Activation of Type III Interferon Genes by Pathogenic Bacteria in Infected Epithelial Cells and Mouse Placenta

• Published in: PloS one Vol. 7; no. 6; p. e39080
• Main Authors: Bierne, Hélène, Travier, Laetitia, Mahlakõiv, Tanel, Tailleux, Ludovic, Subtil, Agathe, Lebreton, Alice, Paliwal, Anupam, Gicquel, Brigitte, Staeheli, Peter, Lecuit, Marc, Cossart, Pascale
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.06.2012; Public Library of Science (PLoS)
• Subjects: Animals; Antigens; Bacteria; Bacteria - pathogenicity; Bacterial diseases; Bacterial genetics; Bacterial infections; Binding sites; Biological response modifiers; Biology; Cellular Biology; Cytokines; Epithelial cells; Epithelial Cells - microbiology; Female; Gastroenterology; Gene expression; Genes; Genetic research; Gram-negative bacteria; Gram-positive bacteria; Health aspects; Hepatocytes; Immune response; Immune system; Immunity; Infection; Infections; Innate immunity; Interferon; Interferons - genetics; Intestine; Intracellular; Kinases; Life Sciences; Ligands; Listeria; Listeria monocytogenes; Listeriosis; Lungs; Medicine; Mice; mRNA; Pathogens; Placenta; Placenta - microbiology; Pregnancy; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA; Rodents; Salmonella; Sexually transmitted diseases; Shigella; Staphylococcal infections; Staphylococcus aureus; STD; Tissues; Tuberculosis; Viral infections; Virology; Viruses; France

Bacterial infections trigger the expression of type I and II interferon genes but little is known about their effect on type III interferon (IFN-λ) genes, whose products play important roles in epithelial innate immunity against viruses. Here, we studied the expression of IFN-λ genes in cultured hum...