs (ref16) 2008; 26 M Xia (ref43) 2000; 108 J Trollor (ref52) 2010; 30 R Zhang (ref42) 2013; 256 M Tan (ref6) 2014; 38 H Vanderstichele (ref23) 2000; 7 G Trinchieri (ref44) 2003; 3 M Folstein (ref22) 1975; 12 P Chakrabarty (ref3) 2010; 24 A Kalb (ref26) 2013; 8 M Alsadany (ref39) 2013; 28 W Swardfager (ref12) 2010; 68 J Vom Berg (ref5) 2012; 18 I Horvath (ref51) 2016; 7 T Erkinjuntti (ref20) 2000; 59 P Johansson (ref17) 2011; 24 D Galimberti (ref41) 2007; 14 L Huang (ref32) 2013; 550 J Jia (ref30) 2005; 383 X Zhu (ref46) 2014; 274 A Koyama (ref15) 2013; 68 V Calsolaro (ref2) 2016; 12 G Pasqualetti (ref13) 2015; 15 Q Yan (ref7) 2003; 23 R Petersen (ref21) 2004; 256 S Ghosh (ref4) 2013; 33 K Blennow (ref24) 1995; 26 D Galimberti (ref29) 2008; 255 K Westin (ref40) 2012; 7 M Rentzos (ref38) 2006; 19 A Croxford (ref45) 2014; 25 S Engelborghs (ref49) 1999; 34 E Rota (ref48) 2006; 27 S Vlad (ref9) 2008; 70 K Bonotis (ref35) 2008; 193 |
| References_xml | – volume: 30 start-page: 178 year: 2015 ident: ref10 article-title: Role of traditional nonsteroidal anti-inflammatory drugs in Alzheimer's disease: a meta-analysis of randomized clinical trials publication-title: Am J Alzheimers Dis Other Demen doi: 10.1177/1533317514542644 – volume: 249 start-page: 110 year: 2006 ident: ref50 article-title: Interleukin-12 is reduced in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia publication-title: J Neurol Sci doi: 10.1016/j.jns.2006.05.063 – volume: 26 start-page: 231 year: 1995 ident: ref24 article-title: Tau protein in cerebrospinal fluid: a biochemical marker for axonal degeneration in Alzheimer disease? publication-title: Mol Chem Neuropathol doi: 10.1007/BF02815140 – volume: 12 start-page: 719 year: 2016 ident: ref2 article-title: Neuroinflammation in Alzheimer's disease: Current evidence and future directions publication-title: Alzheimers Dement doi: 10.1016/j.jalz.2016.02.010 – volume: 70 start-page: 1672 year: 2008 ident: ref9 article-title: Protective effects of NSAIDs on the development of Alzheimer disease publication-title: Neurology doi: 10.1212/01.wnl.0000311269.57716.63 – volume: 24 start-page: 537 year: 2011 ident: ref17 article-title: Cerebrospinal fluid biomarkers for Alzheimer’s disease: diagnostic performance in a homogeneous mono-center population publication-title: J Alzheimers Dis doi: 10.3233/JAD-2011-101878 – volume: 3 start-page: 133 year: 2003 ident: ref44 article-title: Interleukin-12 and the regulation of innate resistance and adaptive immunity publication-title: Nat Rev Immunol doi: 10.1038/nri1001 – volume: 68 start-page: 433 year: 2013 ident: ref15 article-title: The role of peripheral inflammatory markers in dementia and Alzheimer's disease: a meta-analysis publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/gls187 – volume: 63 start-page: 538 year: 2006 ident: ref37 article-title: Intrathecal chemokine synthesis in mild cognitive impairment and Alzheimer disease publication-title: Arch Neurol doi: 10.1001/archneur.63.4.538 – volume: 33 start-page: 5053 year: 2013 ident: ref4 article-title: Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model publication-title: J Neurosci doi: 10.1523/JNEUROSCI.4361-12.2013 – volume: 34 start-page: 523 year: 1999 ident: ref49 article-title: Unchanged levels of interleukins, neopterin, interferon-gamma and tumor necrosis factor-alpha in cerebrospinal fluid of patients with dementia of the Alzheimer type publication-title: Neurochem Int doi: 10.1016/S0197-0186(99)00031-5 – volume: 24 start-page: 548 year: 2010 ident: ref3 article-title: Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition publication-title: FASEB J doi: 10.1096/fj.09-141754 – volume: 23 start-page: 1386 year: 2011 ident: ref27 article-title: Increased serum levels of dehydroepiandrosterone (DHEA) and interleukin-6 (IL-6) in women with mild to moderate Alzheimer's disease publication-title: Int Psychogeriatr doi: 10.1017/S1041610211000810 – volume: 21 start-page: 9 year: 2006 ident: ref33 article-title: Measurement of thirteen biological markers in CSF of patients with Alzheimer's disease and other dementias publication-title: Dement Geriatr Cogn Disord doi: 10.1159/000089137 – volume: 285 start-page: 49 year: 2000 ident: ref25 article-title: Quantification of tau phosphorylated at threonine 181 in human cerebrospinal fluid: a sandwich ELISA with a synthetic phosphopeptide for standardization publication-title: Neurosci Lett doi: 10.1016/S0304-3940(00)01036-3 – volume: 23 start-page: 237 year: 2002 ident: ref36 article-title: Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia publication-title: Neurobiol Aging doi: 10.1016/S0197-4580(01)00285-8 – volume: 114 start-page: 46 year: 2007 ident: ref34 article-title: Altered plasma cytokine levels in Alzheimer's disease: correlation with the disease progression publication-title: Immunol Lett doi: 10.1016/j.imlet.2007.09.002 – volume: 271 start-page: 43 year: 2014 ident: ref47 article-title: Interleukin-23 receptor polymorphisms are associated with Alzheimer's disease in Han Chinese publication-title: J Neuroimmunol doi: 10.1016/j.jneuroim.2014.03.013 – volume: 15 start-page: 17 year: 2015 ident: ref13 article-title: The role of neuroinflammation in dementias publication-title: Curr Neurol Neurosci Rep doi: 10.1007/s11910-015-0531-7 – volume: 550 start-page: 60 year: 2013 ident: ref32 article-title: Decreased serum levels of the angiogenic factors VEGF and TGF-β1 in Alzheimer's disease and amnestic mild cognitive impairment publication-title: Neurosci Lett doi: 10.1016/j.neulet.2013.06.031 – volume: 108 start-page: 227 year: 2000 ident: ref43 article-title: Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer's disease publication-title: J Neuroimmunol doi: 10.1016/S0165-5728(00)00285-X – volume: 34 start-page: 939 year: 1984 ident: ref18 article-title: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease publication-title: Neurology doi: 10.1212/WNL.34.7.939 – volume: 5 start-page: 2 year: 2005 ident: ref8 article-title: Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study publication-title: BMC Geriatr doi: 10.1186/1471-2318-5-2 – volume: 27 start-page: 33 year: 2006 ident: ref48 article-title: Increased intrathecal TGF-beta1, but not IL-12, IFN-gamma and IL-10 levels in Alzheimer's disease patients publication-title: Neurol Sci doi: 10.1007/s10072-006-0562-6 – volume: 12 start-page: 189 year: 1975 ident: ref22 article-title: "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician publication-title: J Psychiatr Res – volume: 59 start-page: 23 year: 2000 ident: ref20 article-title: Research criteria for subcortical vascular dementia in clinical trials publication-title: Neural Transm Suppl – volume: 18 start-page: 1812 year: 2012 ident: ref5 article-title: Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline publication-title: Nat Med doi: 10.1038/nm.2965 – volume: 383 start-page: 12 year: 2005 ident: ref30 article-title: Cerebrospinal fluid tau, Abeta1-42 and inflammatory cytokines in patients with Alzheimer's disease and vascular dementia publication-title: Neurosci Lett doi: 10.1016/j.neulet.2005.03.051 – volume: 37 start-page: S34 issue: Suppl 1 year: 2007 ident: ref1 article-title: Historical insights into cytokines publication-title: Eur J Immunol doi: 10.1002/eji.200737772 – volume: 255 start-page: 539 year: 2008 ident: ref29 article-title: Intrathecal levels of IL-6, IL-11 and LIF in Alzheimer's disease and frontotemporal lobar degeneration publication-title: J Neurol doi: 10.1007/s00415-008-0737-6 – volume: 9 start-page: 81 year: 2012 ident: ref28 article-title: Role of interleukin 6 and alpha-globulins in differentiating Alzheimer and vascular dementias publication-title: Neurodegener Dis doi: 10.1159/000329568 – volume: 43 start-page: 250 year: 1993 ident: ref19 article-title: Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop publication-title: Neurology doi: 10.1212/WNL.43.2.250 – volume: 28 start-page: 54 year: 2013 ident: ref39 article-title: Histone deacetylases enzyme, copper, and IL-8 levels in patients with Alzheimer's disease publication-title: Am J Alzheimers Dis Other Demen doi: 10.1177/1533317512467680 – volume: 274 start-page: 180 year: 2014 ident: ref46 article-title: Association of IL-12A and IL-12B polymorphisms with Alzheimer's disease susceptibility in a Han Chinese population publication-title: J Neuroimmunol doi: 10.1016/j.jneuroim.2014.06.026 – volume: 26 start-page: 343 year: 2008 ident: ref16 article-title: Mixed brain pathologies in dementia: the BrainNet Europe consortium experience publication-title: Dement Geriatr Cogn Disord doi: 10.1159/000161560 – volume: 7 start-page: 245 year: 2000 ident: ref23 article-title: Standardization of measurement of beta-amyloid(1–42) in cerebrospinal fluid and plasma publication-title: Amyloid doi: 10.3109/13506120009146438 – volume: 30 start-page: 569 year: 2010 ident: ref52 article-title: Systemic inflammation is associated with MCI and its subtypes: the Sydney Memory and Aging Study publication-title: Dement Geriatr Cogn Disord doi: 10.1159/000322092 – volume: 23 start-page: 7504 year: 2003 ident: ref7 article-title: Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease publication-title: J Neurosci doi: 10.1523/JNEUROSCI.23-20-07504.2003 – volume: 256 start-page: 38 year: 2013 ident: ref42 article-title: Systemic immune system alterations in early stages of Alzheimer's disease publication-title: J Neuroimmunol doi: 10.1016/j.jneuroim.2013.01.002 – volume: 14 start-page: e3 year: 2007 ident: ref41 article-title: IP-10 serum levels are not increased in mild cognitive impairment and Alzheimer's disease publication-title: Eur J Neurol doi: 10.1111/j.1468-1331.2006.01637.x – volume: 68 start-page: 930 year: 2010 ident: ref12 article-title: A meta-analysis of cytokines in Alzheimer's disease publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2010.06.012 – volume: 25 start-page: 415 year: 2014 ident: ref45 article-title: IL-12-and IL-23 in health and disease publication-title: Cytokine Growth Factor Rev doi: 10.1016/j.cytogfr.2014.07.017 – volume: 7 start-page: 34 year: 2016 ident: ref51 article-title: Pro-inflammatory S100A9 protein as a robust biomarker differentiating early stages of cognitive impairment in Alzheimer's disease publication-title: ACS Chem Neurosci doi: 10.1021/acschemneuro.5b00265 – volume: 8 start-page: e62679 year: 2013 ident: ref26 article-title: Acetylcholinesterase inhibitors reduce neuroinflammation and -degeneration in the cortex and hippocampus of a surgery stress rat model publication-title: PloS One doi: 10.1371/journal.pone.0062679 – volume: 7 start-page: e30525 year: 2012 ident: ref40 article-title: CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer's disease publication-title: PloS One doi: 10.1371/journal.pone.0030525 – volume: 44 start-page: 385 year: 2015 ident: ref11 article-title: Anti-inflammatory drugs and risk of Alzheimer's disease: an updated systematic review and meta-analysis publication-title: J Alzheimers Dis doi: 10.3233/JAD-141506 – volume: 38 start-page: 56 year: 2016 ident: ref14 article-title: Multiplex analyte assays to characterize different dementias: brain inflammatory cytokines in poststroke and other dementias publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2015.10.021 – volume: 19 start-page: 114 year: 2006 ident: ref38 article-title: IL-15 is elevated in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia publication-title: J Geriatr Psychiatry Neurol doi: 10.1177/0891988706286226 – volume: 256 start-page: 183 year: 2004 ident: ref21 article-title: Mild cognitive impairment as a diagnostic entity publication-title: J Intern Med doi: 10.1111/j.1365-2796.2004.01388.x – volume: 11 start-page: 51 year: 2011 ident: ref31 article-title: Identification of peripheral inflammatory markers between normal control and Alzheimer's disease publication-title: BMC Neurol doi: 10.1186/1471-2377-11-51 – volume: 38 start-page: 633 year: 2014 ident: ref6 article-title: IL12/23 p40 inhibition ameliorates Alzheimer's disease-associated neuropathology and spatial memory in SAMP8 mice publication-title: J Alzheimers Dis doi: 10.3233/JAD-131148 – volume: 193 start-page: 183 year: 2008 ident: ref35 article-title: Systemic immune aberrations in Alzheimer's disease patients publication-title: J Neuroimmunol doi: 10.1016/j.jneuroim.2007.10.020 |
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| Snippet | The role of inflammation in Alzheimer's disease (AD) and other cognitive disorders is unclear. In a well-defined mono-center population, we measured cytokines... Background The role of inflammation in Alzheimer's disease (AD) and other cognitive disorders is unclear. In a well-defined mono-center population, we measured... Background The role of inflammation in Alzheimer’s disease (AD) and other cognitive disorders is unclear. In a well-defined mono-center population, we measured... BackgroundThe role of inflammation in Alzheimer's disease (AD) and other cognitive disorders is unclear. In a well-defined mono-center population, we measured... Background The role of inflammation in Alzheimer’s disease (AD) and other cognitive disorders is unclear. In a well-defined mono-center population, we measured... |
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| SubjectTerms | Abuse Activation Activation analysis Advertisements Aged Aged, 80 and over Aging Aging (artificial) Alcohols Alzheimer Disease - blood Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - immunology Alzheimer Inflammation Cognitive impairment Cerebrospinal fluid Interleukin Cytokine Chemokin Steroid homone Alzheimer's disease Amyloid beta-Peptides - cerebrospinal fluid Analysis Animal models Annan klinisk medicin Annan medicin och hälsovetenskap Anti-inflammatory agents Arches Astrocytes Attitude control Autocrine signalling Biology and Life Sciences Biomarkers Biomarkers - blood Biomarkers - cerebrospinal fluid Blood Blood circulation Body mass Body Mass Index Brain Cerebrospinal fluid Chemokines Cholinesterase Cholinesterase inhibitors Clinical Medicine Cognitive ability Cognitive disorders Cognitive Dysfunction - blood Cognitive Dysfunction - cerebrospinal fluid Cognitive Dysfunction - immunology Cohort Studies Cytokines Dementia Dementia disorders Diabetes mellitus Drug abuse Drugs Dura mater Endocrinology Evaluation Family physicians Female Glucocorticoids Growth factors Health aspects Hip Hospitals Humans Immune system Inactivation Inflammation Inhibitors Interferon Interleukin 1 Interleukin 6 Interleukin-12 Subunit p40 - blood Interleukin-12 Subunit p40 - cerebrospinal fluid Klinisk medicin Male Markers Mathematical models Medicine Medicine and Health Sciences Mental disorders Mental Status Schedule Mice Microglia Migration Multiplexing Myocardial infarction Necrosis Nervous system Neurochemistry Neurodegenerative diseases Neurologi Neurology Neurons Neurosciences Nonsteroidal anti-inflammatory drugs Other Clinical Medicine Other Medical and Health Sciences Pathogenesis Peptide Fragments - cerebrospinal fluid Phosphorylation Physiology Proteins Psychiatry Psykiatri Risk Sweden tau Proteins - cerebrospinal fluid Tumor necrosis factor-TNF White People Womens health β-Amyloid |
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| Title | Reduced cerebrospinal fluid concentration of interleukin-12/23 subunit p40 in patients with cognitive impairment |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/28464009 https://www.proquest.com/docview/1894814510 https://www.proquest.com/docview/1894917657 https://pubmed.ncbi.nlm.nih.gov/PMC5413050 https://gup.ub.gu.se/publication/253387 https://doaj.org/article/109000ac268545538644c33fe230bba9 http://dx.doi.org/10.1371/journal.pone.0176760 |
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